AR016877A2 - 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales - Google Patents
6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus salesInfo
- Publication number
- AR016877A2 AR016877A2 ARP980104218A ARP980104218A AR016877A2 AR 016877 A2 AR016877 A2 AR 016877A2 AR P980104218 A ARP980104218 A AR P980104218A AR P980104218 A ARP980104218 A AR P980104218A AR 016877 A2 AR016877 A2 AR 016877A2
- Authority
- AR
- Argentina
- Prior art keywords
- tert
- substituted
- diseases
- methanol
- compounds
- Prior art date
Links
- -1 6-tert-butyloxycarbonyl aminopyridine-2-ylmethyl chloride Chemical compound 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 102000007202 Muscarinic M3 Receptor Human genes 0.000 abstract 1
- 108010008405 Muscarinic M3 Receptor Proteins 0.000 abstract 1
- ZXPOIGFEWVCWLA-UHFFFAOYSA-N [6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridin-2-yl]methyl methanesulfonate Chemical compound CC(C)(C)OC(=O)NC1=CC=CC(COS(C)(=O)=O)=N1 ZXPOIGFEWVCWLA-UHFFFAOYSA-N 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 150000003842 bromide salts Chemical class 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- RCLIUAJKGDHJMP-UHFFFAOYSA-N tert-butyl n-[6-(hydroxymethyl)pyridin-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=CC(CO)=N1 RCLIUAJKGDHJMP-UHFFFAOYSA-N 0.000 abstract 1
- ORUGTGTZBRUQIT-UHFFFAOYSA-N tert-butyl n-pyridin-2-ylcarbamate Chemical class CC(C)(C)OC(=O)NC1=CC=CC=N1 ORUGTGTZBRUQIT-UHFFFAOYSA-N 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere a 6-ter-butiloxicarbonilaminopiridinas 2 sustituidas por grupos metanol o metilo y sus sales de metanosulfonato, cloruro o bromuro. Enparticular se refiere a 6-terbutiloxicarbonilaminopiridina-2-metanol, metansulfonato de 6-ter-butiloxicarbonilaminopiridin-2-il-metilo, cloruro de 6-ter-butiloxicarbonil aminopiridin-2-ilmetilo y bromuro de 6-ter-butiloxicarbonilamino-piridin-2-ilmetilo. Los compuestos de la invencion son utiles comoreactivos para preparar derivados de piperidina 1,4-disustituida que contienen fluor. Los derivados preparados a partir de los compuestos de la invenciontienen no solo un antagonismo potente y selectivo para los receptores M3 muscarínicos sino también tienen pocos efectos colaterales. Más aun, exhibenuna excelente actividad oral, duracion de accion y farmacocinética. Por lo tanto son utiles para el tratamiento profilaxis de las enfermedades respiratorias,las enfermedades urinarias y las enfermedades digestivas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21943696 | 1996-08-01 | ||
| JP5397997 | 1997-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016877A2 true AR016877A2 (es) | 2001-08-01 |
Family
ID=26394715
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103516A AR008272A1 (es) | 1996-08-01 | 1997-08-01 | Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion |
| ARP980104219A AR017021A1 (es) | 1996-08-01 | 1998-08-25 | Acido 2-hidroxiacetico |
| ARP980104218A AR016877A2 (es) | 1996-08-01 | 1998-08-25 | 6-ter-butiloxicarbonilaminopiridinas 2-sustituidas y sus sales |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103516A AR008272A1 (es) | 1996-08-01 | 1997-08-01 | Derivados de piperidina 1,4-disustituida que contienen fluor, composicion farmaceutica compuesta de los mismos y un proceso para su preparacion |
| ARP980104219A AR017021A1 (es) | 1996-08-01 | 1998-08-25 | Acido 2-hidroxiacetico |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5948792A (es) |
| EP (1) | EP0930298B1 (es) |
| JP (1) | JP3063164B2 (es) |
| KR (1) | KR20000022214A (es) |
| CN (1) | CN1226888A (es) |
| AR (3) | AR008272A1 (es) |
| AT (1) | ATE229941T1 (es) |
| AU (1) | AU716050B2 (es) |
| BG (1) | BG103114A (es) |
| BR (1) | BR9711108A (es) |
| CA (1) | CA2261680C (es) |
| CO (1) | CO4960641A1 (es) |
| CZ (1) | CZ33199A3 (es) |
| DE (1) | DE69718026T2 (es) |
| EE (1) | EE9900038A (es) |
| ES (1) | ES2188961T3 (es) |
| HR (1) | HRP970426A2 (es) |
| HU (1) | HUP9902381A3 (es) |
| ID (1) | ID17259A (es) |
| IL (1) | IL127685A0 (es) |
| IS (1) | IS4960A (es) |
| NO (1) | NO990472D0 (es) |
| NZ (1) | NZ333842A (es) |
| PE (1) | PE92198A1 (es) |
| PL (1) | PL331431A1 (es) |
| SK (1) | SK12299A3 (es) |
| TR (2) | TR199900204T2 (es) |
| WO (1) | WO1998005641A1 (es) |
| YU (1) | YU1299A (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180823B1 (en) | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| WO2000061572A1 (en) * | 1999-04-08 | 2000-10-19 | Merck & Co., Inc. | Diastereoselective preparation of michael adducts |
| WO2000066579A1 (en) * | 1999-04-28 | 2000-11-09 | Banyu Pharmaceutical Co., Ltd. | Processes for the preparation of piperidylmethylpyridine derivatives |
| WO2001013918A1 (en) * | 1999-08-23 | 2001-03-01 | H. Lundbeck A/S | Treatment of urinary incontinence |
| DE60021282T2 (de) | 1999-12-07 | 2006-05-18 | Theravance, Inc., South San Francisco | Carbamat-derivate als muscarin-rezeptor antonisten |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| AU2525801A (en) * | 1999-12-17 | 2001-06-25 | Sanofi-Synthelabo | Phenoxypropanolamines, method for producing them and pharmaceutical compositionscontaining them |
| US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
| US6469172B2 (en) | 2000-03-08 | 2002-10-22 | Merck & Co., Inc. | Process for the preparation of chemical compounds |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| EP1302458A4 (en) * | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | ESTERDERIVATE |
| NZ526580A (en) | 2000-12-22 | 2005-04-29 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as M3 antagonists |
| DE60121813T2 (de) * | 2000-12-28 | 2007-09-20 | Almirall Ag | Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten |
| DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
| KR20040039436A (ko) * | 2001-09-27 | 2004-05-10 | 파마시아 에이비 | 약학 조성물 |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| AU2002345266B2 (en) | 2002-07-08 | 2009-07-02 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| HK1079787A1 (zh) | 2002-07-31 | 2006-04-13 | Ranbaxy Laboratories Limited | 用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物 |
| US6583103B1 (en) | 2002-08-09 | 2003-06-24 | S.C. Johnson & Son, Inc. | Two part cleaning formula resulting in an effervescent liquid |
| WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
| EP1534675B1 (en) | 2002-08-23 | 2009-02-25 | Ranbaxy Laboratories, Ltd. | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists |
| JP2006506392A (ja) * | 2002-10-29 | 2006-02-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | ムスカリン受容体アンタゴニストとしての第四級アンモニウム化合物 |
| TWI295669B (en) | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| ATE400553T1 (de) * | 2002-12-10 | 2008-07-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors |
| AU2003303041B2 (en) | 2002-12-13 | 2008-07-24 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| DE60225195T2 (de) | 2002-12-23 | 2009-02-26 | Ranbaxy Laboratories, Ltd. | Flavaxat-derivate als muscarin-rezeptor antagonisten |
| US7488748B2 (en) * | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| EP1618091A1 (en) | 2003-04-09 | 2006-01-25 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| AU2003223010A1 (en) | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EA009059B1 (ru) | 2003-04-10 | 2007-10-26 | Рэнбакси Лабораториз Лимитед | Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора |
| JP2006522787A (ja) | 2003-04-11 | 2006-10-05 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体 |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| WO2005007645A1 (en) | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| ES2329586T3 (es) | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| BRPI0418212A (pt) * | 2003-12-29 | 2007-04-27 | Banyu Pharma Co Ltd | composto ou um sal deste farmaceuticamente aceitável, ativador da glicocinase, e, medicamentos para a terapia e/ou prevenção da diabete, e da obesidade |
| WO2006005980A1 (en) * | 2004-06-16 | 2006-01-19 | Ranbaxy Laboratories Limited | Xanthine derivatives useful as muscarinic receptor antagonists |
| US20080262075A1 (en) * | 2004-08-19 | 2008-10-23 | Ranbaxy Laboratories Limited | Pyrrolidine Derivatives as Muscarinic Receptor Antagonists |
| WO2006032994A2 (en) * | 2004-09-24 | 2006-03-30 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| EP1797040A1 (en) * | 2004-09-29 | 2007-06-20 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| RU2398773C2 (ru) | 2004-11-02 | 2010-09-10 | Баниу Фармасьютикал Ко., Лтд. | Арилоксизамещенное производное бензимидазола |
| US20100016400A1 (en) * | 2004-11-19 | 2010-01-21 | Naresh Kumar | Azabicyclic muscarinic receptor antagonists |
| EP1828126A1 (en) * | 2004-12-15 | 2007-09-05 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
| WO2006117754A1 (en) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists |
| WO2007037534A1 (ja) * | 2005-09-30 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | ２－へテロアリール置換インドール誘導体 |
| WO2007039884A1 (en) * | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
| AU2006305619A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| US20090010923A1 (en) * | 2007-04-24 | 2009-01-08 | University Of Maryland, Baltimore | Treatment of cancer with anti-muscarinic receptor agents |
| JP5656288B2 (ja) * | 2007-09-07 | 2015-01-21 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物 |
| BRPI0820819B1 (pt) * | 2007-12-21 | 2021-06-08 | F. Hoffmann-La Roche Ag | formulação de anticorpos humanizados b-ly 1 e seu uso |
| CN104876854B (zh) * | 2015-04-16 | 2017-03-01 | 御盛隆堂药业有限责任公司 | 羟基乙酸酯衍生物及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| IT1231238B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati ammidinici |
| GB8825505D0 (en) * | 1988-11-01 | 1988-12-07 | Pfizer Ltd | Therapeutic agents |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
| WO1995006635A1 (en) * | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| JP3294961B2 (ja) * | 1993-12-10 | 2002-06-24 | 杏林製薬株式会社 | 新規イミダゾール誘導体及びその製造法 |
| JPH07258250A (ja) * | 1994-03-25 | 1995-10-09 | Yamanouchi Pharmaceut Co Ltd | エステル誘導体 |
| US5750540A (en) * | 1995-04-28 | 1998-05-12 | Banyu Pharmaceutical Co., Ltd. | 1,4-di-substituted piperidine derivatives |
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| ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
-
1997
- 1997-07-24 PE PE1997000659A patent/PE92198A1/es not_active Application Discontinuation
- 1997-07-28 EP EP97933037A patent/EP0930298B1/en not_active Expired - Lifetime
- 1997-07-28 HU HU9902381A patent/HUP9902381A3/hu unknown
- 1997-07-28 IL IL12768597A patent/IL127685A0/xx unknown
- 1997-07-28 PL PL97331431A patent/PL331431A1/xx unknown
- 1997-07-28 DE DE69718026T patent/DE69718026T2/de not_active Expired - Lifetime
- 1997-07-28 CZ CZ99331A patent/CZ33199A3/cs unknown
- 1997-07-28 AU AU36351/97A patent/AU716050B2/en not_active Ceased
- 1997-07-28 EE EEP199900038A patent/EE9900038A/xx unknown
- 1997-07-28 YU YU1299A patent/YU1299A/sh unknown
- 1997-07-28 SK SK122-99A patent/SK12299A3/sk unknown
- 1997-07-28 CA CA002261680A patent/CA2261680C/en not_active Expired - Fee Related
- 1997-07-28 KR KR1019980710633A patent/KR20000022214A/ko not_active Ceased
- 1997-07-28 BR BR9711108A patent/BR9711108A/pt not_active IP Right Cessation
- 1997-07-28 ES ES97933037T patent/ES2188961T3/es not_active Expired - Lifetime
- 1997-07-28 WO PCT/JP1997/002600 patent/WO1998005641A1/ja not_active Ceased
- 1997-07-28 AT AT97933037T patent/ATE229941T1/de not_active IP Right Cessation
- 1997-07-28 TR TR1999/00204T patent/TR199900204T2/xx unknown
- 1997-07-28 JP JP10507794A patent/JP3063164B2/ja not_active Expired - Fee Related
- 1997-07-28 TR TR2000/01482T patent/TR200001482T2/xx unknown
- 1997-07-28 CN CN97196911A patent/CN1226888A/zh active Pending
- 1997-07-30 HR HR53,979/97A patent/HRP970426A2/hr not_active Application Discontinuation
- 1997-07-31 US US08/903,768 patent/US5948792A/en not_active Expired - Lifetime
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- 1997-08-01 AR ARP970103516A patent/AR008272A1/es not_active Application Discontinuation
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1998
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1999
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- 1999-01-28 NZ NZ333842A patent/NZ333842A/en unknown
- 1999-01-29 IS IS4960A patent/IS4960A/is unknown
- 1999-02-01 NO NO990472A patent/NO990472D0/no not_active Application Discontinuation
- 1999-04-13 US US09/290,607 patent/US6040449A/en not_active Expired - Fee Related
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