AP2329A - 2-Substituted phenyl-5, 7-dihydrocarbyl-3, 7-dihydropyrrolo [2,3-d] pyrimidin-4 - one derivatives, the preparation and the pharmaceutical use thereof. - Google Patents

2-Substituted phenyl-5, 7-dihydrocarbyl-3, 7-dihydropyrrolo [2,3-d] pyrimidin-4 - one derivatives, the preparation and the pharmaceutical use thereof.

Info

Publication number: AP2329A
Authority: AP; ARIPO
Prior art keywords: dihydropyrrolo; dihydrocarbyl; pyrimidin; derivatives; preparation
Prior art date: 2003-06-06

Application number

AP2006003481A

Other languages

English (en)

Other versions

AP2006003481A0 (en

Inventor

Yongfeng Wang

Kejun Zhao

Original Assignee

Yantze River Pharmaceutical Group Co Ltd

Tianjin North Pharma Sci Tech Co Tld

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2004-05-14

Publication date

2011-12-02

2004-05-14 Application filed by Yantze River Pharmaceutical Group Co Ltd, Tianjin North Pharma Sci Tech Co Tld filed Critical Yantze River Pharmaceutical Group Co Ltd

2006-02-28 Publication of AP2006003481A0 publication Critical patent/AP2006003481A0/xx

2011-12-02 Application granted granted Critical

2011-12-02 Publication of AP2329A publication Critical patent/AP2329A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Pregnancy & Childbirth (AREA)
Psychiatry (AREA)
Obesity (AREA)
Hematology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2006003481A 2003-06-06 2004-05-14 2-Substituted phenyl-5, 7-dihydrocarbyl-3, 7-dihydropyrrolo [2,3-d] pyrimidin-4 - one derivatives, the preparation and the pharmaceutical use thereof. AP2329A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CNB03142399XA CN100374441C (zh)	2003-06-06	2003-06-06	二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
PCT/CN2004/000487 WO2004108726A1 (en)	2003-06-06	2004-05-14	2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE [2,3-d] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF

Publications (2)

Publication Number	Publication Date
AP2006003481A0 AP2006003481A0 (en)	2006-02-28
AP2329A true AP2329A (en)	2011-12-02

Family

ID=33494609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003481A AP2329A (en)	2003-06-06	2004-05-14	2-Substituted phenyl-5, 7-dihydrocarbyl-3, 7-dihydropyrrolo [2,3-d] pyrimidin-4 - one derivatives, the preparation and the pharmaceutical use thereof.

Country Status (15)

Country	Link
US (3)	US7745433B2 (de)
EP (1)	EP1634883B1 (de)
JP (1)	JP4917428B2 (de)
KR (1)	KR101081446B1 (de)
CN (1)	CN100374441C (de)
AP (1)	AP2329A (de)
AT (1)	ATE491710T1 (de)
BR (1)	BRPI0411402A (de)
CA (1)	CA2528008C (de)
DE (1)	DE602004030564D1 (de)
IL (1)	IL172369A (de)
MX (1)	MXPA05013176A (de)
RU (1)	RU2323220C2 (de)
WO (1)	WO2004108726A1 (de)
ZA (1)	ZA200600107B (de)

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KR100792126B1 (ko)	2006-04-04	2008-01-04	동아제약주식회사	피라졸로피리미디논 화합물을 유효성분으로 함유하는전립선 비대증 예방 및 치료제
RU2418590C2 (ru) *	2006-04-04	2011-05-20	Донг-А Фарматех Ко. Лтд.	Средство для предупреждения и лечения гиперплазии предстательной железы, содержащее производное пиразолопиримидинона
CN101456862B (zh) *	2007-12-12	2012-10-24	上海特化医药科技有限公司	含有吡唑并嘧啶酮的苯基胍衍生物、其药物组合物及其制备方法和用途
CN101747282A (zh)	2008-12-10	2010-06-23	上海特化医药科技有限公司	一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
AR077898A1 (es) *	2009-08-26	2011-09-28	Nycomed Gmbh	Metilpirrolopirimidincarboxamidas
CN102329325B (zh) *	2010-07-07	2013-11-27	中国科学院广州生物医药与健康研究院	吡咯并嘧啶酮类dpp-iv抑制剂
CN102311447B (zh) *	2010-07-07	2013-11-27	中国科学院广州生物医药与健康研究院	杂环并嘧啶酮类dpp-iv抑制剂
WO2012118042A1 (ja) *	2011-02-28	2012-09-07	独立行政法人国立循環器病研究センター	悪性腫瘍転移抑制用医薬
HK1202112A1 (en) *	2012-06-07	2015-09-18	霍夫曼-拉罗奇有限公司	Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
CN104530054B (zh) *	2014-12-19	2018-01-19	扬子江药业集团有限公司	盐酸优克那非的多晶型物及其制备方法
CN106333953A (zh) *	2015-07-08	2017-01-18	珠海津之敦医药科技有限公司	尤克那非新用途
CA3060525A1 (en) *	2017-05-22	2018-11-29	Topadur Pharma Ag	Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
CN114437080A (zh) *	2020-11-02	2022-05-06	扬子江药业集团有限公司	优克那非氧化物及其制备方法和用途
CN112266349B (zh) *	2020-11-17	2022-02-15	上海凌凯医药科技有限公司	一种制备2-氨基-4-甲基-1-丙基-1h-吡咯-3-甲腈的方法
CN112961160A (zh) *	2021-03-05	2021-06-15	遂成药业股份有限公司	一种西地那非的改良合成工艺

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WO2002016364A1 (en)	2000-08-23	2002-02-28	Lg Life Sciences Ltd.	Polyethoxylated pyrazolo pyrimidinone derivatives, process for preparation thereof and pharmaceutical compositions comprising the same for the treatment of impotence
GB0106661D0 (en) *	2001-03-16	2001-05-09	Pfizer Ltd	Pharmaceutically active compounds
DE10163991A1 (de) *	2001-12-24	2003-07-03	Merck Patent Gmbh	Pyrrolo-pyrimidine

2003
- 2003-06-06 CN CNB03142399XA patent/CN100374441C/zh not_active Expired - Lifetime
2004
- 2004-05-14 BR BRPI0411402-7A patent/BRPI0411402A/pt not_active Application Discontinuation
- 2004-05-14 DE DE602004030564T patent/DE602004030564D1/de not_active Expired - Lifetime
- 2004-05-14 JP JP2006508096A patent/JP4917428B2/ja not_active Expired - Lifetime
- 2004-05-14 US US10/559,516 patent/US7745433B2/en not_active Expired - Lifetime
- 2004-05-14 EP EP04732925A patent/EP1634883B1/de not_active Expired - Lifetime
- 2004-05-14 AT AT04732925T patent/ATE491710T1/de not_active IP Right Cessation
- 2004-05-14 AP AP2006003481A patent/AP2329A/xx active
- 2004-05-14 MX MXPA05013176A patent/MXPA05013176A/es active IP Right Grant
- 2004-05-14 RU RU2005141447/04A patent/RU2323220C2/ru active
- 2004-05-14 CA CA2528008A patent/CA2528008C/en not_active Expired - Lifetime
- 2004-05-14 WO PCT/CN2004/000487 patent/WO2004108726A1/zh not_active Ceased
2005
- 2005-12-05 IL IL172369A patent/IL172369A/en not_active IP Right Cessation
- 2005-12-06 KR KR1020057023465A patent/KR101081446B1/ko not_active Expired - Lifetime
2006
- 2006-01-05 ZA ZA200600107A patent/ZA200600107B/en unknown
2008
- 2008-03-06 US US12/043,700 patent/US7741483B2/en not_active Expired - Lifetime
2010
- 2010-01-11 US US12/685,376 patent/US8461165B2/en not_active Expired - Fee Related

Non-Patent Citations (1)

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Title
EGER K. ET AL.: 'Synthesis of pyrrolo[2,3-d]pyrimidine ribosides and their potential in chemotherapeutics' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 27, no. 7, 1990, pages 2069 - 2075 *

Also Published As

Publication number	Publication date
EP1634883A1 (de)	2006-03-15
IL172369A (en)	2014-01-30
US20100204223A1 (en)	2010-08-12
EP1634883A4 (de)	2008-07-02
ATE491710T1 (de)	2011-01-15
BRPI0411402A (pt)	2006-10-31
US8461165B2 (en)	2013-06-11
RU2005141447A (ru)	2007-07-20
EP1634883B1 (de)	2010-12-15
CA2528008A1 (en)	2004-12-16
RU2323220C2 (ru)	2008-04-27
AP2006003481A0 (en)	2006-02-28
IL172369A0 (en)	2006-04-10
KR101081446B1 (ko)	2011-11-08
CN1552714A (zh)	2004-12-08
CN100374441C (zh)	2008-03-12
MXPA05013176A (es)	2006-06-23
JP4917428B2 (ja)	2012-04-18
JP2008500944A (ja)	2008-01-17
ZA200600107B (en)	2007-04-25
DE602004030564D1 (de)	2011-01-27
US7745433B2 (en)	2010-06-29
US20080167462A1 (en)	2008-07-10
US20060173025A1 (en)	2006-08-03
CA2528008C (en)	2010-02-16
US7741483B2 (en)	2010-06-22
WO2004108726A1 (en)	2004-12-16
KR20060036396A (ko)	2006-04-28

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IL191960A (en)	2015-11-30	History of imidazo [5,1– a] pyridine and pharmaceutical preparations containing them
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