ES2297902T5 - Compuestos novedosos agonistas de exendina - Google Patents

Compuestos novedosos agonistas de exendina Download PDF

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Publication number
ES2297902T5
ES2297902T5 ES98958573T ES98958573T ES2297902T5 ES 2297902 T5 ES2297902 T5 ES 2297902T5 ES 98958573 T ES98958573 T ES 98958573T ES 98958573 T ES98958573 T ES 98958573T ES 2297902 T5 ES2297902 T5 ES 2297902T5
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ES
Spain
Prior art keywords
ala
gly
ser
xaa31
val
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Expired - Lifetime
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ES98958573T
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ES2297902T3 (es
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Nigel Robert Arnold Beeley
Kathryn S. Prickett
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Amylin Pharmaceuticals LLC
AstraZeneca Pharmaceuticals LP
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Amylin Pharmaceuticals LLC
AstraZeneca Pharmaceuticals LP
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22066811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2297902(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amylin Pharmaceuticals LLC, AstraZeneca Pharmaceuticals LP filed Critical Amylin Pharmaceuticals LLC
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Publication of ES2297902T3 publication Critical patent/ES2297902T3/es
Publication of ES2297902T5 publication Critical patent/ES2297902T5/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuesto peptídico de fórmula [I] [SEQ. ID. NO. 4] en el que dicho compuesto peptídico muestra actividad agonista de exendina: Xaa1 Xaa2 Xaa3 Xaa4 Xaa5 Xaa6 Xaa7 Xaa8 Xaa9 Xaa10 Xaa11 Xaa12 Xaa13 Xaa14 Xaa15 Xaa16 Xaa17 Ala Xaa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Xaa25 Xaa26 Xaa27 Xaa28-Z1; en el que Xaa1 es His, Arg, Tyr, Ala, Norval, Val o Norleu; Xaa2 es Ser, Gly, Ala o Thr; Xaa3 es Ala, Asp o Glu; Xaa4 es Ala, Norval, Val, Norleu o Gly; Xaa5 es Ala o Thr; Xaa6 es Phe, Tyr o naftilalanina; Xaa7 es Thr o Ser; Xaa8 es Ala, Ser o Thr; Xaa9 es Ala, Norval, Val, Norleu, Asp o Glu; Xaa10 es Ala, Leu, Ile, Val, pentilglicina o Met; Xaa11 es Ala o Ser; Xaa12 es Ala o Lys; Xaa13 es Ala o Gln; Xaa14 es Ala, Leu, Ile, pentilglicina, Val o Met; Xaa15 es Ala o Glu; Xaa16 es Ala o Glu; Xaa17 es Ala o Glu; Xaa19 es Ala o Val; Xaa20 es Ala o Arg; Xaa21 es Ala o Leu; Xaa22 es Phe, Tyr o naftilalanina; Xaa23 es Ile, Val, Leu, pentilglicina, terc-butilglicina o Met; Xaa24 es Ala, Glu o Asp; Xaa25 es Ala, Trp,Phe, Tyr o naftilalanina; Xaa26 es Ala o Leu; Xaa27 es Ala o Lys; Xaa28 es Ala o Asn; y Z1 es Gly Gly-Z2 Gly Gly Xaa31-Z2, Gly Gly Xaa31 Ser-Z2, Gly Gly Xaa31 Ser Ser-Z2, Gly Gly Xaa31 Ser Ser Gly-Z2, Gly Gly Xaa31 Ser Ser Gly Ala-Z2, Gly Gly Xaa31 Ser Ser Gly Ala Xaa36-Z2, Gly Gly Xaa31 Ser Ser Gly Ala Xaa36 Xaa37-Z2, Gly Gly Xaa31 Ser Ser Gly Ala Xaa36 Xaa37 Xaa38-Z2 o Gly Gly Xaa31 Ser Ser Gly Ala Xaa36 Xaa37 Xaa38 Xaa39-Z2; en el que Xaa31, Xaa36, Xaa37 y Xaa38 se seleccionan independientemente del grupo que consiste en Pro, homoprolina, 3Hyp, 4Hyp, tioprolina, N-alquilglicina, N-alquilpentilglicina y N-alquilalanina; Xaa39 es Ser o Tyr; y Z2 es -OH o -NH2; siempre que no más de tres de Xaa3, Xaa4, Xaa5, Xaa6, Xaa8, Xaa9, Xaa10, Xaa11, Xaa12, Xaa13, Xaa14, Xaa15, Xaa16, Xaa17, Xaa19, Xaa20, Xaa21, Xaa24, Xaa25, Xaa26, Xaa27 y Xaa28 sean Ala; y también siempre que, si Xaa1 es His, Arg o Tyr, entonces al menos uno de Xaa3, Xaa4 y Xaa9 sea Ala; y sales farmacéuticamente aceptables del mismo; y en el que Xaa1, Xaa3 o Xaa9 es Ala.
ES98958573T 1997-11-14 1998-11-13 Compuestos novedosos agonistas de exendina Expired - Lifetime ES2297902T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6602997P 1997-11-14 1997-11-14
US66029P 1997-11-14
PCT/US1998/024273 WO1999025728A1 (en) 1997-11-14 1998-11-13 Novel exendin agonist compounds

Publications (2)

Publication Number Publication Date
ES2297902T3 ES2297902T3 (es) 2008-05-01
ES2297902T5 true ES2297902T5 (es) 2013-07-09

Family

ID=22066811

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98958573T Expired - Lifetime ES2297902T5 (es) 1997-11-14 1998-11-13 Compuestos novedosos agonistas de exendina

Country Status (13)

Country Link
EP (1) EP1032587B2 (es)
JP (1) JP2001523688A (es)
AT (1) ATE383867T1 (es)
AU (1) AU756836B2 (es)
BR (1) BR9814189A (es)
CA (1) CA2309356C (es)
CY (1) CY1107883T1 (es)
DE (1) DE69839021T3 (es)
DK (1) DK1032587T4 (es)
ES (1) ES2297902T5 (es)
NZ (1) NZ504256A (es)
PT (1) PT1032587E (es)
WO (1) WO1999025728A1 (es)

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* Cited by examiner, † Cited by third party
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