AR031853A1 - Derivados biciclicos de amino acidos con puente aza, proceso para preparar un intermediario, composicion farmaceutica que los comprende y uso de tales derivados en la fabricacion de un medicamento para tratar trastornos mediados por integrina - Google Patents
Derivados biciclicos de amino acidos con puente aza, proceso para preparar un intermediario, composicion farmaceutica que los comprende y uso de tales derivados en la fabricacion de un medicamento para tratar trastornos mediados por integrinaInfo
- Publication number
- AR031853A1 AR031853A1 ARP010103131A ARP010103131A AR031853A1 AR 031853 A1 AR031853 A1 AR 031853A1 AR P010103131 A ARP010103131 A AR P010103131A AR P010103131 A ARP010103131 A AR P010103131A AR 031853 A1 AR031853 A1 AR 031853A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- independently selected
- optionally
- amino
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 16
- 229910052757 nitrogen Inorganic materials 0.000 abstract 10
- 125000002950 monocyclic group Chemical group 0.000 abstract 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 8
- 125000004429 atom Chemical group 0.000 abstract 7
- 125000005842 heteroatom Chemical group 0.000 abstract 7
- 229910052760 oxygen Inorganic materials 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 229910052717 sulfur Inorganic materials 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 4
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 229940127449 Integrin Receptor Antagonists Drugs 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados bicíclicos con puente aza que tiene la formula (1) y sales farmacéuticamente aceptables, mezclas racémicas, diastereomeros y enantiomeros de los mismos, donde Y se selecciona del grupo que consiste en un enlace, -C(O)-, -C(O)O-, C(O)NH- y -SO2-, R1 se selecciona del grupo que consiste en R7 y R8; R2, R3, R4 y R5 se seleccionan de manera independiente del grupo que consiste en un enlace, hidrogeno y alquilo de C1-8, donde el alquilo de C1-8 está sustituido de manera opcional con uno a tres sustituyentes que se seleccionan de manera independiente de R9, siempre R2, R3, R4 o R5 solo puedan ser un enlace cuando se forma un anillo monocíclico donde los siguientes anillos monocíclicos se pueden formar de R2, R3, R4 y R5; cuando R2 y R3 comprenden un enlace y alquilo C1-8 u opcionalmente cuando tanto R2 como R3 son alquilo de C1-8, R2 y R3 junto con los átomos a los que cada uno se encuentran unidos formarán un anillo monocíclico de cuatro a siete miembros que contienen de manera opcional uno o dos heteroátomos adicionales que se seleccionan de manera independiente del grupo que consiste en N, O y S, donde R3 y R4 comprenden un enlace y alquilo de C1-8 u opcionalmente cuando tanto R3 como R4 son alquilo de C1-8, R2 y R3 junto con los átomos a los que cada uno se encuentran unidos formarán un anillo monocíclico de cinco a siete miembros que contienen de manera opcional uno o dos heteroátomos adicionales que se seleccionan de manera independiente del grupo que consiste en N, O y S; donde R3 y R5 comprenden un enlace y alquilo de C1-8 u opcionalmente cuando tanto R3 como R5 son alquilo de C1-8, R2 y R3 junto con los átomos a los que cada uno se encuentran unidos formarán un anillo monocíclico de cuatro a siete miembros que contienen de manera opcional uno o dos heteroátomos adicionales que se seleccionan de manera independiente del grupo que consiste en N, O y S, donde R4 y R5 comprenden un enlace y alquilo de C1-8 u opcionalmente cuando tanto R4 como R5 son alquilo de C1-8, R2 y R3 junto con los átomos a los que cada uno se encuentran unidos formarán un anillo monocíclico de cuatro a siete miembros que contienen de manera opcional uno o dos heteroátomos adicionales que se seleccionan de manera independiente del grupo que consiste en N, O y S; R6 se presenta de manera opcional y es uno a tres sustituyentes que se seleccionan de manera independiente del grupo que consiste en halogeno, alcoxi C1-8 , R10, R12, -N(R11)C(O)-R10, -N(R11)C(O)-R12, -N(R11)SO2-R10, -N(R11)SO2-R12, -N(R11)C(O)-N(R11,R12), -N(R11)C(O)-N(R12,R17), -C(O)-N(R11, R10), -C(O)-N(R11,R12), -C(O)-N(R12, R17), -OC(O)-N(R11, R10), -OC(O).N(R11, R12), -OC(O)-N(R12, R17), -OC(O)-R10, -OC(O)-R12, -O-R10 y R10-(C1-8)alcoxi; R7, R9, R10 y R14, se seleccionan de manera independiente del grupo que consiste en cicloalquilo, heterociclilo, arilo y heteroarilo sustituidos de manera opcional con uno a cinco sustituyentes que se seleccionan de manera independiente del grupo que consiste en halogeno, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxi C1-8, alquilcarbonilo C1-8, alcoxicarbonilo C1-8, carboxilo, arilo, heteroarilo, arilcarbonilo, heteroarilcarbonilo, arilsulfonilo, amino, N-alquil (C1-8) amino, N,N-dialquil(C1-8)amino, -CF3 y -OCF3; donde cicloalquilo y heterociclilo están sustituidos de manera opcional con uno a tres sustituyentes oxo, y donde los sustituyentes arilo y heteroarilo y la porcion arilo del sustituyente arilcarbonilo están sustituidos de manera opcional con uno a cinco sustituyentes que se seleccionan de manera independiente del grupo que consiste en halogeno, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxi C1-8, carboxilo, amino, N-alquil(C1-8)amino, N,N-dialquil(C1-8)amino, -CF3 y -OCF3; R8, R12, R13 y R17 se seleccionan de manera independiente del grupo que consiste en alquilo C1-8, alquenilo C2-8, alquinilo C2-8, y (halo)1-3(C1-8)alquilo; donde alquilo C1-8, alquenilo C2-8, alquinilo C2-8 están sustituidos de manera opcional sobre un carbono terminal con uno a tres sustituyentes que se seleccionan de manera independiente de R14; R11 se selecciona del grupo que consiste en hidrogeno y alquilo C1-8; A es alquileno C1-4 sustituido de manera opcional con uno o dos sustituyentes que se seleccionan de manera independiente de R13; cuando R3 es alquilo C1-8 opcionalmente A y R3 junto con los átomos a los que cada uno están unidos pueden formar un anillo monocíclico de cinco a siete miembros que contengan de manera opcional uno a dos heteroátomos adicionales que se seleccionan de manera independiente del grupo que consiste en N, O y S; cuando R4 es alquilo C1-8 opcionalmente A y R4 junto con los átomos a los que cada uno están unidos pueden formar un anillo monocíclico de cinco a siete miembros que contengan de manera opcional un heteroátomo adicional que se selecciona del grupo que consiste en N, O y S; cuando R5 es alquilo C1-8 opcionalmente A y R5 junto con los átomos a los que cada uno están unidos pueden formar un anillo monocíclico de tres a siete miembros que contengan de manera opcional un o dos heteroátomos adicionales que se seleccionan de manera independiente del grupo que consiste en N, O y S, y B1 y B2 se seleccionan de manera independiente del grupo que consiste en alquileno C1-8 y alquenileno C2-8 sustituidos de manera opcional con uno o dos sustituyentes del grupo que consiste en halogeno, hidroxi, hidroxi (C1-8)alquilo, hidroxi(C1-8)alcoxi, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxi C1-8, carboxilo, amino, N-alquil(C1-8)amino, N,N-dialquil(C1-8)amino, -CF3 y -OCF3. Los compuestos son antagonistas receptores de a4 integrina, en particular, antagonistas receptores de integrina a4b1 y a4b7. Además se dan a conocer: un proceso para preparar intermediarios, composiciones farmacéuticas que comprenden a dichos derivados, y el uso de tales derivados para fabricar medicamentos para tratar trastornos mediados por integrina que incluyen, pero que no se limitan a trastornos inflamatorios, trastornos autoinmunes y trastornos de proliferacion celular.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21569500P | 2000-06-30 | 2000-06-30 | |
| US09/891,602 US6960597B2 (en) | 2000-06-30 | 2001-06-26 | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031853A1 true AR031853A1 (es) | 2003-10-08 |
Family
ID=26910288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103131A AR031853A1 (es) | 2000-06-30 | 2001-06-29 | Derivados biciclicos de amino acidos con puente aza, proceso para preparar un intermediario, composicion farmaceutica que los comprende y uso de tales derivados en la fabricacion de un medicamento para tratar trastornos mediados por integrina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6960597B2 (es) |
| EP (1) | EP1303492A2 (es) |
| JP (1) | JP2004506612A (es) |
| KR (1) | KR20030014287A (es) |
| CN (1) | CN1449385A (es) |
| AR (1) | AR031853A1 (es) |
| AU (1) | AU2001273095A1 (es) |
| BR (1) | BR0112359A (es) |
| CA (1) | CA2415088A1 (es) |
| HK (1) | HK1052343A1 (es) |
| HU (1) | HUP0301195A2 (es) |
| IL (1) | IL154053A0 (es) |
| MX (1) | MXPA03000814A (es) |
| NO (1) | NO20026252L (es) |
| NZ (1) | NZ523852A (es) |
| PL (1) | PL359997A1 (es) |
| RU (1) | RU2003102631A (es) |
| WO (1) | WO2002002556A2 (es) |
| YU (1) | YU98902A (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| ATE497385T1 (de) | 2000-08-18 | 2011-02-15 | Ajinomoto Kk | Neue phenylalanin-derivate |
| JP4895067B2 (ja) | 2000-09-29 | 2012-03-14 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
| US7115628B2 (en) * | 2001-07-18 | 2006-10-03 | Merck & Co., Inc. | Bridged piperidine derivatives as melanocortin receptor agonists |
| UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| UY28170A1 (es) * | 2003-01-24 | 2004-07-30 | Elan Pharm Inc | Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantes. |
| US20050176755A1 (en) * | 2003-10-31 | 2005-08-11 | Dyatkin Alexey B. | Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists |
| EP1700850B1 (en) | 2003-12-22 | 2015-07-15 | Ajinomoto Co., Inc. | Phenylalanine derivative |
| WO2005077915A1 (en) * | 2004-02-10 | 2005-08-25 | Janssen Pharmaceutica, N.V. | Pyridazinones as antagonists of a4 integrins |
| DE602005002251D1 (de) * | 2004-02-10 | 2007-10-11 | Janssen Pharmaceutica Nv | Pyridazinonharnstoffe als antagonisten von a4-integrinen |
| US7220742B2 (en) * | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| EP1753455A2 (en) | 2004-06-04 | 2007-02-21 | Genentech, Inc. | Method for treating multiple sclerosis |
| WO2006096807A1 (en) * | 2005-03-08 | 2006-09-14 | Janssen Pharmaceutica N.V. | Aza-bridged-bicyclic amino acid derivatives as alpha 4 integrin antagonists |
| ES2646326T3 (es) | 2005-08-03 | 2017-12-13 | Sprout Pharmaceuticals, Inc. | Uso de flibanserina en el tratamiento de la obesidad |
| KR101360803B1 (ko) * | 2005-08-15 | 2014-02-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 베타모방제의 제조방법 |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| WO2008000760A1 (en) | 2006-06-30 | 2008-01-03 | Boehringer Ingelheim International Gmbh | Flibanserin for the treatment of urinary incontinence and related diseases |
| UY30543A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de beta- agonistas |
| UY30542A1 (es) * | 2006-08-18 | 2008-03-31 | Boehringer Ingelheim Int | Formulacion de aerosol para la inhalacion de agonistas beta |
| CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | 建南德克公司 | 治療進展型多發性硬化症之方法 |
| CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| AU2010332010A1 (en) * | 2009-12-14 | 2012-08-02 | Inspire Pharmaceuticals, Inc. | Bridged bicyclic Rho kinase inhibitor compounds, composition and use |
| WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| US8999975B2 (en) | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
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-
2001
- 2001-06-26 US US09/891,602 patent/US6960597B2/en not_active Expired - Fee Related
- 2001-06-29 YU YU98902A patent/YU98902A/sh unknown
- 2001-06-29 MX MXPA03000814A patent/MXPA03000814A/es unknown
- 2001-06-29 RU RU2003102631/04A patent/RU2003102631A/ru not_active Application Discontinuation
- 2001-06-29 JP JP2002507808A patent/JP2004506612A/ja active Pending
- 2001-06-29 NZ NZ523852A patent/NZ523852A/en unknown
- 2001-06-29 EP EP01952331A patent/EP1303492A2/en not_active Withdrawn
- 2001-06-29 PL PL01359997A patent/PL359997A1/xx not_active Application Discontinuation
- 2001-06-29 AU AU2001273095A patent/AU2001273095A1/en not_active Abandoned
- 2001-06-29 CN CN01814699A patent/CN1449385A/zh active Pending
- 2001-06-29 KR KR1020027017914A patent/KR20030014287A/ko not_active Ceased
- 2001-06-29 WO PCT/US2001/020857 patent/WO2002002556A2/en not_active Ceased
- 2001-06-29 AR ARP010103131A patent/AR031853A1/es unknown
- 2001-06-29 IL IL15405301A patent/IL154053A0/xx unknown
- 2001-06-29 BR BR0112359-9A patent/BR0112359A/pt not_active IP Right Cessation
- 2001-06-29 HK HK03104413.8A patent/HK1052343A1/zh unknown
- 2001-06-29 HU HU0301195A patent/HUP0301195A2/hu unknown
- 2001-06-29 CA CA002415088A patent/CA2415088A1/en not_active Abandoned
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2002
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Also Published As
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| HK1052343A1 (zh) | 2004-02-06 |
| NO20026252D0 (no) | 2002-12-27 |
| IL154053A0 (en) | 2003-07-31 |
| CN1449385A (zh) | 2003-10-15 |
| WO2002002556A2 (en) | 2002-01-10 |
| JP2004506612A (ja) | 2004-03-04 |
| US6960597B2 (en) | 2005-11-01 |
| YU98902A (sh) | 2006-05-25 |
| MXPA03000814A (es) | 2004-11-01 |
| AU2001273095A1 (en) | 2002-01-14 |
| EP1303492A2 (en) | 2003-04-23 |
| HUP0301195A2 (hu) | 2003-08-28 |
| US20020091115A1 (en) | 2002-07-11 |
| WO2002002556A3 (en) | 2002-07-18 |
| NO20026252L (no) | 2003-02-26 |
| NZ523852A (en) | 2004-11-26 |
| BR0112359A (pt) | 2003-05-27 |
| CA2415088A1 (en) | 2002-01-10 |
| KR20030014287A (ko) | 2003-02-15 |
| PL359997A1 (en) | 2004-09-06 |
| RU2003102631A (ru) | 2004-09-27 |
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