AP240A - Synergistic therapeutic compositions of renin inhibitor and angiotensins and methods. - Google Patents

Synergistic therapeutic compositions of renin inhibitor and angiotensins and methods. Download PDF

Info

Publication number: AP240A
Authority: AP; ARIPO
Prior art keywords: amount; angiotensin; inhibitor; antagonist; pharmaceutical composition
Prior art date: 1990-05-11

Application number

APAP/P/1991/000258A

Other languages

English (en)

Other versions

AP9100258A0 (en

Inventor

Anthony Andrea Fossa

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1991-05-06

Publication date

1993-02-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24080550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP240(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-05-06 Application filed by Pfizer filed Critical Pfizer

1991-07-31 Publication of AP9100258A0 publication Critical patent/AP9100258A0/xx

1993-02-18 Application granted granted Critical

1993-02-18 Publication of AP240A publication Critical patent/AP240A/en

Links

239000000203 mixture Substances 0.000 title claims abstract description 41
238000000034 method Methods 0.000 title claims abstract description 36
239000002461 renin inhibitor Substances 0.000 title claims description 94
229940086526 renin-inhibitors Drugs 0.000 title claims description 94
230000001225 therapeutic effect Effects 0.000 title claims description 58
230000002195 synergetic effect Effects 0.000 title claims description 27
108010064733 Angiotensins Proteins 0.000 title claims 10
102000015427 Angiotensins Human genes 0.000 title claims 10
239000002416 angiotensin derivative Substances 0.000 title 1
239000005541 ACE inhibitor Substances 0.000 claims description 81
239000005557 antagonist Substances 0.000 claims description 73
241000124008 Mammalia Species 0.000 claims description 39
230000000694 effects Effects 0.000 claims description 34
239000008194 pharmaceutical composition Substances 0.000 claims description 31
229960000830 captopril Drugs 0.000 claims description 28
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical group SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 28
239000003112 inhibitor Substances 0.000 claims description 17
229940123413 Angiotensin II antagonist Drugs 0.000 claims description 15
239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 15
229940086440 Angiotensin I converting enzyme inhibitor Drugs 0.000 claims description 14
239000003814 drug Substances 0.000 claims description 14
239000003085 diluting agent Substances 0.000 claims description 13
229940124597 therapeutic agent Drugs 0.000 claims description 12
101800000734 Angiotensin-1 Proteins 0.000 claims description 9
102400000344 Angiotensin-1 Human genes 0.000 claims description 9
108010061435 Enalapril Proteins 0.000 claims description 7
229960000873 enalapril Drugs 0.000 claims description 7
GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims description 7
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
108010007859 Lisinopril Proteins 0.000 claims description 6
229960002394 lisinopril Drugs 0.000 claims description 6
RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims description 6
229960003401 ramipril Drugs 0.000 claims description 6
HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims description 6
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims description 3
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims description 3
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 claims description 3
UVZMNGNFERVGRC-UHFFFAOYSA-N 4-cyclohexylbutanoic acid Chemical compound OC(=O)CCCC1CCCCC1 UVZMNGNFERVGRC-UHFFFAOYSA-N 0.000 claims description 2
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230000001077 hypotensive effect Effects 0.000 description 3
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239000011734 sodium Substances 0.000 description 3
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239000003826 tablet Substances 0.000 description 2
WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 description 1
102000004881 Angiotensinogen Human genes 0.000 description 1
108090001067 Angiotensinogen Proteins 0.000 description 1
101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 description 1
244000025254 Cannabis sativa Species 0.000 description 1
241000700198 Cavia Species 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
244000182067 Fraxinus ornus Species 0.000 description 1
235000002917 Fraxinus ornus Nutrition 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
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BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
244000000231 Sesamum indicum Species 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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244000061456 Solanum tuberosum Species 0.000 description 1
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
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239000000783 alginic acid Substances 0.000 description 1
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150000004781 alginic acids Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
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235000019445 benzyl alcohol Nutrition 0.000 description 1
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210000001715 carotid artery Anatomy 0.000 description 1
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235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000011597 hartley guinea pig Methods 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
230000010354 integration Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000004731 jugular vein Anatomy 0.000 description 1
229960003299 ketamine Drugs 0.000 description 1
VCMGMSHEPQENPE-UHFFFAOYSA-N ketamine hydrochloride Chemical compound [Cl-].C=1C=CC=C(Cl)C=1C1([NH2+]C)CCCCC1=O VCMGMSHEPQENPE-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229940063711 lasix Drugs 0.000 description 1
239000006210 lotion Substances 0.000 description 1
235000014659 low sodium diet Nutrition 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
239000008203 oral pharmaceutical composition Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000003961 penetration enhancing agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
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235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052573 porcelain Inorganic materials 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

APAP/P/1991/000258A 1990-05-11 1991-05-06 Synergistic therapeutic compositions of renin inhibitor and angiotensins and methods. AP240A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52236090A	1990-05-11	1990-05-11

Publications (2)

Publication Number	Publication Date
AP9100258A0 AP9100258A0 (en)	1991-07-31
AP240A true AP240A (en)	1993-02-18

Family

ID=24080550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1991/000258A AP240A (en)	1990-05-11	1991-05-06	Synergistic therapeutic compositions of renin inhibitor and angiotensins and methods.

Country Status (33)

Country	Link
US (2)	US6900234B1 (is)
EP (1)	EP0527879B1 (is)
JP (2)	JPH0729938B2 (is)
KR (1)	KR970005839B1 (is)
CN (7)	CN1879884A (is)
AP (1)	AP240A (is)
AT (1)	ATE148632T1 (is)
AU (1)	AU653724B2 (is)
BG (1)	BG61831B1 (is)
BR (1)	BR9106438A (is)
CA (1)	CA2081564C (is)
DE (1)	DE69124598T2 (is)
DK (1)	DK0527879T3 (is)
EG (1)	EG19648A (is)
ES (1)	ES2097208T3 (is)
GR (1)	GR3022997T3 (is)
GT (1)	GT199100032A (is)
HU (1)	HU227346B1 (is)
IE (1)	IE911592A1 (is)
IL (1)	IL98055A (is)
IS (1)	IS2042B (is)
MA (1)	MA22150A1 (is)
MY (1)	MY114347A (is)
NO (1)	NO924321L (is)
NZ (1)	NZ238118A (is)
PE (1)	PE30891A1 (is)
PT (1)	PT97615B (is)
RO (1)	RO115786B1 (is)
RU (1)	RU2147875C1 (is)
TW (1)	TW203553B (is)
WO (1)	WO1991017771A1 (is)
YU (1)	YU49094B (is)
ZA (1)	ZA913539B (is)

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1991
- 1991-04-22 HU HU9203522A patent/HU227346B1/hu unknown
- 1991-04-22 ES ES91909382T patent/ES2097208T3/es not_active Expired - Lifetime
- 1991-04-22 CA CA002081564A patent/CA2081564C/en not_active Expired - Lifetime
- 1991-04-22 WO PCT/US1991/002733 patent/WO1991017771A1/en not_active Ceased
- 1991-04-22 BR BR919106438A patent/BR9106438A/pt not_active Application Discontinuation
- 1991-04-22 RU RU92016534A patent/RU2147875C1/ru active
- 1991-04-22 DK DK91909382.3T patent/DK0527879T3/da active
- 1991-04-22 EP EP91909382A patent/EP0527879B1/en not_active Expired - Lifetime
- 1991-04-22 KR KR1019920702805A patent/KR970005839B1/ko not_active Expired - Lifetime
- 1991-04-22 JP JP3508991A patent/JPH0729938B2/ja not_active Expired - Lifetime
- 1991-04-22 DE DE69124598T patent/DE69124598T2/de not_active Expired - Lifetime
- 1991-04-22 AU AU78591/91A patent/AU653724B2/en not_active Expired
- 1991-04-22 RO RO92-01405A patent/RO115786B1/ro unknown
- 1991-04-22 AT AT91909382T patent/ATE148632T1/de not_active IP Right Cessation
- 1991-05-01 TW TW080103439A patent/TW203553B/zh not_active IP Right Cessation
- 1991-05-03 IL IL9805591A patent/IL98055A/en not_active IP Right Cessation
- 1991-05-06 AP APAP/P/1991/000258A patent/AP240A/en active
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- 1991-05-10 CN CNA2007101867127A patent/CN101156949A/zh active Pending
- 1991-05-10 IE IE159291A patent/IE911592A1/en not_active IP Right Cessation
- 1991-05-10 YU YU81991A patent/YU49094B/sh unknown
- 1991-05-10 CN CNA2006101018493A patent/CN1915428A/zh active Pending
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1992
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- 1992-11-10 NO NO92924321A patent/NO924321L/no unknown
1994
- 1994-06-27 JP JP6144998A patent/JP2635291B2/ja not_active Expired - Lifetime
1995
- 1995-06-05 US US08/463,878 patent/US6900234B1/en not_active Expired - Lifetime
- 1995-06-05 US US08/465,660 patent/US6716875B1/en not_active Expired - Lifetime
1997
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2000
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Also Published As

Publication number	Publication date
MY114347A (en)	2002-10-31
BG97068A (bg)	1993-12-24
GT199100032A (es)	1992-10-31
ATE148632T1 (de)	1997-02-15
YU49094B (sh)	2003-12-31
GR3022997T3 (en)	1997-07-30
CN1065140C (zh)	2001-05-02
IL98055A (en)	1996-10-31
DK0527879T3 (da)	1997-07-14
US6716875B1 (en)	2004-04-06
HU227346B1 (en)	2011-04-28
AU653724B2 (en)	1994-10-13
IL98055A0 (en)	1992-06-21
HU9203522D0 (en)	1993-01-28
BG61831B1 (bg)	1998-07-31
CN1307901A (zh)	2001-08-15
JPH0748280A (ja)	1995-02-21
JP2635291B2 (ja)	1997-07-30
IS2042B (is)	2005-09-15
BR9106438A (pt)	1993-05-18
DE69124598T2 (de)	1997-05-28
HUT62804A (en)	1993-06-28
IS3703A7 (is)	1991-11-12
JPH05505618A (ja)	1993-08-19
CN100358578C (zh)	2008-01-02
HK1094148A1 (en)	2007-03-23
ZA913539B (en)	1992-12-30
MA22150A1 (fr)	1991-12-31
AU7859191A (en)	1991-12-10
CA2081564C (en)	1998-02-03
CN1824315A (zh)	2006-08-30
CN1824315B (zh)	2011-01-12
CN101156949A (zh)	2008-04-09
CN1056426A (zh)	1991-11-27
CN1915428A (zh)	2007-02-21
CA2081564A1 (en)	1991-11-12
ES2097208T3 (es)	1997-04-01
NO924321L (no)	1993-01-08
NO924321D0 (no)	1992-11-10
PT97615B (pt)	1998-08-31
US6900234B1 (en)	2005-05-31
TW203553B (is)	1993-04-11
CN1879884A (zh)	2006-12-20
NZ238118A (en)	1997-06-24
DE69124598D1 (de)	1997-03-20
EP0527879B1 (en)	1997-02-05
PT97615A (pt)	1992-03-31
EG19648A (en)	1995-09-30
RO115786B1 (ro)	2000-06-30
CN1502370A (zh)	2004-06-09
YU81991A (sh)	1994-06-24
AP9100258A0 (en)	1991-07-31
PE30891A1 (es)	1991-11-27
JPH0729938B2 (ja)	1995-04-05
WO1991017771A1 (en)	1991-11-28
KR970005839B1 (ko)	1997-04-21
EP0527879A1 (en)	1993-02-24
IE911592A1 (en)	1991-11-20
RU2147875C1 (ru)	2000-04-27

Publication	Publication Date	Title
AP240A (en)	1993-02-18	Synergistic therapeutic compositions of renin inhibitor and angiotensins and methods.
US5821232A (en)	1998-10-13	Synergistic therapeutic compositions and methods
US20120053222A1 (en)	2012-03-01	Novel Metabolic Disease Therapy
EP0498361A2 (en)	1992-08-12	Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor
Feuerstein et al.	1999	An inhibitory anti-factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis
SK14962001A3 (sk)	2002-06-04	Farmaceutický prípravok obsahujúci inhibítor trombínu s nízkou molekulovou hmotnosťou a jeho prekurzor
Karagiannis et al.	2010	The effect of antihypertensive agents on insulin sensitivity, lipids and haemostasis
KR20010099628A (ko)	2001-11-09	복합 장기장애에 대한 예방 및 치료제
CZ292946B6 (cs)	2004-01-14	Farmaceutický prostředek pro snížení krevního tlaku a léčení městnavého srdečního selhání a použití
HK1094148B (en)	2011-09-09	Synergistic therapeutic compositions and methods
HK1115536A (en)	2008-12-05	A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug