AR053151A1 - Recuperacion de 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) a partir de licores madre - Google Patents

Recuperacion de 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) a partir de licores madre

Info

Publication number
AR053151A1
AR053151A1 ARP060100772A ARP060100772A AR053151A1 AR 053151 A1 AR053151 A1 AR 053151A1 AR P060100772 A ARP060100772 A AR P060100772A AR P060100772 A ARP060100772 A AR P060100772A AR 053151 A1 AR053151 A1 AR 053151A1
Authority
AR
Argentina
Prior art keywords
cci
hydroximethyl
rapamycin
hydroxy
mother liquors
Prior art date
Application number
ARP060100772A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR053151A1 publication Critical patent/AR053151A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treating Waste Gases (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Reivindicacion 1:Un proceso para recuperar CC1-779 a partir de licores madre, que comprende: (a) concentra el licor madre; (b) someter el CCI-779 obtenido mediante concentracion del licor madre a tratamiento con un buffer regulador de pH que posee un pH en el rango de aproximadamente 5 a aproximadamente 5,5; (c) someter la mezcla a extraccion por solvente; (d) secar y concentrar la capa orgánica resultante; y (e) recristalizar el CCI-779.
ARP060100772A 2005-03-02 2006-03-01 Recuperacion de 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) a partir de licores madre AR053151A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65753405P 2005-03-02 2005-03-02

Publications (1)

Publication Number Publication Date
AR053151A1 true AR053151A1 (es) 2007-04-25

Family

ID=36602445

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060100772A AR053151A1 (es) 2005-03-02 2006-03-01 Recuperacion de 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) a partir de licores madre

Country Status (21)

Country Link
US (1) US7288647B2 (es)
EP (1) EP1853611A1 (es)
JP (1) JP2008531685A (es)
KR (1) KR20070107072A (es)
CN (1) CN101133066A (es)
AR (1) AR053151A1 (es)
AU (1) AU2006218916A1 (es)
BR (1) BRPI0607390A2 (es)
CA (1) CA2599580A1 (es)
CR (1) CR9325A (es)
GT (1) GT200600095A (es)
IL (1) IL185078A0 (es)
MX (1) MX2007010715A (es)
MY (1) MY138328A (es)
NI (1) NI200700226A (es)
NO (1) NO20074101L (es)
PE (1) PE20061293A1 (es)
RU (1) RU2007130407A (es)
TW (1) TW200643023A (es)
WO (1) WO2006093743A1 (es)
ZA (1) ZA200707526B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007067566A2 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
CN101321770A (zh) * 2005-12-07 2008-12-10 惠氏公司 由雷帕霉素42-酯硼酸酯制备雷帕霉素42-酯的可放大方法
AR058282A1 (es) * 2005-12-07 2008-01-30 Wyeth Corp Forma cristalina purificada de cci-779, un proceso para la preparacion del mismo, un metodo para monitorear la cristalizacion del cci-779, un kit y una composicion farmaceutica que lo comprenden y su uso en la fabricacion de un medicamento para el tratamiento del cancer.
US20070203169A1 (en) * 2006-02-28 2007-08-30 Zhao Jonathon Z Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993749A (en) 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
EP1646635A1 (en) * 2003-07-16 2006-04-19 Wyeth Cci-779 isomer c
JP4227649B2 (ja) 2003-08-07 2009-02-18 ワイス Ｃｃｉ−７７９の位置選択的合成
US20060015840A1 (en) * 2004-03-31 2006-01-19 Wendall Marvel Parameter-based software development, distribution, and disaster recovery

Also Published As

Publication number Publication date
PE20061293A1 (es) 2006-12-22
NI200700226A (es) 2008-07-03
RU2007130407A (ru) 2009-04-10
US20060199253A1 (en) 2006-09-07
BRPI0607390A2 (pt) 2017-08-22
MY138328A (en) 2009-05-29
EP1853611A1 (en) 2007-11-14
CN101133066A (zh) 2008-02-27
IL185078A0 (en) 2007-12-03
NO20074101L (no) 2007-09-26
CA2599580A1 (en) 2006-09-08
GT200600095A (es) 2006-10-25
CR9325A (es) 2008-01-21
MX2007010715A (es) 2007-10-12
US7288647B2 (en) 2007-10-30
JP2008531685A (ja) 2008-08-14
KR20070107072A (ko) 2007-11-06
AU2006218916A1 (en) 2006-09-08
WO2006093743A1 (en) 2006-09-08
TW200643023A (en) 2006-12-16
ZA200707526B (en) 2010-02-24

Similar Documents

Publication Publication Date Title
AR064958A1 (es) Procesos para la produccion de oxido de etileno y glicol de etileno
BR112013015463B8 (pt) Aparelho e método para desgaseificar água de processo carregada com compostos gasosos dissolvidos
AR107649A1 (es) Método para producir d-psicosa de alta pureza
RU2013131043A (ru) Извлечение ценных соединений лития из насыщенного раствора солей натрия
MX9305770A (es) Procedimiento para la obtencion de la 10-desacetil-baccatina iii.
MX2009004403A (es) Procedimiento de separacion.
BRPI0804497B8 (pt) método para coletar ácido (met)acrílico e aparato para coletar ácido (met)acrílico
BRPI0506140A (pt) processo para recuperação de nìquel e cobalto
BR112015020774B1 (pt) método de refino de 1,5-diaminopentano
Rosa et al. Functional and phylogenetic characterization of proteins detected in various nematode intestinal compartments
BR112015030446A2 (pt) processo para redução do carbono orgânico total em águas residuais
BR112018005810A2 (pt) método de produção de lignina purificada, lignina purificada, composição de resina e corpo moldeado
AR053151A1 (es) Recuperacion de 42-ester de rapamicina con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) a partir de licores madre
NO20053148L (no) Method and apparatus for energy reduction in acid gas capture processes.
ES2558581T3 (es) Procesos de purificación de teicoplanina
BR112019006773A2 (pt) processo e instalação para tratar água produzida a partir de um campo de óleo e gás
AR071084A1 (es) Metodo para la produccion de sucralosa
ES2608041T3 (es) Procedimiento para la producción de di- y poliaminas de la serie de difenilmetano
CN104744299A (zh) 高纯有机溶剂乙腈的提纯方法
MY147592A (en) Process for extracting and recovering polyhydroxyalkanoates (phas) from cellular biomass
IL272809B2 (en) Improved resorbable polymer purification process
AR073807A1 (es) Proceso para preparar el malato de sunitinib, sal de un acido mas debil que el malato como compuesto intermediario, y proceso para preparar dicha sal intermediaria.
BRPI0515272A (pt) processos para a preparação de ácido (met)acrìlico e de polìmero pelo menos parcialmente baseado em ácido (met)acrìlico, dispositivos para a preparação dos referidos ácido (met)acrìlico e polìmero, fibras, filmes, espumas e compósitos pelo menos parcialmente baseados nos referidos ácido (met)acrìlico e polìmero, e uso dos referidos ácido (met)acrìlico e polìmero na produção de fibras, filmes, espumas e compósitos
BRPI0415019A (pt) processo para a purificação da mesotriona
MX2015008901A (es) Método para extraer ácido ferúlico y/o sales del mismo.

Legal Events

Date Code Title Description
FB Suspension of granting procedure