AR004368A1 - Compuestos de piperidina -1,-4 sustituida, procedimientos para prepararlos y un procedimiento para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina mediante dichos compuestos. - Google Patents

Compuestos de piperidina -1,-4 sustituida, procedimientos para prepararlos y un procedimiento para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina mediante dichos compuestos.

Info

Publication number: AR004368A1
Authority: AR; Argentina
Prior art keywords: preparing; compounds; indanon; methylpiperidine; dimetoxi
Prior art date: 1995-12-15

Application number

ARP960105577A

Other languages

English (en)

Spanish (es)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-15

Filing date

1996-12-10

Publication date

1998-11-04

1996-12-10 Application filed by Pfizer filed Critical Pfizer

1998-11-04 Publication of AR004368A1 publication Critical patent/AR004368A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 title abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
IHMQOBPGHZFGLC-UHFFFAOYSA-N 5,6-dimethoxy-2,3-dihydroinden-1-one Chemical compound C1=C(OC)C(OC)=CC2=C1C(=O)CC2 IHMQOBPGHZFGLC-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000003053 piperidines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

ARP960105577A 1995-12-15 1996-12-10 Compuestos de piperidina -1,-4 sustituida, procedimientos para prepararlos y un procedimiento para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina mediante dichos compuestos. AR004368A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US875395P	1995-12-15	1995-12-15

Publications (1)

Publication Number	Publication Date
AR004368A1 true AR004368A1 (es)	1998-11-04

Family

ID=21733469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP960105577A AR004368A1 (es)	1995-12-15	1996-12-10	Compuestos de piperidina -1,-4 sustituida, procedimientos para prepararlos y un procedimiento para preparar 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina mediante dichos compuestos.

Country Status (33)

Country	Link
EP (1)	EP0883607A1 (fr)
JP (1)	JP3066083B2 (fr)
KR (1)	KR20000064387A (fr)
AP (1)	AP708A (fr)
AR (1)	AR004368A1 (fr)
AU (1)	AU716462B2 (fr)
BG (1)	BG102525A (fr)
BR (1)	BR9612018A (fr)
CA (1)	CA2237647A1 (fr)
CO (1)	CO4750831A1 (fr)
CZ (1)	CZ180898A3 (fr)
DZ (1)	DZ2141A1 (fr)
GT (1)	GT199600092A (fr)
HN (1)	HN1996000065A (fr)
HR (1)	HRP960592A2 (fr)
HU (1)	HUP9904275A3 (fr)
IL (3)	IL124452A0 (fr)
IS (1)	IS4752A (fr)
MA (1)	MA24032A1 (fr)
NO (1)	NO982712D0 (fr)
NZ (1)	NZ318843A (fr)
OA (1)	OA10694A (fr)
PE (1)	PE25698A1 (fr)
PL (1)	PL197306B1 (fr)
RO (1)	RO121382B1 (fr)
RU (1)	RU2160731C2 (fr)
SK (1)	SK75498A3 (fr)
TN (1)	TNSN96153A1 (fr)
TW (1)	TW414787B (fr)
UY (1)	UY24401A1 (fr)
WO (1)	WO1997022584A1 (fr)
YU (1)	YU49486B (fr)
ZA (1)	ZA9610533B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999036405A1 (fr)	1998-01-16	1999-07-22	Eisai Co., Ltd.	Procede de production de derive de donepezil
IL125809A (en)	1998-08-17	2005-08-31	Finetech Lab Ltd	Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) *	2002-07-24	2006-12-12	Dr. Reddy's Laboratories Limited	Process for preparation of donepezil
IL150982A (en)	2002-07-30	2007-02-11	Ori Lerman	Process for making Donafzil
IL151253A0 (en) *	2002-08-14	2003-04-10	Finetech Lab Ltd	Process for production of highly pure donepezil hydrochloride
US6649765B1 (en)	2003-02-12	2003-11-18	Usv Limited, Bsd Marg.	Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en)	2003-02-12	2005-10-11	Usv, Limited	Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
EP1608371A1 (fr) *	2003-03-21	2005-12-28	Ranbaxy Laboratories, Ltd.	Procede de preparation de donepezil et de ses derives
WO2004099142A1 (fr) *	2003-05-05	2004-11-18	Ranbaxy Laboratories Limited	Sel de bromhydrate de benzyl-piperidylmethyl-indanone et ses polymorphes
EP1654230A1 (fr)	2003-07-01	2006-05-10	Hetero Drugs Limited	Preparation d'intermediaires pour inhibiteurs de l'acetyl cholinesterase
CN1280273C (zh) *	2003-11-05	2006-10-18	天津和美生物技术有限公司	合成多奈哌齐及其衍生物的方法
AU2005288521A1 (en)	2004-09-29	2006-04-06	Chemagis Ltd.	Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
CN100436416C (zh) *	2005-07-29	2008-11-26	西南合成制药股份有限公司	盐酸多奈哌齐合成工艺
GB0515803D0 (en)	2005-07-30	2005-09-07	Pliva Hrvatska D O O	Intermediate compounds
AR057910A1 (es)	2005-11-18	2007-12-26	Synthon Bv	Proceso para preparar donepezilo
KR20080085195A (ko) *	2006-01-04	2008-09-23	씨아이피엘에이 엘티디.	도네페질의 제조방법 및 중간체
EP2114166A4 (fr) *	2006-12-11	2011-05-25	Reviva Pharmaceuticals Inc	Compositions, synthèse et procédés d'utilisation d'inhibiteurs de cholinestérase à base d'indanone
WO2013078608A1 (fr)	2011-11-29	2013-06-06	Ziqiang Gu	Pamoate de donepezil et ses procédés de fabrication et d'utilisation
ES2888074T3 (es)	2013-08-16	2021-12-30	Univ Maastricht	Tratamiento del deterioro cognitivo con inhibidor de PDE4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI95572C (fi) *	1987-06-22	1996-02-26	Eisai Co Ltd	Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) *	1989-01-20	1991-04-12	Rhone Poulenc Sante	Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) *	1994-11-08	1996-08-29	Bayer Ag	Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

1996
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 EP EP96931937A patent/EP0883607A1/fr not_active Withdrawn
- 1996-10-11 CA CA002237647A patent/CA2237647A1/fr not_active Abandoned
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/fr not_active Ceased
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Ceased
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ318843A (en)	2000-01-28
NO982712L (no)	1998-06-12
HUP9904275A3 (en)	2001-05-28
KR20000064387A (ko)	2000-11-06
PE25698A1 (es)	1998-05-21
HUP9904275A2 (hu)	2000-05-28
ZA9610533B (en)	1998-06-15
TW414787B (en)	2000-12-11
PL197306B1 (pl)	2008-03-31
EP0883607A1 (fr)	1998-12-16
BR9612018A (pt)	1999-02-17
RU2160731C2 (ru)	2000-12-20
AU7092596A (en)	1997-07-14
OA10694A (en)	2001-05-04
CZ180898A3 (cs)	1999-05-12
CA2237647A1 (fr)	1997-06-26
WO1997022584A1 (fr)	1997-06-26
BG102525A (en)	1999-05-31
AU716462B2 (en)	2000-02-24
PL327512A1 (en)	1998-12-21
NO982712D0 (no)	1998-06-12
MA24032A1 (fr)	1997-07-01
IL136421A0 (en)	2001-06-14
SK75498A3 (en)	1999-08-06
YU49486B (sh)	2006-08-17
HN1996000065A (es)	1997-06-26
RO121382B1 (ro)	2007-04-30
TNSN96153A1 (fr)	2005-03-15
HRP960592A2 (en)	1998-06-30
YU66096A (en)	1999-11-22
MX9804820A (es)	1998-10-31
UY24401A1 (es)	1997-06-09
JP3066083B2 (ja)	2000-07-17
GT199600092A (es)	1998-05-12
IS4752A (is)	1998-05-22
AP9600892A0 (en)	1997-01-31
DZ2141A1 (fr)	2002-07-23
IL136420A0 (en)	2001-06-14
CO4750831A1 (es)	1999-03-31
IL124452A0 (en)	1998-12-06
JPH11500756A (ja)	1999-01-19
AP708A (en)	1998-12-04

Publication	Publication Date	Title
FI20011806A7 (fi)	2001-09-13	Menetelmä uuden, terapeuttisesti käyttökelpoisen, dimeerisen, piperidiini-, tetrahydropyridiini- tai piperatsiinijohdannaisen valmistamiseksi
ATE224715T1 (de)	2002-10-15	Formulierung von d-threo methylphenidat mit verzögerter freisetzung
DK0855999T3 (da)	2002-01-21	1-(1,2-disubstituerede piperidinyl)-4-substituerede piperidinderivater som tachykininreceptorantagonister
DE3784669D1 (de)	1993-04-15	Vorrichtung zum befestigen einer ersatzbahn, die eine programmierte bewegung durchfuehrt, ohne eine solche bewegung zu unterbrechen.
NO902505L (no)	1990-12-13	Tubulaert element som har en foring og fremgangsmaate for aafore et tubulaert element.
IL136421A0 (en)	2001-06-14	Intermediates for preparing 1-benzyl -4-((5,6- dimethoxy -1-indanon)-2-yl) methylpiperidine
IT1284694B1 (it)	1998-05-21	Dispositivo endomidollare per la chiodatura di ossa.
DK204388A (da)	1989-01-05	Substituerede piperidiner til anvendelse som opioidantagonister og fremgangsmaade til fremstilling af saadenne forbindelser
DK0843679T3 (da)	2002-02-25	1-(1,2-disubstitueret piperidinyl)-4-(kondenseret midazol)-piperidinderivater
FR2653989B1 (fr)	1992-01-17	Implant dentaire, outillage et procede de mise en place.
KR900700420A (ko)	1990-08-13	2,3-디플루오로벤젠의 제조방법
DE69007213D1 (de)	1994-04-14	Leistungsapparat, Leistungsübertrager/Verteilereinheit, sowie ein Auslöseverfahren hierfür.
ITMI950389A0 (it)	1995-03-01	Procedimento per la metilazione del 2,2,6,6-tetrametil-4-piperidone (triacetonammina)
EP0157399A3 (en)	1986-02-05	4-(5h-dibenzoûa,d¨cyclohepten-5-yl) piperidine compounds
NO905511L (no)	1991-06-24	Fremgangsmaate for fremstilling av 1-(4-fluorfenyl)-2-(4-((4-metansulfonamido- eller 4-acetamidofenyl)carbonyl)-1-piperidinyl)-etanon.
ECSP961971A (es)	1997-12-23	Procedimientos e intermedios para preparar 1 - bencil-4-(5,6-dimetoxi -1-indanon)- 2--il)metilpiperidina
DK215388D0 (da)	1988-04-20	Fremgangsmaade og indretning til renovering af en fra en vaeg udragende, armeret betonplade
SI0765311T1 (en)	2001-02-28	4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidines, tetrahydropyridines or piperazines
DK0950052T3 (da)	2005-01-10	Fremgangsmåde til fremstilling af et tetrahydropyridin-derivat
DK89588A (da)	1989-08-23	Fremgangsmaade og maskine til boejning af bygningsstaalsnet til boejlekurve
ITTO960428A0 (it)	1996-05-21	Dispositivo endomidollare per la chiodatura di ossa.