BRPI9905902B8 - "molécula polinucleotídica isolada, plasmídeo, e método para produzir um vírus prrs norte-americano" - Google Patents
"molécula polinucleotídica isolada, plasmídeo, e método para produzir um vírus prrs norte-americano"Info
- Publication number
- BRPI9905902B8 BRPI9905902B8 BRPI9905902A BR9905902A BRPI9905902B8 BR PI9905902 B8 BRPI9905902 B8 BR PI9905902B8 BR PI9905902 A BRPI9905902 A BR PI9905902A BR 9905902 A BR9905902 A BR 9905902A BR PI9905902 B8 BRPI9905902 B8 BR PI9905902B8
- Authority
- BR
- Brazil
- Prior art keywords
- north american
- viral vectors
- american prrs
- isolated polynucleotide
- virus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10041—Use of virus, viral particle or viral elements as a vector
- C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10062—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11334598P | 1998-12-22 | 1998-12-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9905902A BR9905902A (pt) | 2000-12-12 |
| BRPI9905902B1 BRPI9905902B1 (pt) | 2015-09-01 |
| BRPI9905902B8 true BRPI9905902B8 (pt) | 2021-05-25 |
Family
ID=22348908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9905902A BRPI9905902B8 (pt) | 1998-12-22 | 1999-12-17 | "molécula polinucleotídica isolada, plasmídeo, e método para produzir um vírus prrs norte-americano" |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6500662B1 (pt) |
| EP (2) | EP1018557B9 (pt) |
| JP (7) | JP4113642B2 (pt) |
| CN (1) | CN1171996C (pt) |
| AR (2) | AR025146A1 (pt) |
| AT (1) | ATE309364T1 (pt) |
| AU (1) | AU769841B2 (pt) |
| BR (1) | BRPI9905902B8 (pt) |
| CA (2) | CA2290220C (pt) |
| CY (2) | CY1105680T1 (pt) |
| DE (1) | DE69928209T9 (pt) |
| DK (2) | DK1018557T5 (pt) |
| ES (2) | ES2459568T3 (pt) |
| MX (1) | MXPA03009354A (pt) |
| NZ (2) | NZ513289A (pt) |
| PT (1) | PT1627919E (pt) |
| ZA (1) | ZA997289B (pt) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| US7691389B2 (en) * | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| US7618797B2 (en) * | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| JP3961222B2 (ja) | 1999-03-08 | 2007-08-22 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | Prrsvワクチン |
| EP1183332B1 (en) | 1999-04-22 | 2010-07-14 | United States Department Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
| JPWO2002038753A1 (ja) * | 2000-11-09 | 2004-03-18 | 渡辺 純一 | 病原体に感染した動物の病態または生存に影響を与える遺伝子のスクリーニング方法 |
| US6841364B2 (en) | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
| US7906311B2 (en) | 2002-03-20 | 2011-03-15 | Merial Limited | Cotton rat lung cells for virus culture |
| PL1651265T3 (pl) | 2003-07-24 | 2008-10-31 | Merial Ltd | Formulacje szczepionek zawierających emulsję olej w wodzie |
| CA2571452A1 (en) | 2004-06-18 | 2006-01-26 | Regents Of The University Of Minnesota | Identifying virally infected and vaccinated organisms |
| KR100872840B1 (ko) | 2004-07-09 | 2008-12-22 | (주)씨아이디 | 돼지생식기호흡기증후군 바이러스에 대한 전체-길이의감염성이 있는 cDNA 클론 및 이의 용도 |
| US7632636B2 (en) * | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
| CA2586153C (en) * | 2004-11-11 | 2012-04-03 | Pfizer Products Inc. | Mutant porcine reproductive and respiratory syndrome virus |
| CA2587321A1 (en) | 2005-01-13 | 2006-07-20 | Boehringer Ingelheim Vetmedica Gmbh | Improved prrs vaccines |
| EP1856141A1 (en) * | 2005-02-25 | 2007-11-21 | Pfizer Products Inc. | N protein mutants of porcine reproductive and respiratory syndrome virus |
| PL1904631T3 (pl) * | 2005-06-24 | 2012-10-31 | Univ Minnesota | Wirusy PRRS, klony zakaźne, ich mutanty i sposoby stosowania |
| PL1929047T3 (pl) * | 2005-08-30 | 2010-08-31 | Univ Nebraska | Sposoby i kompozycje do szczepienia zwierząt antygenami PRRSV o ulepszonej immunogenności |
| PL2106440T3 (pl) * | 2007-01-12 | 2016-02-29 | Univ Illinois | Komórki niepochodzące od małp do hodowli wirusa zespołu rozrodczo-oddechowego świń (PRRS) |
| US7666585B2 (en) | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
| ES2389748T3 (es) * | 2007-06-25 | 2012-10-31 | South Dakota State University | Virus del síndrome reproductivo y respiratorio porcino de tipo 1 norteamericano recombinante y métodos de uso |
| JP5619004B2 (ja) * | 2008-08-25 | 2014-11-05 | ベーリンガーインゲルハイム フェトメディカ インコーポレイテッド | 高病原性ブタ繁殖・呼吸障害症候群(hpprrs)のワクチン |
| US8012735B2 (en) * | 2009-03-02 | 2011-09-06 | University Of Kentucky Research Foundation | Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
| DK2475384T3 (en) * | 2009-09-10 | 2016-10-24 | Merial Inc | NEW VACCINE FORMULATIONS COMPREHENSIVE saponin-CONTAINING ADJUVANTS |
| UA108902C2 (uk) * | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
| AU2012217170B2 (en) | 2011-02-17 | 2016-07-28 | Boehringer Ingelheim Vetmedica Gmbh | Commercial scale process for production of PRRSV |
| WO2012110489A2 (en) | 2011-02-17 | 2012-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Novel european prrsv strain |
| WO2013017568A1 (en) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF |
| US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| MX2014013964A (es) * | 2012-05-17 | 2015-03-04 | Zoetis Llc | Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete. |
| US9579373B2 (en) | 2013-03-15 | 2017-02-28 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
| CA2925281C (en) | 2013-09-25 | 2022-05-03 | Zoetis Services Llc | Pcv2b divergent vaccine composition and methods of use |
| AU2014369774B2 (en) * | 2013-12-20 | 2020-11-26 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus variant, European PRRS virus cDNA clone, and uses thereof |
| CN104198773A (zh) * | 2014-08-29 | 2014-12-10 | 苏州市吴中区胥口广博模具加工厂 | 三轴联动式大型电路板测试夹具的第二转轴组 |
| TWI554609B (zh) | 2014-11-19 | 2016-10-21 | 國立屏東科技大學 | 抗豬生殖與呼吸綜合症病毒感染之重組融合抗原基因、重組融合抗原蛋白及含彼之次單位疫苗組成物 |
| EP3344289B1 (en) | 2015-08-31 | 2020-01-29 | Boehringer Ingelheim Vetmedica GmbH | Pestivirus vaccines for congenital tremors |
| US10188725B2 (en) | 2015-12-14 | 2019-01-29 | Elanco Us Inc. | Hybrid core feline vaccines |
| MX393666B (es) | 2016-08-05 | 2025-03-24 | Hipra Scient S L U | CLON DE ADNc DEL VIRUS DEL SÍNDROME REPRODUCTIVO Y RESPIRATORIO PORCINO Y USOS DEL MISMO. |
| UA124976C2 (uk) | 2016-12-14 | 2021-12-22 | Зоетіс Сервісіз Ллс | Вакцина для захисту тварини свині від зараження вірусом prrs |
| CN107586780B (zh) * | 2017-10-25 | 2019-10-11 | 中国农业科学院兰州兽医研究所 | 一种抑制猪繁殖与呼吸综合征病毒的长链非编码rna |
| CN109943590B (zh) * | 2019-04-18 | 2022-11-18 | 西南大学 | 一种复制缺陷型猪圆环病毒、其制备方法及应用 |
| CN111996174A (zh) * | 2020-02-06 | 2020-11-27 | 广西大学 | 猪繁殖与呼吸综合征病毒及其克隆载体和插入基因方法 |
| US20250332242A1 (en) | 2024-04-30 | 2025-10-30 | Zoetis Services Llc | Porcine endogenous retrovirus (perv)-free porcine circovirus type 2d-based vaccines and methods of use |
| US20250332243A1 (en) | 2024-04-30 | 2025-10-30 | Zoetis Services Llc | Methods of manufacturing porcine endogenous retrovirus (perv) free animal health vaccines |
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| US4452747A (en) | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
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| US4921706A (en) | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
| US4606940A (en) | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
| US5009956A (en) | 1987-02-24 | 1991-04-23 | Univ Minnesota | Phospholipase A2-resistant liposomes |
| IT8819772A0 (it) * | 1988-03-15 | 1988-03-15 | Honeywell Bull Spa | Dispositivo selettivo a terra per apparecchiature elettroniche. |
| US4927637A (en) | 1989-01-17 | 1990-05-22 | Liposome Technology, Inc. | Liposome extrusion method |
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