AR032570A1 - Construcciones de polinucleotidicas para aumentar la produccion de lisina - Google Patents
Construcciones de polinucleotidicas para aumentar la produccion de lisinaInfo
- Publication number
- AR032570A1 AR032570A1 ARP020100424A ARP020100424A AR032570A1 AR 032570 A1 AR032570 A1 AR 032570A1 AR P020100424 A ARP020100424 A AR P020100424A AR P020100424 A ARP020100424 A AR P020100424A AR 032570 A1 AR032570 A1 AR 032570A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- dapb
- asd
- ask
- ddh
- Prior art date
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 5
- 101150073654 dapB gene Proteins 0.000 abstract 4
- 239000004472 Lysine Substances 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 235000019766 L-Lysine Nutrition 0.000 abstract 2
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 abstract 2
- 101710130262 Probable Vpr-like protein Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- GMKMEZVLHJARHF-UHFFFAOYSA-N 2,6-diaminopimelic acid Chemical compound OC(=O)C(N)CCCC(N)C(O)=O GMKMEZVLHJARHF-UHFFFAOYSA-N 0.000 abstract 1
- 108010055400 Aspartate kinase Proteins 0.000 abstract 1
- 108020004652 Aspartate-Semialdehyde Dehydrogenase Proteins 0.000 abstract 1
- 108010014468 Dihydrodipicolinate Reductase Proteins 0.000 abstract 1
- 101000787195 Escherichia coli (strain K12) Aldose sugar dehydrogenase YliI Proteins 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 101000728677 Pseudomonas sp Bifunctional aspartate aminotransferase and L-aspartate beta-decarboxylase Proteins 0.000 abstract 1
- 101150057904 ddh gene Proteins 0.000 abstract 1
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 abstract 1
- 101150109073 ldhD gene Proteins 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se refiere a la produccion de lisina, y provee varias moléculas polinucleotídicas aisladas que son utiles para la produccion de L-lisina. Uno de dichos polinucleotidos codifica aspartato quinasa (ask), una aspartato-semialdehído dehidrogenasa (asd) y una dihidrodipicolinato reductasa (dapB). Otros polipéptidos codifican ask, asd, dapB y una diaminopimelato dehidrogenasa (ddh); ask, asd, dapB, ddh y un polipéptido ORF2; y ask, asd, dapB, ddh, ORF2 y una diaminopimelato decarboxilasa (IysA). Se provee además métodos para preparar y usar los polinucleotidos, y métodos para aumentar la produccion de L-lisina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26718301P | 2001-02-08 | 2001-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032570A1 true AR032570A1 (es) | 2003-11-12 |
Family
ID=23017664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100424A AR032570A1 (es) | 2001-02-08 | 2002-02-08 | Construcciones de polinucleotidicas para aumentar la produccion de lisina |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1368367B1 (es) |
| AR (1) | AR032570A1 (es) |
| BR (1) | BRPI0207037B1 (es) |
| CA (1) | CA2437656C (es) |
| IL (2) | IL156997A0 (es) |
| MX (1) | MXPA03007089A (es) |
| NO (1) | NO20033452L (es) |
| NZ (1) | NZ527129A (es) |
| WO (1) | WO2002064610A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102233376B1 (ko) * | 2019-09-26 | 2021-03-30 | 씨제이제일제당 주식회사 | 메조 디아미노피멜레이트 디하이드로게네이즈 변이형 폴리펩타이드 및 이를 이용한 l-쓰레오닌 생산방법 |
| CN116042416B (zh) * | 2023-01-09 | 2024-09-27 | 天津科技大学 | 高产ε-聚赖氨酸的多基因过表达链霉菌工程菌株及方法与应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1045451B (it) | 1966-03-23 | 1980-05-10 | Ajinomoto Kk | Metodo per recuperare lisina da brodo di fermentazione |
| JPS56160997A (en) | 1980-05-16 | 1981-12-11 | Ajinomoto Co Inc | Preparation of l-lysine by fermenaition method |
| US5236831A (en) | 1981-12-29 | 1993-08-17 | Kiowa Hakko Kogyo Co., Ltd. | Amino acid synthesis in corynebacteria using E. coli genes |
| JPH06102028B2 (ja) | 1985-10-04 | 1994-12-14 | 協和醗酵工業株式会社 | アミノ酸の製造法 |
| DE3908201A1 (de) | 1989-03-14 | 1990-09-27 | Degussa | Verfahren zur fermentativen herstellung von l-lysin |
| JPH07155184A (ja) * | 1993-12-08 | 1995-06-20 | Ajinomoto Co Inc | 発酵法によるｌ−リジンの製造法 |
| JP3783065B2 (ja) | 1994-03-04 | 2006-06-07 | 味の素株式会社 | Ｌ−リジンの製造法 |
| DK0841395T3 (da) | 1995-06-07 | 2012-01-09 | Ajinomoto Kk | Fremgangsmåde til at fremstille L-lysin |
| JP4035855B2 (ja) | 1996-06-05 | 2008-01-23 | 味の素株式会社 | Ｌ−リジンの製造法 |
| SK285201B6 (sk) | 1996-12-05 | 2006-08-03 | Ajinomoto Co., Inc. | Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7 |
| HK1042321B (en) | 1999-04-19 | 2012-02-24 | 协和发酵工业株式会社 | Novel desensitized aspartokinase |
| US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
-
2002
- 2002-02-08 AR ARP020100424A patent/AR032570A1/es not_active Application Discontinuation
- 2002-02-08 NZ NZ527129A patent/NZ527129A/en not_active IP Right Cessation
- 2002-02-08 EP EP02709367.3A patent/EP1368367B1/en not_active Expired - Lifetime
- 2002-02-08 CA CA002437656A patent/CA2437656C/en not_active Expired - Fee Related
- 2002-02-08 MX MXPA03007089A patent/MXPA03007089A/es active IP Right Grant
- 2002-02-08 IL IL15699702A patent/IL156997A0/xx unknown
- 2002-02-08 BR BRPI0207037-5A patent/BRPI0207037B1/pt not_active IP Right Cessation
- 2002-02-08 WO PCT/US2002/003469 patent/WO2002064610A1/en not_active Ceased
-
2003
- 2003-07-17 IL IL156997A patent/IL156997A/en active IP Right Revival
- 2003-08-04 NO NO20033452A patent/NO20033452L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1368367B1 (en) | 2017-05-03 |
| NZ527129A (en) | 2005-05-27 |
| BRPI0207037B1 (pt) | 2015-07-07 |
| MXPA03007089A (es) | 2004-10-15 |
| WO2002064610A1 (en) | 2002-08-22 |
| CA2437656A1 (en) | 2002-08-22 |
| BR0207037A (pt) | 2004-06-22 |
| NO20033452L (no) | 2003-10-07 |
| IL156997A (en) | 2014-08-31 |
| IL156997A0 (en) | 2004-02-08 |
| EP1368367A4 (en) | 2004-09-01 |
| EP1368367A1 (en) | 2003-12-10 |
| NO20033452D0 (no) | 2003-08-04 |
| CA2437656C (en) | 2009-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |