NO924321L - Synergistiske terapeutiske blandinger og fremgangsmaater - Google Patents

Synergistiske terapeutiske blandinger og fremgangsmaater

Info

Publication number: NO924321L
Authority: NO; Norway
Prior art keywords: mammal; synergistic; angiotensin; blood pressure; heart failure
Prior art date: 1990-05-11

Application number

NO92924321A

Other languages

English (en)

Norwegian (no)

Other versions

NO924321D0 (no

Inventor

Anthony Andrea Fossa

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1992-11-10

Publication date

1993-01-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24080550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO924321(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-11-10 Application filed by Pfizer filed Critical Pfizer

1992-11-10 Publication of NO924321D0 publication Critical patent/NO924321D0/no

1993-01-08 Publication of NO924321L publication Critical patent/NO924321L/no

Links

230000002195 synergetic effect Effects 0.000 title abstract 5
230000001225 therapeutic effect Effects 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 3
241000124008 Mammalia Species 0.000 abstract 4
206010019280 Heart failures Diseases 0.000 abstract 3
230000036772 blood pressure Effects 0.000 abstract 3
229940123413 Angiotensin II antagonist Drugs 0.000 abstract 2
239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
239000002532 enzyme inhibitor Substances 0.000 abstract 2
229940125532 enzyme inhibitor Drugs 0.000 abstract 2
239000002461 renin inhibitor Substances 0.000 abstract 2
229940086526 renin-inhibitors Drugs 0.000 abstract 2
235000013547 stew Nutrition 0.000 abstract 2
229940124597 therapeutic agent Drugs 0.000 abstract 2
101800000734 Angiotensin-1 Proteins 0.000 abstract 1
102400000344 Angiotensin-1 Human genes 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO92924321A 1990-05-11 1992-11-10 Synergistiske terapeutiske blandinger og fremgangsmaater NO924321L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52236090A	1990-05-11	1990-05-11
PCT/US1991/002733 WO1991017771A1 (en)	1990-05-11	1991-04-22	Synergistic therapeutic compositions and methods

Publications (2)

Publication Number	Publication Date
NO924321D0 NO924321D0 (no)	1992-11-10
NO924321L true NO924321L (no)	1993-01-08

Family

ID=24080550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO92924321A NO924321L (no)	1990-05-11	1992-11-10	Synergistiske terapeutiske blandinger og fremgangsmaater

Country Status (33)

Country	Link
US (2)	US6900234B1 (is)
EP (1)	EP0527879B1 (is)
JP (2)	JPH0729938B2 (is)
KR (1)	KR970005839B1 (is)
CN (7)	CN1915428A (is)
AP (1)	AP240A (is)
AT (1)	ATE148632T1 (is)
AU (1)	AU653724B2 (is)
BG (1)	BG61831B1 (is)
BR (1)	BR9106438A (is)
CA (1)	CA2081564C (is)
DE (1)	DE69124598T2 (is)
DK (1)	DK0527879T3 (is)
EG (1)	EG19648A (is)
ES (1)	ES2097208T3 (is)
GR (1)	GR3022997T3 (is)
GT (1)	GT199100032A (is)
HU (1)	HU227346B1 (is)
IE (1)	IE911592A1 (is)
IL (1)	IL98055A (is)
IS (1)	IS2042B (is)
MA (1)	MA22150A1 (is)
MY (1)	MY114347A (is)
NO (1)	NO924321L (is)
NZ (1)	NZ238118A (is)
PE (1)	PE30891A1 (is)
PT (1)	PT97615B (is)
RO (1)	RO115786B1 (is)
RU (1)	RU2147875C1 (is)
TW (1)	TW203553B (is)
WO (1)	WO1991017771A1 (is)
YU (1)	YU49094B (is)
ZA (1)	ZA913539B (is)

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RU2147875C1 (ru) *	1990-05-11	2000-04-27	Пфайзер Инк.	Способ и композиция для снижения кровяного давления и лечения застойной сердечной недостаточности у млекопитающего
EP0629408A1 (en) *	1993-06-16	1994-12-21	LABORATOIRES MERCK, SHARP & DOHME-CHIBRET	Combination of angiotensin converting enzyme inhibitors and AII antagonists
DE4340437C1 (de) *	1993-11-27	1995-05-24	Karla Dr Lehmann	Verwendung von Lithiumverbindungen zur Behandlung von Herzinsuffizienz einschließlich ihrer Folgeerkrankungen
WO1996031234A1 (en) *	1995-04-07	1996-10-10	Novartis Ag	Combination compositions containing benazepril or benazeprilat and valsartan
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US6107323A (en)	1996-04-05	2000-08-22	Takeda Chemical Industries, Ltd.	Pharmaceutical composition
ATE216881T1 (de) *	1996-06-24	2002-05-15	Merck & Co Inc	Zusammensetzung auf basis von enalapril und losartan
US6087386A (en) *	1996-06-24	2000-07-11	Merck & Co., Inc.	Composition of enalapril and losartan
AU9509798A (en) *	1997-09-25	1999-04-12	University Of Florida	Antisense oligonucleotide compositions targeted to angiotensi n converting enzy me mrna and methods of use
KR20010033473A (ko) *	1997-12-23	2001-04-25	로즈 암스트롱, 크리스틴 에이. 트러트웨인	Ａｃｅ 저해제-ｍｍｐ 저해제의 병용 제제
US6087343A (en) *	1998-09-14	2000-07-11	University Of Florida	Antisense oligonucleotides targeted to β-1 adrenoceptor and methods of use
US6387894B1 (en) *	1999-06-11	2002-05-14	Pfizer Inc.	Use of CRF antagonists and renin-angiotensin system inhibitors
US8168616B1 (en) *	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
WO2004002549A1 (en) *	2002-06-28	2004-01-08	Novartis Ag	Use of organic compounds
HRP20150037T4 (hr)	2003-04-08	2022-09-02	Progenics Pharmaceuticals, Inc.	Farmaceutske formulacije koje sadrže metilnaltrekson
US20040265238A1 (en) *	2003-06-27	2004-12-30	Imtiaz Chaudry	Inhalable formulations for treating pulmonary hypertension and methods of using same
EP2248520A3 (en) *	2004-10-08	2010-11-17	Novartis AG	Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
CN101171010B (zh) *	2005-03-07	2014-09-17	芝加哥大学	阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8518962B2 (en)	2005-03-07	2013-08-27	The University Of Chicago	Use of opioid antagonists
US9662325B2 (en)	2005-03-07	2017-05-30	The University Of Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8524731B2 (en)	2005-03-07	2013-09-03	The University Of Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057035A1 (es)	2005-05-25	2007-11-14	Progenics Pharm Inc	SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es)	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh)	2006-08-04	2015-07-01	Wyeth Corp	用於非經腸道傳輸化合物之配方及其用途
TW200817048A (en) *	2006-09-08	2008-04-16	Wyeth Corp	Dry powder compound formulations and uses thereof
CL2007002689A1 (es)	2006-09-18	2008-04-18	Vitae Pharmaceuticals Inc	Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
CA2682129A1 (en)	2007-03-29	2008-10-09	Progenics Pharmaceuticals, Inc.	Crystal forms and uses thereof
US8546418B2 (en)	2007-03-29	2013-10-01	Progenics Pharmaceuticals, Inc.	Peripheral opioid receptor antagonists and uses thereof
PT2139890E (pt)	2007-03-29	2014-09-03	Wyeth Llc	Antagonistas do receptor opióide periférico e respectivas utilizações
EP2240489A1 (en)	2008-02-06	2010-10-20	Progenics Pharmaceuticals, Inc.	Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2278966B1 (en)	2008-03-21	2019-10-09	The University of Chicago	Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en)	2008-09-30	2017-04-25	Wyeth	Peripheral opioid receptor antagonists and uses thereof
AR077692A1 (es)	2009-08-06	2011-09-14	Vitae Pharmaceuticals Inc	Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
CN102423483A (zh) *	2011-11-24	2012-04-25	西北农林科技大学	一种复方雷米普利纳米乳抗高血压药物
CN114032273B (zh) *	2021-11-17	2024-02-02	山东省科学院生物研究所	一种多功能西洋参水解肽及其制备方法和应用

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IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4749688A (en)	1986-06-20	1988-06-07	Schering Corporation	Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1334092C (en)	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
DE3633861A1 (de) *	1986-10-04	1988-04-07	Thomae Gmbh Dr K	Neue imidazo-benzoxazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
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US4895834A (en) *	1986-12-15	1990-01-23	Warner-Lambert Company	Renin inhibitors III
WO1988005432A1 (fr) *	1987-01-23	1988-07-28	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de 5-hydroxyindole-3-carboxamide et son usage en medecine
US4962105A (en)	1987-10-19	1990-10-09	Ciba-Geigy Corporation	Potentiation of antihypertensive effect of ace inhibitors
US5015651A (en)	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
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CA1338238C (en)	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
IL91780A (en)	1988-10-04	1995-08-31	Abbott Lab	History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
RU2147875C1 (ru) *	1990-05-11	2000-04-27	Пфайзер Инк.	Способ и композиция для снижения кровяного давления и лечения застойной сердечной недостаточности у млекопитающего

1991
- 1991-04-22 RU RU92016534A patent/RU2147875C1/ru active
- 1991-04-22 AT AT91909382T patent/ATE148632T1/de not_active IP Right Cessation
- 1991-04-22 WO PCT/US1991/002733 patent/WO1991017771A1/en not_active Ceased
- 1991-04-22 AU AU78591/91A patent/AU653724B2/en not_active Expired
- 1991-04-22 ES ES91909382T patent/ES2097208T3/es not_active Expired - Lifetime
- 1991-04-22 DK DK91909382.3T patent/DK0527879T3/da active
- 1991-04-22 RO RO92-01405A patent/RO115786B1/ro unknown
- 1991-04-22 CA CA002081564A patent/CA2081564C/en not_active Expired - Lifetime
- 1991-04-22 BR BR919106438A patent/BR9106438A/pt not_active Application Discontinuation
- 1991-04-22 DE DE69124598T patent/DE69124598T2/de not_active Expired - Lifetime
- 1991-04-22 EP EP91909382A patent/EP0527879B1/en not_active Expired - Lifetime
- 1991-04-22 HU HU9203522A patent/HU227346B1/hu unknown
- 1991-04-22 JP JP3508991A patent/JPH0729938B2/ja not_active Expired - Lifetime
- 1991-04-22 KR KR1019920702805A patent/KR970005839B1/ko not_active Expired - Lifetime
- 1991-05-01 TW TW080103439A patent/TW203553B/zh not_active IP Right Cessation
- 1991-05-03 IL IL9805591A patent/IL98055A/en not_active IP Right Cessation
- 1991-05-06 AP APAP/P/1991/000258A patent/AP240A/en active
- 1991-05-08 EG EG27891A patent/EG19648A/xx active
- 1991-05-08 MA MA22420A patent/MA22150A1/fr unknown
- 1991-05-09 PT PT97615A patent/PT97615B/pt not_active IP Right Cessation
- 1991-05-10 IS IS3703A patent/IS2042B/is unknown
- 1991-05-10 GT GT199100032A patent/GT199100032A/es unknown
- 1991-05-10 IE IE159291A patent/IE911592A1/en not_active IP Right Cessation
- 1991-05-10 NZ NZ238118A patent/NZ238118A/en unknown
- 1991-05-10 MY MYPI91000798A patent/MY114347A/en unknown
- 1991-05-10 PE PE1991185538A patent/PE30891A1/es unknown
- 1991-05-10 CN CNA2006101018493A patent/CN1915428A/zh active Pending
- 1991-05-10 CN CN2005100035730A patent/CN1824315B/zh not_active Expired - Lifetime
- 1991-05-10 CN CNB2003101199156A patent/CN100358578C/zh not_active Expired - Lifetime
- 1991-05-10 CN CN91103177A patent/CN1065140C/zh not_active Expired - Lifetime
- 1991-05-10 YU YU81991A patent/YU49094B/sh unknown
- 1991-05-10 CN CNA2007101867127A patent/CN101156949A/zh active Pending
- 1991-05-10 CN CNA2006100934632A patent/CN1879884A/zh active Pending
- 1991-05-10 ZA ZA913539A patent/ZA913539B/xx unknown
1992
- 1992-11-10 NO NO92924321A patent/NO924321L/no unknown
- 1992-11-10 BG BG97068A patent/BG61831B1/bg unknown
1994
- 1994-06-27 JP JP6144998A patent/JP2635291B2/ja not_active Expired - Lifetime
1995
- 1995-06-05 US US08/463,878 patent/US6900234B1/en not_active Expired - Lifetime
- 1995-06-05 US US08/465,660 patent/US6716875B1/en not_active Expired - Lifetime
1997
- 1997-04-01 GR GR970400671T patent/GR3022997T3/el unknown
2000
- 2000-04-29 CN CN00108186A patent/CN1307901A/zh active Pending

Also Published As

Publication number	Publication date
TW203553B (is)	1993-04-11
EP0527879A1 (en)	1993-02-24
YU49094B (sh)	2003-12-31
MA22150A1 (fr)	1991-12-31
HU227346B1 (en)	2011-04-28
GT199100032A (es)	1992-10-31
IS2042B (is)	2005-09-15
HUT62804A (en)	1993-06-28
CN1879884A (zh)	2006-12-20
EG19648A (en)	1995-09-30
ES2097208T3 (es)	1997-04-01
DE69124598D1 (de)	1997-03-20
CN1915428A (zh)	2007-02-21
ATE148632T1 (de)	1997-02-15
CN1502370A (zh)	2004-06-09
CN1065140C (zh)	2001-05-02
PT97615A (pt)	1992-03-31
IL98055A (en)	1996-10-31
AU7859191A (en)	1991-12-10
IS3703A7 (is)	1991-11-12
JP2635291B2 (ja)	1997-07-30
GR3022997T3 (en)	1997-07-30
US6900234B1 (en)	2005-05-31
CA2081564A1 (en)	1991-11-12
YU81991A (sh)	1994-06-24
ZA913539B (en)	1992-12-30
BG97068A (bg)	1993-12-24
JPH0729938B2 (ja)	1995-04-05
JPH05505618A (ja)	1993-08-19
NO924321D0 (no)	1992-11-10
DE69124598T2 (de)	1997-05-28
AU653724B2 (en)	1994-10-13
PT97615B (pt)	1998-08-31
JPH0748280A (ja)	1995-02-21
CN1824315B (zh)	2011-01-12
CN100358578C (zh)	2008-01-02
NZ238118A (en)	1997-06-24
MY114347A (en)	2002-10-31
PE30891A1 (es)	1991-11-27
RO115786B1 (ro)	2000-06-30
CN1056426A (zh)	1991-11-27
BG61831B1 (bg)	1998-07-31
AP240A (en)	1993-02-18
RU2147875C1 (ru)	2000-04-27
WO1991017771A1 (en)	1991-11-28
US6716875B1 (en)	2004-04-06
CN101156949A (zh)	2008-04-09
IL98055A0 (en)	1992-06-21
AP9100258A0 (en)	1991-07-31
HK1094148A1 (en)	2007-03-23
BR9106438A (pt)	1993-05-18
KR970005839B1 (ko)	1997-04-21
EP0527879B1 (en)	1997-02-05
IE911592A1 (en)	1991-11-20
DK0527879T3 (da)	1997-07-14
CN1307901A (zh)	2001-08-15
HU9203522D0 (en)	1993-01-28
CA2081564C (en)	1998-02-03
CN1824315A (zh)	2006-08-30

Publication	Publication Date	Title
MY114347A (en)	2002-10-31	Synergistic therapeutic compositions and methods.
RU92016534A (ru)	1995-06-19	Синергетические терапевтические композиции и способы достижения синергетического терапевтического эффекта
NO923130L (no)	1993-02-15	Behandling av kongestiv hjertesvikt
Edwards et al.	1985	Angiotensin-converting enzyme inhibitors: past, present, and bright future
Brown et al.	1998	Angiotensin-converting enzyme inhibitors
NO20055863L (no)	2001-09-12	W-karboksyarylsubstituerte difenylureaforbindelser som raf-kinaseinhibitorer
NO920298L (no)	1992-07-31	2,3,6-substituerte kinazolinoner
WO2003057225A3 (en)	2004-04-08	Phosphate transport inhibitors
NO20056252L (no)	2005-12-30	Terapeutiske og profylaktiske metoder for neuromuskulaere lidelser
NO950774L (no)	1995-09-04	Fremgangsmåte for inhibering av bentap og nedsettelse av serumkolesterol
PL308217A1 (en)	1995-07-24	Derivatives of 1-(oxo-acetyl)-piperidine-2-carboxylic as agents sensibilising multiple-drug-resistant cancer cells
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