AR008120A1 - Compuestos inhibidores de fosfatasa, metodos para su preparacion, metodos para su uso, uso de los mismos para la fabricacion de composiciones utiles parainhibir fosfatasa de proteina y proliferacion celular, y una composicion farmaceutica que los comprende. - Google Patents

Compuestos inhibidores de fosfatasa, metodos para su preparacion, metodos para su uso, uso de los mismos para la fabricacion de composiciones utiles parainhibir fosfatasa de proteina y proliferacion celular, y una composicion farmaceutica que los comprende.

Info

Publication number: AR008120A1
Authority: AR; Argentina
Prior art keywords: methods; phosphatase; cell proliferation; compounds; protein phosphatase
Prior art date: 1996-07-30

Application number

ARP970103452A

Other languages

English (en)

Spanish (es)

Original Assignee

Univ Pittsburgh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-30

Filing date

1997-07-30

Publication date

1999-12-09

1997-07-30 Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh

1999-12-09 Publication of AR008120A1 publication Critical patent/AR008120A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 6
108700019535 Phosphoprotein Phosphatases Proteins 0.000 title abstract 3
102000045595 Phosphoprotein Phosphatases Human genes 0.000 title abstract 3
230000004663 cell proliferation Effects 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title 2
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 title 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
125000002785 azepinyl group Chemical group 0.000 abstract 2
125000002393 azetidinyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002576 diazepinyl group Chemical group N1N=C(C=CC=C1)* 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000002883 imidazolyl group Chemical group 0.000 abstract 2
125000001041 indolyl group Chemical group 0.000 abstract 2
125000000842 isoxazolyl group Chemical group 0.000 abstract 2
125000002971 oxazolyl group Chemical group 0.000 abstract 2
125000003566 oxetanyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 2
125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 2
125000003226 pyrazolyl group Chemical group 0.000 abstract 2
125000005494 pyridonyl group Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000005493 quinolyl group Chemical group 0.000 abstract 2
125000003831 tetrazolyl group Chemical group 0.000 abstract 2
125000001425 triazolyl group Chemical group 0.000 abstract 2
101000741929 Caenorhabditis elegans Serine/threonine-protein phosphatase 2A catalytic subunit Proteins 0.000 abstract 1
101000624625 Homo sapiens M-phase inducer phosphatase 1 Proteins 0.000 abstract 1
101000624631 Homo sapiens M-phase inducer phosphatase 2 Proteins 0.000 abstract 1
101000624643 Homo sapiens M-phase inducer phosphatase 3 Proteins 0.000 abstract 1
102100023326 M-phase inducer phosphatase 1 Human genes 0.000 abstract 1
102100023325 M-phase inducer phosphatase 2 Human genes 0.000 abstract 1
102100023330 M-phase inducer phosphatase 3 Human genes 0.000 abstract 1
229940122907 Phosphatase inhibitor Drugs 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
-1 piperyl Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

ARP970103452A 1996-07-30 1997-07-30 Compuestos inhibidores de fosfatasa, metodos para su preparacion, metodos para su uso, uso de los mismos para la fabricacion de composiciones utiles parainhibir fosfatasa de proteina y proliferacion celular, y una composicion farmaceutica que los comprende. AR008120A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/688,530 US5700821A (en)	1996-07-30	1996-07-30	Phosphatase inhibitors and methods of use thereof

Publications (1)

Publication Number	Publication Date
AR008120A1 true AR008120A1 (es)	1999-12-09

Family

ID=24764793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP970103452A AR008120A1 (es)	1996-07-30	1997-07-30	Compuestos inhibidores de fosfatasa, metodos para su preparacion, metodos para su uso, uso de los mismos para la fabricacion de composiciones utiles parainhibir fosfatasa de proteina y proliferacion celular, y una composicion farmaceutica que los comprende.

Country Status (8)

Country	Link
US (4)	US5700821A (2)
EP (1)	EP0959884A1 (2)
JP (1)	JP3268782B2 (2)
AR (1)	AR008120A1 (2)
AU (1)	AU715546B2 (2)
CA (1)	CA2261793A1 (2)
IL (1)	IL128217A0 (2)
WO (1)	WO1998004257A1 (2)

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US6602713B1 (en)	2001-02-09	2003-08-05	Isis Pharmaceuticals, Inc.	Antisense modulation of protein phosphatase 2 catalytic subunit beta expression
US20040121973A1 (en) *	2002-02-05	2004-06-24	Monia Brett P	Antisense modulation of protein phosphatase 2 Catalytic subunit alpha expression
US6465250B1 (en)	2001-02-09	2002-10-15	Isis Pharmaceuticals, Inc.	Antisense modulation of protein phosphatase 2 catalytic subunit alpha expression
US7244622B2 (en) *	1996-04-03	2007-07-17	Applera Corporation	Device and method for multiple analyte detection
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US6277566B1 (en) *	1998-02-13	2001-08-21	Phillip A. Beachy	Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor
JP2002512811A (ja) *	1998-04-27	2002-05-08	ユニバーシティーヘルスネットワーク	遺伝子スクリーニング法及び関連アッセイ法
US7051360B1 (en) *	1998-11-30	2006-05-23	United Video Properties, Inc.	Interactive television program guide with selectable languages
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
CA2361838A1 (en) *	1999-02-03	2000-08-10	Jining Bai	Method of treating cancer by restoration of pp32 function
AU6396600A (en) *	1999-08-04	2001-03-05	Chemrx Advanced Technologies, Inc.	Solid phase synthesis of oxa- and thiazoles
CA2383603A1 (en) *	1999-08-31	2001-03-08	Neil R. Taylor	Method of identifying inhibitors of cdc25
WO2001027077A2 (en) *	1999-10-12	2001-04-19	Basf Aktiengesellschaft	Hydroxysulfonylalkylene-, phosphonoalkylene- or difluoro(phosphononon)methyl- substituted benzene, or benzofuran derivatives as non-peptidic cdc25 inhibitors
US6620882B1 (en)	2000-05-02	2003-09-16	Advanced Syntech, Llc	Solid support template for preparation of highly functionalized heterocycle compounds
US20030027308A1 (en) *	2000-05-30	2003-02-06	Sugen Incorporated	Novel human protein phosphatases identified from genomic sequencing
FR2812945B1 (fr) *	2000-08-10	2002-10-04	Aventis Pharma Sa	Utilisation de la proteine grf1 et cellules exprimant la proteine grf1 pour le criblage de molecules
US20040157306A1 (en) *	2000-11-13	2004-08-12	Sugen Incorporated	Mammalian protein phosphatases
WO2002070680A1 (en) *	2001-03-01	2002-09-12	Basf Aktiengesellschaft	Method of identifying inhibitors of cdc25
US20030120073A1 (en) *	2001-04-25	2003-06-26	Seto Christopher T.	Alpha-ketocarboxylic acid based inhibitors of phosphoryl tyrosine phosphatases
US20030124590A1 (en) *	2001-10-16	2003-07-03	Kosaku Uyeda	Carbohydrate response element binding protein and uses thereof
EP1446487A1 (en) *	2001-11-13	2004-08-18	Sugen, Inc.	Mammalian protein phosphatases
CA2477604A1 (en) *	2002-03-13	2003-09-25	Signum Biosciences, Inc.	Modulation of protein methylation and phosphoprotein phosphate
US20050074831A1 (en) *	2002-03-19	2005-04-07	Jasna Jerecic	Interaction of NMDA receptor with protein serine threonine phosphatases
US20040023382A1 (en) *	2002-07-31	2004-02-05	Isis Pharmaceuticals Inc.	Antisense modulation of PPP3CB expression
US6828149B2 (en)	2002-06-20	2004-12-07	Isis Pharmaceuticals, Inc.	Antisense modulation of PPP3R1 expression
US20060275758A1 (en) *	2002-06-25	2006-12-07	Serono Genetics Institute S.A.	Use of pp2a phosphatase modulators in the treatment of mental disorders
MXPA05002197A (es) *	2002-10-02	2005-06-08	Aventis Pharma Gmbh	Derivados de hidroxifenilundecano, un procedimiento para su produccion y su uso.
WO2006084033A1 (en)	2005-02-03	2006-08-10	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
US7923041B2 (en)	2005-02-03	2011-04-12	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
DE102006033321A1 (de) *	2006-07-17	2008-01-24	Westfälische Wilhelms-Universität Münster	Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen
KR100980328B1 (ko) *	2007-12-14	2010-09-06	한국생명공학연구원	단백질 포스파타제의 활성을 억제하는트리아졸릴-티오-에타논 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 암 예방 및 치료용조성물
CN102014897B (zh)	2008-04-21	2015-08-05	西格纳姆生物科学公司	化合物、组合物和其制备方法
JP2025513455A (ja)	2022-04-22	2025-04-24	バーテックスファーマシューティカルズインコーポレイテッド	疼痛の治療のためのヘテロアリール化合物
CN119454697B (zh) *	2025-01-07	2025-04-08	首都医科大学附属北京地坛医院	一种小分子化合物在制备抗肝损伤或抗肝纤维化药物中的应用

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US5539122A (en) *	1989-05-23	1996-07-23	Abbott Laboratories	Retroviral protease inhibiting compounds
US5280034A (en) *	1991-08-23	1994-01-18	E. R. Squibb & Sons, Inc.	Bis-heterocyclic prostaglandin analogs
US5639725A (en) *	1994-04-26	1997-06-17	Children's Hospital Medical Center Corp.	Angiostatin protein
US5770620A (en) *	1995-06-19	1998-06-23	Ontogen Corporation	Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors

1996
- 1996-07-30 US US08/688,530 patent/US5700821A/en not_active Expired - Fee Related
1997
- 1997-07-30 JP JP50912898A patent/JP3268782B2/ja not_active Expired - Fee Related
- 1997-07-30 IL IL12821797A patent/IL128217A0/xx unknown
- 1997-07-30 WO PCT/US1997/013408 patent/WO1998004257A1/en not_active Ceased
- 1997-07-30 CA CA002261793A patent/CA2261793A1/en not_active Abandoned
- 1997-07-30 AR ARP970103452A patent/AR008120A1/es unknown
- 1997-07-30 EP EP97935213A patent/EP0959884A1/en not_active Withdrawn
- 1997-07-30 AU AU38205/97A patent/AU715546B2/en not_active Ceased
- 1997-08-22 US US08/917,453 patent/US5856506A/en not_active Expired - Fee Related
- 1997-08-22 US US08/917,454 patent/US6040323A/en not_active Expired - Fee Related
- 1997-08-22 US US08/917,016 patent/US5925660A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU3820597A (en)	1998-02-20
US5925660A (en)	1999-07-20
JP2000515165A (ja)	2000-11-14
US6040323A (en)	2000-03-21
AU715546B2 (en)	2000-02-03
CA2261793A1 (en)	1998-02-05
EP0959884A4 (2)	1999-12-15
WO1998004257A1 (en)	1998-02-05
JP3268782B2 (ja)	2002-03-25
EP0959884A1 (en)	1999-12-01
US5856506A (en)	1999-01-05
US5700821A (en)	1997-12-23
IL128217A0 (en)	1999-11-30

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