AR042931A2 - Uso de un compuesto fotoactivo para la manufactura de una composicion farmaceutica para el tratamiento de la neovasculatura coroidal - Google Patents

Uso de un compuesto fotoactivo para la manufactura de una composicion farmaceutica para el tratamiento de la neovasculatura coroidal

Info

Publication number
AR042931A2
AR042931A2 ARP040100227A ARP040100227A AR042931A2 AR 042931 A2 AR042931 A2 AR 042931A2 AR P040100227 A ARP040100227 A AR P040100227A AR P040100227 A ARP040100227 A AR P040100227A AR 042931 A2 AR042931 A2 AR 042931A2
Authority
AR
Argentina
Prior art keywords
neovasculature
alkyl
pharmaceutical composition
photoactive compound
manufacture
Prior art date
Application number
ARP040100227A
Other languages
English (en)
Original Assignee
Quadra Logic Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadra Logic Tech Inc filed Critical Quadra Logic Tech Inc
Publication of AR042931A2 publication Critical patent/AR042931A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

Uso de un compuesto fotoactivo para la manufactura de una composición farmacéutica para el tratamiento de la neovasculatura coridal en un sujeto humano con terapia fotodinámicas repetida, cada terapia fotodinámica consiste en la irradiación del tejido ocular del sujeto que contiene dicha neovasculatura con luz por un tiempo y en una intensidad suficiente para dicha neovasculatura, la irradiación se lleva a cabo después de que ha transcurrido un tiempo suficiente para localizar una cantidad eficaz previamente administrada del compuesto fotoactivo al tejido ocular. Los compuestos fotoactivos preferidos que se pueden emplear pueden ser porfirina verde, hematoporfirina, clorina o florina. Una formulación preferida de la composición farmacéutica es una preparación liposomal. Preferentemente la porfirina verde es la fórmula 1-3 o 1-4 donde cada uno de R1 y R2 se selecciona independientemente del grupo que consta de carbalcoxilo C2-6, alquilo C1-6, arilsulfonilo C6-10, ciano, y -CONR5CO, donde R5 es arilo C6-10 o alquilo C1-6, cada 3 es independientemente carboxilo, carboxialquilo C2-6 o una sal, amida, éster o acilhidrazona de los mismos o bien, es alquilo C1-6; R4 es CH=CH2 o -CH(OR4)CH3, donde R4 es H o bien alquilo C1-6 optativamente sustituido con un sustituyente hidrofílico. Reivindicación 25: El uso de acuerdo con la cláusula 1, caracterizado porque dicha irradiación es con luz emitida de un láser.
ARP040100227A 1996-03-11 2004-01-26 Uso de un compuesto fotoactivo para la manufactura de una composicion farmaceutica para el tratamiento de la neovasculatura coroidal AR042931A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/613,420 US5756541A (en) 1996-03-11 1996-03-11 Vision through photodynamic therapy of the eye

Publications (1)

Publication Number Publication Date
AR042931A2 true AR042931A2 (es) 2005-07-06

Family

ID=24457246

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP970100946A AR004422A1 (es) 1996-03-11 1997-03-10 Uso de un compuesto fotoactivo para la manufactura de una composicion farmaceutica para mejorar la agudeza visual
ARP040100227A AR042931A2 (es) 1996-03-11 2004-01-26 Uso de un compuesto fotoactivo para la manufactura de una composicion farmaceutica para el tratamiento de la neovasculatura coroidal

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP970100946A AR004422A1 (es) 1996-03-11 1997-03-10 Uso de un compuesto fotoactivo para la manufactura de una composicion farmaceutica para mejorar la agudeza visual

Country Status (21)

Country Link
US (6) US5756541A (es)
EP (1) EP0894009B1 (es)
JP (2) JP2000506173A (es)
KR (1) KR100433507B1 (es)
CN (1) CN1104908C (es)
AR (2) AR004422A1 (es)
AT (1) ATE301473T1 (es)
CA (1) CA2248087C (es)
CZ (1) CZ299301B6 (es)
DE (1) DE69733943T2 (es)
DK (1) DK0894009T3 (es)
ES (1) ES2246505T3 (es)
FI (1) FI981954L (es)
HU (1) HU227978B1 (es)
IL (4) IL126099A (es)
NO (1) NO984163L (es)
NZ (1) NZ331736A (es)
PL (1) PL188888B1 (es)
TW (1) TW448045B (es)
WO (1) WO1997033619A1 (es)
ZA (1) ZA971820B (es)

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US5776966A (en) 1992-05-27 1998-07-07 University Of British Columbia Selective cell inactivation in blood
CA2536069C (en) * 1994-03-14 2008-06-03 Massachusetts Eye And Ear Infirmary Use of green porphyrins in ocular diagnosis and therapy
JP2961074B2 (ja) 1995-09-06 1999-10-12 明治製菓株式会社 光化学療法用の新生血管閉塞剤

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