ECSP099461A - Compuesto heteromonocíclico y uso del mismo - Google Patents
Compuesto heteromonocíclico y uso del mismoInfo
- Publication number
- ECSP099461A ECSP099461A EC2009009461A ECSP099461A ECSP099461A EC SP099461 A ECSP099461 A EC SP099461A EC 2009009461 A EC2009009461 A EC 2009009461A EC SP099461 A ECSP099461 A EC SP099461A EC SP099461 A ECSP099461 A EC SP099461A
- Authority
- EC
- Ecuador
- Prior art keywords
- formula
- compound
- same
- group
- diseases
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto de la presente invención representado por la fórmula (I):en donde R1 es un grupo oxo, =N-R o similar; un grupo representado por la fórmula: es un grupo representado por la fórmula: R2 es un grupo representado por la fórmula: R3 y R4 son cada uno H, o C1-C6 alquilo, C3-C6 cicloalquilo, C1-C6 alcoxi, C1-C6 alquilamino, di(C1-C6)alquilamino o C1-C6 alquiltio, cada uno de los cuales es opcionalmente substituido; y R5 es H, o un grupo C1-C6 alquilo, C2-C6 alquenilo, cíclico, cada uno de los cuales es opcionalmente substituido, -CO-R8 o -O-R8', o una sal del mismo. El compuesto de la presente invención es útil como un fármaco para la profilaxis o tratamiento de enfermedades circulatorias, enfermedades metabólicas y/o enfermedades del sistema nervioso central.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006317839 | 2006-11-24 | ||
| JP2007232106 | 2007-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP099461A true ECSP099461A (es) | 2009-11-30 |
Family
ID=39205144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2009009461A ECSP099461A (es) | 2006-11-24 | 2009-06-23 | Compuesto heteromonocíclico y uso del mismo |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20080207654A1 (es) |
| EP (2) | EP2074117A2 (es) |
| JP (1) | JP2010510962A (es) |
| KR (1) | KR20090085117A (es) |
| AR (1) | AR063912A1 (es) |
| AU (1) | AU2007322608A1 (es) |
| BR (1) | BRPI0719060A2 (es) |
| CA (1) | CA2670404A1 (es) |
| CL (1) | CL2007003352A1 (es) |
| CO (1) | CO6231035A2 (es) |
| CR (1) | CR10847A (es) |
| EA (1) | EA200970510A1 (es) |
| EC (1) | ECSP099461A (es) |
| IL (1) | IL198819A0 (es) |
| MA (1) | MA30985B1 (es) |
| MX (1) | MX2009005449A (es) |
| NO (1) | NO20092415L (es) |
| PE (1) | PE20081228A1 (es) |
| TN (1) | TN2009000199A1 (es) |
| TW (1) | TW200829581A (es) |
| WO (1) | WO2008062905A2 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7103906B1 (en) | 2000-09-29 | 2006-09-05 | International Business Machines Corporation | User controlled multi-device media-on-demand system |
| BRPI0114571B1 (pt) | 2000-10-11 | 2016-11-08 | Rovi Guides Inc | sistemas e métodos para proporcionar armazenamento de dados em servidores em sistema de expedição de mídia em demanda ou por demanda |
| US8086575B2 (en) | 2004-09-23 | 2011-12-27 | Rovi Solutions Corporation | Methods and apparatus for integrating disparate media formats in a networked media system |
| US9681105B2 (en) | 2005-12-29 | 2017-06-13 | Rovi Guides, Inc. | Interactive media guidance system having multiple devices |
| US8607287B2 (en) | 2005-12-29 | 2013-12-10 | United Video Properties, Inc. | Interactive media guidance system having multiple devices |
| US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| MX2009005449A (es) * | 2006-11-24 | 2009-06-02 | Takeda Pharmaceutical | Compuesto heteromonociclico y uso del mismo. |
| US20090019492A1 (en) | 2007-07-11 | 2009-01-15 | United Video Properties, Inc. | Systems and methods for mirroring and transcoding media content |
| MA33071B1 (fr) * | 2009-01-30 | 2012-02-01 | Takeda Pharmaceutical | Compose a noyau condenses et son utilisation |
| WO2010095462A1 (ja) | 2009-02-23 | 2010-08-26 | 興和株式会社 | 新規な3-(5-アルコキシピリミジン-2-イル)ピリミジン-4(3h)-オン構造を有する化合物及びこれを含有する医薬 |
| EP2420501A4 (en) * | 2009-04-17 | 2012-08-29 | Kowa Co | NOVEL COMPOUND HAVING 3-HETEROARYLPYRIMIDIN-4- (3H) -ONE STRUCTURE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME |
| WO2010137336A1 (ja) | 2009-05-29 | 2010-12-02 | 興和株式会社 | 新規なα-フェノキシベンゼン酢酸誘導体及びこれを含有する医薬 |
| WO2011024468A1 (ja) | 2009-08-27 | 2011-03-03 | 興和株式会社 | 新規なスルホンアミド誘導体及びこれを含有する医薬 |
| US9014546B2 (en) | 2009-09-23 | 2015-04-21 | Rovi Guides, Inc. | Systems and methods for automatically detecting users within detection regions of media devices |
| KR20120095370A (ko) * | 2009-09-29 | 2012-08-28 | 코와 가부시키가이샤 | 신규한 페닐피리딘 유도체 및 이것을 함유하는 의약 |
| US20120225896A1 (en) * | 2009-12-22 | 2012-09-06 | Kowa Company, Ltd. | Novel 2-pyridone derivative and pharmaceutical product containing same |
| JPWO2011105099A1 (ja) * | 2010-02-25 | 2013-06-20 | 興和株式会社 | 新規な4−アルコキシピリミジン構造を有する化合物及びこれを含有する医薬 |
| EP2581373A4 (en) * | 2010-05-11 | 2013-10-23 | 8337187 Canada Inc | BENZO OR PYRIDO IMIDAZOLE DERIVATIVE |
| WO2012011592A1 (ja) * | 2010-07-23 | 2012-01-26 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| AU2011313150A1 (en) | 2010-10-07 | 2013-04-18 | Takeda Pharmaceutical Company Limited | 1,4-oxazepane derivatives |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| WO2012078684A1 (en) | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted pyridinone-pyridinyl compounds |
| US8507499B2 (en) | 2010-12-06 | 2013-08-13 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
| US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
| JP5583841B2 (ja) | 2011-03-14 | 2014-09-03 | 興和株式会社 | 新規なフェニルピリジン誘導体及びこれを含有する医薬 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9056110B2 (en) | 2011-12-06 | 2015-06-16 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| CN104136431B (zh) * | 2011-12-21 | 2017-03-15 | 小野药品工业株式会社 | 作为凝血因子XIa抑制剂的吡啶酮和嘧啶酮衍生物 |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| HUE054178T2 (hu) | 2013-06-07 | 2021-08-30 | Aclaris Therapeutics Inc | Metil/fluor-piridinil-metoxi-szubsztituált piridinon-piridinil-vegyületek és fluor-pirimidinil-metoxi-szubsztituált piridinon-piridinil-vegyületek |
| ES2761571T3 (es) | 2013-06-20 | 2020-05-20 | Bayer Cropscience Ag | Derivados de arilsulfuro y arilsulfóxido como acaricidas e insecticidas |
| JP2016526538A (ja) | 2013-06-20 | 2016-09-05 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺ダニ剤及び殺虫剤としてのアリールスルフィド誘導体及びアリールスルホキシド誘導体 |
| US9674563B2 (en) | 2013-11-04 | 2017-06-06 | Rovi Guides, Inc. | Systems and methods for recommending content |
| CA2929394C (en) | 2013-12-19 | 2021-11-16 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
| RU2693622C2 (ru) | 2014-04-01 | 2019-07-03 | Мерк Шарп И Доум Корп. | Пролекарственные средства ингибиторов обратной транскриптазы вич |
| EP3231803B1 (en) | 2014-12-10 | 2020-07-01 | ONO Pharmaceutical Co., Ltd. | Dihydroindolizinone derivative |
| MX2019000512A (es) | 2016-07-12 | 2019-05-02 | Bayer Cropscience Ag | Compuestos biciclicos como plaguicidas. |
| KR101984121B1 (ko) * | 2017-08-21 | 2019-05-30 | 보령제약 주식회사 | 피리미디논 유도체 화합물 및 이의 용도 |
| CN115484952B (zh) | 2020-03-27 | 2024-10-18 | 阿克拉瑞斯治疗股份有限公司 | 被取代的吡啶酮-吡啶基化合物的方法、组合物和结晶形式 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411980A (en) * | 1989-07-28 | 1995-05-02 | Merck & Co., Inc. | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists |
| JPH03218371A (ja) | 1989-08-02 | 1991-09-25 | Takeda Chem Ind Ltd | ピラゾール誘導体 |
| EP0411507B1 (en) * | 1989-08-02 | 1994-10-26 | Takeda Chemical Industries, Ltd. | Pyrazole derivatives, their production and use |
| ATE169915T1 (de) * | 1990-02-15 | 1998-09-15 | Takeda Chemical Industries Ltd | Pyrimidindionderivate, deren herstellung und verwendung |
| JP3032844B2 (ja) | 1990-02-15 | 2000-04-17 | 武田薬品工業株式会社 | ピリミジンジオン誘導体 |
| JP3114073B2 (ja) | 1990-03-07 | 2000-12-04 | 武田薬品工業株式会社 | アンジオテンシンii拮抗薬−含窒素異項環化合物 |
| CA2037630C (en) * | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
| US5166206A (en) * | 1990-03-30 | 1992-11-24 | Merck & Co., Inc. | Substituted pyrimidines, pyrimidinones and pyridopyrimidines |
| US5472967A (en) * | 1991-02-20 | 1995-12-05 | Synthelabo | 4-pyrimidinone derivatives their preparation and their application in therapy |
| IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them |
| IT1250749B (it) * | 1991-08-02 | 1995-04-21 | Luso Farmaco Inst | Composti eterociclici ad attivita' a ii antagonista |
| JPH06239859A (ja) | 1992-09-14 | 1994-08-30 | Takeda Chem Ind Ltd | アンギオテンシンii拮抗作用を有する環状化合物およびその用途 |
| DE69333489T2 (de) | 1992-09-14 | 2005-04-14 | Takeda Chemical Industries, Ltd. | Heterocyclische Verbindungen und ihre Verwendung als Angiotensin II Antagonisten |
| JP3412887B2 (ja) | 1992-12-22 | 2003-06-03 | 武田薬品工業株式会社 | アンギオテンシンii拮抗作用を有する複素環化合物およびその用途 |
| DE69330593T2 (de) * | 1992-12-22 | 2002-06-27 | Takeda Chemical Industries, Ltd. | Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung |
| US20010020100A1 (en) * | 1994-06-14 | 2001-09-06 | G.D. Searle & Co. | N-substituted-1, 2, 4-triazolone compounds for treatment of cardiovascular disorders |
| US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
| US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
| AU1285499A (en) | 1997-10-30 | 1999-05-24 | Merck & Co., Inc. | Somatostatin agonists |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| WO2001025228A1 (en) | 1999-10-07 | 2001-04-12 | Tadeka Chemical Industries, Ltd. | Amine derivatives |
| PL356487A1 (en) | 1999-11-10 | 2004-06-28 | Takeda Chemical Industries, Ltd. | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
| CA2407149C (en) | 2000-04-28 | 2010-10-12 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| US6974806B2 (en) | 2000-07-13 | 2005-12-13 | Takeda Pharmaceutical Company Limited | Lipid-rich plaque inhibitors |
| WO2003042204A1 (en) | 2001-10-19 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Amine derivative |
| AU2003202488A1 (en) | 2002-01-11 | 2003-07-30 | Takeda Pharmaceutical Company Limited | Coumarin derivatives, process for their production and use thereof |
| WO2004048363A1 (ja) | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | イミダゾール誘導体、その製造法および用途 |
| US7803940B2 (en) * | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| MX2009005449A (es) * | 2006-11-24 | 2009-06-02 | Takeda Pharmaceutical | Compuesto heteromonociclico y uso del mismo. |
-
2007
- 2007-11-21 MX MX2009005449A patent/MX2009005449A/es not_active Application Discontinuation
- 2007-11-21 EP EP07832719A patent/EP2074117A2/en not_active Withdrawn
- 2007-11-21 JP JP2009521472A patent/JP2010510962A/ja not_active Abandoned
- 2007-11-21 BR BRPI0719060-3A2A patent/BRPI0719060A2/pt not_active IP Right Cessation
- 2007-11-21 AU AU2007322608A patent/AU2007322608A1/en not_active Abandoned
- 2007-11-21 CA CA002670404A patent/CA2670404A1/en not_active Abandoned
- 2007-11-21 EP EP10173592A patent/EP2256115A1/en not_active Withdrawn
- 2007-11-21 US US11/943,910 patent/US20080207654A1/en not_active Abandoned
- 2007-11-21 US US12/516,099 patent/US20100056526A1/en not_active Abandoned
- 2007-11-21 EA EA200970510A patent/EA200970510A1/ru unknown
- 2007-11-21 WO PCT/JP2007/073004 patent/WO2008062905A2/en not_active Ceased
- 2007-11-21 KR KR1020097012959A patent/KR20090085117A/ko not_active Withdrawn
- 2007-11-23 AR ARP070105204A patent/AR063912A1/es not_active Application Discontinuation
- 2007-11-23 PE PE2007001629A patent/PE20081228A1/es not_active Application Discontinuation
- 2007-11-23 TW TW096144409A patent/TW200829581A/zh unknown
- 2007-11-23 CL CL200703352A patent/CL2007003352A1/es unknown
-
2009
- 2009-05-19 IL IL198819A patent/IL198819A0/en unknown
- 2009-05-20 TN TNP2009000199A patent/TN2009000199A1/fr unknown
- 2009-06-09 CR CR10847A patent/CR10847A/es unknown
- 2009-06-10 MA MA31977A patent/MA30985B1/fr unknown
- 2009-06-23 EC EC2009009461A patent/ECSP099461A/es unknown
- 2009-06-24 CO CO09065607A patent/CO6231035A2/es not_active Application Discontinuation
- 2009-06-24 NO NO20092415A patent/NO20092415L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20080207654A1 (en) | 2008-08-28 |
| KR20090085117A (ko) | 2009-08-06 |
| US20100056526A1 (en) | 2010-03-04 |
| BRPI0719060A2 (pt) | 2014-02-04 |
| PE20081228A1 (es) | 2008-10-29 |
| JP2010510962A (ja) | 2010-04-08 |
| AU2007322608A2 (en) | 2009-07-16 |
| TN2009000199A1 (en) | 2010-10-18 |
| CR10847A (es) | 2009-07-13 |
| TW200829581A (en) | 2008-07-16 |
| EP2074117A2 (en) | 2009-07-01 |
| IL198819A0 (en) | 2010-02-17 |
| CL2007003352A1 (es) | 2008-07-04 |
| NO20092415L (no) | 2009-08-17 |
| EP2256115A1 (en) | 2010-12-01 |
| AR063912A1 (es) | 2009-02-25 |
| WO2008062905A3 (en) | 2008-12-04 |
| CA2670404A1 (en) | 2008-05-29 |
| CO6231035A2 (es) | 2010-12-20 |
| MX2009005449A (es) | 2009-06-02 |
| AU2007322608A1 (en) | 2008-05-29 |
| WO2008062905A2 (en) | 2008-05-29 |
| MA30985B1 (fr) | 2009-12-01 |
| EA200970510A1 (ru) | 2009-12-30 |
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