ATE473271T1 - Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen - Google Patents
Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungenInfo
- Publication number
- ATE473271T1 ATE473271T1 AT04751538T AT04751538T ATE473271T1 AT E473271 T1 ATE473271 T1 AT E473271T1 AT 04751538 T AT04751538 T AT 04751538T AT 04751538 T AT04751538 T AT 04751538T AT E473271 T1 ATE473271 T1 AT E473271T1
- Authority
- AT
- Austria
- Prior art keywords
- vectors
- cells
- producing
- transgenic plants
- compositions obtained
- Prior art date
Links
- 230000002480 immunoprotective effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46799803P | 2003-05-05 | 2003-05-05 | |
| PCT/US2004/014182 WO2004098533A2 (en) | 2003-05-05 | 2004-05-04 | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473271T1 true ATE473271T1 (de) | 2010-07-15 |
Family
ID=33435152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04751538T ATE473271T1 (de) | 2003-05-05 | 2004-05-04 | Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7132291B2 (de) |
| EP (1) | EP1620550B1 (de) |
| KR (1) | KR20060035596A (de) |
| CN (1) | CN100393870C (de) |
| AR (1) | AR044246A1 (de) |
| AT (1) | ATE473271T1 (de) |
| AU (1) | AU2004235813B2 (de) |
| BR (1) | BRPI0410340A (de) |
| CA (1) | CA2524293A1 (de) |
| DE (1) | DE602004028004D1 (de) |
| NZ (1) | NZ543348A (de) |
| WO (1) | WO2004098533A2 (de) |
| ZA (1) | ZA200508930B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1833030B (zh) | 2003-05-22 | 2014-07-23 | 美国弗劳恩霍夫股份有限公司 | 用于表达、传递及纯化目标多肽的重组载体分子 |
| CN1326998C (zh) * | 2004-11-25 | 2007-07-18 | 中国农业科学院哈尔滨兽医研究所 | 编码h5亚型禽流感病毒血凝素蛋白的基因及其应用 |
| EP1919504B1 (de) | 2005-08-03 | 2013-10-16 | iBio, Inc. | Antikörper gegen bacillus anthracis protektiv antigen |
| KR20080075855A (ko) | 2005-11-04 | 2008-08-19 | 다우 아그로사이언시즈 엘엘씨 | 재조합 식물 현탁배양을 이용한 백신 마스터 세포주제조방법 |
| WO2007095320A2 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Hpv antigens, vaccine compositions, and related methods |
| WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| US8124103B2 (en) * | 2006-02-13 | 2012-02-28 | Fraunhofer Usa, Inc | Influenza antigens, vaccine compositions, and related methods |
| JP2009535306A (ja) * | 2006-04-21 | 2009-10-01 | ダウ・アグロサイエンス・エル・エル・シー | 鳥インフルエンザに対するワクチンおよび使用方法 |
| KR100766775B1 (ko) * | 2006-04-24 | 2007-11-01 | 대한민국 | 장출혈성대장균(ehec) 감염증 예방용 톡소이드 백신 |
| CN100487119C (zh) * | 2006-05-09 | 2009-05-13 | 中国农业科学院哈尔滨兽医研究所 | 表达禽流感病毒H5亚型HA蛋白的重组新城疫LaSota弱毒疫苗株 |
| JP2009540801A (ja) * | 2006-06-16 | 2009-11-26 | ダウ・アグロサイエンス・エル・エル・シー | トリインフルエンザ赤血球凝集素の新規なdna配列、ベクターおよびタンパク質 |
| US20080241188A1 (en) * | 2007-03-30 | 2008-10-02 | Zeon Corporation | Turkey herpesvirus vectored recombinant containing avian influenza genes |
| CN101687024A (zh) * | 2007-04-28 | 2010-03-31 | 美国弗劳恩霍夫股份有限公司 | 锥虫抗原、疫苗组合物和相关方法 |
| PL2155880T3 (pl) * | 2007-06-15 | 2017-06-30 | Medicago Inc. | Modyfikacja wytwarzania glikoproteiny w roślinach |
| KR100964462B1 (ko) * | 2007-07-10 | 2010-06-16 | 성균관대학교산학협력단 | 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법 |
| US8404252B2 (en) | 2007-07-11 | 2013-03-26 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| WO2009076778A1 (en) * | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CA2696764A1 (en) * | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
| EA034733B1 (ru) * | 2008-01-21 | 2020-03-13 | Медикаго Инк. | Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение |
| WO2010003235A1 (en) * | 2008-07-08 | 2010-01-14 | Medicago Inc. | Soluble recombinant influenza antigens |
| DK2318530T3 (en) | 2008-07-18 | 2016-10-03 | Medicago Inc | Ny epitope to immunization against influenza |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| US9233148B2 (en) * | 2009-01-09 | 2016-01-12 | Samuel Bogoch | Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| BRPI1015053A2 (pt) | 2009-06-24 | 2019-07-09 | Medicago Inc | partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina |
| SI3354657T1 (sl) * | 2009-09-22 | 2022-05-31 | Medicago Inc. | Postopek za pripravo iz rastlin izpeljanih beljakovin |
| US8784819B2 (en) | 2009-09-29 | 2014-07-22 | Ibio Inc. | Influenza hemagglutinin antibodies, compositions and related methods |
| EA030095B1 (ru) | 2009-12-28 | 2018-06-29 | ДиЭсЭм АйПи АССЕТС Б.В. | Получение белка гемагглютинин-нейраминидазы в микроводорослях |
| EP3213766A1 (de) | 2009-12-28 | 2017-09-06 | Merial Ltd. | Rekombinantes ndv-antigen und verwendungen davon |
| US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| WO2011123495A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| PH12013500719A1 (en) | 2010-10-27 | 2013-05-20 | Philip Morris Products Sa | Methods for capturing virus like particles from plants using expanded bed chromatography |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EP2758075B1 (de) | 2011-09-20 | 2023-05-03 | Icahn School of Medicine at Mount Sinai | Influenzavirus-impfstoffe und verwendungen davon |
| RU2682752C2 (ru) * | 2011-09-30 | 2019-03-21 | Медикаго Инк. | Повышение выхода вирусоподобных частиц в растениях |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| EP2934581B1 (de) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenzavirus-impfstoffe und verwendungen davon |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| KR102199018B1 (ko) | 2013-03-28 | 2021-01-07 | 메디카고 인코포레이티드 | 식물에서 인플루엔자 바이러스-유사 입자 생산 |
| WO2015103704A1 (en) | 2014-01-10 | 2015-07-16 | Medicago Inc. | Cpmv enhancer elements |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| EP3471767A4 (de) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | Influenzavirus-hämagglutinin-proteine und verwendungen davon |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| WO2020219719A1 (en) | 2019-04-24 | 2020-10-29 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| CN115003328A (zh) | 2019-10-22 | 2022-09-02 | 西奈山伊坎医学院 | 重组神经氨酸酶及其用途 |
| US20240352473A1 (en) * | 2021-08-24 | 2024-10-24 | Futuragene Israel Ltd. | Sequences and promoters for use in plant cells and methods of making and using such sequences |
| WO2023237726A1 (en) * | 2022-06-10 | 2023-12-14 | Pantarhei Oncology B.V. | An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339307C (en) * | 1988-09-06 | 1997-08-19 | Roy Curtiss, Iii | Oral immunization by transgenic plants |
| US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
| US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
| US20010053367A1 (en) * | 1991-08-26 | 2001-12-20 | Prodigene, Inc. | Vaccines expressed in plants |
| US5426108A (en) * | 1993-11-10 | 1995-06-20 | American Cyanamid Company | Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2 |
| DE69533964T2 (de) * | 1994-10-24 | 2006-03-30 | The Texas A & M University System, College Station | Orale immunisierung durch verwendung von transgenen pflanzen |
| EP0770397B1 (de) * | 1995-10-18 | 2004-04-21 | Akzo Nobel N.V. | Newcastle-Krankheitsvirus-Kombinationsimpfstoff |
| US6395964B1 (en) * | 1995-10-24 | 2002-05-28 | The Texas A&M University System | Oral immunization with transgenic plants |
| EP0974660A1 (de) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle-Krankheitsvirus Infektiöser Klone, Impfstoffe und Diagnosetest |
| AU2001270164A1 (en) * | 2000-06-26 | 2002-01-08 | The United States Of America As Represented By The Secretary Of Agriculture | Production of vaccines using transgenic plants |
| ATE491034T1 (de) * | 2001-04-13 | 2010-12-15 | Thompson Boyce Plant Res | Verfahren und zusammensetzungen für stabile transgene pharmazeutika und ihre verwendung als kontrazeptiva |
-
2004
- 2004-05-04 KR KR1020057020819A patent/KR20060035596A/ko not_active Ceased
- 2004-05-04 AT AT04751538T patent/ATE473271T1/de not_active IP Right Cessation
- 2004-05-04 US US10/838,834 patent/US7132291B2/en not_active Expired - Fee Related
- 2004-05-04 BR BRPI0410340-8A patent/BRPI0410340A/pt not_active IP Right Cessation
- 2004-05-04 WO PCT/US2004/014182 patent/WO2004098533A2/en not_active Ceased
- 2004-05-04 DE DE602004028004T patent/DE602004028004D1/de not_active Expired - Lifetime
- 2004-05-04 NZ NZ543348A patent/NZ543348A/en not_active Application Discontinuation
- 2004-05-04 CA CA002524293A patent/CA2524293A1/en not_active Abandoned
- 2004-05-04 CN CNB2004800120987A patent/CN100393870C/zh not_active Expired - Fee Related
- 2004-05-04 AU AU2004235813A patent/AU2004235813B2/en not_active Ceased
- 2004-05-04 ZA ZA200508930A patent/ZA200508930B/en unknown
- 2004-05-04 EP EP04751538A patent/EP1620550B1/de not_active Expired - Lifetime
- 2004-05-05 AR ARP040101521A patent/AR044246A1/es unknown
-
2006
- 2006-06-08 US US11/450,102 patent/US7407802B2/en not_active Expired - Fee Related
-
2008
- 2008-04-30 US US12/150,900 patent/US20090017065A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1620550B1 (de) | 2010-07-07 |
| US7407802B2 (en) | 2008-08-05 |
| WO2004098533A2 (en) | 2004-11-18 |
| US20090017065A1 (en) | 2009-01-15 |
| US20080076177A1 (en) | 2008-03-27 |
| EP1620550A4 (de) | 2006-06-14 |
| AR044246A1 (es) | 2005-09-07 |
| US20050048074A1 (en) | 2005-03-03 |
| CN1788077A (zh) | 2006-06-14 |
| AU2004235813A1 (en) | 2004-11-18 |
| BRPI0410340A (pt) | 2006-05-30 |
| DE602004028004D1 (de) | 2010-08-19 |
| EP1620550A2 (de) | 2006-02-01 |
| CA2524293A1 (en) | 2004-11-18 |
| ZA200508930B (en) | 2007-03-28 |
| KR20060035596A (ko) | 2006-04-26 |
| WO2004098533A3 (en) | 2005-08-04 |
| NZ543348A (en) | 2008-08-29 |
| US7132291B2 (en) | 2006-11-07 |
| AU2004235813B2 (en) | 2010-07-29 |
| CN100393870C (zh) | 2008-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |