AR071262A2 - Peptidos derivados de una proteina de vih-1gagp24, composiciones de vacunas kit de inmunoensayo y un metodo para detectar anticuerpos inducidos por vih - Google Patents

Peptidos derivados de una proteina de vih-1gagp24, composiciones de vacunas kit de inmunoensayo y un metodo para detectar anticuerpos inducidos por vih

Info

Publication number
AR071262A2
AR071262A2 ARP080105262A ARP080105262A AR071262A2 AR 071262 A2 AR071262 A2 AR 071262A2 AR P080105262 A ARP080105262 A AR P080105262A AR P080105262 A ARP080105262 A AR P080105262A AR 071262 A2 AR071262 A2 AR 071262A2
Authority
AR
Argentina
Prior art keywords
xaa
ala
gly
leu
thr
Prior art date
Application number
ARP080105262A
Other languages
English (en)
Inventor
B Sorensen
Original Assignee
Bionor Immuno As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionor Immuno As filed Critical Bionor Immuno As
Publication of AR071262A2 publication Critical patent/AR071262A2/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16211Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

Péptido derivado de una proteína de VIH-1 gagp24, que comprende una secuencia de aminoácidos seleccionada de: (1) Xaa1 Ala Xaa3 Xaa4 Xaa5 Ala Xaa7 Xaa8 Xaa9 Leu Leu Xaa12 Xaa13 Xaa14 -Z- Xaa15 Xaa16 His GIn Xaa19 Ala Xaa21 Xaa22 (SEC ID N°: 9) donde Xaa en posicion 1 es Tyr, Trp, Phe o Gly, Xaa en posicion 3 es Thr, Ala, Val, Ile o Leu, Xaa en posicion 4 es Pro o Ser, Xaa en posicion 5 es GIn, His, Gly, Thr, Ser o Tyr, Xaa en posicion 7 es Leu, Ile o Val, Xaa en posicion 8 es Asn o Tyr, Xaa en posicion 9 es Thr, Met, Leu o Ala, Xaa en posicion 12 es Ser, Thr o Asn, Xaa en posicion 13 es Thr, Ile, Val o Ala, Xaa en posicion 14 es Val o Ile, Xaa en posicion 15 es Gly o ninguno, Xaa en posicion 16 es Gly o ninguno, Xaa en posicion 19 es Ala o Gly, Xaa en posicion 20 es Ala, Xaa en posicion 21 es Met, Leu, Cys o ninguno, Xaa en posicion 22 es Gln, Glu, His, Gly o ninguno donde el enlace -Z- es opcional y tiene el significado PEG, PEG modificado y/o [Gly]n, donde n = 1, 2 o 3, (ii) Xaa1 Xaa2 Xaa3 Xaa4 Xaa5 Xaa6 Xaa7 Gly Xaa9 Leu Val -Z- Tyr Xaa13 Xaa14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Ala Xaa23 Xaa24 Xaa25 Xaa26 (SEQ ID N°: 4) donde los aminoácidos de la cadena tienen los siguientes significados: Xaa en posicion 1 es Pro, Tyr o Phe, Xaa en posicion 2 es Ile, Val o Leu, Xaa en posicion 3 es Ile, Ala, Val, Met o Leu, Xaa en posicion 4 es GIn, Ser, Thr o Val, Xaa en posicion 5 es Asn, Asp o Thr, Xaa en posicion 6 es Ile, Ala, Leu o Met, Xaa en posicion 7 es GIn, Glu, Lys o Gly, Xaa en posicion 9 es Gln o Ile, Xaa en posicion 13 se omite, Xaa en posicion 14 es Ala, Ser, Asn, Val o Pro, Xaa en posicion 15 es Ile, Leu, Met o Val, Xaa en posicion 16 es Ser o Thr, Xaa en posicion 17 es Pro o Ala, Xaa en posicion 18 es Arg o Lys, Xaa en posicion 19 es Thr o Ser, Xaa en posicion 20 es Leu o Ser, Xaa en posicion 21 es Asn, Phe o Val, Xaa en posicion 23 es Trp, Tyr, Gly o ninguno, Xaa en posicion 24 es Val, Leu, Gly o ninguno, Xaa en posicion 25 es Lys, Arg, Gly o ninguno, Xaa en posicion 26 es Val, Ala, Cys, Gly o ninguno donde -Z- es un enlace opcional y tiene el significado PEG, PEG modificado y/o [Gly]n donde n = 1, 2 o 3, (iii) Xaa1 Xaa2 Ala Leu Ala Gly Xaa7 Xaa8 Xaa9 Leu Xaa11 Xaa12 Xaa13 Xaa14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 (SEQ ID N°: 15) donde Xaa en posicion 1 es Trp o Tyr, Xaa en posicion 2 es Ser o Ala, Xaa en posicion 7 es Thr, Ala o Ser, Xaa en posicion 8 es Ser o Thr, Xaa en posicion 9 es Ser o Thr, Xaa en posicion 11 es Leu, Pro, Val o Gln, Xaa en posicion 12 es Gln, Ala o His, Xaa en posicion 13 es Glu o Gly, Xaa en posicion 14 es Gln o His, Xaa en posicion 15 es Ile, Leu, Val o Met, Xaa en posicion 16 es Gly, Ala, GIn, Thr, Asn, Arg, His o Ile, Xaa en posicion 17 es Trp o Tyr, Xaa en posicion 18 es Thr, Met, Leu o Ile, Xaa en posicion 19 es Thr o Ser, Xaa en posicion 20 es Cys, Gly o ninguno, Xaa en posicion 21 es Gly o ninguno y donde los extremos terminales de las secuencias pueden ser grupos carboxilo o amino libres, amidas, acilos, acetilos o sales de los mismos, dos o más de los residuos Cys pueden formar parte de un enlace de disulfuro intercadena, un puente -S-(CH2)p-S- o un puente -(CH2)p donde p = 1-8 opcionalmente intervenido por uno o más heteroátomos como O, N y S y/o dichas secuencias peptídicas están inmovilizadas a un soporte solido. Composiciones de vacunas, kit de inmunoensayo y un método para detectar anticuerpos inducidos por VIH.
ARP080105262A 2000-09-04 2008-12-03 Peptidos derivados de una proteina de vih-1gagp24, composiciones de vacunas kit de inmunoensayo y un metodo para detectar anticuerpos inducidos por vih AR071262A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO20004413A NO314588B1 (no) 2000-09-04 2000-09-04 HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV

Publications (1)

Publication Number Publication Date
AR071262A2 true AR071262A2 (es) 2010-06-09

Family

ID=19911533

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ARP010104196A AR033998A1 (es) 2000-09-04 2001-09-04 Peptidos de vih, antigenos, composiciones de vacunas, kit de inmunoensayo y un metodo para detectar anticuerpos inducidos por vih
ARP080105262A AR071262A2 (es) 2000-09-04 2008-12-03 Peptidos derivados de una proteina de vih-1gagp24, composiciones de vacunas kit de inmunoensayo y un metodo para detectar anticuerpos inducidos por vih

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Application Number Title Priority Date Filing Date
ARP010104196A AR033998A1 (es) 2000-09-04 2001-09-04 Peptidos de vih, antigenos, composiciones de vacunas, kit de inmunoensayo y un metodo para detectar anticuerpos inducidos por vih

Country Status (19)

Country Link
US (2) US7009037B2 (es)
EP (2) EP1878742A3 (es)
JP (2) JP2004508381A (es)
CN (2) CN101104636A (es)
AR (2) AR033998A1 (es)
AT (1) ATE406380T1 (es)
AU (3) AU2001282706B2 (es)
BR (1) BR0114036A (es)
CA (1) CA2421193A1 (es)
DE (1) DE60135564D1 (es)
EA (1) EA006308B1 (es)
ES (1) ES2312465T3 (es)
HU (1) HUP0303134A3 (es)
MY (1) MY136081A (es)
NO (1) NO314588B1 (es)
NZ (2) NZ524556A (es)
SK (1) SK287917B6 (es)
WO (1) WO2002020554A2 (es)
ZA (1) ZA200301740B (es)

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EP3468617A4 (en) 2016-06-08 2020-01-22 American Gene Technologies International Inc. SYSTEM FOR THE NON-INTEGRAL VIRAL ISSUE AND PROCEDURE RELATING TO IT
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Also Published As

Publication number Publication date
HK1059940A1 (en) 2004-07-23
EP1878742A2 (en) 2008-01-16
NZ524556A (en) 2005-01-28
HUP0303134A2 (hu) 2005-03-29
ZA200301740B (en) 2004-06-21
NO20004413D0 (no) 2000-09-04
EA200300336A1 (ru) 2003-08-28
NO20004413L (no) 2002-03-05
CN101104636A (zh) 2008-01-16
AU2001282706B2 (en) 2007-03-22
NO314588B1 (no) 2003-04-14
EP1878742A3 (en) 2008-04-30
AU8270601A (en) 2002-03-22
AU2007202739A1 (en) 2007-07-05
CN1460111A (zh) 2003-12-03
AU2007202739B2 (en) 2009-12-03
ES2312465T3 (es) 2009-03-01
AR033998A1 (es) 2004-01-21
EP1322665A2 (en) 2003-07-02
WO2002020554A3 (en) 2002-06-13
JP2004508381A (ja) 2004-03-18
DE60135564D1 (de) 2008-10-09
US20040115615A1 (en) 2004-06-17
SK4022003A3 (en) 2003-09-11
US7612168B2 (en) 2009-11-03
EP1322665B1 (en) 2008-08-27
JP2011219481A (ja) 2011-11-04
CA2421193A1 (en) 2002-03-14
WO2002020554A2 (en) 2002-03-14
MY136081A (en) 2008-08-29
ATE406380T1 (de) 2008-09-15
NZ535148A (en) 2007-06-29
US7009037B2 (en) 2006-03-07
BR0114036A (pt) 2003-07-22
US20070237783A1 (en) 2007-10-11
CN1282656C (zh) 2006-11-01
SK287917B6 (sk) 2012-03-02
HUP0303134A3 (en) 2012-09-28
EA006308B1 (ru) 2005-10-27

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