AP3083A - Compositions for treating centrally mediated nausea and vomiting - Google Patents

Compositions for treating centrally mediated nausea and vomiting

Info

Publication number
AP3083A
AP3083A AP2012006278A AP2012006278A AP3083A AP 3083 A AP3083 A AP 3083A AP 2012006278 A AP2012006278 A AP 2012006278A AP 2012006278 A AP2012006278 A AP 2012006278A AP 3083 A AP3083 A AP 3083A
Authority
AP
ARIPO
Prior art keywords
vomiting
compositions
centrally mediated
treating
nausea
Prior art date
Application number
AP2012006278A
Other languages
English (en)
Other versions
AP2012006278A0 (en
Inventor
Fabio Trento
Sergio Cantoreggi
Giorgia Rossi
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43608757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3083(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of AP2012006278A0 publication Critical patent/AP2012006278A0/xx
Application granted granted Critical
Publication of AP3083A publication Critical patent/AP3083A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Paints Or Removers (AREA)
  • Medicines Containing Plant Substances (AREA)
AP2012006278A 2009-11-18 2010-11-18 Compositions for treating centrally mediated nausea and vomiting AP3083A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26247009P 2009-11-18 2009-11-18
US38270910P 2010-09-14 2010-09-14
PCT/IB2010/003106 WO2011061622A1 (en) 2009-11-18 2010-11-18 Compositions for treating centrally mediated nausea and vomiting

Publications (2)

Publication Number Publication Date
AP2012006278A0 AP2012006278A0 (en) 2012-06-30
AP3083A true AP3083A (en) 2015-01-31

Family

ID=43608757

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2012006278A AP3083A (en) 2009-11-18 2010-11-18 Compositions for treating centrally mediated nausea and vomiting

Country Status (40)

Country Link
US (1) US12042494B2 (pl)
EP (3) EP2361090B1 (pl)
JP (1) JP5890780B2 (pl)
KR (1) KR101615108B1 (pl)
CN (6) CN107050455B (pl)
AP (1) AP3083A (pl)
AU (1) AU2010320598B2 (pl)
BR (1) BR112012011485B1 (pl)
CA (1) CA2778301C (pl)
CL (1) CL2012001276A1 (pl)
CO (1) CO6551693A2 (pl)
CR (1) CR20120216A (pl)
CU (1) CU24048B1 (pl)
CY (1) CY1118062T1 (pl)
DK (2) DK2722045T3 (pl)
DO (1) DOP2012000138A (pl)
EA (1) EA026815B1 (pl)
EC (1) ECSP12011907A (pl)
ES (4) ES2623503T3 (pl)
GE (1) GEP20156226B (pl)
GT (1) GT201200156A (pl)
HK (2) HK1214148A1 (pl)
HR (3) HRP20140759T1 (pl)
HU (1) HUE029677T2 (pl)
IL (1) IL219576A (pl)
LT (1) LT2722045T (pl)
MA (1) MA33810B1 (pl)
MX (1) MX2012005347A (pl)
MY (1) MY159393A (pl)
NI (1) NI201200090A (pl)
NZ (1) NZ599439A (pl)
PE (1) PE20121483A1 (pl)
PH (1) PH12012500887A1 (pl)
PL (3) PL2722044T3 (pl)
PT (2) PT2722045T (pl)
RS (2) RS55206B1 (pl)
SI (2) SI2361090T1 (pl)
SM (1) SMT201400112B (pl)
TN (1) TN2012000170A1 (pl)
WO (1) WO2011061622A1 (pl)

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Publication number Priority date Publication date Assignee Title
EP2722045B1 (en) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions for treating centrally mediated nausea and vomiting
HRP20140759T1 (hr) 2009-11-18 2014-10-24 Helsinn Healthcare S.A. Kompozicije za lijeäśenje središnje posredovane muäśnine i povraä†anja
DK2729147T3 (en) 2011-07-04 2017-12-18 Irbm - Science Park S P A NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA
ES2579616T3 (es) * 2011-10-18 2016-08-12 Helsinn Healthcare Sa Combinaciones terapéuticas de netupitant y palonosetrón
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
US9403772B2 (en) 2011-11-29 2016-08-02 Helsinn Healthcare Sa 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator
CN103520725B (zh) * 2012-07-05 2017-10-24 海思科医药集团股份有限公司 一种治疗呕吐的药物组合物
WO2016141341A1 (en) 2015-03-04 2016-09-09 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
CN106902086B (zh) * 2015-12-23 2020-10-20 江苏恒瑞医药股份有限公司 一种包含奈妥匹坦的固体组合物
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
GB201702250D0 (en) 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
CN108721214B (zh) * 2017-04-14 2020-06-16 和龙 奈妥吡坦和帕洛诺司琼复方纳米粒溶液、纳米粒及制备方法和用途
CN108853010A (zh) * 2017-05-15 2018-11-23 和龙 奈妥吡坦环糊精包合物、复方组合制剂及其制备方法和用途
CN109200018A (zh) * 2017-07-04 2019-01-15 南京诺瑞特医药科技有限公司 含有奈妥吡坦的微乳制剂
HRP20250615T1 (hr) * 2017-11-17 2025-07-18 Vanda Pharmaceuticals Inc. Tradipitant za upotrebu u liječenju gastropareze
JP2021512869A (ja) * 2018-02-02 2021-05-20 ユーストラリス ファーマシューティカルズ リミテッド （トレーディング アズ プレススラ ニューロ） 経口製剤及びその使用
MX2023007578A (es) * 2020-12-25 2023-07-06 Shanghai Shengdi Pharmaceutical Co Ltd Uso del compuesto profarmaco antagonista nk1 en combinacion con un antagonista del receptor 5-ht3.
IL321446A (en) 2022-12-12 2025-08-01 Tiefenbacher Alfred E Gmbh & Co Kg Fixed-dose combination including netopitant and flunosterone
EP4385500A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Fixed dose combination comprising netupitant and palonosetron
WO2024126408A1 (en) 2022-12-12 2024-06-20 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Antioxidant-free fixed dose combination of netupitant and palonosetron
EP4385497A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Antioxidant-free fixed dose combination of netupitant and palonosetron
WO2025246530A1 (en) * 2024-05-30 2025-12-04 The Chinese University Of Hong Kong Personalized anti-emetic treatment for chemotherapy-induced nausea and vomiting

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CA2415890C (en) 2000-07-14 2009-04-07 F. Hoffmann-La Roche Ag N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
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MY143789A (en) * 2003-02-18 2011-07-15 Helsinn Healthcare Sa Use of palonosetron treating post- operative nausea and vomiting
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DE WIT R: "Current position of 5HT3 antagonists and the additional value of NK1 antagonists; a new class of antiemetics.", BRITISH JOURNAL OF CANCER 16 JUN 2003 LNKD- PUBMED:12799621, vol. 88, no. 12, 16 June 2003 (2003-06-16) , pages 1823-1827, XP002626041 *
DIEMUNSCH P ET AL: "Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting.", BRITISH JOURNAL OF ANAESTHESIA JUL 2009 LNKD- PUBMED:19454547, vol. 103, no. 1, July 2009 (2009-07), pages 7-13, XP002626040 *
DIEMUNSCH PIERRE ET AL: "Potential of substance P antagonists as antiemetics", 1 January 2003 (2003-01-01), ANTIEMETIC THERAPY, BASEL [U.A.] : KARGER, CH, PAGE(S) 78 - 97, XP008133831, ISBN: 978-3-8055-7547-8 * the whole document * *
GRUNBERG STEVEN M ET AL: "Effectiveness of a single-day three-drug regimen of dexamethasone, palonosetron, and aprepitant for the prevention of acute and delayed nausea and vomiting caused by moderately emetogenic chemotherapy.", SUPPORTIVE CARE IN CANCER : OFFICIAL JOURNAL OF THE MULTINATIONAL ASSOCIATION OF SUPPORTIVE CARE IN CANCER MAY 2009 LNKD- PUBMED:19037667, vol. 17, no. 5, May 2009 (2009-05), pages 589-594, XP002626042 *

Also Published As

Publication number Publication date
CR20120216A (es) 2012-07-24
GEP20156226B (en) 2015-01-26
CN106421793A (zh) 2017-02-22
EP2727590A1 (en) 2014-05-07
CY1118062T1 (el) 2017-06-28
ES2494015T3 (es) 2014-09-12
CA2778301C (en) 2016-06-14
CN106421793B (zh) 2023-06-16
EP2722044B1 (en) 2017-01-04
GT201200156A (es) 2014-03-27
ES2623503T3 (es) 2017-07-11
PE20121483A1 (es) 2012-12-02
CN102655864A (zh) 2012-09-05
DK2361090T3 (da) 2014-08-25
IL219576A0 (en) 2012-06-28
CN104856998A (zh) 2015-08-26
EA201290356A1 (ru) 2012-12-28
HRP20161277T1 (hr) 2016-11-18
KR20120101456A (ko) 2012-09-13
ES2559475T3 (es) 2016-02-12
DK2722045T3 (en) 2016-10-24
CU24048B1 (es) 2014-12-26
SI2361090T1 (sl) 2014-09-30
AU2010320598B2 (en) 2016-06-16
PL2361090T3 (pl) 2014-10-31
HK1214147A1 (zh) 2016-07-22
AP2012006278A0 (en) 2012-06-30
HK1214148A1 (zh) 2016-07-22
HRP20170419T1 (hr) 2017-06-02
RS55206B1 (sr) 2017-01-31
CU20120078A7 (es) 2012-10-15
DOP2012000138A (es) 2012-11-15
PL2722044T3 (pl) 2017-08-31
CN104856999A (zh) 2015-08-26
CN107050455B (zh) 2020-09-29
PT2361090E (pt) 2014-09-03
EA026815B1 (ru) 2017-05-31
ES2595077T3 (es) 2016-12-27
BR112012011485A2 (pt) 2018-04-03
MA33810B1 (fr) 2012-12-03
CA2778301A1 (en) 2011-05-26
CO6551693A2 (es) 2012-10-31
US20230263799A1 (en) 2023-08-24
CN106512010A (zh) 2017-03-22
HUE029677T2 (hu) 2017-03-28
NI201200090A (es) 2012-11-13
CN107050455A (zh) 2017-08-18
US12042494B2 (en) 2024-07-23
WO2011061622A1 (en) 2011-05-26
EP2727590B1 (en) 2015-10-21
PL2722045T3 (pl) 2017-03-31
SI2722045T1 (sl) 2017-02-28
TN2012000170A1 (en) 2013-12-12
BR112012011485B1 (pt) 2021-06-29
PT2722045T (pt) 2016-10-18
JP5890780B2 (ja) 2016-03-22
SMT201400112B (it) 2014-11-10
EP2361090B1 (en) 2014-05-21
MX2012005347A (es) 2012-08-03
AU2010320598A1 (en) 2012-06-14
JP2013511507A (ja) 2013-04-04
ECSP12011907A (es) 2012-10-30
MY159393A (en) 2016-12-30
IL219576A (en) 2017-08-31
KR101615108B1 (ko) 2016-05-12
NZ599439A (en) 2014-06-27
PH12012500887A1 (en) 2016-08-26
LT2722045T (lt) 2016-09-26
CL2012001276A1 (es) 2012-12-07
EP2361090A1 (en) 2011-08-31
EP2722044A1 (en) 2014-04-23
HRP20140759T1 (hr) 2014-10-24
RS53491B1 (sr) 2015-02-27

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