AR086510A2 - Agentes de union especifica al factor de crecimiento de hepatocitos - Google Patents

Agentes de union especifica al factor de crecimiento de hepatocitos

Info

Publication number
AR086510A2
AR086510A2 ARP120101798A ARP120101798A AR086510A2 AR 086510 A2 AR086510 A2 AR 086510A2 AR P120101798 A ARP120101798 A AR P120101798A AR P120101798 A ARP120101798 A AR P120101798A AR 086510 A2 AR086510 A2 AR 086510A2
Authority
AR
Argentina
Prior art keywords
hgf
antibody
mouse
binding
polynucleotide encoding
Prior art date
Application number
ARP120101798A
Other languages
English (en)
Original Assignee
Amgen Inc
Abgenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Abgenix Inc filed Critical Amgen Inc
Publication of AR086510A2 publication Critical patent/AR086510A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cosmetics (AREA)

Abstract

Reivindicación 3: Un anticuerpo aislado capaz de unirse a un polipéptido HGF quimérico humano/ratón, caracterizado porque el polipéptido quimérico comprende una molécula HGF de ratón que tiene los aminoácidos 507 - 585 de la HGF humana en lugar de la secuencia homóloga de ratón, y donde el anticuerpo no se une de manera significativa a una HGF de ratón, y donde el anticuerpo es capaz de neutralizar la unión de HGF a c-Met.Reivindicación 5: Una célula huésped que comprende un primer polinucleótido que codifica una cadena liviana y un segundo polinucleótido que codifica una cadena pesada, caracterizado porque la cadena liviana y la cadena pesada son capaces de formar un anticuerpo que puede unir al menos un polipéptido que consiste en una secuencia de aminoácidos seleccionada de SEQ ID Nº 164 y 165, y donde el anticuerpo es capaz de neutralizar la unión de HGF a c-Met. Reivindicación 7: Una célula huésped que comprende un primer polinucleótido que codifica una cadena liviana y un segundo polinucleótido que codifica una cadena pesada, caracterizado porque la cadena liviana y la cadena pesada son capaces de formar un anticuerpo que puede unirse a un polipéptido HGF quimérico humano/ratón, donde el polipéptido quimérico comprende una molécula HGF de ratón que tiene los aminoácidos 507 - 585 de la HGF humana en lugar de la secuencia homóloga de ratón, donde el anticuerpo no se une de manera significativa a la HGF de ratón, y donde el anticuerpo es capaz de neutralizar la unión de HGF a c-Met. Reivindicación 9: Uso del anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 a 4 caracterizado porque es para la manufactura de un medicamento para el tratamiento de cáncer.
ARP120101798A 2003-07-18 2012-05-21 Agentes de union especifica al factor de crecimiento de hepatocitos AR086510A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48868103P 2003-07-18 2003-07-18

Publications (1)

Publication Number Publication Date
AR086510A2 true AR086510A2 (es) 2013-12-18

Family

ID=34193077

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP040102530A AR042955A1 (es) 2003-07-18 2004-07-16 Agentes de union especifica al factor de crecimiento de hepatocitos
ARP120101798A AR086510A2 (es) 2003-07-18 2012-05-21 Agentes de union especifica al factor de crecimiento de hepatocitos
ARP120101799A AR086511A2 (es) 2003-07-18 2012-05-21 Agentes de union especifica al factor de crecimiento de hepatocitos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP040102530A AR042955A1 (es) 2003-07-18 2004-07-16 Agentes de union especifica al factor de crecimiento de hepatocitos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP120101799A AR086511A2 (es) 2003-07-18 2012-05-21 Agentes de union especifica al factor de crecimiento de hepatocitos

Country Status (26)

Country Link
US (2) US8609090B2 (es)
EP (2) EP1648998B1 (es)
JP (4) JP5105874B2 (es)
KR (2) KR101254371B1 (es)
CN (3) CN103880955A (es)
AR (3) AR042955A1 (es)
AU (1) AU2004265595B2 (es)
BR (1) BRPI0412885A (es)
CA (1) CA2532027C (es)
DK (1) DK1648998T3 (es)
EA (1) EA015363B1 (es)
ES (1) ES2523837T3 (es)
HK (1) HK1199266A1 (es)
IL (1) IL172906A0 (es)
ME (1) MEP31408A (es)
MX (1) MXPA06000508A (es)
NO (1) NO20060600L (es)
NZ (1) NZ544797A (es)
PL (1) PL1648998T3 (es)
PT (1) PT1648998E (es)
RS (1) RS53476B (es)
SG (1) SG131943A1 (es)
SI (1) SI1648998T1 (es)
TW (3) TWI476206B (es)
WO (1) WO2005017107A2 (es)
ZA (2) ZA200601353B (es)

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EP1648998A2 (en) 2006-04-26
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AU2004265595A1 (en) 2005-02-24
WO2005017107A3 (en) 2007-03-01
IL172906A0 (en) 2006-06-11
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CA2532027A1 (en) 2005-02-24
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