AR100209A1 - Inhibidores de glyt1 para su uso en el tratamiento de trastornos hematológicos - Google Patents
Inhibidores de glyt1 para su uso en el tratamiento de trastornos hematológicosInfo
- Publication number
- AR100209A1 AR100209A1 ARP150101268A ARP150101268A AR100209A1 AR 100209 A1 AR100209 A1 AR 100209A1 AR P150101268 A ARP150101268 A AR P150101268A AR P150101268 A ARP150101268 A AR P150101268A AR 100209 A1 AR100209 A1 AR 100209A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- treatment
- substituted
- glyt1
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Son inhibidores de GlyT1, para su uso en el tratamiento de trastornos hematológicos, en particular, para su uso en el tratamiento de enfermedad de células falciformes y talasemia, o para el tratamiento de pacientes con síndromes de sobrecarga de hierro, tales como la hemocromatosis hereditaria. Reivindicación 5: Un inhibidor de GlyT1 de acuerdo con una cualquiera de las reivindicaciones 1 - 4, en el que el inhibidor de GlyT1 se selecciona de un compuesto de fórmula (1) en los que R¹ es halógeno, alquilo inferior sustituido con halógeno, ciano o S(O)₂-alquilo inferior; R² es alquilo inferior, alquilo inferior sustituido con halógeno o es (CH₂)ₒ-cicloalquilo; R³ es alquilo inferior, NH₂ o amino sustituido con uno o dos alquilos inferiores; X C o N; n es 1 ó 2; o es 0, 1 ó 2; así como sales de adición de ácido farmacéuticamente aceptables del mismo; o es un compuesto de fórmula (2) en el que R¹ es halógeno, alquilo inferior, alquilo inferior sustituido con halógeno, alcoxi, ciano o S(O)₂-alquilo inferior; R² es alquilo inferior, alquilo inferior sustituido con halógeno o es (CH₂)ₒ-cicloalquilo; R³ es alquilo inferior, NH₂ o amino sustituido con uno o dos alquilos inferiores; X es C o N; X¹ es C o N; en el que solo uno de X y X¹ es N; n es 1 ó 2; o es 0, 1 ó 2; así como sales de adición de ácido farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166497 | 2014-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100209A1 true AR100209A1 (es) | 2016-09-21 |
Family
ID=50677958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101268A AR100209A1 (es) | 2014-04-30 | 2015-04-28 | Inhibidores de glyt1 para su uso en el tratamiento de trastornos hematológicos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9877963B2 (es) |
| EP (1) | EP3137073B1 (es) |
| JP (1) | JP6283766B2 (es) |
| KR (1) | KR101869185B1 (es) |
| CN (1) | CN106163520B (es) |
| AR (1) | AR100209A1 (es) |
| CY (1) | CY1120508T1 (es) |
| ES (1) | ES2683184T3 (es) |
| HR (1) | HRP20181205T1 (es) |
| MA (1) | MA39927B1 (es) |
| MY (1) | MY189930A (es) |
| PH (1) | PH12016501784A1 (es) |
| PT (1) | PT3137073T (es) |
| RS (1) | RS57535B1 (es) |
| SG (2) | SG10201909382UA (es) |
| SI (1) | SI3137073T1 (es) |
| TR (1) | TR201809598T4 (es) |
| WO (1) | WO2015165842A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3199156A1 (de) * | 2016-02-01 | 2017-08-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von glycin-transporter-1-antagonisten als zentralnervöse analgetika |
| CU20200106A7 (es) * | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| US11813257B2 (en) | 2020-01-09 | 2023-11-14 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors |
| MX2023010477A (es) * | 2021-03-12 | 2023-11-09 | Disc Medicine Inc | Composiciones y metodos para tratar la anemia asociada con un trastorno ribosomico. |
| AU2022273051A1 (en) * | 2021-05-14 | 2023-12-07 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors |
| US20240390362A1 (en) * | 2021-05-27 | 2024-11-28 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with a solid form of bitopertin |
| CN119584967A (zh) * | 2022-05-31 | 2025-03-07 | 迪斯克医药公司 | 用甘氨酸转运抑制剂治疗肝性卟啉症的组合物和方法 |
| AU2024339974A1 (en) * | 2023-09-15 | 2026-03-26 | Disc Medicine, Inc. | Glyt-1 inhibitors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS53252B (sr) * | 2003-08-11 | 2014-08-29 | F.Hoffmann-La Roche Ag. | Piperazin sa or-supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1 |
| DE602006010665D1 (en) * | 2005-02-07 | 2010-01-07 | Hoffmann La Roche | Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1 |
-
2015
- 2015-04-27 WO PCT/EP2015/059037 patent/WO2015165842A1/en not_active Ceased
- 2015-04-27 EP EP15717916.9A patent/EP3137073B1/en active Active
- 2015-04-27 RS RS20180897A patent/RS57535B1/sr unknown
- 2015-04-27 HR HRP20181205TT patent/HRP20181205T1/hr unknown
- 2015-04-27 KR KR1020167030222A patent/KR101869185B1/ko active Active
- 2015-04-27 ES ES15717916.9T patent/ES2683184T3/es active Active
- 2015-04-27 PT PT157179169T patent/PT3137073T/pt unknown
- 2015-04-27 CN CN201580016721.4A patent/CN106163520B/zh active Active
- 2015-04-27 SG SG10201909382U patent/SG10201909382UA/en unknown
- 2015-04-27 SI SI201530334T patent/SI3137073T1/sl unknown
- 2015-04-27 TR TR2018/09598T patent/TR201809598T4/tr unknown
- 2015-04-27 SG SG11201608397UA patent/SG11201608397UA/en unknown
- 2015-04-27 JP JP2017505724A patent/JP6283766B2/ja active Active
- 2015-04-27 MY MYPI2016001545A patent/MY189930A/en unknown
- 2015-04-27 MA MA39927A patent/MA39927B1/fr unknown
- 2015-04-28 AR ARP150101268A patent/AR100209A1/es not_active Application Discontinuation
-
2016
- 2016-09-13 PH PH12016501784A patent/PH12016501784A1/en unknown
- 2016-10-26 US US15/334,722 patent/US9877963B2/en active Active
-
2018
- 2018-08-06 CY CY20181100809T patent/CY1120508T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015165842A1 (en) | 2015-11-05 |
| KR101869185B1 (ko) | 2018-06-19 |
| SI3137073T1 (sl) | 2018-09-28 |
| CY1120508T1 (el) | 2019-07-10 |
| ES2683184T3 (es) | 2018-09-25 |
| HRP20181205T1 (hr) | 2018-09-21 |
| PH12016501784B1 (en) | 2016-11-07 |
| TR201809598T4 (tr) | 2018-07-23 |
| EP3137073B1 (en) | 2018-06-06 |
| EP3137073A1 (en) | 2017-03-08 |
| RS57535B1 (sr) | 2018-10-31 |
| JP6283766B2 (ja) | 2018-02-21 |
| PT3137073T (pt) | 2018-07-27 |
| SG11201608397UA (en) | 2016-11-29 |
| CN106163520A (zh) | 2016-11-23 |
| MY189930A (en) | 2022-03-22 |
| MA39927A (fr) | 2017-03-08 |
| MA39927B1 (fr) | 2018-09-28 |
| SG10201909382UA (en) | 2019-11-28 |
| US20170042888A1 (en) | 2017-02-16 |
| KR20160130517A (ko) | 2016-11-11 |
| JP2017511385A (ja) | 2017-04-20 |
| US9877963B2 (en) | 2018-01-30 |
| PH12016501784A1 (en) | 2016-11-07 |
| CN106163520B (zh) | 2019-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |