AR044246A1 - Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas - Google Patents

Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas

Info

Publication number
AR044246A1
AR044246A1 ARP040101521A ARP040101521A AR044246A1 AR 044246 A1 AR044246 A1 AR 044246A1 AR P040101521 A ARP040101521 A AR P040101521A AR P040101521 A ARP040101521 A AR P040101521A AR 044246 A1 AR044246 A1 AR 044246A1
Authority
AR
Argentina
Prior art keywords
preparation
vectors
cells
immunoprotector
transgenic plants
Prior art date
Application number
ARP040101521A
Other languages
English (en)
Original Assignee
Dow Agrosciences Llc
Thompson Boyce Plant Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc, Thompson Boyce Plant Res filed Critical Dow Agrosciences Llc
Publication of AR044246A1 publication Critical patent/AR044246A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente se refiere a la producción de vectores y métodos útiles para la preparación de células de plantas genéticamente transformadas que expresan inmunógenos de organismos patógenos los cuales son utilizados para producir partículas inmunoprotectoras útiles en la preparación de vacunas, incluye genes vegetales optimizados que codifican la proteína HN del virus de la enfermedad de Newcastle, también se refiere a métodos de producción de un antígeno en una planta transgénica. Reivindicación 1: Una secuencia nucleotídica optimizada vegetal aislada que codifica el antígeno HN del virus de la enfermedad de Newcastle que comprende la secuencia de SEQ ID Nº:1.
ARP040101521A 2003-05-05 2004-05-05 Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas AR044246A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46799803P 2003-05-05 2003-05-05

Publications (1)

Publication Number Publication Date
AR044246A1 true AR044246A1 (es) 2005-09-07

Family

ID=33435152

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101521A AR044246A1 (es) 2003-05-05 2004-05-05 Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas

Country Status (13)

Country Link
US (3) US7132291B2 (es)
EP (1) EP1620550B1 (es)
KR (1) KR20060035596A (es)
CN (1) CN100393870C (es)
AR (1) AR044246A1 (es)
AT (1) ATE473271T1 (es)
AU (1) AU2004235813B2 (es)
BR (1) BRPI0410340A (es)
CA (1) CA2524293A1 (es)
DE (1) DE602004028004D1 (es)
NZ (1) NZ543348A (es)
WO (1) WO2004098533A2 (es)
ZA (1) ZA200508930B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
CN1326998C (zh) * 2004-11-25 2007-07-18 中国农业科学院哈尔滨兽医研究所 编码h5亚型禽流感病毒血凝素蛋白的基因及其应用
EP1919504B1 (en) 2005-08-03 2013-10-16 iBio, Inc. Antibody to bacillus anthracis protective antigen
JP2009514547A (ja) 2005-11-04 2009-04-09 ダウ・アグロサイエンス・エル・エル・シー 組み換え植物懸濁培養物を使用するワクチンマスター細胞系統の調製
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
WO2007095320A2 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
AU2007215080A1 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
JP2009535306A (ja) * 2006-04-21 2009-10-01 ダウ・アグロサイエンス・エル・エル・シー 鳥インフルエンザに対するワクチンおよび使用方法
KR100766775B1 (ko) * 2006-04-24 2007-11-01 대한민국 장출혈성대장균(ｅｈｅｃ) 감염증 예방용 톡소이드 백신
CN100487119C (zh) * 2006-05-09 2009-05-13 中国农业科学院哈尔滨兽医研究所 表达禽流感病毒H5亚型HA蛋白的重组新城疫LaSota弱毒疫苗株
EP2029167A4 (en) * 2006-06-16 2010-06-16 Dow Agrosciences Llc NEW DNA SEQUENCES, VECTORS AND PROTEINS OF BIRD FLUID HEMOGGLUTININE
US20080241188A1 (en) * 2007-03-30 2008-10-02 Zeon Corporation Turkey herpesvirus vectored recombinant containing avian influenza genes
BRPI0810865A2 (pt) * 2007-04-28 2017-05-09 Fraunhofer Usa Inc antígenos de tripanossoma, composições vacinais, e métodos relacionados
BRPI0812538B1 (pt) * 2007-06-15 2021-03-16 Medicago Inc. processo para a síntese de uma proteína de interesse com fucosilação e xilosilação reduzidas, ácido nucleico, e proteína híbrida gnt1-galt
KR100964462B1 (ko) * 2007-07-10 2010-06-16 성균관대학교산학협력단 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법
US8404252B2 (en) * 2007-07-11 2013-03-26 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CA2615372A1 (en) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CN101820903A (zh) * 2007-08-20 2010-09-01 美国弗劳恩霍夫股份有限公司 预防性和治疗性流感疫苗、抗原、组合物和方法
EP2610345B1 (en) * 2007-11-27 2015-08-19 Medicago Inc. Recombinant influenza virus-like particles (VLPS) produced in transgenic plants expressing hemagglutinin
EA034733B1 (ru) 2008-01-21 2020-03-13 Медикаго Инк. Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение
DK2294202T3 (en) 2008-07-08 2015-08-31 Medicago Inc SOLUBLE RECOMBINANT INFLUENZA ANTIGENES
JP5813505B2 (ja) 2008-07-18 2015-11-17 メディカゴ インコーポレイテッド 新規インフルエンザウイルス免疫エピトープ
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US9233148B2 (en) * 2009-01-09 2016-01-12 Samuel Bogoch Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza
WO2010117786A1 (en) 2009-03-30 2010-10-14 Mount Sinai School Of Medicine Of New York University Influenza virus vaccines and uses thereof
DK2445928T3 (en) 2009-06-24 2018-05-28 Medicago Inc CHEMICAL INFLUENZA VIRUS-LIKE PARTICLES INCLUDING HEMAGGLUTIN
ES2642631T3 (es) 2009-09-22 2017-11-17 Medicago Inc. Método de preparación de VLP derivadas de plantas
EP2483307A1 (en) 2009-09-29 2012-08-08 Fraunhofer USA, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
EA030095B1 (ru) 2009-12-28 2018-06-29 ДиЭсЭм АйПи АССЕТС Б.В. Получение белка гемагглютинин-нейраминидазы в микроводорослях
WO2011090708A2 (en) 2009-12-28 2011-07-28 Merial Limited Recombinant ndv antigen and uses thereof
CN102939096B (zh) 2010-02-18 2016-03-02 西奈山医学院 用于预防和治疗流感病毒疾病的疫苗
WO2011123495A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
PH12013500719A1 (en) 2010-10-27 2013-05-20 Philip Morris Products Sa Methods for capturing virus like particles from plants using expanded bed chromatography
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
ES2953393T3 (es) 2011-09-20 2023-11-10 Icahn School Med Mount Sinai Vacunas contra el virus de la influenza y sus usos
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
PT2760882T (pt) * 2011-09-30 2023-08-07 Medicago Inc Aumento do rendimento de partícula semelhante a vírus em plantas
SG11201504728RA (en) 2012-12-18 2015-07-30 Icahn School Med Mount Sinai Influenza virus vaccines and uses thereof
WO2014159960A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
IL241692B2 (en) 2013-03-28 2023-12-01 Medicago Inc Influenza virus-like particle production in plants
AU2015205805B2 (en) 2014-01-10 2020-11-12 Aramis Biotechnologies Inc. CPMV enhancer elements
US10736956B2 (en) 2015-01-23 2020-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
US11266734B2 (en) 2016-06-15 2022-03-08 Icahn School Of Medicine At Mount Sinai Influenza virus hemagglutinin proteins and uses thereof
EP3606555A4 (en) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF
EP3810634A4 (en) 2018-06-21 2022-07-27 Icahn School of Medicine at Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
US12545718B2 (en) 2019-04-24 2026-02-10 Icahn School Of Medicine At Mount Sinai Anti-influenza B virus neuraminidase antibodies and uses thereof
BR112024002008A2 (pt) * 2021-08-24 2024-04-30 Futuragene Israel Ltd Sequência de ácido nucleico, construção, célula vegetal, planta, e, método para expressar um elemento transcrito em uma planta
WO2023237726A1 (en) * 2022-06-10 2023-12-14 Pantarhei Oncology B.V. An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE218797T1 (de) 1988-09-06 2002-06-15 Univ Washington Orale-immunisierung durch verwendung von transgenen pflanzen
US20010053367A1 (en) * 1991-08-26 2001-12-20 Prodigene, Inc. Vaccines expressed in plants
US6034298A (en) 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
US5612487A (en) * 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
US5426108A (en) 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
ATE287947T1 (de) 1994-10-24 2005-02-15 Texas A & M Univ Sys Orale immunisierung durch verwendung von transgenen pflanzen
US5733556A (en) 1995-10-18 1998-03-31 Akzo Nobel N.V. Newcastle disease virus combination vaccine
US6395964B1 (en) 1995-10-24 2002-05-28 The Texas A&M University System Oral immunization with transgenic plants
EP0974660A1 (en) 1998-06-19 2000-01-26 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Newcastle disease virus infectious clones, vaccines and diagnostic assays
AU2001270164A1 (en) 2000-06-26 2002-01-08 The United States Of America As Represented By The Secretary Of Agriculture Production of vaccines using transgenic plants
EP1389997B1 (en) * 2001-04-13 2010-12-08 Boyce Thompson Institute For Plant Research Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives

Also Published As

Publication number Publication date
EP1620550A4 (en) 2006-06-14
EP1620550B1 (en) 2010-07-07
DE602004028004D1 (de) 2010-08-19
ZA200508930B (en) 2007-03-28
ATE473271T1 (de) 2010-07-15
EP1620550A2 (en) 2006-02-01
CN100393870C (zh) 2008-06-11
US7132291B2 (en) 2006-11-07
US20080076177A1 (en) 2008-03-27
US20050048074A1 (en) 2005-03-03
AU2004235813A1 (en) 2004-11-18
CN1788077A (zh) 2006-06-14
WO2004098533A3 (en) 2005-08-04
NZ543348A (en) 2008-08-29
KR20060035596A (ko) 2006-04-26
CA2524293A1 (en) 2004-11-18
BRPI0410340A (pt) 2006-05-30
AU2004235813B2 (en) 2010-07-29
US20090017065A1 (en) 2009-01-15
WO2004098533A2 (en) 2004-11-18
US7407802B2 (en) 2008-08-05

Similar Documents

Publication Publication Date Title
AR044246A1 (es) Vectores y celulas para la preparacion de composiciones inmunoprotectoras derivadas de plantas transgenicas
AR111197A2 (es) AXMI-031, AXMI-039, AXMI-040 Y AXMI-049, UNA FAMILIA DE GENES DE d-ENDOTOXINAS, Y MÉTODOS PARA USARLOS
AR099694A2 (es) Polinucleótido; vector recombinante; planta transgénica y método para producir aceite de semillas
CY1121353T1 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοi και χρησεις
AR091299A1 (es) Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para mejorar el rendimiento de las plantas
AR086243A1 (es) Polipeptidos y polinucleotidos aislados y metodos para su uso, para aumentar el rendimiento, la biomasa, el indice de crecimiento, el vigor, el contenido de aceite, la tolerancia al estres abiotico de las plantas y la eficiencia en el uso del nitrogeno
AR078052A1 (es) Gen plaguicida axmi 205 de chromobacterium y metodos para su uso
MX2019004610A (es) Composiciones y métodos para alterar la floración y arquitectura de planta para mejorar el potencial de rendimiento.
AR092839A1 (es) Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para mejorar el rendimiento y/o caracteristicas agricolas de las plantas
AR036818A1 (es) Composiciones y metodos para promover resistencia a nematodos en plantas
AR087480A2 (es) Metodo para preparar una planta de cebada que posee una mutacion en el gen lox-1, composiciones de malta y metodos de produccion
AR087952A1 (es) Polinucleotidos y polipeptidos aislados y metodos de utilizacion de los mismos para aumentar el rendimiento y/o las caracteristicas agricolas de plantas
AR080975A1 (es) Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para mejorar el rendimiento de la planta y/o las caracteristicas agricolas
AR076635A1 (es) Plantas que tienen incrementada la tolerancia al estres abiotico y/o los rasgos relacionados con el rendimiento y un metodo para producirlas
AR060750A1 (es) Metodos para producir cruzas fertiles entre especies de soja salvajes y domesticas
AR081303A1 (es) Disminucion del contenido de acidos grasos saturados de semillas vegetales
AR061294A1 (es) Plantas con caracteristicas de crecimiento mejoradas y metodo para prepararlas
AR053893A1 (es) Plantas con caracteristicas de crecimiento mejorado y metodo para desarrollar las mismas
CN109321534A (zh) 一种重组基因viii型新城疫病毒弱毒株
AR126966A2 (es) Una planta transgénica que presenta un rendimiento mejorado y tolerancia al estrés abiótico, y método de obtención de dicha planta
AR066813A1 (es) Vector poxvirus recombinante de mapache (rrcnv) vacuna recombinante contra la rabia plasmido pfd2003-gpv-pv y metodos para hacer el vector poxvirus recombinante de mapache y para inducir una respuesta inmune protectora contra la rabia
JP2018530323A5 (es)
AR096405A2 (es) Molécula de ácido nucleico que confiere tolerancia al herbicida dicamba, métodos para producir plantas tolerantes a dicamba y para métodos para controlar el crecimiento de malezas
WO2005032457A3 (en) Vectors and methods for immunization against norwalk virus using transgenic plants
AR067138A1 (es) Aumento del rendimiento en plantas por modulacion del gen myb-ada2 de maiz

Legal Events

Date Code Title Description
FB Suspension of granting procedure