AR068695A2 - Uso de un compuesto de tiazol que comprende un derivado de tiazol para la fabricacion de un medicamento para la prevencion y el tratamiento de en-fermedades causadas por la produccion anormal de citocinas y/o la acele-racion de la adhesion de neutrofilos y/o la produccion anormal de tnf- alfa - Google Patents

Uso de un compuesto de tiazol que comprende un derivado de tiazol para la fabricacion de un medicamento para la prevencion y el tratamiento de en-fermedades causadas por la produccion anormal de citocinas y/o la acele-racion de la adhesion de neutrofilos y/o la produccion anormal de tnf- alfa

Info

Publication number
AR068695A2
AR068695A2 ARP060105088A ARP060105088A AR068695A2 AR 068695 A2 AR068695 A2 AR 068695A2 AR P060105088 A ARP060105088 A AR P060105088A AR P060105088 A ARP060105088 A AR P060105088A AR 068695 A2 AR068695 A2 AR 068695A2
Authority
AR
Argentina
Prior art keywords
group
tiazol
alkoxy
production
prevention
Prior art date
Application number
ARP060105088A
Other languages
English (en)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR068695A2 publication Critical patent/AR068695A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Uso de un compuesto de tiazol, para la produccion de un medicamento para la prevencion y el tratamiento de enfermedades causadas por la produccion anormal de citocinas, en donde al menos un ingrediente activo es seleccionado del grupo integrado por derivados de tiazol representados por la formula general (1) {en la cual R1 es un grupo fenilo que puede tener uno o más grupos alcoxilo C1-6 como sustituyentes en el anillo fenilo; y R2 es un grupo representado por la formula general (2) [en la cual los grupos R3, que pueden ser iguales o diferentes, son un grupo carboxilo, un grupo alcoxi C1-6, un grupo alquilo C1-6, un grupo alquenilo C2-6, un grupo representado por la formula (A)L-NR4R5 (en la cual (A) es un grupo alquileno C1-6; R4 y R5, que pueden ser iguales o diferentes, son un átomo de hidrogeno o un grupo alquilo C1-6 y L es 0 o 1), un grupo alquilo C1-6 sustituido por un grupo hidroxilo, un grupo alcoxilo C1-6 sustituido por un grupo alcoxilo C1-6, un grupo alcoxicarbonilo C1-6 sustituido por un grupo alcoxilo C1-6, o un grupo alcoxilo C1-6 sustituido por un grupo carboxilo; y m es un entero que oscila entre 1 y 3] o un residuo de anillo heterocíclico que posee 1-2 heteroátomos seleccionados del grupo integrado por átomos de nitrogeno, de oxígeno y de azufre, y como substituyentes de 1 a 3 grupos seleccionados entre los grupos carboxilo y alcoxilo C1-6} y sales de los mismos.
ARP060105088A 1996-09-30 2006-11-21 Uso de un compuesto de tiazol que comprende un derivado de tiazol para la fabricacion de un medicamento para la prevencion y el tratamiento de en-fermedades causadas por la produccion anormal de citocinas y/o la acele-racion de la adhesion de neutrofilos y/o la produccion anormal de tnf- alfa AR068695A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25853396 1996-09-30

Publications (1)

Publication Number Publication Date
AR068695A2 true AR068695A2 (es) 2009-12-02

Family

ID=17321550

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP970104495A AR009376A1 (es) 1996-09-30 1997-09-30 COMPOSICION FARMACEUTICA QUE COMPRENDE UN DERIVADO DE TIAZOL PARA LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR LA PRODUCCIoN ANORMAL DE CITOCINAS Y/O LA ACELERACION DE LA ADHESION DE NEUTROFILOS Y/O LA PRODUCCION ANORMAL DE TNF-ALFA, Y USO DE DICHOS DERIVADOS DE TIAZOL PAA LA PREPARAC
ARP060105088A AR068695A2 (es) 1996-09-30 2006-11-21 Uso de un compuesto de tiazol que comprende un derivado de tiazol para la fabricacion de un medicamento para la prevencion y el tratamiento de en-fermedades causadas por la produccion anormal de citocinas y/o la acele-racion de la adhesion de neutrofilos y/o la produccion anormal de tnf- alfa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP970104495A AR009376A1 (es) 1996-09-30 1997-09-30 COMPOSICION FARMACEUTICA QUE COMPRENDE UN DERIVADO DE TIAZOL PARA LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR LA PRODUCCIoN ANORMAL DE CITOCINAS Y/O LA ACELERACION DE LA ADHESION DE NEUTROFILOS Y/O LA PRODUCCION ANORMAL DE TNF-ALFA, Y USO DE DICHOS DERIVADOS DE TIAZOL PAA LA PREPARAC

Country Status (17)

Country Link
US (5) US6291487B1 (es)
EP (1) EP0957915B1 (es)
KR (2) KR100503704B1 (es)
CN (2) CN1190193C (es)
AR (2) AR009376A1 (es)
AT (1) ATE288267T1 (es)
AU (1) AU714349B2 (es)
BR (1) BR9712140A (es)
CA (1) CA2265746C (es)
DE (1) DE69732428T2 (es)
EG (1) EG24160A (es)
ES (1) ES2237803T3 (es)
ID (1) ID21933A (es)
MY (1) MY128323A (es)
PT (1) PT957915E (es)
TW (1) TW529950B (es)
WO (1) WO1998014191A1 (es)

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US6583163B2 (en) 2003-06-24
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PT957915E (pt) 2005-04-29
HK1064038A1 (en) 2005-01-21
ID21933A (id) 1999-08-12
AU714349B2 (en) 1999-12-23
CN1232396A (zh) 1999-10-20
CN1494904A (zh) 2004-05-12
MY128323A (en) 2007-01-31
KR100503704B1 (ko) 2005-07-25
CA2265746A1 (en) 1998-04-09
DE69732428T2 (de) 2005-12-29
EP0957915B1 (en) 2005-02-02
CN1190193C (zh) 2005-02-23
US20070105911A1 (en) 2007-05-10
ATE288267T1 (de) 2005-02-15
AU4322197A (en) 1998-04-24
US8354439B2 (en) 2013-01-15
US20020013469A1 (en) 2002-01-31
DE69732428D1 (de) 2005-03-10
BR9712140A (pt) 1999-08-31
WO1998014191A1 (en) 1998-04-09
EG24160A (en) 2008-08-20
CA2265746C (en) 2004-04-20
KR20050042829A (ko) 2005-05-11
TW529950B (en) 2003-05-01
CN1236769C (zh) 2006-01-18
KR20000048603A (ko) 2000-07-25
HK1022419A1 (en) 2000-08-11
US6291487B1 (en) 2001-09-18
ES2237803T3 (es) 2005-08-01
US20040014792A1 (en) 2004-01-22
AR009376A1 (es) 2000-04-12

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