AR045695A1 - Compuestos de benzo[a]pirano[3,2-h]acridin-7-ona, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen - Google Patents

Compuestos de benzo[a]pirano[3,2-h]acridin-7-ona, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Info

Publication number: AR045695A1
Authority: AR; Argentina
Prior art keywords: branched; linear; group; alkyl; atom
Prior art date: 2003-06-25

Application number

ARP040102226A

Other languages

English (en)

Spanish (es)

Inventor

John Hickman

Alain Pierre

Stephane Leonce

Bruno Pfeiffer

Pierre Renard

Michel Koch

Francois Tillekin

Sylvie Michel

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-25

Filing date

2004-06-25

Publication date

2005-11-09

2004-06-25 Application filed by Servier Lab filed Critical Servier Lab

2005-11-09 Publication of AR045695A1 publication Critical patent/AR045695A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 15
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
229910052757 nitrogen Inorganic materials 0.000 abstract 12
125000003118 aryl group Chemical group 0.000 abstract 9
-1 diastereoisomers Chemical class 0.000 abstract 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 7
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 6
125000004122 cyclic group Chemical group 0.000 abstract 6
125000002950 monocyclic group Chemical group 0.000 abstract 6
229910052760 oxygen Inorganic materials 0.000 abstract 6
239000001301 oxygen Substances 0.000 abstract 6
125000005842 heteroatom Chemical group 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 4
125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
229910052717 sulfur Inorganic materials 0.000 abstract 4
125000004434 sulfur atom Chemical group 0.000 abstract 4
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000004429 atom Chemical group 0.000 abstract 3
125000004430 oxygen atom Chemical group O* 0.000 abstract 3
125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
125000004450 alkenylene group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229910052705 radium Inorganic materials 0.000 abstract 2
229910052701 rubidium Inorganic materials 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
229910003827 NRaRb Inorganic materials 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
125000003725 azepanyl group Chemical group 0.000 abstract 1
125000004069 aziridinyl group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000005959 diazepanyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000005961 oxazepanyl group Chemical group 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
125000000466 oxiranyl group Chemical group 0.000 abstract 1
125000005936 piperidyl group Chemical group 0.000 abstract 1
125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ARP040102226A 2003-06-25 2004-06-25 Compuestos de benzo[a]pirano[3,2-h]acridin-7-ona, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen AR045695A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0307664A FR2856687B1 (fr)	2003-06-25	2003-06-25	Nouveaux derives de benzo[a]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
AR045695A1 true AR045695A1 (es)	2005-11-09

Family

ID=33396845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP040102226A AR045695A1 (es)	2003-06-25	2004-06-25	Compuestos de benzo[a]pirano[3,2-h]acridin-7-ona, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Country Status (18)

Country	Link
US (1)	US7276512B2 (ru)
EP (1)	EP1491544A1 (ru)
JP (1)	JP2005041864A (ru)
KR (1)	KR20050001451A (ru)
CN (1)	CN1289502C (ru)
AR (1)	AR045695A1 (ru)
AU (1)	AU2004202864A1 (ru)
BR (1)	BRPI0402500A (ru)
CA (1)	CA2472294A1 (ru)
EA (1)	EA007790B1 (ru)
FR (1)	FR2856687B1 (ru)
GE (1)	GEP20063874B (ru)
MA (1)	MA27096A1 (ru)
MX (1)	MXPA04006177A (ru)
NO (1)	NO20042447L (ru)
NZ (1)	NZ533747A (ru)
SG (1)	SG146431A1 (ru)
ZA (1)	ZA200405074B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK2991993T3 (en) *	2013-04-29	2018-07-30	Nerviano Medical Sciences Srl	NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES
CA2986202C (en)	2015-04-27	2023-08-22	The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center	Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions
CN110105318B (zh) *	2019-06-21	2021-04-09	南京林业大学	一种α-吡喃酮类化合物的绿色合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3732204A (en) *	1967-07-17	1973-05-08	Lilly Co Eli	Synthesis of acronycine and related compounds
US3943137A (en) *	1973-07-09	1976-03-09	University Of Kansas Endowment Association	Acronycine derivatives
GB9318935D0 (en) *	1992-10-20	1993-10-27	Zeneca Ltd	Heterocyclic derivatives
US5428040A (en) *	1993-08-31	1995-06-27	The Du Pont Merck Pharmaceutical Company	Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
FR2716197B1 (fr) *	1994-02-17	1996-04-19	Adir	Nouveaux analogues de l'acronycine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2772765B1 (fr) *	1997-12-19	2000-03-17	Adir	Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2795071B1 (fr) *	1999-06-16	2001-07-27	Adir	Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2827864B1 (fr) *	2001-07-25	2005-09-16	Servier Lab	Nouveaux derives de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2003
- 2003-06-25 FR FR0307664A patent/FR2856687B1/fr not_active Expired - Fee Related
2004
- 2004-06-11 NO NO20042447A patent/NO20042447L/no not_active Application Discontinuation
- 2004-06-17 SG SG200404562-1A patent/SG146431A1/en unknown
- 2004-06-18 US US10/872,060 patent/US7276512B2/en not_active Expired - Fee Related
- 2004-06-21 CA CA002472294A patent/CA2472294A1/fr not_active Abandoned
- 2004-06-22 MX MXPA04006177A patent/MXPA04006177A/es active IP Right Grant
- 2004-06-22 EP EP04291568A patent/EP1491544A1/fr not_active Withdrawn
- 2004-06-23 BR BR0402500-8A patent/BRPI0402500A/pt not_active IP Right Cessation
- 2004-06-24 MA MA27749A patent/MA27096A1/fr unknown
- 2004-06-24 NZ NZ533747A patent/NZ533747A/en unknown
- 2004-06-24 GE GE5585A patent/GEP20063874B/en unknown
- 2004-06-24 EA EA200400729A patent/EA007790B1/ru not_active IP Right Cessation
- 2004-06-25 CN CNB2004100501660A patent/CN1289502C/zh not_active Expired - Fee Related
- 2004-06-25 KR KR1020040048091A patent/KR20050001451A/ko not_active Ceased
- 2004-06-25 ZA ZA200405074A patent/ZA200405074B/xx unknown
- 2004-06-25 JP JP2004187151A patent/JP2005041864A/ja active Pending
- 2004-06-25 AU AU2004202864A patent/AU2004202864A1/en not_active Abandoned
- 2004-06-25 AR ARP040102226A patent/AR045695A1/es unknown

Also Published As

Publication number	Publication date
HK1070360A1 (en)	2005-06-17
CN1289502C (zh)	2006-12-13
SG146431A1 (en)	2008-10-30
NZ533747A (en)	2005-12-23
EP1491544A1 (fr)	2004-12-29
NO20042447L (no)	2004-12-27
CN1576277A (zh)	2005-02-09
MXPA04006177A (es)	2005-03-23
US20040266753A1 (en)	2004-12-30
EA007790B1 (ru)	2007-02-27
CA2472294A1 (fr)	2004-12-25
GEP20063874B (en)	2006-07-10
ZA200405074B (en)	2005-06-02
KR20050001451A (ko)	2005-01-06
JP2005041864A (ja)	2005-02-17
BRPI0402500A (pt)	2005-06-14
FR2856687A1 (fr)	2004-12-31
AU2004202864A1 (en)	2005-01-13
MA27096A1 (fr)	2004-12-20
EA200400729A1 (ru)	2004-12-30
US7276512B2 (en)	2007-10-02
FR2856687B1 (fr)	2005-09-16

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Date	Code	Title	Description
2013-09-26	FB	Suspension of granting procedure