AR058249A2 - Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna - Google Patents
Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacunaInfo
- Publication number
- AR058249A2 AR058249A2 ARP070101362A AR058249A2 AR 058249 A2 AR058249 A2 AR 058249A2 AR P070101362 A ARP070101362 A AR P070101362A AR 058249 A2 AR058249 A2 AR 058249A2
- Authority
- AR
- Argentina
- Prior art keywords
- molecula
- nucleotide
- dna sequence
- prrs virus
- vaccine
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 4
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000002458 infectious effect Effects 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 6
- 125000003729 nucleotide group Chemical group 0.000 abstract 6
- 230000000890 antigenic effect Effects 0.000 abstract 3
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229940113082 thymine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10041—Use of virus, viral particle or viral elements as a vector
- C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10062—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pulmonology (AREA)
Abstract
Una molécula aislada de polinucléotido caracterizada porque comprende una secuencia de ADN que codifica una molécula infecciosa de ARN que codifica un virus PRRS norteamericano que está genéticamente modificado de modo tal que comprende uno o más epítopes antigénicos heterologos, donde la secuencia de ADN que codifica la molécula de ARN que codifica el virus PRRS norteamericano es SEQ ID. N°1 o es la secuencia que comienza con e incluye desde el nucleotido 1 hasta incluir el nucleotido 15416 de la SEQ ID. N°1; excepto que el nucleotido que corresponde al nucleotido 12622 de la SEQ ID. N° 1 es una guanina en un lugar de una adenina y el nucleotido que corresponde al nucleotido 1559 de la SEQ. ID. N° 1 es una timina en lugar de una citosina, excepto que comprende uno o más secuencias de nucleotidos adicionales que codifican epítopes antigénicos heterologos, donde cada epítope antigénico heterologo es capaz de inducir una respuesta inmunoportectora efectiva contra un patogeno particular en un mamífero o en un pájaro. Se describe también una célula huésped transfectada, y una vacuna.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11334598P | 1998-12-22 | 1998-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058249A2 true AR058249A2 (es) | 2008-01-30 |
Family
ID=22348908
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106325 AR025146A1 (es) | 1998-12-22 | 1999-12-13 | UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA. |
| ARP070101362 AR058249A2 (es) | 1998-12-22 | 2007-03-30 | Una molecula aislada de polinucleotido que comprende una secuencia de adn que codifica una molecula infecciosa de arn que codifica un virus prrs norteamericano, celula transfectada y vacuna |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106325 AR025146A1 (es) | 1998-12-22 | 1999-12-13 | UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6500662B1 (es) |
| EP (2) | EP1627919B1 (es) |
| JP (7) | JP4113642B2 (es) |
| CN (1) | CN1171996C (es) |
| AR (2) | AR025146A1 (es) |
| AT (1) | ATE309364T1 (es) |
| AU (1) | AU769841B2 (es) |
| BR (1) | BRPI9905902B8 (es) |
| CA (2) | CA2290220C (es) |
| CY (2) | CY1105680T1 (es) |
| DE (1) | DE69928209T9 (es) |
| DK (2) | DK1018557T5 (es) |
| ES (2) | ES2251162T3 (es) |
| MX (1) | MXPA03009354A (es) |
| NZ (2) | NZ501264A (es) |
| PT (1) | PT1627919E (es) |
| ZA (1) | ZA997289B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| US7618797B2 (en) | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| US7691389B2 (en) * | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| CA2366072C (en) | 1999-03-08 | 2007-07-10 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Prrsv vaccines |
| ES2348159T3 (es) | 1999-04-22 | 2010-11-30 | United States Department Of Agriculture | Vacuna contra el sindrome respiratorio y reproductivo porcino basada en el aislado ja-142. |
| JPWO2002038753A1 (ja) * | 2000-11-09 | 2004-03-18 | 渡辺 純一 | 病原体に感染した動物の病態または生存に影響を与える遺伝子のスクリーニング方法 |
| US6841364B2 (en) * | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
| US7906311B2 (en) * | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
| ATE392905T1 (de) * | 2003-07-24 | 2008-05-15 | Merial Ltd | Vakzin-formulierungen mit einer öl-in-wasser- emulsion |
| TW200604526A (en) | 2004-06-18 | 2006-02-01 | Unviersity Of Minnesota | Identifying virally infected and vaccinated organisms |
| KR100872840B1 (ko) | 2004-07-09 | 2008-12-22 | (주)씨아이디 | 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도 |
| US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
| EP1812573A1 (en) * | 2004-11-11 | 2007-08-01 | Pfizer Products Inc. | Mutant porcine reproductive and respiratory syndrome virus |
| DE602006013270D1 (en) | 2005-01-13 | 2010-05-12 | Boehringer Ingelheim Vetmed | Prrs-impfstoffe |
| AU2006253891B2 (en) * | 2005-02-25 | 2011-12-01 | Zoetis P Llc | N Protein Mutants of Porcine reproductive and respiratory syndrome virus |
| PT2369001T (pt) * | 2005-06-24 | 2016-10-25 | Univ Minnesota | Vírus srrp, clones infecciosos, os seus mutantes e processos de utilização |
| CA2620667A1 (en) * | 2005-08-30 | 2007-04-12 | Board Of Regents Of The University Of Nebraska | Methods and compositions for vaccination of animals with prrsv antigens with improved immunogenicity |
| MX2009007457A (es) | 2007-01-12 | 2009-08-12 | Univ Illinois | Celulas que no son de mono para el desarrollo del virus del sindrome porcino reproductor y respiratorio (prrs). |
| US7666585B2 (en) | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
| CN101848995A (zh) * | 2007-06-25 | 2010-09-29 | 南达科他州立大学 | 重组的北美1型猪繁殖与呼吸综合征病毒及使用方法 |
| KR101653177B1 (ko) * | 2008-08-25 | 2016-09-01 | 베링거잉겔하임베트메디카인코퍼레이티드 | 고병원성 돼지 생식기 및 호흡기 증후군(hp prrs)에 대한 백신 |
| US8012735B2 (en) * | 2009-03-02 | 2011-09-06 | University Of Kentucky Research Foundation | Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
| SG179037A1 (en) * | 2009-09-10 | 2012-04-27 | Merial Ltd | New vaccine formulations comprising saponin-containing adjuvants |
| UA108902C2 (uk) * | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
| CA2827337C (en) | 2011-02-17 | 2019-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Commercial scale process for production of prrsv |
| ES2692809T3 (es) | 2011-02-17 | 2018-12-05 | Boehringer Ingelheim Vetmedica Gmbh | Nueva cepa del PRRSV europea |
| US9315781B2 (en) | 2011-07-29 | 2016-04-19 | Boehringer Ingelheim Vetmedica Gmbh | Infectious CDNA clone of european PRRS virus and uses thereof |
| US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| KR102012109B1 (ko) * | 2012-05-17 | 2019-08-19 | 조에티스 엘엘씨 | 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종 |
| US9579373B2 (en) | 2013-03-15 | 2017-02-28 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
| KR102319843B1 (ko) | 2013-09-25 | 2021-10-29 | 조에티스 서비시즈 엘엘씨 | Pcv2b 분지형 백신 조성물 및 사용 방법 |
| CN105829528B (zh) * | 2013-12-20 | 2019-10-22 | 勃林格殷格翰动物保健有限公司 | PRRS病毒变体、欧洲PRRS病毒cDNA克隆及其用途 |
| CN104198773A (zh) * | 2014-08-29 | 2014-12-10 | 苏州市吴中区胥口广博模具加工厂 | 三轴联动式大型电路板测试夹具的第二转轴组 |
| TWI554609B (zh) | 2014-11-19 | 2016-10-21 | 國立屏東科技大學 | 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物 |
| US9920302B2 (en) | 2015-08-31 | 2018-03-20 | Boehringer Ingelheim Vetmedica Gmbh | Pestivirus vaccines for congenital tremors |
| WO2017106079A1 (en) | 2015-12-14 | 2017-06-22 | Boehringer Ingelheim Vetmedica, Inc. | Hybrid core feline vaccines |
| US11332739B2 (en) | 2016-08-05 | 2022-05-17 | Hipra Scientific, S.L.U. | Porcine reproductive and respiratory syndrome virus cDNA clone and uses thereof |
| CA3047294A1 (en) | 2016-12-14 | 2018-06-21 | Zoetis Services Llc | Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning |
| CN107586780B (zh) * | 2017-10-25 | 2019-10-11 | 中国农业科学院兰州兽医研究所 | 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna |
| CN109943590B (zh) * | 2019-04-18 | 2022-11-18 | 西南大学 | 一种复制缺陷型猪圆环病毒、其制备方法及应用 |
| CN111996174A (zh) * | 2020-02-06 | 2020-11-27 | 广西大学 | 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法 |
| US20250332242A1 (en) | 2024-04-30 | 2025-10-30 | Zoetis Services Llc | Porcine endogenous retrovirus (perv)-free porcine circovirus type 2d-based vaccines and methods of use |
| US20250332243A1 (en) | 2024-04-30 | 2025-10-30 | Zoetis Services Llc | Methods of manufacturing porcine endogenous retrovirus (perv) free animal health vaccines |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3137631A (en) | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
| US3959457A (en) | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
| US4015100A (en) | 1974-01-07 | 1977-03-29 | Avco Everett Research Laboratory, Inc. | Surface modification |
| JPS5186117A (en) | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
| US4205060A (en) | 1978-12-20 | 1980-05-27 | Pennwalt Corporation | Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use |
| US4452747A (en) | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
| US4744933A (en) | 1984-02-15 | 1988-05-17 | Massachusetts Institute Of Technology | Process for encapsulation and encapsulated active material system |
| US5008050A (en) | 1984-06-20 | 1991-04-16 | The Liposome Company, Inc. | Extrusion technique for producing unilamellar vesicles |
| US4921706A (en) | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
| US4606940A (en) | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
| US5009956A (en) | 1987-02-24 | 1991-04-23 | Univ Minnesota | Phospholipase A2-resistant liposomes |
| IT8819772A0 (it) * | 1988-03-15 | 1988-03-15 | Honeywell Bull Spa | Dispositivo selettivo a terra per apparecchiature elettroniche. |
| US4927637A (en) | 1989-01-17 | 1990-05-22 | Liposome Technology, Inc. | Liposome extrusion method |
| US4944948A (en) | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
| US5132117A (en) | 1990-01-11 | 1992-07-21 | Temple University | Aqueous core microcapsules and method for their preparation |
| CA2290906C (en) | 1991-06-06 | 2003-04-01 | Stichting Centraal Diergeneeskundig Instituut | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits |
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| KR100241221B1 (ko) | 1991-08-26 | 2000-03-02 | 에드워드 콜린스 제임스 | 돼지 불임 및 호흡기계 중후백신 및 그의 진단법 |
| KR0138092B1 (ko) | 1991-08-26 | 1998-04-30 | 제임스 씨. 데세사레 | 미확인(Mystery) 돼지 질병 관련 바이러스제 |
| US5846805A (en) | 1991-08-26 | 1998-12-08 | Boehringer Ingelheim Animal Health, Inc. | Culture of swine infertility and respiratory syndrome virus in simian cells |
| AU2696792A (en) | 1991-09-16 | 1993-04-27 | David A Benfield | Vaccine for mystery swine disease and method for diagnosis thereof |
| FR2686097B1 (fr) | 1992-01-14 | 1994-12-30 | Rhone Merieux | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
| US5203054A (en) | 1992-09-28 | 1993-04-20 | Emhart Inc. | Retainer for trunk lid torsion bars |
| US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
| US6592873B1 (en) | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
| US6251397B1 (en) * | 1992-10-30 | 2001-06-26 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same |
| US6773908B1 (en) * | 1992-10-30 | 2004-08-10 | Iowa State University Research Foundation, Inc. | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) |
| NZ261992A (en) | 1993-02-08 | 1996-06-25 | Bayer Ag | Porcine reproductive and respiratory syndrome virus, cultures, attenuated forms and vaccines thereof |
| ES2074950B1 (es) | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
| ATE235959T1 (de) | 1994-04-15 | 2003-04-15 | Univ Temple | Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln |
| MX9700817A (es) * | 1994-08-05 | 1997-05-31 | Univ Minnesota | Secuencia viral de nucleotidos de "vr-2332" y metodos de uso. |
| EP0732340B1 (en) | 1995-03-14 | 2004-06-09 | Akzo Nobel N.V. | Expression of porcine reproductive respiratory syndrome virus polypeptides in the same cell |
| JP3135069B2 (ja) | 1996-03-01 | 2001-02-13 | シェーリング コーポレイション | ブタ生殖および呼吸症候群ワクチン |
| EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| WO1998055626A2 (en) | 1997-06-05 | 1998-12-10 | Origen, Inc. | Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine |
| US6288199B1 (en) * | 1999-11-02 | 2001-09-11 | Ppg Industries Ohio, Inc. | Blocked isocyanate-based compounds and compositions containing the same |
-
1999
- 1999-11-23 NZ NZ501264A patent/NZ501264A/en not_active IP Right Cessation
- 1999-11-23 NZ NZ51328999A patent/NZ513289A/xx not_active IP Right Cessation
- 1999-11-23 CA CA2290220A patent/CA2290220C/en not_active Expired - Lifetime
- 1999-11-23 CA CA 2440933 patent/CA2440933A1/en not_active Abandoned
- 1999-11-24 ZA ZA9907289A patent/ZA997289B/xx unknown
- 1999-11-25 ES ES99309409T patent/ES2251162T3/es not_active Expired - Lifetime
- 1999-11-25 DK DK99309409T patent/DK1018557T5/da active
- 1999-11-25 PT PT05018141T patent/PT1627919E/pt unknown
- 1999-11-25 AT AT99309409T patent/ATE309364T1/de active
- 1999-11-25 EP EP20050018141 patent/EP1627919B1/en not_active Expired - Lifetime
- 1999-11-25 DK DK05018141T patent/DK1627919T3/en active
- 1999-11-25 ES ES05018141T patent/ES2459568T3/es not_active Expired - Lifetime
- 1999-11-25 DE DE1999628209 patent/DE69928209T9/de active Active
- 1999-11-25 EP EP19990309409 patent/EP1018557B9/en not_active Expired - Lifetime
- 1999-11-29 AU AU61733/99A patent/AU769841B2/en not_active Expired
- 1999-12-13 AR ARP990106325 patent/AR025146A1/es active IP Right Grant
- 1999-12-17 BR BRPI9905902A patent/BRPI9905902B8/pt not_active IP Right Cessation
- 1999-12-21 JP JP36218699A patent/JP4113642B2/ja not_active Expired - Lifetime
- 1999-12-22 CN CNB99126505XA patent/CN1171996C/zh not_active Expired - Lifetime
- 1999-12-22 US US09/470,661 patent/US6500662B1/en not_active Expired - Lifetime
-
2000
- 2000-12-06 JP JP2000372087A patent/JP4159242B2/ja not_active Expired - Lifetime
- 2000-12-06 JP JP2000372096A patent/JP4130729B2/ja not_active Expired - Lifetime
-
2002
- 2002-04-22 US US10/127,391 patent/US7232680B2/en not_active Expired - Lifetime
-
2003
- 2003-10-10 MX MXPA03009354 patent/MXPA03009354A/es active IP Right Grant
- 2003-10-22 JP JP2003362438A patent/JP2004081218A/ja not_active Withdrawn
-
2006
- 2006-02-07 CY CY061100160T patent/CY1105680T1/el unknown
-
2007
- 2007-03-30 AR ARP070101362 patent/AR058249A2/es not_active Application Discontinuation
-
2008
- 2008-01-28 JP JP2008016640A patent/JP2008113670A/ja active Pending
- 2008-02-19 JP JP2008037593A patent/JP4335287B2/ja not_active Expired - Lifetime
- 2008-05-27 JP JP2008137495A patent/JP2008289485A/ja active Pending
-
2014
- 2014-04-03 CY CY20141100252T patent/CY1115010T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR025146A1 (es) | UNA MOLÉCULA AISLADA DE POLINUCLEoTIDO QUE COMPRENDE UNA SECUENCIA DE ADN QUE CODIFICA UN VIRUS PRRS NORTEAMERICANO, CÉLULA HUESPED, PLÁSMIDO, MÉTODO PARA GENERAR UN VIRUS PRRS NORTEAMERICANO Y VACUNA. | |
| CA2272046A1 (en) | Infectious clones of rna viruses and vaccines and diagnostic assays derived thereof | |
| Fernández et al. | The motif V of plum pox potyvirus CI RNA helicase is involved in NTP hydrolysis and is essential for virus RNA replication | |
| AR044724A1 (es) | Promotores del virus de la rizadura amarilla del cestrum | |
| CA2389206A1 (en) | Activation of hcv-specific t cells | |
| MX9204685A (es) | Secuencia de adn que codifica una proteina superficial externa (ospa) o derivado de la misma composicion de vacuna qe comprende tal proteina. | |
| BR0010361A (pt) | Seq ências genÈmicas de neisseria e uso destas | |
| ES2075901T3 (es) | Sistemas de expresion de virus recombinantes de arn con cadena negativa y vacunas. | |
| DK0702085T4 (da) | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus | |
| DE69925618D1 (de) | Rna krebsimpfstoff und verfahren zu dessen benutzung | |
| TR200401186T4 (tr) | Rekombinant bir RNA-virüs oluşumunu yönlendirebilen nükleik asit sekansları içerikli suni kromozom yapıları. | |
| HUP0500722A2 (hu) | Attenuált veszettség vírus, a veszettség elleni vakcináláshoz és a központi idegrendszer génterápiájához egy nukleoprotein mutációval a foszforilezés helyén | |
| PT1119630E (pt) | Construcoes de acido nucleico para imunizacao genetica | |
| Beer et al. | Phylogenetic Analysis of the 5′‐Untranslated Region of German BVDV Type II Isolates | |
| DE69929530D1 (de) | Attenuierte pferdeherpesvirus | |
| DE60040219D1 (de) | Infektiöses cdna klon des gb-virus b und dessen verwendungen | |
| DE69106141D1 (de) | Non-a non-b sequenzen. | |
| DK1227840T3 (da) | Adjuverede, genetiske vacciner | |
| ATE160377T1 (de) | Erzeugung von hybrid-genen und proteinen durch rekombination mittels viren | |
| DE60229966D1 (de) | Diabetesmodell | |
| ES2367245T8 (es) | Virus recombinante que expresa adn foráneo que codifica cd80 felino, cd28 felino, ctla-4felino o cd86 felino y usos del mismo. | |
| ATE389726T1 (de) | Infektiöse vektoren und pflanzenklone, die sich von turnip mosaikvirus herleiten | |
| KR960041360A (ko) | 돼지파보바이러스의 vp2 단백질의 대량 생산방법 및 돼지파보바이러스 감염증용 백신의 제조방법 | |
| TH14141A (th) | โมเลกุลของรีคอมบิแนนท์ดีเอนเอทีประมวลรหัสของ?เอนไซม์อะมิโนเปปติเดสและการใช้งานของมันสำหรับการ?เตรียมวัคซีนต่อการติดหนอนพยาธิ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |