PT3137073T - Inibidores do glyt1 para utilização no tratamento de distúrbios hematológicos - Google Patents
Inibidores do glyt1 para utilização no tratamento de distúrbios hematológicosInfo
- Publication number
- PT3137073T PT3137073T PT157179169T PT15717916T PT3137073T PT 3137073 T PT3137073 T PT 3137073T PT 157179169 T PT157179169 T PT 157179169T PT 15717916 T PT15717916 T PT 15717916T PT 3137073 T PT3137073 T PT 3137073T
- Authority
- PT
- Portugal
- Prior art keywords
- treatment
- hematological disorders
- glyt1 inhibitors
- glyt1
- inhibitors
- Prior art date
Links
- 208000014951 hematologic disease Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166497 | 2014-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3137073T true PT3137073T (pt) | 2018-07-27 |
Family
ID=50677958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT157179169T PT3137073T (pt) | 2014-04-30 | 2015-04-27 | Inibidores do glyt1 para utilização no tratamento de distúrbios hematológicos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9877963B2 (pt) |
| EP (1) | EP3137073B1 (pt) |
| JP (1) | JP6283766B2 (pt) |
| KR (1) | KR101869185B1 (pt) |
| CN (1) | CN106163520B (pt) |
| AR (1) | AR100209A1 (pt) |
| CY (1) | CY1120508T1 (pt) |
| ES (1) | ES2683184T3 (pt) |
| HR (1) | HRP20181205T1 (pt) |
| MA (1) | MA39927B1 (pt) |
| MY (1) | MY189930A (pt) |
| PH (1) | PH12016501784B1 (pt) |
| PT (1) | PT3137073T (pt) |
| RS (1) | RS57535B1 (pt) |
| SG (2) | SG10201909382UA (pt) |
| SI (1) | SI3137073T1 (pt) |
| TR (1) | TR201809598T4 (pt) |
| WO (1) | WO2015165842A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3199156A1 (de) * | 2016-02-01 | 2017-08-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von glycin-transporter-1-antagonisten als zentralnervöse analgetika |
| CU20200106A7 (es) * | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| KR20220125326A (ko) * | 2020-01-09 | 2022-09-14 | 디스크 메디슨, 인크. | 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법 |
| JP2024509267A (ja) * | 2021-03-12 | 2024-02-29 | ディスク・メディシン・インコーポレイテッド | リボソーム障害に関連する貧血を処置するための組成物および方法 |
| CN117979967A (zh) * | 2021-05-14 | 2024-05-03 | 迪斯克医药公司 | 用甘氨酸转运蛋白抑制剂治疗红细胞生成性原卟啉病、x连锁原卟啉病或先天性红细胞生成性卟啉病的方法 |
| EP4347023A4 (en) * | 2021-05-27 | 2025-04-16 | Disc Medicine, Inc. | Method for treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with a solid form of bitopertin |
| EP4531854A4 (en) * | 2022-05-31 | 2026-06-17 | Disc Medicine Inc | COMPOSITIONS AND METHODS OF TREATMENT OF HEPATIC PORPHYRIAS WITH GLYCINE TRANSPORT INHIBITORS |
| WO2025059425A1 (en) * | 2023-09-15 | 2025-03-20 | Disc Medicine, Inc. | Glyt-1 inhibitors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ544820A (en) * | 2003-08-11 | 2009-02-28 | Hoffmann La Roche | Piperazine with or-substituted phenyl group and their use as GlyT1 inhibitors |
| WO2006082001A1 (en) * | 2005-02-07 | 2006-08-10 | F.Hoffmann-La Roche Ag | Heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1 |
-
2015
- 2015-04-27 MA MA39927A patent/MA39927B1/fr unknown
- 2015-04-27 CN CN201580016721.4A patent/CN106163520B/zh active Active
- 2015-04-27 MY MYPI2016001545A patent/MY189930A/en unknown
- 2015-04-27 KR KR1020167030222A patent/KR101869185B1/ko active Active
- 2015-04-27 RS RS20180897A patent/RS57535B1/sr unknown
- 2015-04-27 SI SI201530334T patent/SI3137073T1/sl unknown
- 2015-04-27 HR HRP20181205TT patent/HRP20181205T1/hr unknown
- 2015-04-27 TR TR2018/09598T patent/TR201809598T4/tr unknown
- 2015-04-27 SG SG10201909382U patent/SG10201909382UA/en unknown
- 2015-04-27 SG SG11201608397UA patent/SG11201608397UA/en unknown
- 2015-04-27 JP JP2017505724A patent/JP6283766B2/ja active Active
- 2015-04-27 PT PT157179169T patent/PT3137073T/pt unknown
- 2015-04-27 ES ES15717916.9T patent/ES2683184T3/es active Active
- 2015-04-27 WO PCT/EP2015/059037 patent/WO2015165842A1/en not_active Ceased
- 2015-04-27 EP EP15717916.9A patent/EP3137073B1/en active Active
- 2015-04-28 AR ARP150101268A patent/AR100209A1/es not_active Application Discontinuation
-
2016
- 2016-09-13 PH PH12016501784A patent/PH12016501784B1/en unknown
- 2016-10-26 US US15/334,722 patent/US9877963B2/en active Active
-
2018
- 2018-08-06 CY CY20181100809T patent/CY1120508T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12016501784A1 (en) | 2016-11-07 |
| SG11201608397UA (en) | 2016-11-29 |
| JP6283766B2 (ja) | 2018-02-21 |
| JP2017511385A (ja) | 2017-04-20 |
| EP3137073B1 (en) | 2018-06-06 |
| MA39927A (fr) | 2017-03-08 |
| MA39927B1 (fr) | 2018-09-28 |
| PH12016501784B1 (en) | 2016-11-07 |
| CY1120508T1 (el) | 2019-07-10 |
| TR201809598T4 (tr) | 2018-07-23 |
| WO2015165842A1 (en) | 2015-11-05 |
| US20170042888A1 (en) | 2017-02-16 |
| CN106163520A (zh) | 2016-11-23 |
| SG10201909382UA (en) | 2019-11-28 |
| KR101869185B1 (ko) | 2018-06-19 |
| ES2683184T3 (es) | 2018-09-25 |
| MY189930A (en) | 2022-03-22 |
| SI3137073T1 (sl) | 2018-09-28 |
| CN106163520B (zh) | 2019-12-13 |
| HRP20181205T1 (hr) | 2018-09-21 |
| EP3137073A1 (en) | 2017-03-08 |
| AR100209A1 (es) | 2016-09-21 |
| US9877963B2 (en) | 2018-01-30 |
| KR20160130517A (ko) | 2016-11-11 |
| RS57535B1 (sr) | 2018-10-31 |
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