AR010932A1 - Derivados de la piperazina, un procedimiento para prepararlos, el empleo de los mismos en la elaboracion de medicamentos, las preparaciones farmaceuticasque los contienen y un procedimiento para elaborar estas preparaciones farmaceuticas. - Google Patents
Derivados de la piperazina, un procedimiento para prepararlos, el empleo de los mismos en la elaboracion de medicamentos, las preparaciones farmaceuticasque los contienen y un procedimiento para elaborar estas preparaciones farmaceuticas.Info
- Publication number
- AR010932A1 AR010932A1 ARP980103491A ARP980103491A AR010932A1 AR 010932 A1 AR010932 A1 AR 010932A1 AR P980103491 A ARP980103491 A AR P980103491A AR P980103491 A ARP980103491 A AR P980103491A AR 010932 A1 AR010932 A1 AR 010932A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical preparations
- procedure
- atoms
- medicines
- ch2nha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
El invento se refiere a los derivados de la piperazina de formula I, en donde R1 representa un resto de indol-3-ilo no sustituido o mono o disustituidocon Hal, CN, A, AO, OH, CONH2, CONHA, CONA2, COOH, COOA, CH2OH, CH2OA, CH2NH, CH2NHA y/oCH2NA 2, R2 representa 2-oxo-2H-1-benzopiran-6-ilo o 2-oxo-2H-1-benzopiran-4-ilo no sustituido o mono o disustituido con A, AO, OH, Hal, CN, NO2, NH2, NHA, NA2, COA, CONH2, CONHA, CONA2, CH2OH, CH2OA, CH2NH2, CH2NHA, CH2NA2, COOHy/o COOA, Halrepresenta F, CI, Br o I, A representa alquilo de cadena recta o ramificada con 1 a 10 átomos de C y que puede estar sustituido con 1 a 5 átomosde F y/o CI, o cicloalquilo de 3 a 10 átomos de C, m es 2, 3 o 4, y a sus sales.El invento también serefiere a un pro cedimiento para preparar estos compuestos,a las preparaciones farmaceuticas que los contienen y al empleo de los mismos en la elaboracion de medicamentos destinados al tratamiento y la profilaxis delos ataques de pánico, lasdepresiones, la esquizof renia, los comportamientos obsesivos, la discinesia tardía, los trastornos en el aprendizaje, lostrastornos seniles de la memoria, y destinados también a ejercer una influencia positiva sobre los comportamientos ensituaciones de tension y al trata miento ya la lucha contra las secuelas de un infarto cerebral tal como un ataque de apoplejía y las isquemias cerebrales. Los compuestos de formula I son agonistas5-Ht1a potentes e inhiben la reabsorcion de 5-HT.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19730989A DE19730989A1 (de) | 1997-07-18 | 1997-07-18 | Piperazin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010932A1 true AR010932A1 (es) | 2000-07-12 |
Family
ID=7836208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103491A AR010932A1 (es) | 1997-07-18 | 1998-07-17 | Derivados de la piperazina, un procedimiento para prepararlos, el empleo de los mismos en la elaboracion de medicamentos, las preparaciones farmaceuticasque los contienen y un procedimiento para elaborar estas preparaciones farmaceuticas. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6251908B1 (es) |
| EP (1) | EP0998474B1 (es) |
| JP (1) | JP2001510193A (es) |
| KR (1) | KR100528684B1 (es) |
| CN (1) | CN1093127C (es) |
| AR (1) | AR010932A1 (es) |
| AT (1) | ATE353326T1 (es) |
| AU (1) | AU731332B2 (es) |
| BR (1) | BR9810607A (es) |
| CA (1) | CA2296687A1 (es) |
| DE (2) | DE19730989A1 (es) |
| ES (1) | ES2281131T3 (es) |
| HU (1) | HUP0002718A3 (es) |
| ID (1) | ID24663A (es) |
| MY (1) | MY132794A (es) |
| NO (1) | NO20000216L (es) |
| PL (1) | PL191078B1 (es) |
| RU (1) | RU2194048C2 (es) |
| SK (1) | SK352000A3 (es) |
| TW (1) | TW425398B (es) |
| UA (1) | UA59407C2 (es) |
| WO (1) | WO1999003855A1 (es) |
| ZA (1) | ZA986390B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001014330A2 (en) * | 1999-08-23 | 2001-03-01 | Solvay Pharmaceuticals B.V. | Phenylpiperazines as serotonin reuptake inhibitors |
| JP2004513924A (ja) * | 2000-11-14 | 2004-05-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 組み合わせた５−ｈｔ１ａアゴニストおよびセロトニン再取り込み阻害剤の新規な使用 |
| AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| DE10112151A1 (de) * | 2001-03-14 | 2002-09-19 | Merck Patent Gmbh | Substituierte Benzofuran-2-carbonsäureamide |
| ES2323451T7 (es) | 2001-07-20 | 2011-08-01 | Psychogenics Inc. | Tratamiento para el trastorno de hiperactividad con deficit de atencion. |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| DE10259244A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
| DE10305739A1 (de) * | 2003-02-11 | 2004-08-19 | Merck Patent Gmbh | Benzofuranderivate |
| DE10315285A1 (de) * | 2003-04-04 | 2004-10-14 | Merck Patent Gmbh | Chromenonindole |
| GT200600414A (es) * | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
| RU2329044C1 (ru) * | 2006-11-16 | 2008-07-20 | Андрей Александрович Иващенко | Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство |
| US9090638B2 (en) | 2008-04-17 | 2015-07-28 | Thomas Daly | Biological buffers with wide buffering ranges |
| US8822728B2 (en) | 2008-04-17 | 2014-09-02 | Thomas Daly | Biological buffers with wide buffering ranges |
| US8034951B2 (en) * | 2008-04-17 | 2011-10-11 | Thomas Daly | Biological buffers with wide buffering ranges |
| US8519141B2 (en) | 2008-04-17 | 2013-08-27 | Thomas Daly | Biological buffers with wide buffering ranges |
| US8334402B2 (en) * | 2008-04-17 | 2012-12-18 | Thomas Daly | Biological buffers with wide buffering ranges |
| US7939659B2 (en) * | 2008-04-17 | 2011-05-10 | Thomas Daly | Biological buffers with wide buffering ranges |
| US9447310B2 (en) | 2008-04-17 | 2016-09-20 | Thomas P. Daly | Biological buffers with wide buffering ranges |
| US20170313920A1 (en) | 2010-10-06 | 2017-11-02 | Thomas P. Daly | Biological Buffers with Wide Buffering Ranges |
| US7635791B2 (en) * | 2008-04-17 | 2009-12-22 | Tpat Ip Llc | Biological buffers with wide buffering ranges |
| ES2675544T3 (es) * | 2008-05-30 | 2018-07-11 | Psychogenics Inc. | Tratamiento para trastornos mentales y neurológicos |
| US8609392B2 (en) | 2009-05-12 | 2013-12-17 | Transgene S.A. | Method for orthopoxvirus production and purification |
| CN102206214B (zh) * | 2011-04-07 | 2014-03-12 | 华中科技大学 | 苯并吡喃酮类衍生物及其应用 |
| US9475754B2 (en) | 2011-10-06 | 2016-10-25 | Thomas P. Daly | Biological buffers with wide buffering ranges |
| ES2751944T3 (es) * | 2012-05-23 | 2020-04-02 | Nerviano Medical Sciences Srl | Proceso para la preparación de N-[5-(3,5-difluoro-bencil)-1H-indazol-3-il]-4-(4-metil-piperazin-1-il)-2-(tetrahidro-piran-4-ilamino)-benzamida |
| WO2015014256A1 (en) | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| CN105418506B (zh) * | 2014-09-19 | 2018-04-24 | 上海医药工业研究院 | 乙酰苄胺哌嗪类衍生物及其作为脑神经保护剂的应用 |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| CN120817935A (zh) * | 2024-04-15 | 2025-10-21 | 复旦大学附属肿瘤医院 | 一种杂(芳)环取代环状二胺类化合物及其在制备治疗和/或预防肿瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB146691A (en) * | 1919-05-29 | 1920-07-15 | William Herbert Tripp | Apparatus for indicating and recording side drift or leeway of aircraft |
| FR2189027B1 (es) | 1972-06-21 | 1976-03-05 | Leurquin Laboratoires Fr | |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| GB9514901D0 (en) * | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| CZ24499A3 (cs) * | 1996-07-26 | 1999-05-12 | Nissan Chemical Industries, Ltd. | Derivát chromanu a farmaceutický prostředek, který ho obsahuje |
| KR100545329B1 (ko) * | 1997-07-25 | 2006-01-24 | 하. 룬트벡 아크티에 셀스카브 | 인돌 및 2,3-디히드로인돌 유도체, 그들의 제조방법 및 사용 |
-
1997
- 1997-07-18 DE DE19730989A patent/DE19730989A1/de not_active Withdrawn
-
1998
- 1998-06-29 WO PCT/EP1998/003956 patent/WO1999003855A1/de not_active Ceased
- 1998-06-29 ES ES98938671T patent/ES2281131T3/es not_active Expired - Lifetime
- 1998-06-29 US US09/462,468 patent/US6251908B1/en not_active Expired - Fee Related
- 1998-06-29 RU RU2000102920/04A patent/RU2194048C2/ru not_active IP Right Cessation
- 1998-06-29 BR BR9810607-4A patent/BR9810607A/pt not_active Application Discontinuation
- 1998-06-29 EP EP98938671A patent/EP0998474B1/de not_active Expired - Lifetime
- 1998-06-29 SK SK35-2000A patent/SK352000A3/sk unknown
- 1998-06-29 DE DE59813899T patent/DE59813899D1/de not_active Expired - Fee Related
- 1998-06-29 CN CN98807377A patent/CN1093127C/zh not_active Expired - Fee Related
- 1998-06-29 KR KR10-2000-7000522A patent/KR100528684B1/ko not_active Expired - Fee Related
- 1998-06-29 UA UA2000020920A patent/UA59407C2/uk unknown
- 1998-06-29 CA CA002296687A patent/CA2296687A1/en not_active Abandoned
- 1998-06-29 ID IDW20000151A patent/ID24663A/id unknown
- 1998-06-29 JP JP2000503079A patent/JP2001510193A/ja active Pending
- 1998-06-29 HU HU0002718A patent/HUP0002718A3/hu unknown
- 1998-06-29 PL PL338075A patent/PL191078B1/pl not_active IP Right Cessation
- 1998-06-29 AT AT98938671T patent/ATE353326T1/de not_active IP Right Cessation
- 1998-06-29 AU AU87302/98A patent/AU731332B2/en not_active Ceased
- 1998-07-16 MY MYPI98003262A patent/MY132794A/en unknown
- 1998-07-17 ZA ZA986390A patent/ZA986390B/xx unknown
- 1998-07-17 AR ARP980103491A patent/AR010932A1/es unknown
- 1998-07-17 TW TW087111694A patent/TW425398B/zh not_active IP Right Cessation
-
2000
- 2000-01-17 NO NO20000216A patent/NO20000216L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE19730989A1 (de) | 1999-01-21 |
| UA59407C2 (uk) | 2003-09-15 |
| US6251908B1 (en) | 2001-06-26 |
| JP2001510193A (ja) | 2001-07-31 |
| CN1093127C (zh) | 2002-10-23 |
| HUP0002718A3 (en) | 2001-11-28 |
| NO20000216D0 (no) | 2000-01-17 |
| NO20000216L (no) | 2000-01-17 |
| ID24663A (id) | 2000-07-27 |
| DE59813899D1 (de) | 2007-03-22 |
| CN1264379A (zh) | 2000-08-23 |
| ES2281131T3 (es) | 2007-09-16 |
| CA2296687A1 (en) | 1999-01-28 |
| ATE353326T1 (de) | 2007-02-15 |
| AU731332B2 (en) | 2001-03-29 |
| KR20010021957A (ko) | 2001-03-15 |
| RU2194048C2 (ru) | 2002-12-10 |
| EP0998474B1 (de) | 2007-02-07 |
| AU8730298A (en) | 1999-02-10 |
| PL191078B1 (pl) | 2006-03-31 |
| KR100528684B1 (ko) | 2005-11-15 |
| MY132794A (en) | 2007-10-31 |
| PL338075A1 (en) | 2000-09-25 |
| ZA986390B (en) | 1999-05-24 |
| BR9810607A (pt) | 2000-07-11 |
| WO1999003855A1 (de) | 1999-01-28 |
| HUP0002718A2 (hu) | 2001-10-28 |
| EP0998474A1 (de) | 2000-05-10 |
| TW425398B (en) | 2001-03-11 |
| SK352000A3 (en) | 2000-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |