DK0843679T3 - 1-(1,2-disubstitueret piperidinyl)-4-(kondenseret midazol)-piperidinderivater - Google Patents

1-(1,2-disubstitueret piperidinyl)-4-(kondenseret midazol)-piperidinderivater

Info

Publication number: DK0843679T3
Authority: DK; Denmark
Prior art keywords: midazole; condensed; piperidine derivatives; disubstituted piperidinyl; disubstituted
Prior art date: 1995-12-27

Application number

DK96944693T

Other languages

English (en)

Inventor

Frans Eduard Janssens

Joseph Elisabeth Leenaerts

Roosbroeck Yves Emiel Mari Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-20

Publication date

2002-02-25

1996-12-20 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2002-02-25 Application granted granted Critical

2002-02-25 Publication of DK0843679T3 publication Critical patent/DK0843679T3/da

Links

-1 1,2-Disubstituted Piperidinyl Chemical group 0.000 title 1
150000003053 piperidines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK96944693T 1995-12-27 1996-12-20 1-(1,2-disubstitueret piperidinyl)-4-(kondenseret midazol)-piperidinderivater DK0843679T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95203652		1995-12-27
PCT/EP1996/005885 WO1997024356A1 (en)	1995-12-27	1996-12-20	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Publications (1)

Publication Number	Publication Date
DK0843679T3 true DK0843679T3 (da)	2002-02-25

Family

ID=8221024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96944693T DK0843679T3 (da)	1995-12-27	1996-12-20	1-(1,2-disubstitueret piperidinyl)-4-(kondenseret midazol)-piperidinderivater

Country Status (29)

Country	Link
US (1)	US6251894B1 (da)
EP (1)	EP0843679B1 (da)
JP (1)	JP4097043B2 (da)
KR (1)	KR100485147B1 (da)
CN (1)	CN1066733C (da)
AR (2)	AR005278A1 (da)
AT (1)	ATE208392T1 (da)
AU (1)	AU716071B2 (da)
BR (1)	BR9612307A (da)
CA (1)	CA2238817C (da)
CY (1)	CY2271B1 (da)
CZ (1)	CZ295861B6 (da)
DE (1)	DE69616802T2 (da)
DK (1)	DK0843679T3 (da)
EA (1)	EA001374B1 (da)
ES (1)	ES2167619T3 (da)
HU (1)	HU229766B1 (da)
IL (2)	IL124642A (da)
MY (1)	MY117680A (da)
NO (1)	NO310916B1 (da)
NZ (1)	NZ325845A (da)
PL (1)	PL183767B1 (da)
PT (1)	PT843679E (da)
SI (1)	SI0843679T1 (da)
SK (1)	SK283540B6 (da)
TR (1)	TR199801210T2 (da)
TW (1)	TW382017B (da)
WO (1)	WO1997024356A1 (da)
ZA (1)	ZA9610889B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW527186B (en)	1996-03-19	2003-04-11	Janssen Pharmaceutica Nv	Fused imidazole derivatives as multidrug resistance modulators
AU1146099A (en)	1997-09-18	1999-04-05	Janssen Pharmaceutica N.V.	Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
HK1043128B (zh)	1998-12-19	2007-01-19	詹森药业有限公司	抗组胺的螺环化合物
WO2001030348A1 (en) *	1999-10-25	2001-05-03	Janssen Pharmaceutica N.V.	Use of substance p antagonists for influencing the circadian timing system
CN100491378C (zh)	2001-06-12	2009-05-27	詹森药业有限公司	新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
US20030083345A1 (en) *	2001-07-10	2003-05-01	Torsten Hoffmann	Method of treatment and/or prevention of brain, spinal or nerve injury
HRP20040427B1 (hr) *	2001-11-23	2012-09-30	Janssen Pharmaceutica N.V.	Uporaba antihistaminika za akutno smanjenje povi‹enog intrakranijalnog tlaka
WO2003050123A1 (en) *	2001-12-10	2003-06-19	Kyorin Pharmaceutical Co., Ltd.	Fused bicyclic pyridine derivatives as tachykinin receptor antagonists
RU2301806C2 (ru) *	2002-01-16	2007-06-27	Янссен Фармацевтика Н.В.	Прукалоприд-n-оксид
US6995153B2 (en) *	2002-01-18	2006-02-07	Kyorin Pharmaceutical. Co., Ltd.	Fused bicyclic pyrimidine derivatives
EP1489083B1 (en) *	2002-03-26	2007-06-06	Kyorin Pharmaceutical Co., Ltd.	Fused bicyclic pyridine derivative as tachykinin receptor antagonist
JO2696B1 (en)	2002-12-23	2013-03-03	شركة جانسين فارماسوتيكا ان. في	Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
US7514424B2 (en) *	2002-12-23	2009-04-07	Janssen Pharmaceutica N.V.	Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists
JO2676B1 (en)	2004-04-06	2012-06-17	جانسين فارماسوتيكا ان. في	Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines
JO2525B1 (en) *	2004-04-08	2010-03-17	شركة جانسين فارماسوتيكا ان. في	Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin
NZ556629A (en)	2005-03-03	2010-04-30	Janssen Pharmaceutica Nv	Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists
DE602006016244D1 (de)	2005-03-08	2010-09-30	Janssen Pharmaceutica Nv	Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
US20100184819A1 (en) *	2007-07-19	2010-07-22	Robert Vink	Method for reducing intracranial pressure
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
ES2672099T3 (es)	2011-07-04	2018-06-12	Irbm - Science Park S.P.A.	Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
EP3758688B1 (en)	2018-02-26	2024-03-27	Ospedale San Raffaele S.r.l.	Nk-1 antagonists for use in the treatment of ocular pain
EP4117673A1 (en)	2020-03-11	2023-01-18	Ospedale San Raffaele S.r.l.	Treatment of stem cell deficiency

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4329353A (en)	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US5393753A (en) *	1990-10-10	1995-02-28	Schering Corporation	Substituted imidazobenzazepines
IL101851A (en) *	1991-06-13	1996-05-14	Janssen Pharmaceutica Nv	10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
IL101850A (en) *	1991-06-13	1996-01-31	Janssen Pharmaceutica Nv	11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
EP0708776B1 (en) *	1993-07-13	2001-01-03	Janssen Pharmaceutica N.V.	Antiallergic imidazoazepines
WO1996002503A1 (en)	1994-07-15	1996-02-01	Meiji Seika Kabushiki Kaisha	Novel compound having platelet aggregation inhibitor effect
NZ321575A (en)	1995-10-30	1999-05-28	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

1996
- 1996-12-13 TW TW085115390A patent/TW382017B/zh not_active IP Right Cessation
- 1996-12-20 AU AU13086/97A patent/AU716071B2/en not_active Ceased
- 1996-12-20 NZ NZ325845A patent/NZ325845A/xx not_active IP Right Cessation
- 1996-12-20 IL IL12464296A patent/IL124642A/en not_active IP Right Cessation
- 1996-12-20 DE DE69616802T patent/DE69616802T2/de not_active Expired - Lifetime
- 1996-12-20 JP JP52403397A patent/JP4097043B2/ja not_active Expired - Fee Related
- 1996-12-20 ES ES96944693T patent/ES2167619T3/es not_active Expired - Lifetime
- 1996-12-20 HU HU9903948 patent/HU229766B1/hu not_active IP Right Cessation
- 1996-12-20 PT PT96944693T patent/PT843679E/pt unknown
- 1996-12-20 BR BR9612307A patent/BR9612307A/pt not_active IP Right Cessation
- 1996-12-20 TR TR1998/01210T patent/TR199801210T2/xx unknown
- 1996-12-20 PL PL96327136A patent/PL183767B1/pl unknown
- 1996-12-20 SI SI9630419T patent/SI0843679T1/xx unknown
- 1996-12-20 CN CN96199396A patent/CN1066733C/zh not_active Expired - Fee Related
- 1996-12-20 AT AT96944693T patent/ATE208392T1/de active
- 1996-12-20 KR KR10-1998-0704830A patent/KR100485147B1/ko not_active Expired - Fee Related
- 1996-12-20 EP EP96944693A patent/EP0843679B1/en not_active Expired - Lifetime
- 1996-12-20 IL IL12464196A patent/IL124641A/en not_active IP Right Cessation
- 1996-12-20 EA EA199800603A patent/EA001374B1/ru not_active IP Right Cessation
- 1996-12-20 CA CA002238817A patent/CA2238817C/en not_active Expired - Fee Related
- 1996-12-20 CZ CZ19981865A patent/CZ295861B6/cs not_active IP Right Cessation
- 1996-12-20 DK DK96944693T patent/DK0843679T3/da active
- 1996-12-20 SK SK830-98A patent/SK283540B6/sk unknown
- 1996-12-20 WO PCT/EP1996/005885 patent/WO1997024356A1/en not_active Ceased
- 1996-12-23 ZA ZA9610889A patent/ZA9610889B/xx unknown
- 1996-12-26 AR ARP960105895A patent/AR005278A1/es active IP Right Grant
- 1996-12-27 MY MYPI96005516A patent/MY117680A/en unknown
1998
- 1998-05-27 NO NO19982405A patent/NO310916B1/no not_active IP Right Cessation
- 1998-06-22 US US09/102,136 patent/US6251894B1/en not_active Expired - Lifetime
2002
- 2002-04-25 CY CY0200023A patent/CY2271B1/xx unknown
2005
- 2005-12-16 AR ARP050105316A patent/AR051817A2/es active IP Right Grant

Also Published As

Publication number	Publication date
TW382017B (en)	2000-02-11
SK83098A3 (en)	1999-01-11
MY117680A (en)	2004-07-31
SK283540B6 (sk)	2003-09-11
KR19990076715A (ko)	1999-10-15
PL327136A1 (en)	1998-11-23
US6251894B1 (en)	2001-06-26
KR100485147B1 (ko)	2005-09-13
HU229766B1 (hu)	2014-06-30
NO982405L (no)	1998-08-19
IL124641A (en)	2001-11-25
BR9612307A (pt)	1999-07-13
IL124642A0 (en)	1998-12-06
EP0843679B1 (en)	2001-11-07
JP2000506503A (ja)	2000-05-30
PL183767B1 (pl)	2002-07-31
CN1066733C (zh)	2001-06-06
EA199800603A1 (ru)	1998-12-24
HUP9903948A3 (hu)	2000-04-28
CY2271B1 (en)	2003-07-04
EP0843679A1 (en)	1998-05-27
WO1997024356A1 (en)	1997-07-10
AR005278A1 (es)	1999-04-28
PT843679E (pt)	2002-04-29
JP4097043B2 (ja)	2008-06-04
ZA9610889B (en)	1998-06-23
TR199801210T2 (xx)	1999-10-21
CZ186598A3 (cs)	1998-11-11
CN1206417A (zh)	1999-01-27
ATE208392T1 (de)	2001-11-15
CA2238817A1 (en)	1997-07-10
EA001374B1 (ru)	2001-02-26
AU1308697A (en)	1997-07-28
HK1011206A1 (en)	1999-07-09
IL124641A0 (en)	1998-12-06
IL124642A (en)	2002-08-14
NO310916B1 (no)	2001-09-17
HUP9903948A2 (hu)	2000-03-28
NZ325845A (en)	1999-06-29
AR051817A2 (es)	2007-02-14
NO982405D0 (no)	1998-05-27
SI0843679T1 (en)	2002-06-30
CA2238817C (en)	2006-10-17
DE69616802T2 (de)	2002-07-04
DE69616802D1 (de)	2001-12-13
AU716071B2 (en)	2000-02-17
CZ295861B6 (cs)	2005-11-16
ES2167619T3 (es)	2002-05-16

Publication	Publication Date	Title
DK0862566T3 (da)	2000-06-13	1-(1,2-Disubstitueret piperidinyl)-4-substituerede piperazindeivater
CZ186498A3 (cs)	1998-12-16	1-(1,2-Disubstituovaný piperidinyl)-4-substituované deriváty piperidinu
DE69616802D1 (de)	2001-12-13	1-(1,2-disubstituierte piperidinyl)-4-(kondensierte imidazole)-piperidin derivate
TR199600930A2 (tr)	1997-06-21	Kristal yapida (R)-(-)-2-{N-£4-(1,1-dioksido-3-okzo-2, 3-dihidrobenzizotiazol-2-il)-butil\|- aminometil}-kroman hidroklorür.
DE69718026D1 (de)	2003-01-30	Fluorierte 1,4-disubstituierte piperidin-derivate
DE69531331D1 (de)	2003-08-28	Phenylpiperidinderivate als neurokinin antagonists
NO991563L (no)	1999-06-03	N-substituerte, azaheterosykliske forbindelser
FI964898A7 (fi)	1996-12-05	4-aryyli-1-(indaanimetyyli-, dihydrobentsofuraanimetyyli- tai dihydrobentsotiofeenimetyyli) piperidiinejä, -tetra-hydropyridiinejä tai -piperatsiineja
BR9606815A (pt)	1997-12-30	Derivados de piperidina 4-(1H-indolil-1-il)-1-substituídos antipsicóticos
NO944487D0 (no)	1994-11-23	8-klor-11[1-[(5-metyl-3-pyridyl)metylÅ-4-piperidylidenÅ-6,11-dihydro-5H-benzo[5,6Åsyklohepta-[1,2-bÅpyridinfumarat
FI955916L (fi)	1995-12-08	N-((1-(4-(4-fluorifenoksi)butyyli)-4-piperidinyyli)-N-metyyliamino)-2-bentsotiatsololeja luokan III rytmihäiriölääkkeinä
ITMI950389A0 (it)	1995-03-01	Procedimento per la metilazione del 2,2,6,6-tetrametil-4-piperidone (triacetonammina)
ZA9610894B (en)	1998-06-23	1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives.