ES2095992T3 - Procedimiento para la separacion de los enantiomeros de la 5-hetaril-1,3,4-tiadiazinona. - Google Patents

Procedimiento para la separacion de los enantiomeros de la 5-hetaril-1,3,4-tiadiazinona.

Info

Publication number
ES2095992T3
ES2095992T3 ES92114505T ES92114505T ES2095992T3 ES 2095992 T3 ES2095992 T3 ES 2095992T3 ES 92114505 T ES92114505 T ES 92114505T ES 92114505 T ES92114505 T ES 92114505T ES 2095992 T3 ES2095992 T3 ES 2095992T3
Authority
ES
Spain
Prior art keywords
resolution
enantiomers
tiadiazinone
hetharyl
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92114505T
Other languages
English (en)
Inventor
Rochus Dr Jonas
Peter Ersing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2095992T3 publication Critical patent/ES2095992T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA SEPARACION DE ENANTIOMEROS DE TIADIACINONAS 5-HETARILO-1,3,4 DE LA FORMULA I MEDIANTE DISOCIACION CINETICA DE RACEMATO, CARACTERIZADO PORQUE SE DISUELVE RACEMICO I EN UN DISOLVENTE INERTE O MEZCLAS DE DISOLVENTES, SE ACILA CON UN CLORURO DE ACIDO QUIRAL, LA MEZCLA DE DIASTEROMEROS ORIGINADA SE TRANSFORMA CON UNA AMINA, SE ALCANZA POR ELLO UNA DISOCIACION COMPLETA DE UN DIAESTEROMERO Y UNA DISOCIACION INSIGNIFICANTE DE LOS OTROS DIAESTEROMEROS EN LOS ENANTIOMEROS TOMADOS POR BASE, FINALMENTE LOS PRODUCTOS DE DISOCIACION SE SEPARAN Y EL DIAESTEROMERO PURO RESIDUAL, SE TRANSFORMA POR REACCION CON UNA AMINA O CON UN ALCOHOL EN EL CORRESPONDIENTE ENANTIOMERRO PURO.
ES92114505T 1991-09-02 1992-08-26 Procedimiento para la separacion de los enantiomeros de la 5-hetaril-1,3,4-tiadiazinona. Expired - Lifetime ES2095992T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4129062A DE4129062A1 (de) 1991-09-02 1991-09-02 Verfahren zur enantiomerentrennung von 5-hetaryl-1,3,4-thiadiazinonen

Publications (1)

Publication Number Publication Date
ES2095992T3 true ES2095992T3 (es) 1997-03-01

Family

ID=6439631

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92114505T Expired - Lifetime ES2095992T3 (es) 1991-09-02 1992-08-26 Procedimiento para la separacion de los enantiomeros de la 5-hetaril-1,3,4-tiadiazinona.

Country Status (20)

Country Link
US (1) US5206363A (es)
EP (1) EP0530657B1 (es)
JP (1) JPH05202041A (es)
KR (1) KR930006016A (es)
AT (1) ATE144982T1 (es)
AU (1) AU658215B2 (es)
CA (1) CA2077031A1 (es)
CZ (1) CZ281376B6 (es)
DE (2) DE4129062A1 (es)
DK (1) DK0530657T3 (es)
ES (1) ES2095992T3 (es)
GR (1) GR3022443T3 (es)
HU (1) HU212178B (es)
MX (1) MX9204972A (es)
NO (1) NO300498B1 (es)
PL (1) PL169606B1 (es)
RU (1) RU2053231C1 (es)
SK (1) SK263492A3 (es)
TW (1) TW234113B (es)
ZA (1) ZA926617B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19500558A1 (de) * 1995-01-11 1996-07-18 Merck Patent Gmbh 3-Alkoxycarbonyl-thiadiazinone
DE19707641C1 (de) * 1997-02-26 1998-03-26 Merck Patent Gmbh Enantiomerentrennung von 5-Hetaryl-1,3,4-thiadiazinonen
DE19929785A1 (de) 1999-06-29 2001-01-04 Bayer Ag Tetrahydrochinolinyl-6-methyldihydrothiadiazinon-Derivate und ihre Verwendung
WO2001051089A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler
US7741317B2 (en) * 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77031A (en) * 1985-11-12 1995-12-08 Yeda Res & Dev Kinetic resolution of racemic mixtures by polymer-bound crystallization inhibitors
US4716246A (en) * 1986-08-22 1987-12-29 Merck & Co., Inc. Process for L-dopa
AU614965B2 (en) * 1987-06-06 1991-09-19 Merck Patent Gesellschaft Mit Beschrankter Haftung Thiadiazinones

Also Published As

Publication number Publication date
TW234113B (es) 1994-11-11
CZ281376B6 (cs) 1996-09-11
AU2205192A (en) 1993-03-11
ATE144982T1 (de) 1996-11-15
EP0530657B1 (de) 1996-11-06
DE59207484D1 (de) 1996-12-12
CZ263492A3 (en) 1993-03-17
NO923412D0 (no) 1992-09-01
PL169606B1 (pl) 1996-08-30
EP0530657A1 (de) 1993-03-10
PL295804A2 (en) 1993-03-08
GR3022443T3 (en) 1997-04-30
DK0530657T3 (da) 1997-04-07
HU9202806D0 (en) 1992-11-30
NO300498B1 (no) 1997-06-09
MX9204972A (es) 1993-03-01
CA2077031A1 (en) 1993-03-03
NO923412L (no) 1993-03-03
ZA926617B (en) 1993-03-25
HU212178B (en) 1996-03-28
JPH05202041A (ja) 1993-08-10
KR930006016A (ko) 1993-04-20
SK278678B6 (en) 1997-12-10
US5206363A (en) 1993-04-27
RU2053231C1 (ru) 1996-01-27
SK263492A3 (en) 1997-12-10
AU658215B2 (en) 1995-04-06
DE4129062A1 (de) 1993-03-04
HUT63414A (en) 1993-08-30

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