AR065723A1 - Composicion anestesica nanoparticulada para la administracion topica - Google Patents
Composicion anestesica nanoparticulada para la administracion topicaInfo
- Publication number
- AR065723A1 AR065723A1 ARP080101035A ARP080101035A AR065723A1 AR 065723 A1 AR065723 A1 AR 065723A1 AR P080101035 A ARP080101035 A AR P080101035A AR P080101035 A ARP080101035 A AR P080101035A AR 065723 A1 AR065723 A1 AR 065723A1
- Authority
- AR
- Argentina
- Prior art keywords
- poly
- anesthetic composition
- topical administration
- anesthetic
- amino
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 230000003444 anaesthetic effect Effects 0.000 title abstract 5
- 238000011200 topical administration Methods 0.000 title abstract 3
- -1 poly (alkyl methacrylate Chemical compound 0.000 abstract 8
- 239000003589 local anesthetic agent Substances 0.000 abstract 3
- 239000002105 nanoparticle Substances 0.000 abstract 3
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 210000004400 mucous membrane Anatomy 0.000 abstract 2
- VLPIATFUUWWMKC-SNVBAGLBSA-N (2r)-1-(2,6-dimethylphenoxy)propan-2-amine Chemical compound C[C@@H](N)COC1=C(C)C=CC=C1C VLPIATFUUWWMKC-SNVBAGLBSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 abstract 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 abstract 1
- LNETULKMXZVUST-UHFFFAOYSA-N 1-naphthoic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=CC2=C1 LNETULKMXZVUST-UHFFFAOYSA-N 0.000 abstract 1
- AFENDNXGAFYKQO-UHFFFAOYSA-N 2-hydroxybutyric acid Chemical class CCC(O)C(O)=O AFENDNXGAFYKQO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 229920002101 Chitin Polymers 0.000 abstract 1
- 229920001661 Chitosan Polymers 0.000 abstract 1
- 229920001651 Cyanoacrylate Polymers 0.000 abstract 1
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 abstract 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 1
- 229920002201 Oxidized cellulose Polymers 0.000 abstract 1
- 229920002732 Polyanhydride Polymers 0.000 abstract 1
- 150000001241 acetals Chemical class 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229960005274 benzocaine Drugs 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 229960003150 bupivacaine Drugs 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960002023 chloroprocaine Drugs 0.000 abstract 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical class C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 abstract 1
- 229960003976 etidocaine Drugs 0.000 abstract 1
- 229960004194 lidocaine Drugs 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 abstract 1
- 125000005395 methacrylic acid group Chemical group 0.000 abstract 1
- 229960003404 mexiletine Drugs 0.000 abstract 1
- 229940107304 oxidized cellulose Drugs 0.000 abstract 1
- 229920001308 poly(aminoacid) Polymers 0.000 abstract 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 abstract 1
- 229920002627 poly(phosphazenes) Polymers 0.000 abstract 1
- 229920001610 polycaprolactone Polymers 0.000 abstract 1
- 229920000728 polyester Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000004926 polymethyl methacrylate Substances 0.000 abstract 1
- 229920002635 polyurethane Polymers 0.000 abstract 1
- 229960001896 pramocaine Drugs 0.000 abstract 1
- DQKXQSGTHWVTAD-UHFFFAOYSA-N pramocaine Chemical compound C1=CC(OCCCC)=CC=C1OCCCN1CCOCC1 DQKXQSGTHWVTAD-UHFFFAOYSA-N 0.000 abstract 1
- 229960001807 prilocaine Drugs 0.000 abstract 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229960004919 procaine Drugs 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- 229960001549 ropivacaine Drugs 0.000 abstract 1
- 229920001897 terpolymer Polymers 0.000 abstract 1
- 229960002372 tetracaine Drugs 0.000 abstract 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 abstract 1
- 229950002569 trimecaine Drugs 0.000 abstract 1
- GOZBHBFUQHMKQB-UHFFFAOYSA-N trimecaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C GOZBHBFUQHMKQB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Uso de dichas nanopartículas poliméricas que comprenden por lo menos un agente anestésico local, en la preparacion de una composicion anestésica para la administracion topica sobre la piel o mucosas. Reivindicacion 1: Composicion anestésica para laadministracion topica sobre la piel o mucosas caracterizada porque comprende por lo menos un agente anestésico local en nanopartículas poliméricas en una cantidad terapéuticamente eficaz y por lo menos un agente que aumenta la viscosidad. Reivindicacion 2: La composicion anestésica, de acuerdo con la reivindicacion 1, caracterizada porque los polímeros utilizados en la produccion de las nanopartículas pueden ser seleccionados del grupo constituido por: poli (?-caprolactona);copolímeros del ácido metacrílico y de ésteres acrílicos o metacrílicos; poli (metacrilato de alquilo); poli (metacrilato de metilo), poli (láctico), poli (láctico-glicolico), poli (glicolico), poli (caprolactona), poli (amidas), poli (anhídridos),poli (aminoácidos), poli (ésteres), poli (cianoacrilatos), poli (fosfacenos), poli (fosfoésteres), poli (esteramidas), poli (dioxanonas), poli (acetales), poli (cetales), poli (carbonatos), poli (ortocarbonatos), poli (uretanos) degradables,quitinas, quitosana, poli (hidroxibutiratos), poli (hidroxivaleratos), poli (ácido málico), poli (alquilenooxalatos), poli (alquilenosuccinatos), poli (hidroxibutiratos-co-hidroxivaleratos), y copolímeros terpolímeros, celulosa oxidada, ocombinaciones o mezclas de estos materiales. Reivindicacion 3: La composicion anestésica, de acuerdo con la reivindicacion 1 o 2, caracterizada porque los agentes anestésicos locales se pueden seleccionar del grupo que consiste en: éster debenzoato o amino-éster, anilida amino-amida, naftoato amino-éster, ácido benzoico, pramoxina, diclonina, mexiletina, lidocaína, prilocaína, bupivacaína, mepivocaína, etidocaína, butanilcaína, trimecaína, tetracaína, benzocaína, ropivacaína,dibucaína, procaína, clorprocaína, butambeno, picrato, dibucaína, articaína e xilocaína, y sus sales, derivados o mezclas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0700832A BRPI0700832B8 (pt) | 2007-03-16 | 2007-03-16 | composição anestésica tópica compreendendo suspensão de nanocápsulas poliméricas de lidocaína e prilocaína |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065723A1 true AR065723A1 (es) | 2009-06-24 |
Family
ID=39765309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101035A AR065723A1 (es) | 2007-03-16 | 2008-03-13 | Composicion anestesica nanoparticulada para la administracion topica |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8568788B2 (es) |
| EP (1) | EP2134334B1 (es) |
| JP (1) | JP5496684B2 (es) |
| AR (1) | AR065723A1 (es) |
| BR (1) | BRPI0700832B8 (es) |
| CL (1) | CL2008000728A1 (es) |
| CO (1) | CO6220944A2 (es) |
| EC (1) | ECSP099691A (es) |
| ES (1) | ES2804466T3 (es) |
| HU (1) | HUE051155T2 (es) |
| MX (1) | MX2009009853A (es) |
| PE (2) | PE20081883A1 (es) |
| PL (1) | PL2134334T3 (es) |
| PT (1) | PT2134334T (es) |
| WO (1) | WO2008113144A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2400210T3 (es) | 2008-10-02 | 2013-04-08 | Mylan Inc. | Método para preparar un laminado de adhesivo multicapa |
| BR102012022036B1 (pt) * | 2012-08-31 | 2019-10-01 | Biolab Sanus Farmacêutica Ltda. | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
| BR102014028009B1 (pt) | 2014-11-10 | 2023-04-18 | Universidade Federal De Pelotas | Composições filmogênicas para bioadesivos anestésicos tópicos (bats) para liberação controlada de princípios ativos e bioadesivos anestésicos tópicos |
| WO2019028339A1 (en) | 2017-08-04 | 2019-02-07 | Eric Haas | MICROPARTICLES AND NANOPARTICLES OF ANESTHETIC AGENTS, AND METHODS OF MAKING AND USING THEM |
| CN113244167B (zh) * | 2021-05-20 | 2022-11-29 | 河北科技大学 | 一种盐酸利多卡因凝胶及其制备方法 |
| RU208882U1 (ru) * | 2021-08-25 | 2022-01-19 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" | Раневая атравматическая повязка для животных |
| CN119950421B (zh) * | 2025-04-11 | 2025-07-08 | 北华大学 | 一种含有三甲卡因的麻醉制剂及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7713618L (sv) * | 1977-12-01 | 1979-06-02 | Astra Laekemedel Ab | Lokalanestetisk blandning |
| FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
| DE4120760A1 (de) * | 1991-06-24 | 1993-03-04 | 3 M Medica Gmbh | Traegersysteme fuer arzneimittel |
| JPH09255565A (ja) * | 1996-03-26 | 1997-09-30 | Daikyo Yakuhin Kogyo Kk | 皮膚局所麻酔用ヒドロゲルパッチ |
| EP1009390A4 (en) * | 1997-07-02 | 2004-05-06 | Euro Celtique Sa | LONG-EFFECT ANESTHESIA INJECTED IN JOINT AND BODY SPACES |
| US5993836A (en) * | 1998-04-28 | 1999-11-30 | Castillo; James G. | Topical anesthetic formulation |
| KR100463167B1 (ko) * | 2001-04-13 | 2004-12-23 | 주식회사 태평양 | 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물 |
| US20070154527A1 (en) * | 2001-10-12 | 2007-07-05 | Monosoirx, Llc | Topical film compositions for delivery of actives |
| WO2006002365A2 (en) * | 2004-06-24 | 2006-01-05 | Angiotech International Ag | Microparticles with high loadings of a bioactive agent |
| US8940311B2 (en) * | 2004-10-21 | 2015-01-27 | Tae-Hong Lim | In situ controlled release drug delivery system |
| WO2006091719A2 (en) * | 2005-02-23 | 2006-08-31 | Sontra Medical Corporation | Compositions and methods enhancing transdermal delivery of drugs and biologics |
-
2007
- 2007-03-16 BR BRPI0700832A patent/BRPI0700832B8/pt active IP Right Grant
-
2008
- 2008-03-12 EP EP08714517.3A patent/EP2134334B1/en active Active
- 2008-03-12 HU HUE08714517A patent/HUE051155T2/hu unknown
- 2008-03-12 CL CL200800728A patent/CL2008000728A1/es unknown
- 2008-03-12 ES ES08714517T patent/ES2804466T3/es active Active
- 2008-03-12 PT PT87145173T patent/PT2134334T/pt unknown
- 2008-03-12 PL PL08714517T patent/PL2134334T3/pl unknown
- 2008-03-12 US US12/531,404 patent/US8568788B2/en active Active
- 2008-03-12 WO PCT/BR2008/000070 patent/WO2008113144A1/en not_active Ceased
- 2008-03-12 MX MX2009009853A patent/MX2009009853A/es active IP Right Grant
- 2008-03-12 JP JP2009553872A patent/JP5496684B2/ja active Active
- 2008-03-13 AR ARP080101035A patent/AR065723A1/es not_active Application Discontinuation
- 2008-03-13 PE PE2008000474A patent/PE20081883A1/es not_active Application Discontinuation
- 2008-03-13 PE PE2013000512A patent/PE20131337A1/es active IP Right Grant
-
2009
- 2009-10-14 EC EC2009009691A patent/ECSP099691A/es unknown
- 2009-10-14 CO CO09114245A patent/CO6220944A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009009853A (es) | 2010-02-18 |
| CO6220944A2 (es) | 2010-11-19 |
| PL2134334T3 (pl) | 2021-03-08 |
| EP2134334A1 (en) | 2009-12-23 |
| WO2008113144A1 (en) | 2008-09-25 |
| BRPI0700832A (pt) | 2008-11-04 |
| PE20131337A1 (es) | 2013-11-18 |
| EP2134334A4 (en) | 2013-04-24 |
| HUE051155T2 (hu) | 2021-03-01 |
| BRPI0700832B1 (pt) | 2017-12-26 |
| EP2134334B1 (en) | 2020-05-13 |
| BRPI0700832B8 (pt) | 2021-05-25 |
| ES2804466T3 (es) | 2021-02-08 |
| US8568788B2 (en) | 2013-10-29 |
| JP2010521498A (ja) | 2010-06-24 |
| JP5496684B2 (ja) | 2014-05-21 |
| ECSP099691A (es) | 2010-02-26 |
| PT2134334T (pt) | 2020-08-20 |
| US20100086614A1 (en) | 2010-04-08 |
| CL2008000728A1 (es) | 2008-09-26 |
| PE20081883A1 (es) | 2008-12-27 |
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