AR020016A2 - Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento - Google Patents
Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamentoInfo
- Publication number
- AR020016A2 AR020016A2 ARP990106085A ARP990106085A AR020016A2 AR 020016 A2 AR020016 A2 AR 020016A2 AR P990106085 A ARP990106085 A AR P990106085A AR P990106085 A ARP990106085 A AR P990106085A AR 020016 A2 AR020016 A2 AR 020016A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- groups
- halogen atoms
- group
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 2
- 229960003276 erythromycin Drugs 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un compuesto de la formula (1) o una sal farmacéuticamente aceptable de los mismos, en la que: R es un grupo alquilo C3-8 ramificado en alfa, alquenilo,alquinilo, alcoxialquilo o alquiltioalquilo, cualquiera de los cuales pueden estar opcionalmente sustituidos con uno o más grupos hidroxilo; un grupocicloalquilalquilo C5-8 en el que el grupo alquilo es un grupo alquilo C2-5 ramificado en alfa; un grupo cicloalquilo C3-8 o cicloalquenilo C5-8, cualquiera delos cuales puede estar opcionalmente sustituidos con grupos metilo, o uno o más hidroxilo, o uno o más grupos alquilo C1-4 o átomos de halogeno; o un anilloheterocíclico de 3 a 6 eslabones que contiene oxígeno o azufre que puede estar saturado o total o parcialmente insaturado y que puedeestar opcionalmentesustituido con uno o más grupos alquilo C1-4, o átomos de halogeno; o R es fenilo que puede estar opcionalmente sustituido con al menos un sustituyenteseleccionado entre los grupos alquilo C1-4, alcoxi C1-4, alquiltio C1-4, átomosde halogeno, grupos hidroxilo, trifluorometilo y ciano; o R puede tener laformula (2) como se muestra a continuacion, en la que X1 es O, S, -CH2-, a, b, c, y d se seleccionan independientemente cada uno de ellos entre un numeroentero que oscila entre0 y 2 y a + b + c + d menor igual a 5; o R es CH2R24, donde R24 es H, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxialquilo oalquiltioalquilo que contiene de 1 a 6 átomos de carbono en cada grupo alquilo o alcoxi, donde cualquiera de dichos grupo alquilo, alcoxi, alquenilo oalquinilo pueden estar sustituidos por uno o más grupos hidroxilo o por uno o más átomos de halogeno; o un cicloalquilo C3-8 o cicloalquenilo C5-8, pudiendoestar cualquiera de ellos opcionalmente sustituido por metiloo uno o más grupos alquilo C1-4 o átomos de halogeno; o un heterociclo de 3 a 6 miembros quecontiene oxígeno o azufre, que puede estar saturado o total o parcialmente insaturado y que opcionalmente puede estar sustituido por uno o más grupos alquiloC1-4 o átomos de halogeno; o un grupo de la formula SR23, donde R23 es alquilo C1-8,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7035898P | 1998-01-02 | 1998-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020016A2 true AR020016A2 (es) | 2002-03-27 |
Family
ID=22094819
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106716A AR012764A1 (es) | 1998-01-02 | 1998-12-29 | Compuestos derivados de la eritromicina, composiciones que los contienen, usos y procedimientos para prepararlos. |
| ARP990106085A AR020016A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento |
| ARP990106083A AR019789A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento |
| ARP990106084A AR019790A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen. uso para preparar un medicamento |
| ARP990106082A AR019788A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen, uso y procedimientos para prepararlos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106716A AR012764A1 (es) | 1998-01-02 | 1998-12-29 | Compuestos derivados de la eritromicina, composiciones que los contienen, usos y procedimientos para prepararlos. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106083A AR019789A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento |
| ARP990106084A AR019790A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen. uso para preparar un medicamento |
| ARP990106082A AR019788A2 (es) | 1998-01-02 | 1999-11-30 | Compuestos derivados de la eritromicina, composiciones que los contienen, uso y procedimientos para prepararlos |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6825171B2 (es) |
| EP (2) | EP1044208A1 (es) |
| JP (1) | JP2002500231A (es) |
| KR (1) | KR20010033822A (es) |
| CN (1) | CN1285841A (es) |
| AP (1) | AP1060A (es) |
| AR (5) | AR012764A1 (es) |
| AT (1) | ATE377018T1 (es) |
| AU (1) | AU759019B2 (es) |
| BG (1) | BG104640A (es) |
| BR (1) | BR9812992A (es) |
| CA (1) | CA2317131C (es) |
| CO (1) | CO4970773A1 (es) |
| CZ (1) | CZ20002456A3 (es) |
| DE (1) | DE69838651T9 (es) |
| DZ (1) | DZ2699A1 (es) |
| EA (1) | EA200000600A1 (es) |
| ES (1) | ES2294641T3 (es) |
| GT (1) | GT199800207A (es) |
| HR (1) | HRP20000444A2 (es) |
| HU (1) | HUP0100566A3 (es) |
| IL (1) | IL136721A0 (es) |
| IS (1) | IS5527A (es) |
| MA (1) | MA26588A1 (es) |
| NO (1) | NO20003346L (es) |
| NZ (1) | NZ504987A (es) |
| OA (1) | OA11440A (es) |
| PA (1) | PA8465901A1 (es) |
| PE (1) | PE20000119A1 (es) |
| PL (1) | PL341647A1 (es) |
| SK (1) | SK9772000A3 (es) |
| TN (1) | TNSN98236A1 (es) |
| UY (2) | UY25331A1 (es) |
| WO (1) | WO1999035157A1 (es) |
| YU (1) | YU40900A (es) |
| ZA (1) | ZA9811940B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP9801420A0 (en) | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| GB9814006D0 (en) | 1998-06-29 | 1998-08-26 | Biotica Tech Ltd | Polyketides and their synthesis |
| EP1749832A3 (en) * | 1998-12-10 | 2008-03-26 | Pfizer Products Incorporated | Carbamate and carbazate ketolide antibiotics |
| EP1298138B1 (en) * | 1998-12-10 | 2006-11-02 | Pfizer Products Inc. | Carbamate and Carbazate Ketolide Antibiotics |
| ES2273964T3 (es) | 1998-12-10 | 2007-05-16 | Pfizer Products Inc. | Antibioticos de carbamato y carbazato cetolida. |
| EP1754700A3 (en) | 1999-01-27 | 2007-05-09 | Kosan Biosciences, Inc. | Synthesis of oligoketides |
| AP2001002222A0 (en) | 1999-01-27 | 2001-09-30 | Pfizer Prod Inc | Ketolide antibiotics. |
| US6451768B1 (en) * | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| US6590083B1 (en) * | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6395710B1 (en) | 1999-04-16 | 2002-05-28 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| IL145976A0 (en) | 1999-04-16 | 2002-07-25 | Ortho Mcneil Pharm Inc | Ketolide antibacterials |
| IL145739A0 (en) * | 1999-05-24 | 2002-07-25 | Pfizer Prod Inc | 13-methyl-erythromycin derivatives |
| ID27331A (id) * | 1999-09-29 | 2001-03-29 | Pfizer Prod Inc | Pembuatan antibiotik-antibiotik ketolida karbamat |
| EP1114826A3 (en) * | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
| US6562795B2 (en) | 2000-02-18 | 2003-05-13 | Kosan Biosciences, Inc. | Motilide compounds |
| US20020115621A1 (en) | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| US6472372B1 (en) | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| JP4509553B2 (ja) * | 2001-07-03 | 2010-07-21 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド |
| CN1589277A (zh) | 2001-09-17 | 2005-03-02 | 奥索-麦克尼尔药品公司 | 6－o－氨基甲酸酯－11,12－内酯－酮内酯抗菌剂 |
| AU2002346475A1 (en) | 2001-12-05 | 2003-06-23 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-acyl ketolide derivatives of erythromycine useful as antibacterials |
| WO2003102010A1 (en) | 2002-05-31 | 2003-12-11 | Janssen Pharmaceutica N.V. | 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents |
| EP1618120A2 (en) | 2003-04-25 | 2006-01-25 | Chiron Corporation | Novel ketolide derivatives |
| EP2233493A1 (en) | 2004-12-21 | 2010-09-29 | Pfizer Products Inc. | Macrolides |
| EP2029147B1 (en) | 2006-06-12 | 2010-05-19 | Ramot at Tel-Aviv University Ltd. | Methods for treating cancer |
| WO2014102778A2 (en) | 2012-12-24 | 2014-07-03 | Ramot At Tel-Aviv University Ltd. | Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US5486697A (en) | 1994-11-14 | 1996-01-23 | California Institute Of Technology | Array of micro-machined mass energy micro-filters for charged particles |
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| DK0910633T3 (da) | 1996-07-05 | 2010-03-29 | Biotica Tech Ltd | Hybrid polyketidsyntase I-gen |
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| NL1006540C2 (nl) | 1997-07-10 | 1999-01-15 | Skf Ind Trading & Dev | Elektrische actuator met regelsensor, alsmede schijfrem omvattende een dergelijke actuator. |
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1998
- 1998-12-17 AP APAP/P/1998/001421A patent/AP1060A/en active
- 1998-12-21 EP EP98959099A patent/EP1044208A1/en not_active Withdrawn
- 1998-12-21 CA CA002317131A patent/CA2317131C/en not_active Expired - Fee Related
- 1998-12-21 NZ NZ504987A patent/NZ504987A/xx unknown
- 1998-12-21 HR HR20000444A patent/HRP20000444A2/hr not_active Application Discontinuation
- 1998-12-21 AT AT05106836T patent/ATE377018T1/de not_active IP Right Cessation
- 1998-12-21 YU YU40900A patent/YU40900A/sh unknown
- 1998-12-21 ES ES05106836T patent/ES2294641T3/es not_active Expired - Lifetime
- 1998-12-21 HU HU0100566A patent/HUP0100566A3/hu unknown
- 1998-12-21 SK SK977-2000A patent/SK9772000A3/sk unknown
- 1998-12-21 JP JP2000527553A patent/JP2002500231A/ja active Pending
- 1998-12-21 PL PL98341647A patent/PL341647A1/xx unknown
- 1998-12-21 EP EP05106836A patent/EP1642901B1/en not_active Expired - Lifetime
- 1998-12-21 EA EA200000600A patent/EA200000600A1/ru unknown
- 1998-12-21 KR KR1020007007378A patent/KR20010033822A/ko not_active Ceased
- 1998-12-21 AU AU15015/99A patent/AU759019B2/en not_active Ceased
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- 1998-12-21 IL IL13672198A patent/IL136721A0/xx unknown
- 1998-12-21 WO PCT/IB1998/002100 patent/WO1999035157A1/en not_active Ceased
- 1998-12-21 BR BR9812992-9A patent/BR9812992A/pt not_active Application Discontinuation
- 1998-12-21 CN CN98812832A patent/CN1285841A/zh active Pending
- 1998-12-21 CZ CZ20002456A patent/CZ20002456A3/cs unknown
- 1998-12-28 PE PE1998001285A patent/PE20000119A1/es not_active Application Discontinuation
- 1998-12-29 AR ARP980106716A patent/AR012764A1/es not_active Application Discontinuation
- 1998-12-30 DZ DZ980309A patent/DZ2699A1/xx active
- 1998-12-30 UY UY25331A patent/UY25331A1/es not_active Application Discontinuation
- 1998-12-30 CO CO98077582A patent/CO4970773A1/es unknown
- 1998-12-30 TN TNTNSN98236A patent/TNSN98236A1/fr unknown
- 1998-12-30 MA MA25408A patent/MA26588A1/fr unknown
- 1998-12-30 PA PA19988465901A patent/PA8465901A1/es unknown
- 1998-12-30 GT GT199800207A patent/GT199800207A/es unknown
- 1998-12-30 ZA ZA9811940A patent/ZA9811940B/xx unknown
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1999
- 1999-06-25 UY UY25587A patent/UY25587A1/es not_active Application Discontinuation
- 1999-11-30 AR ARP990106085A patent/AR020016A2/es not_active Application Discontinuation
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2000
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2003
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