AR036672A1 - Derivados de pirrolidinona - Google Patents

Derivados de pirrolidinona

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Publication number
AR036672A1
AR036672A1 ARP020103733A ARP020103733A AR036672A1 AR 036672 A1 AR036672 A1 AR 036672A1 AR P020103733 A ARP020103733 A AR P020103733A AR P020103733 A ARP020103733 A AR P020103733A AR 036672 A1 AR036672 A1 AR 036672A1
Authority
AR
Argentina
Prior art keywords
heterocycle
alkynyl
cycloalkyl
alkenyl
aryl
Prior art date
Application number
ARP020103733A
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English (en)
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of AR036672A1 publication Critical patent/AR036672A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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Abstract

Composiciones farmacéuticas y compuestos útiles en el tratamiento de condiciones mediadas por CCR2, MCP-1 o la interacción de los mismos. Los compuestos son pirrolidinonas y pirrolidin-tionas. Reivindicación 1: Una composición farmacéutica que comprende un compuesto conforme a la fórmula (1), en donde: Y es oxígeno o azufre; G y G', junto con el enlace que los une, son HC-CH o C=C; V es arilo, heterociclo o cicloalquilo; Z es halógeno, alquilo, alquenilo, alquinilo, hidroxilo, amino, alcoxi, ariloxi, nitro o ciano; R1 es hidrógeno, halógeno, alquilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, arilo o heterociclo; R2 es hidrógeno o hidroxilo; R3 es -C(O)R3a, -C(O)OR3a, -C(O)N(R3a)(R3b), -S(O)2R3a, -S(O)R3a ó -SR3a, donde R3a y R3b tienen, independientemente, el mismo significado que R1; R4 es hidroxilo, sulfanilo o amino; t es 0, 1, 2, 3, 4 ó 5; o una sal farmacéuticamente aceptable o degradable metabólicamente derivada del mismo, junto con un diluyente o vehículo farmacéuticamente aceptable.
ARP020103733A 2001-10-03 2002-10-03 Derivados de pirrolidinona AR036672A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97014001A 2001-10-03 2001-10-03
US40080702P 2002-08-01 2002-08-01

Publications (1)

Publication Number Publication Date
AR036672A1 true AR036672A1 (es) 2004-09-22

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ARP020103733A AR036672A1 (es) 2001-10-03 2002-10-03 Derivados de pirrolidinona

Country Status (19)

Country Link
US (3) US20050004180A1 (es)
EP (1) EP1434577A1 (es)
JP (1) JP2005523238A (es)
KR (1) KR20040048936A (es)
CN (1) CN1564685A (es)
AR (1) AR036672A1 (es)
BG (1) BG108660A (es)
BR (1) BR0212968A (es)
CA (1) CA2463198A1 (es)
CO (1) CO5390075A1 (es)
CZ (1) CZ2004442A3 (es)
HU (1) HUP0402503A2 (es)
IL (1) IL160642A0 (es)
MX (1) MXPA04002982A (es)
NO (1) NO20041767L (es)
NZ (1) NZ532018A (es)
PL (1) PL370355A1 (es)
RU (1) RU2004109818A (es)
WO (1) WO2003030897A1 (es)

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CA2565280A1 (en) * 2004-05-26 2005-12-15 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
RU2007108289A (ru) * 2004-08-11 2008-09-20 Янссен Фармацевтика Н.В. (Be) Меркаптоимидазолы, предназначенные для использования в качестве антагонистов рецептора ccr2
US20080187508A1 (en) * 2004-09-08 2008-08-07 Boys Town National Research Hospital Treatment of Golmerular Basement Membrane Disease Involving Matrix Metalloproteinase-12
US20090012148A1 (en) * 2005-11-01 2009-01-08 Maxfield Frederick R Reducing cellular cholesterol levels and/or treating or preventing phospholipidosis
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008127274A2 (en) * 2006-09-22 2008-10-23 Ptc Therapeutics, Inc. Heterocyclic inhibitors of bacterial peptidyl trna hydrolase and uses thereof
EP2089383B1 (en) * 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
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WO2008103367A2 (en) * 2007-02-20 2008-08-28 Sergey Kozmin Method for assembling high-purity chemical libraries, proapoptotic compounds discovered by same
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