AR008251A1 - Procedimiento para la separacion de los enantiomeros de una mezcla de enantiomeros de preparacion de la trans-2-(2-pirimidinil)-7-(hidroximetiloctahidro-2h-pirido[1,2-a]pirazina) - Google Patents
Procedimiento para la separacion de los enantiomeros de una mezcla de enantiomeros de preparacion de la trans-2-(2-pirimidinil)-7-(hidroximetiloctahidro-2h-pirido[1,2-a]pirazina)Info
- Publication number
- AR008251A1 AR008251A1 ARP970102855A ARP970102855A AR008251A1 AR 008251 A1 AR008251 A1 AR 008251A1 AR P970102855 A ARP970102855 A AR P970102855A AR P970102855 A ARP970102855 A AR P970102855A AR 008251 A1 AR008251 A1 AR 008251A1
- Authority
- AR
- Argentina
- Prior art keywords
- separation
- hydroximetiloctahidro
- pirimidinyl
- pirido
- pyrazine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000926 separation method Methods 0.000 title abstract 3
- GXWNSJYVSIJRLS-UHFFFAOYSA-N 6-bromo-8-methylimidazo[1,2-a]pyrazine Chemical compound CC1=NC(Br)=CN2C=CN=C12 GXWNSJYVSIJRLS-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la separación de una mezcla racémica de un enantiómero de fórmula I y un enantiómero de fórmula II mediante la formaciónde una sal diastereoisómera, de forma que la pureza óptica del diastereómero separado sea al menos aproximadamente el 9805% donde el procedimiento comprendela formación de una solución metanólica de los compuestos su reacción con ácido cítrico y la obtención de las sales de tartrato de estos compuesstos y suseparación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2051196P | 1996-07-01 | 1996-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008251A1 true AR008251A1 (es) | 1999-12-29 |
Family
ID=21799016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102855A AR008251A1 (es) | 1996-07-01 | 1997-06-27 | Procedimiento para la separacion de los enantiomeros de una mezcla de enantiomeros de preparacion de la trans-2-(2-pirimidinil)-7-(hidroximetiloctahidro-2h-pirido[1,2-a]pirazina) |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0912569A1 (es) |
| JP (1) | JPH11512751A (es) |
| KR (1) | KR20000022490A (es) |
| CN (1) | CN1221418A (es) |
| AR (1) | AR008251A1 (es) |
| AU (1) | AU2974497A (es) |
| BR (1) | BR9710018A (es) |
| CA (1) | CA2259496A1 (es) |
| CZ (1) | CZ434998A3 (es) |
| ID (1) | ID19779A (es) |
| IL (1) | IL127037A0 (es) |
| PL (1) | PL330962A1 (es) |
| TR (1) | TR199802743T2 (es) |
| WO (1) | WO1998000425A1 (es) |
| YU (1) | YU61098A (es) |
| ZA (1) | ZA975806B (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX19222A (es) * | 1989-01-23 | 1993-12-01 | Pfizer | Agentes ansioliticos bis-aza-biciclicos |
| DK0569387T3 (da) * | 1991-01-31 | 1995-07-03 | Pfizer | Optisk adskillelse af trans-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2H-pyrido/1,2-a/ pyrazin |
-
1997
- 1997-06-16 CZ CZ984349A patent/CZ434998A3/cs unknown
- 1997-06-16 CA CA002259496A patent/CA2259496A1/en not_active Abandoned
- 1997-06-16 PL PL97330962A patent/PL330962A1/xx unknown
- 1997-06-16 WO PCT/IB1997/000704 patent/WO1998000425A1/en not_active Ceased
- 1997-06-16 IL IL12703797A patent/IL127037A0/xx unknown
- 1997-06-16 BR BR9710018A patent/BR9710018A/pt unknown
- 1997-06-16 KR KR1019980710931A patent/KR20000022490A/ko not_active Ceased
- 1997-06-16 CN CN97195398A patent/CN1221418A/zh active Pending
- 1997-06-16 AU AU29744/97A patent/AU2974497A/en not_active Abandoned
- 1997-06-16 TR TR1998/02743T patent/TR199802743T2/xx unknown
- 1997-06-16 EP EP97924195A patent/EP0912569A1/en not_active Withdrawn
- 1997-06-16 JP JP9536562A patent/JPH11512751A/ja active Pending
- 1997-06-27 AR ARP970102855A patent/AR008251A1/es unknown
- 1997-06-30 ZA ZA975806A patent/ZA975806B/xx unknown
- 1997-06-30 ID IDP972265A patent/ID19779A/id unknown
-
1998
- 1998-12-29 YU YU61098A patent/YU61098A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU61098A (sh) | 1999-09-27 |
| IL127037A0 (en) | 1999-09-22 |
| CA2259496A1 (en) | 1998-01-08 |
| TR199802743T2 (xx) | 1999-03-22 |
| WO1998000425A1 (en) | 1998-01-08 |
| PL330962A1 (en) | 1999-06-21 |
| BR9710018A (pt) | 1999-08-10 |
| JPH11512751A (ja) | 1999-11-02 |
| KR20000022490A (ko) | 2000-04-25 |
| CZ434998A3 (cs) | 1999-11-17 |
| CN1221418A (zh) | 1999-06-30 |
| AU2974497A (en) | 1998-01-21 |
| ZA975806B (en) | 1998-12-30 |
| EP0912569A1 (en) | 1999-05-06 |
| ID19779A (id) | 1998-07-30 |
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