AR074072A1 - Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme - Google Patents

Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme

Info

Publication number: AR074072A1
Authority: AR; Argentina
Prior art keywords: imidazol; piperidin; prepare; attached; pharmaceutical composition
Prior art date: 2008-11-11

Application number

ARP090104158A

Other languages

English (en)

Spanish (es)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-11

Filing date

2009-10-28

Publication date

2010-12-22

2009-10-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2010-12-22 Publication of AR074072A1 publication Critical patent/AR074072A1/es

Links

208000005017 glioblastoma Diseases 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
WOGOXEPEEXSPAF-UHFFFAOYSA-N 1h-imidazole;piperidine Chemical compound C1=CNC=N1.C1CCNCC1 WOGOXEPEEXSPAF-UHFFFAOYSA-N 0.000 title 1
239000002131 composite material Substances 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
-1 imidazole-piperidine-pyrrole pyrimidin-6-one compound Chemical class 0.000 abstract 5
229910052757 nitrogen Inorganic materials 0.000 abstract 3
125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 abstract 1
201000010915 Glioblastoma multiforme Diseases 0.000 abstract 1
101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
125000002393 azetidinyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
229940043355 kinase inhibitor Drugs 0.000 abstract 1
239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
DDWJFSYHYPDQEL-UHFFFAOYSA-N pyrimidine;1h-pyrrole Chemical compound C=1C=CNC=1.C1=CN=CN=C1 DDWJFSYHYPDQEL-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Child & Adolescent Psychology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ARP090104158A 2008-11-11 2009-10-28 Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme AR074072A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11327308P	2008-11-11	2008-11-11

Publications (1)

Publication Number	Publication Date
AR074072A1 true AR074072A1 (es)	2010-12-22

Family

ID=41402451

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ARP090104158A AR074072A1 (es)	2008-11-11	2009-10-28	Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme

Country Status (36)

Country	Link
US (1)	US8148387B2 (2)
EP (1)	EP2358710B1 (2)
JP (1)	JP5432275B2 (2)
KR (1)	KR101334460B1 (2)
CN (1)	CN102216302B (2)
AR (1)	AR074072A1 (2)
AU (1)	AU2009314324B2 (2)
BR (1)	BRPI0921916A2 (2)
CA (1)	CA2743019C (2)
CO (1)	CO6382114A2 (2)
CR (1)	CR20110240A (2)
CY (1)	CY1113409T1 (2)
DK (1)	DK2358710T3 (2)
DO (1)	DOP2011000129A (2)
EA (1)	EA018947B1 (2)
EC (1)	ECSP11011048A (2)
ES (1)	ES2391704T3 (2)
HN (1)	HN2011001247A (2)
HR (1)	HRP20120738T1 (2)
IL (1)	IL211940A (2)
JO (1)	JO2822B1 (2)
MA (1)	MA32776B1 (2)
MX (1)	MX2011005000A (2)
MY (1)	MY161461A (2)
NZ (1)	NZ592062A (2)
PA (1)	PA8846901A1 (2)
PE (1)	PE20110807A1 (2)
PL (1)	PL2358710T3 (2)
PT (1)	PT2358710E (2)
RS (1)	RS52520B (2)
SI (1)	SI2358710T1 (2)
TN (1)	TN2011000207A1 (2)
TW (1)	TWI422587B (2)
UA (1)	UA100190C2 (2)
WO (1)	WO2010056563A1 (2)
ZA (1)	ZA201102549B (2)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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SG10201402867TA (en)	2009-07-02	2014-08-28	Sanofi Sa	Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
EA020151B1 (ru) *	2009-10-23	2014-09-30	Эли Лилли Энд Компани	Ингибиторы akt и фармацевтические составы, их содержащие
HUE026323T2 (en)	2011-04-07	2016-05-30	Bayer Ip Gmbh	Imidazopyridazines as akt kinase inhibitors
ES2547687T3 (es) *	2011-07-09	2015-10-08	Xuanzhu Pharma Co., Ltd.	Forma cristalina I de sal de un inhibidor de dipeptidil-peptidasa IV y procedimiento de preparación y uso de la misma
PT2755965T (pt)	2011-09-12	2017-11-02	Merck Patent Gmbh	Novas imidazol aminas como moduladores da atividade quinase
US9321760B2 (en)	2011-09-12	2016-04-26	Merck Patent Gmbh	Aminopyrimidine derivatives for use as modulators of kinase activity
EP2920154B1 (en)	2012-11-16	2017-10-11	Merck Patent GmbH	Novel imidazol-piperidinyl derivatives as modulators of kinase activity
US9580443B2 (en)	2012-11-16	2017-02-28	Merck Patent Gmbh	Heterocyclic derivatives as modulators of kinase activity
AR095202A1 (es) *	2013-03-11	2015-09-30	Merck Patent Gmbh	Heterociclos como moduladores de la actividad quinasa
MX2016010268A (es) *	2014-02-11	2016-10-13	Merck Patent Gmbh	Pirimidinimidazolaminas como modulares de actividad de cinasa.
TW201718574A (zh)	2015-08-12	2017-06-01	美國禮來大藥廠	Ｃｇｒｐ受體拮抗劑
PT3459953T (pt)	2016-05-20	2021-07-29	Taiho Pharmaceutical Co Ltd	Novo derivado de 5h-pirrolo[2,3-d]pirimidin-6(7h)-ona
CN115397815B (zh) *	2020-03-17	2024-06-14	江苏恒瑞医药股份有限公司	稠合二环类衍生物、其制备方法及其在医药上的应用
CN113444110B (zh) *	2020-03-25	2023-05-12	江苏恒瑞医药股份有限公司	四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用
JP2024535857A (ja)	2021-09-17	2024-10-02	江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司	縮合二環系誘導体の薬学的に許容される塩、結晶及びそれらの調製方法
WO2024009977A1 (ja) *	2022-07-05	2024-01-11	大鵬薬品工業株式会社	５Ｈ－ピロロ［２，３－ｄ］ピリミジン－６（７Ｈ）－オン及びその塩体の結晶

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WO2005117909A2 (en)	2004-04-23	2005-12-15	Exelixis, Inc.	Kinase modulators and methods of use
MY179032A (en)	2004-10-25	2020-10-26	Cancer Research Tech Ltd	Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
JP5274842B2 (ja)	2004-12-28	2013-08-28	エグゼリクシス，インコーポレイテッド	免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
WO2006091450A1 (en) *	2005-02-18	2006-08-31	Lexicon Genetics Incorporated	4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
US20090325924A1 (en)	2005-06-30	2009-12-31	Stuart Edward	GPCR Agonists
EP2037931A2 (en)	2006-04-25	2009-03-25	Astex Therapeutics Limited	Pharmaceutical combinations of pk inhibitors and other active agents
DK3421471T3 (da)	2006-04-25	2021-06-14	Astex Therapeutics Ltd	Purin- og deazapurinderivater som farmaceutiske forbindelser
WO2008012635A2 (en)	2006-07-26	2008-01-31	Pfizer Products Inc.	Amine derivatives useful as anticancer agents
AR064416A1 (es) *	2006-12-21	2009-04-01	Cancer Rec Tech Ltd	Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
UA99284C2 (ru)	2007-05-11	2012-08-10	Елі Ліллі Енд Компані	ИНГИБИТОРЫ р70 S6-КИНАЗЫ

2009
- 2009-10-28 AR ARP090104158A patent/AR074072A1/es unknown
- 2009-10-29 PA PA20098846901A patent/PA8846901A1/es unknown
- 2009-10-29 TW TW098136731A patent/TWI422587B/zh not_active IP Right Cessation
- 2009-10-29 JO JO2009400A patent/JO2822B1/en active
- 2009-11-03 CN CN2009801449532A patent/CN102216302B/zh active Active
- 2009-11-03 US US12/611,139 patent/US8148387B2/en active Active
- 2009-11-03 PE PE2011001018A patent/PE20110807A1/es not_active Application Discontinuation
- 2009-11-03 DK DK09744896.3T patent/DK2358710T3/da active
- 2009-11-03 NZ NZ592062A patent/NZ592062A/xx not_active IP Right Cessation
- 2009-11-03 HR HRP20120738AT patent/HRP20120738T1/hr unknown
- 2009-11-03 BR BRPI0921916A patent/BRPI0921916A2/pt not_active IP Right Cessation
- 2009-11-03 PL PL09744896T patent/PL2358710T3/pl unknown
- 2009-11-03 ES ES09744896T patent/ES2391704T3/es active Active
- 2009-11-03 JP JP2011536383A patent/JP5432275B2/ja active Active
- 2009-11-03 EP EP09744896A patent/EP2358710B1/en active Active
- 2009-11-03 RS RS20120443A patent/RS52520B/sr unknown
- 2009-11-03 PT PT09744896T patent/PT2358710E/pt unknown
- 2009-11-03 MY MYPI2011002030A patent/MY161461A/en unknown
- 2009-11-03 SI SI200930348T patent/SI2358710T1/sl unknown
- 2009-11-03 AU AU2009314324A patent/AU2009314324B2/en not_active Ceased
- 2009-11-03 CA CA2743019A patent/CA2743019C/en not_active Expired - Fee Related
- 2009-11-03 UA UAA201105367A patent/UA100190C2/ru unknown
- 2009-11-03 EA EA201170680A patent/EA018947B1/ru not_active IP Right Cessation
- 2009-11-03 WO PCT/US2009/063020 patent/WO2010056563A1/en not_active Ceased
- 2009-11-03 MX MX2011005000A patent/MX2011005000A/es active IP Right Grant
- 2009-11-03 KR KR1020117010569A patent/KR101334460B1/ko not_active Expired - Fee Related
2011
- 2011-03-24 IL IL211940A patent/IL211940A/en not_active IP Right Cessation
- 2011-04-06 ZA ZA2011/02549A patent/ZA201102549B/en unknown
- 2011-04-25 TN TN2011000207A patent/TN2011000207A1/fr unknown
- 2011-05-03 HN HN2011001247A patent/HN2011001247A/es unknown
- 2011-05-06 CR CR20110240A patent/CR20110240A/es unknown
- 2011-05-09 DO DO2011000129A patent/DOP2011000129A/es unknown
- 2011-05-09 MA MA33822A patent/MA32776B1/fr unknown
- 2011-05-11 EC EC2011011048A patent/ECSP11011048A/es unknown
- 2011-05-12 CO CO11058555A patent/CO6382114A2/es active IP Right Grant
2012
- 2012-10-05 CY CY20121100928T patent/CY1113409T1/el unknown

Also Published As

Publication number	Publication date
ECSP11011048A (es)	2011-06-30
WO2010056563A1 (en)	2010-05-20
US20100120801A1 (en)	2010-05-13
MY161461A (en)	2017-04-14
IL211940A0 (en)	2011-06-30
CY1113409T1 (el)	2016-06-22
EA201170680A1 (ru)	2011-12-30
SI2358710T1 (sl)	2012-11-30
JP2012508274A (ja)	2012-04-05
RS52520B (sr)	2013-04-30
DK2358710T3 (da)	2012-09-03
HN2011001247A (es)	2013-05-20
MA32776B1 (fr)	2011-11-01
DOP2011000129A (es)	2016-02-29
KR101334460B1 (ko)	2013-12-02
IL211940A (en)	2014-01-30
BRPI0921916A2 (pt)	2015-12-29
NZ592062A (en)	2013-03-28
TN2011000207A1 (en)	2012-12-17
PT2358710E (pt)	2012-10-01
CO6382114A2 (es)	2012-02-15
EP2358710B1 (en)	2012-08-15
AU2009314324A1 (en)	2010-05-20
EA018947B1 (ru)	2013-11-29
JP5432275B2 (ja)	2014-03-05
HRP20120738T1 (hr)	2012-10-31
EP2358710A1 (en)	2011-08-24
CR20110240A (es)	2011-06-09
KR20110074578A (ko)	2011-06-30
ES2391704T3 (es)	2012-11-29
PL2358710T3 (pl)	2012-12-31
MX2011005000A (es)	2011-05-25
TW201022268A (en)	2010-06-16
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Publication	Publication Date	Title
AR074072A1 (es)	2010-12-22	Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
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ECSP088871A (es)	2008-12-30	Derivados de triazolopirazina
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TW200738241A (en)	2007-10-16	Pyridazine derivatives
SV2011004077A (es)	2012-01-04	Derivados aminobutiricos sustituidos como inhibidores de neprilisina
WO2008148868A8 (en)	2009-03-05	Piperidine/piperazine derivatives
IN2012DN03337A (2)	2015-10-23
MX2010002584A (es)	2010-03-26	Derivados de piperidina como agonistas de receptores muscarinicos.
AR073077A1 (es)	2010-10-13	Uso de dabigatran. compuesto. composicion farmaceutica-
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AR062737A1 (es)	2008-11-26	Composicion farmaceutica que comprende un compuesto derivado de aril-azabiciclo, compuesto correspondiente y su uso para la preparacion de un medicamento
AR094122A1 (es)	2015-07-08	Compuestos triciclicos moduladores de la actividad de cftr
MY143568A (en)	2011-05-31	11b-hsd1 inhibitors for the treatment of diabetes
TW200616958A (en)	2006-06-01	New alkyl-pyridines as 11-beta inhibitors for diabetes
AR071721A1 (es)	2010-07-07	Derivados de piridil-prolinamida, composiciones farmaceuticas que los contienen y su uso para el tratamiento de ansiedad, depresion y trastornos del sueno.
TW200740764A (en)	2007-11-01	Pyrazolone derivatives
DE602005021150D1 (de)	2010-06-17	3-substituierte pyridinderivate als h3-antagonisten