BRPI0402500A - Compostos de benzo[alfa]pirano[3,2-h]acridin-7-ona, processo para sua preparação e composições farmacêuticas os contendo - Google Patents
Compostos de benzo[alfa]pirano[3,2-h]acridin-7-ona, processo para sua preparação e composições farmacêuticas os contendoInfo
- Publication number
- BRPI0402500A BRPI0402500A BR0402500-8A BRPI0402500A BRPI0402500A BR PI0402500 A BRPI0402500 A BR PI0402500A BR PI0402500 A BRPI0402500 A BR PI0402500A BR PI0402500 A BRPI0402500 A BR PI0402500A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- acridin
- benzo
- alpha
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 title 1
- UYUXXCRKWXJQED-UHFFFAOYSA-N 3h-acridin-2-one Chemical class C1=CC=CC2=CC3=CC(=O)CC=C3N=C21 UYUXXCRKWXJQED-UHFFFAOYSA-N 0.000 title 1
- 125000005605 benzo group Chemical group 0.000 title 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UUNIOFWUJYBVGQ-UHFFFAOYSA-N 2-amino-4-(3,4-dimethoxyphenyl)-10-fluoro-4,5,6,7-tetrahydrobenzo[1,2]cyclohepta[6,7-d]pyran-3-carbonitrile Chemical compound C1=C(OC)C(OC)=CC=C1C1C(C#N)=C(N)OC2=C1CCCC1=CC=C(F)C=C12 UUNIOFWUJYBVGQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"COMPOSTOS DE BENZO[ALFA]PIRANO[3,2-H]ACRIDIN-7-ONA, PROCESSO PARA SUA PREPARAçãO E COMPOSiçõES FARMACêUTICAS OS CONTENDO". Compostos da fórmula (l): em que: X e Y representam um grupo selecionado de hidrogênio, halogênio, hidróxi, alcóxi, nitro, ciano, alquila, triloalquila e NR~ a~R~ b~, em que R~ a~ e R~ b~ são como definidos na descrição R~ 1~ representa um átomo de hidrogênio ou um grupo alquila R~ 2~ representa um grupo selecionado de um átomo de hidrogênio, alquila, -OR<39><39>~ a~; -NR<39>~ a~R<39>~ b~; -O-T~ a~-OR<39><39>~ a~; -NR<39><39>~ a~-T~ a~-NR<39>~ a~R<39>~ b~; -NR<39><39>~ a~-C(O)-T~ a~H; -O-C(O)-T~ a~H; -O-T~ a~-NR<39>~ a~ R<39>~ b~; -NR<39><39>~ a~-T~ a~-OR<39><39>~ a~; -NR<39><39>~ a~-T~ a~-CO~ 2~R<39><39>~ a~; e -NR~<39><39>~ a~C(O)-T~ a~NR<39>~ a~R<39>~ b~, em que R<39>~ a~, R<39><39>~ a~, R<39>~ b~ e T~ a~ são como definidos na descrição R~ 3~ e R~ 4~ representam um átomo de hidrogênio ou um grupo alquila A representa um grupo da fórmula -CH(R~ 5~)-CH(R~ 6~)-, -CH=C(R~ 7~)-, -C(R~ 7~)=CH-, -C(O)-CH(R~ 8~)- ou -CH(R~ 8~)-C(O), em que R~ 5~, R~ 6~, R~ 7~ e F~ 8~ são como definidos na descrição seus isómeros definidos na descrição, seus N-óxidos, e sais de adição destes com um ácido ou base farmaceuticamente aceitável Medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0307664A FR2856687B1 (fr) | 2003-06-25 | 2003-06-25 | Nouveaux derives de benzo[a]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0402500A true BRPI0402500A (pt) | 2005-06-14 |
Family
ID=33396845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0402500-8A BRPI0402500A (pt) | 2003-06-25 | 2004-06-23 | Compostos de benzo[alfa]pirano[3,2-h]acridin-7-ona, processo para sua preparação e composições farmacêuticas os contendo |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7276512B2 (pt) |
| EP (1) | EP1491544A1 (pt) |
| JP (1) | JP2005041864A (pt) |
| KR (1) | KR20050001451A (pt) |
| CN (1) | CN1289502C (pt) |
| AR (1) | AR045695A1 (pt) |
| AU (1) | AU2004202864A1 (pt) |
| BR (1) | BRPI0402500A (pt) |
| CA (1) | CA2472294A1 (pt) |
| EA (1) | EA007790B1 (pt) |
| FR (1) | FR2856687B1 (pt) |
| GE (1) | GEP20063874B (pt) |
| MA (1) | MA27096A1 (pt) |
| MX (1) | MXPA04006177A (pt) |
| NO (1) | NO20042447L (pt) |
| NZ (1) | NZ533747A (pt) |
| SG (1) | SG146431A1 (pt) |
| ZA (1) | ZA200405074B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2991993T3 (en) * | 2013-04-29 | 2018-07-30 | Nerviano Medical Sciences Srl | NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES |
| IL255290B2 (en) * | 2015-04-27 | 2024-01-01 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Substances that bind to EGF1 and their use in the treatment of inflammatory diseases and tumors |
| CN110105318B (zh) * | 2019-06-21 | 2021-04-09 | 南京林业大学 | 一种α-吡喃酮类化合物的绿色合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732204A (en) * | 1967-07-17 | 1973-05-08 | Lilly Co Eli | Synthesis of acronycine and related compounds |
| US3943137A (en) * | 1973-07-09 | 1976-03-09 | University Of Kansas Endowment Association | Acronycine derivatives |
| GB9318935D0 (en) * | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| FR2716197B1 (fr) * | 1994-02-17 | 1996-04-19 | Adir | Nouveaux analogues de l'acronycine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2772765B1 (fr) * | 1997-12-19 | 2000-03-17 | Adir | Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2795071B1 (fr) * | 1999-06-16 | 2001-07-27 | Adir | Nouveaux derives de carboxylate de 7-oxo-2,3,7,14- tetrahydro-1h-benzo[b]pyrano[3,2,h] acridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2827864B1 (fr) * | 2001-07-25 | 2005-09-16 | Servier Lab | Nouveaux derives de benzo[b]pyrano[3,2-h]acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2003
- 2003-06-25 FR FR0307664A patent/FR2856687B1/fr not_active Expired - Fee Related
-
2004
- 2004-06-11 NO NO20042447A patent/NO20042447L/no not_active Application Discontinuation
- 2004-06-17 SG SG200404562-1A patent/SG146431A1/en unknown
- 2004-06-18 US US10/872,060 patent/US7276512B2/en not_active Expired - Fee Related
- 2004-06-21 CA CA002472294A patent/CA2472294A1/fr not_active Abandoned
- 2004-06-22 EP EP04291568A patent/EP1491544A1/fr not_active Withdrawn
- 2004-06-22 MX MXPA04006177A patent/MXPA04006177A/es active IP Right Grant
- 2004-06-23 BR BR0402500-8A patent/BRPI0402500A/pt not_active IP Right Cessation
- 2004-06-24 MA MA27749A patent/MA27096A1/fr unknown
- 2004-06-24 NZ NZ533747A patent/NZ533747A/en unknown
- 2004-06-24 GE GE5585A patent/GEP20063874B/en unknown
- 2004-06-24 EA EA200400729A patent/EA007790B1/ru not_active IP Right Cessation
- 2004-06-25 AU AU2004202864A patent/AU2004202864A1/en not_active Abandoned
- 2004-06-25 ZA ZA200405074A patent/ZA200405074B/xx unknown
- 2004-06-25 KR KR1020040048091A patent/KR20050001451A/ko not_active Ceased
- 2004-06-25 AR ARP040102226A patent/AR045695A1/es unknown
- 2004-06-25 CN CNB2004100501660A patent/CN1289502C/zh not_active Expired - Fee Related
- 2004-06-25 JP JP2004187151A patent/JP2005041864A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ533747A (en) | 2005-12-23 |
| JP2005041864A (ja) | 2005-02-17 |
| ZA200405074B (en) | 2005-06-02 |
| EA007790B1 (ru) | 2007-02-27 |
| CN1289502C (zh) | 2006-12-13 |
| KR20050001451A (ko) | 2005-01-06 |
| EP1491544A1 (fr) | 2004-12-29 |
| MA27096A1 (fr) | 2004-12-20 |
| GEP20063874B (en) | 2006-07-10 |
| AR045695A1 (es) | 2005-11-09 |
| HK1070360A1 (en) | 2005-06-17 |
| NO20042447L (no) | 2004-12-27 |
| MXPA04006177A (es) | 2005-03-23 |
| US7276512B2 (en) | 2007-10-02 |
| SG146431A1 (en) | 2008-10-30 |
| FR2856687B1 (fr) | 2005-09-16 |
| CN1576277A (zh) | 2005-02-09 |
| EA200400729A1 (ru) | 2004-12-30 |
| US20040266753A1 (en) | 2004-12-30 |
| CA2472294A1 (fr) | 2004-12-25 |
| AU2004202864A1 (en) | 2005-01-13 |
| FR2856687A1 (fr) | 2004-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |