AR058151A1 - Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion - Google Patents

Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion

Info

Publication number: AR058151A1
Authority: AR; Argentina
Prior art keywords: alkyl; compounds; halo; hydrogen; dopamine
Prior art date: 2005-10-26

Application number

ARP060104659A

Other languages

English (en)

Spanish (es)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-26

Filing date

2006-10-25

Publication date

2008-01-23

2006-10-25 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2008-01-23 Publication of AR058151A1 publication Critical patent/AR058151A1/es

Links

150000001875 compounds Chemical class 0.000 title abstract 5
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
229960003638 dopamine Drugs 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
101710107142 Dopamine receptor 2 Proteins 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000010494 dissociation reaction Methods 0.000 abstract 1
230000005593 dissociations Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ARP060104659A 2005-10-26 2006-10-25 Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion AR058151A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05110028		2005-10-26

Publications (1)

Publication Number	Publication Date
AR058151A1 true AR058151A1 (es)	2008-01-23

Family

ID=35734993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP060104659A AR058151A1 (es)	2005-10-26	2006-10-25	Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion

Country Status (34)

Country	Link
US (3)	US8940743B2 (sr)
EP (1)	EP1943242B1 (sr)
JP (1)	JP5140598B2 (sr)
KR (1)	KR101351910B1 (sr)
CN (1)	CN101291925B (sr)
AP (1)	AP2607A (sr)
AR (1)	AR058151A1 (sr)
AT (1)	ATE495167T1 (sr)
AU (1)	AU2006307930B2 (sr)
BR (1)	BRPI0617787A2 (sr)
CA (1)	CA2623160C (sr)
CR (1)	CR10020A (sr)
CY (1)	CY1111977T1 (sr)
DE (1)	DE602006019624D1 (sr)
DK (1)	DK1943242T3 (sr)
EA (1)	EA015681B1 (sr)
EC (1)	ECSP088396A (sr)
ES (1)	ES2359020T3 (sr)
GT (1)	GT200800033A (sr)
HN (1)	HN2008000646A (sr)
HR (1)	HRP20110226T1 (sr)
IL (1)	IL191016A (sr)
JO (1)	JO2769B1 (sr)
MY (1)	MY145609A (sr)
NO (1)	NO20082350L (sr)
NZ (1)	NZ566785A (sr)
PL (1)	PL1943242T3 (sr)
PT (1)	PT1943242E (sr)
RS (1)	RS51674B (sr)
SI (1)	SI1943242T1 (sr)
TW (1)	TWI399373B (sr)
UA (1)	UA94058C2 (sr)
WO (1)	WO2007048779A1 (sr)
ZA (1)	ZA200803668B (sr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO2769B1 (en)	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) *	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
AU2008240729B2 (en)	2007-04-23	2012-08-23	Janssen Pharmaceutica N.V.	Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
KR20100016620A (ko)	2007-04-23	2010-02-12	얀센 파마슈티카 엔.브이.	속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체
WO2008128994A1 (en) *	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
CA2687931C (en) *	2007-05-31	2016-05-24	Boehringer Ingelheim International Gmbh	Ccr2 receptor antagonists and uses thereof
RU2502734C2 (ru) *	2008-07-03	2013-12-27	Янссен Фармацевтика Нв	Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора
US20100041663A1 (en)	2008-07-18	2010-02-18	Novartis Ag	Organic Compounds as Smo Inhibitors
CA2730774C (en)	2008-07-31	2016-09-13	Janssen Pharmaceutica Nv	Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
HUE025547T2 (en)	2008-12-19	2016-02-29	Boehringer Ingelheim Int	Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
PH12012500778A1 (en)	2009-10-30	2012-11-26	Janssen Pharmaceutica Nv	IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
ES2674275T3 (es)	2009-12-17	2018-06-28	Centrexion Therapeutics Corporation	Antagonistas del receptor CCR2 y usos de los mismos
AR080754A1 (es)	2010-03-09	2012-05-09	Janssen Pharmaceutica Nv	Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2576538B1 (en)	2010-06-01	2015-10-28	Boehringer Ingelheim International GmbH	New CCR2 antagonists
BR112013033375B1 (pt)	2011-06-27	2022-05-10	Janssen Pharmaceutica N.V	Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
HK1206250A1 (en)	2012-06-26	2016-01-08	Janssen Pharmaceutica Nv	Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and ped 10 inhibitors for use in the treatment of neurological or metabolic disorders
WO2014009305A1 (en)	2012-07-09	2014-01-16	Janssen Pharmaceutica Nv	Inhibitors of phosphodiesterase 10 enzyme
MX383744B (es)	2015-07-02	2025-03-14	Centrexion Therapeutics Corp	Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona.
US20180350708A1 (en) *	2017-06-06	2018-12-06	Powertech Technology Inc.	Package structure and manufacturing method thereof
EP4574152A1 (en)	2023-12-22	2025-06-25	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Potassium channel activators for use in the treatment of epileptic disorders

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3933823A (en) *	1971-03-29	1976-01-20	E. R. Squibb & Sons, Inc.	Isoxazolopyridine ketone derivatives
DE2341965C3 (de) *	1973-08-20	1979-01-25	C.H. Boehringer Sohn, 6507 Ingelheim	4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen
NO147672C (no)	1975-09-23	1983-05-25	Janssen Pharmaceutica Nv	Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider
US4197304A (en) *	1975-09-23	1980-04-08	Janssen Pharmaceutica N.V.	N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
EG12406A (en) *	1976-08-12	1979-03-31	Janssen Pharmaceutica Nv	Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
DE3218482A1 (de)	1982-05-15	1983-11-17	Bayer Ag, 5090 Leverkusen	Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
ES8802151A1 (es)	1985-07-31	1988-04-01	Janssen Pharmaceutica Nv	Un procedimiento para la preparacion de nuevos piridazinaminas.
MX173362B (es)	1987-03-02	1994-02-23	Pfizer	Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
PT93060B (pt)	1989-02-07	1995-12-29	Sanofi Sa	Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
US5461053A (en) *	1989-02-07	1995-10-24	Sanofi	Pyridazine derivatives
GB9008850D0 (en) *	1990-04-19	1990-06-13	Janssen Pharmaceutica Nv	Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
GB9216298D0 (en)	1991-08-15	1992-09-16	Ici Plc	Piperidine derivatives
CA2176722A1 (en)	1993-12-28	1995-07-06	Ruth E. Ten Brink	Heterocyclic compounds for the treatment of cns and cardiovascular disorders
DE4425145A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung von Thiazol- und Thiadiazolverbindungen
TW406075B (en)	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
US5560931A (en) *	1995-02-14	1996-10-01	Nawosystems L.L.C.	Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
US5753679A (en)	1995-05-10	1998-05-19	Hoffmann-La Roche Inc.	Benzyl-piperidine derivatives
MY116093A (en) *	1996-02-26	2003-11-28	Upjohn Co	Azolyl piperazinyl phenyl oxazolidinone antimicrobials
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives
PL338947A1 (en) *	1997-08-15	2000-12-04	Pfizer Prod Inc	Derivatives of 2-(4-aryl or heteroaryl piperazin-1-ylmethyl)-1h-indole
KR100261139B1 (ko)	1998-01-16	2000-08-01	황준수	신규한 알릴티오피리다진 유도체 및 그의 제조방법
AR028948A1 (es)	2000-06-20	2003-05-28	Astrazeneca Ab	Compuestos novedosos
PL364625A1 (en)	2001-02-23	2004-12-13	Merck & Co, Inc.	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
US7375115B2 (en)	2001-10-09	2008-05-20	Kyorin Pharmaceutical Co., Ltd.	4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
GB0127832D0 (en)	2001-11-20	2002-01-09	Jagotec Ag	Method for the preparation of pharmaceutical nanosuspensions
AU2002360561A1 (en)	2001-12-11	2003-06-23	Sepracor, Inc.	4-substituted piperidines, and methods of use thereof
EP1467981A1 (en)	2002-01-25	2004-10-20	Kylix Pharmaceuticals B.V.	4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
US20030236259A1 (en)	2002-02-05	2003-12-25	Rolf Hohlweg	Novel aryl- and heteroarylpiperazines
AU2003203148A1 (en)	2002-02-05	2003-09-02	High Point Pharmaceuticals, Llc	Novel aryl- and heteroarylpiperazines
AU2003213184A1 (en)	2002-02-22	2003-09-09	Pharmacia And Upjohn Company	Pyridyl sulfone derivatives as 5-ht receptor antagonists
SE0201544D0 (sv)	2002-05-17	2002-05-17	Biovitrum Ab	Novel compounds and thier use
ATE551053T1 (de) *	2002-09-26	2012-04-15	Mandom Corp	Antiseptische bakterizide, und kosmetika, arzneimittel und lebensmittel, die die antiseptischen bakterizide enthalten
ES2211344B1 (es)	2002-12-26	2005-10-01	Almirall Prodesfarma, S.A.	Nuevos derivados de piridazin-3(2h)-ona.
BRPI0408704A (pt)	2003-03-24	2006-03-07	Hoffmann La Roche	benzil-piridazinonas como inibidores de transcriptase reversa
AU2003239845A1 (en)	2003-05-07	2004-11-26	Ifac Gmbh And Co.Kg	Compositions for the targetted release of fragrances and aromas
CA2524498C (en)	2003-05-08	2012-01-24	Kyorin Pharmaceutical Co., Ltd.	4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching
WO2005005779A2 (en)	2003-07-14	2005-01-20	Genesis Mining Technologies (Pty) Ltd	Dual retention cutting arrangement
DK1651615T3 (da)	2003-07-29	2010-05-25	High Point Pharmaceuticals Llc	Pyridazinyl-piperaziner og anvendelse deraf som histamin-H3-receptorligander
EP1648874B1 (en)	2003-07-30	2011-10-05	Xenon Pharmaceuticals Inc.	Piperazine derivatives and their use as therapeutic agents
EP1653969A4 (en)	2003-08-07	2006-12-20	Japan Tobacco Inc	PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
WO2005046581A2 (en)	2003-10-24	2005-05-26	Cheng Tao M D	P18 in stem cell manipulations
KR20070001976A (ko)	2004-02-10	2007-01-04	얀센 파마슈티카 엔.브이.	알파４ 인테그린의 길항제로서의 피리다지논 우레아
WO2005090317A1 (en)	2004-03-23	2005-09-29	F.Hoffmann-La Roche Ag	Non-nucleoside reverse transcriptase inhibitors
CA2563963A1 (en)	2004-04-28	2005-11-10	Pfizer Inc.	3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor
AU2005249494A1 (en)	2004-05-28	2005-12-15	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
ES2251866B1 (es)	2004-06-18	2007-06-16	Laboratorios Almirall S.A.	Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es)	2004-06-21	2007-06-16	Laboratorios Almirall S.A.	Nuevos derivados de piridazin-3(2h)-ona.
EP1807085B1 (en)	2004-09-20	2013-08-21	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
MX2007005205A (es)	2004-10-29	2007-05-11	Kalypsys Inc	Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma.
CA2602654A1 (en) *	2005-04-05	2006-10-12	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Method for shielding functional sites or epitopes on proteins
DE602006010870D1 (de)	2005-06-20	2010-01-14	Schering Corp	Als antagonisten von histamin h3 geeignete piperidinderivate
JO2769B1 (en) *	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2007130383A2 (en)	2006-04-28	2007-11-15	Northwestern University	Compositions and treatments using pyridazine compounds and secretases
EP2054385A2 (en)	2006-08-15	2009-05-06	F. Hoffmann-Roche AG	Phenyl, pyridine and quinoline derivatives
CA2606658A1 (en) *	2006-10-13	2008-04-13	Mike Tyers	Compositions and methods for treating neurological disorders or damage
JO2642B1 (en) *	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
TW200829566A (en)	2006-12-08	2008-07-16	Astrazeneca Ab	Chemical compounds
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
KR20100016620A (ko) *	2007-04-23	2010-02-12	얀센 파마슈티카 엔.브이.	속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체
WO2008128994A1 (en) *	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
AU2008240729B2 (en) *	2007-04-23	2012-08-23	Janssen Pharmaceutica N.V.	Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
PE20091194A1 (es) *	2007-09-20	2009-09-05	Glaxo Group Ltd	Derivados de heterociclicos como moduladores del receptor m1
RU2502734C2 (ru) *	2008-07-03	2013-12-27	Янссен Фармацевтика Нв	Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора
CA2730774C (en)	2008-07-31	2016-09-13	Janssen Pharmaceutica Nv	Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists

2006
- 2006-10-12 JO JO2006368A patent/JO2769B1/en active
- 2006-10-24 SI SI200630966T patent/SI1943242T1/sl unknown
- 2006-10-24 MY MYPI20081298A patent/MY145609A/en unknown
- 2006-10-24 AU AU2006307930A patent/AU2006307930B2/en not_active Ceased
- 2006-10-24 US US12/091,219 patent/US8940743B2/en active Active
- 2006-10-24 RS RS20110153A patent/RS51674B/sr unknown
- 2006-10-24 UA UAA200803291A patent/UA94058C2/ru unknown
- 2006-10-24 BR BRPI0617787-5A patent/BRPI0617787A2/pt not_active IP Right Cessation
- 2006-10-24 DK DK06807495.4T patent/DK1943242T3/da active
- 2006-10-24 NZ NZ566785A patent/NZ566785A/en not_active IP Right Cessation
- 2006-10-24 CN CN2006800389935A patent/CN101291925B/zh active Active
- 2006-10-24 PT PT06807495T patent/PT1943242E/pt unknown
- 2006-10-24 EP EP06807495A patent/EP1943242B1/en active Active
- 2006-10-24 DE DE602006019624T patent/DE602006019624D1/de active Active
- 2006-10-24 KR KR1020087011462A patent/KR101351910B1/ko not_active Expired - Fee Related
- 2006-10-24 ES ES06807495T patent/ES2359020T3/es active Active
- 2006-10-24 EA EA200801184A patent/EA015681B1/ru unknown
- 2006-10-24 AP AP2008004441A patent/AP2607A/xx active
- 2006-10-24 WO PCT/EP2006/067696 patent/WO2007048779A1/en not_active Ceased
- 2006-10-24 PL PL06807495T patent/PL1943242T3/pl unknown
- 2006-10-24 JP JP2008537078A patent/JP5140598B2/ja active Active
- 2006-10-24 CA CA2623160A patent/CA2623160C/en not_active Expired - Fee Related
- 2006-10-24 AT AT06807495T patent/ATE495167T1/de active
- 2006-10-24 HR HR20110226T patent/HRP20110226T1/hr unknown
- 2006-10-25 AR ARP060104659A patent/AR058151A1/es unknown
- 2006-10-25 TW TW095139268A patent/TWI399373B/zh not_active IP Right Cessation
2008
- 2008-03-31 GT GT200800033A patent/GT200800033A/es unknown
- 2008-04-23 EC EC2008008396A patent/ECSP088396A/es unknown
- 2008-04-23 HN HN2008000646A patent/HN2008000646A/es unknown
- 2008-04-25 ZA ZA200803668A patent/ZA200803668B/xx unknown
- 2008-04-27 IL IL191016A patent/IL191016A/en active IP Right Grant
- 2008-05-26 CR CR10020A patent/CR10020A/es unknown
- 2008-05-26 NO NO20082350A patent/NO20082350L/no not_active Application Discontinuation
2011
- 2011-04-12 CY CY20111100375T patent/CY1111977T1/el unknown
2015
- 2015-01-26 US US14/605,873 patent/US9468640B2/en active Active
2016
- 2016-09-13 US US15/264,185 patent/US9751860B2/en active Active

Also Published As

Publication number	Publication date
HK1124317A1 (en)	2009-07-10
HN2008000646A (es)	2011-02-16
NZ566785A (en)	2010-03-26
CY1111977T1 (el)	2015-11-04
CN101291925B (zh)	2013-04-10
US8940743B2 (en)	2015-01-27
GT200800033A (es)	2009-08-20
AP2607A (en)	2013-03-05
ZA200803668B (en)	2009-09-30
CA2623160A1 (en)	2007-05-03
MY145609A (en)	2012-03-15
HRP20110226T1 (hr)	2011-05-31
AP2008004441A0 (en)	2008-04-30
TW200732321A (en)	2007-09-01
EP1943242A1 (en)	2008-07-16
US9751860B2 (en)	2017-09-05
AU2006307930B2 (en)	2011-10-06
PT1943242E (pt)	2011-04-06
IL191016A (en)	2013-10-31
EA200801184A1 (ru)	2008-08-29
ATE495167T1 (de)	2011-01-15
AU2006307930A1 (en)	2007-05-03
US20170022181A1 (en)	2017-01-26
TWI399373B (zh)	2013-06-21
DK1943242T3 (da)	2011-04-26
RS51674B (sr)	2011-10-31
KR20080067658A (ko)	2008-07-21
ECSP088396A (es)	2008-05-30
CR10020A (es)	2009-01-16
ES2359020T3 (es)	2011-05-17
BRPI0617787A2 (pt)	2009-12-01
NO20082350L (no)	2008-07-01
SI1943242T1 (sl)	2011-05-31
JP5140598B2 (ja)	2013-02-06
EA015681B1 (ru)	2011-10-31
CA2623160C (en)	2013-10-15
EP1943242B1 (en)	2011-01-12
US20080227791A1 (en)	2008-09-18
KR101351910B1 (ko)	2014-01-16
DE602006019624D1 (de)	2011-02-24
JO2769B1 (en)	2014-03-15
JP2009514815A (ja)	2009-04-09
CN101291925A (zh)	2008-10-22
WO2007048779A1 (en)	2007-05-03
US9468640B2 (en)	2016-10-18
PL1943242T3 (pl)	2011-06-30
US20150141432A1 (en)	2015-05-21
UA94058C2 (ru)	2011-04-11

Legal Events

Date	Code	Title	Description
2017-01-23	FB	Suspension of granting procedure

Publication	Publication Date	Title
AR058151A1 (es)	2008-01-23	Compuestos antagosnistas de los receptores 2 de dopamina de rapida disociacion
AR065333A1 (es)	2009-06-03	Antagonistas del receptor de dopamina 2 de rapida disociacion
GT200400173A (es)	2005-04-18	Compuestos de aril o heteroaril amida
GT200600165A (es)	2007-03-14	Derivados dihidrobenzofuranos y usos de los mismos
ECSP099461A (es)	2009-11-30	Compuesto heteromonocíclico y uso del mismo
AR079226A1 (es)	2012-01-04	Espiroindolinona- pirrolidinas, procesos de preparacion y uso de los mismos para el tratamiento y profilaxis del cancer
AR073622A1 (es)	2010-11-17	Compuestos de benzo[d]isoxazol moduladores de receptores de dopamina d3 y de la serotonina 5-ht2a, proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos psicoticos
AR091781A1 (es)	2015-02-25	Antagonistas del receptor de 5-ht3
AR084553A1 (es)	2013-05-22	DERIVADOS IMIDAZOLICOS HETEROCICLICOS INHIBIDORES DE b-SECRETASA, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y USO DE LOS MISMOS PARA TRATAR ENFERMEDADES NEURODEGENERATIVAS, EN PARTICULAR ALZHEIMER
AR083831A1 (es)	2013-03-27	Antagonistas del receptor del cgrp de piperidinona carboxamida azaindano
AR090203A1 (es)	2014-10-29	Compuestos heterobiciclicos como inhibidores de pde10
AR087628A1 (es)	2014-04-09	Inhibidores de pde10 de pirimidina
AR059905A1 (es)	2008-05-07	Pirrolidina-3-ilaminas n-substituidas como antagonistas del receptor histamina-3, composicion farmaceutica y proceso para preparar el compuesto
CL2019002919A1 (es)	2020-01-17	Compuestos inhibidores vmat2 y composiciones relacionadas.
AR070885A1 (es)	2010-05-12	Compuestos de azaindol para el tratamiento de trastornos del sistema nervioso central
AR064198A1 (es)	2009-03-18	Piperidinilamino piridazinas como antagonistas del receptor de dopamina 2 de rapida disociacion. procesos de obtencion y composiciones farmaceuticas
GT200600030A (es)	2006-09-27	2-fenil-indoles como antagonistas del receptor de la prostaglandina d2
AR099071A1 (es)	2016-06-29	Antagonistas selectivos de nr2b
BR112013008675A2 (pt)	2016-06-21	métodos e composições para o tratamento de diabetes e dislipidemia
GT200600107A (es)	2006-12-26	Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos
GT200600217A (es)	2007-03-28	Proceso para la sintesis de compuestos organicos
GT200500124A (es)	2005-12-26	(4-metoxi-7-morfolin-4-il-benzotiazol-2-il) amida del acido 4-hidroxi-4-metil-piperidin-1-carboxilico
AR066242A1 (es)	2009-08-05	Tia(di)azoles como antagonistas del recpetor de dopamina 2 de disociacion rapida
ECSP11011196A (es)	2011-08-31	Derivados de piperidina
GT200300212A (es)	2004-05-25	Piperazinas sustituidas heterociclicas para el tratamiento de la esquizofrenia