MA39927B1 - Inhibiteurs de glyt1 pour le traitement de troubles hématologiques - Google Patents
Inhibiteurs de glyt1 pour le traitement de troubles hématologiquesInfo
- Publication number
- MA39927B1 MA39927B1 MA39927A MA39927A MA39927B1 MA 39927 B1 MA39927 B1 MA 39927B1 MA 39927 A MA39927 A MA 39927A MA 39927 A MA39927 A MA 39927A MA 39927 B1 MA39927 B1 MA 39927B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- hematological disorders
- glyt1 inhibitors
- glyt1
- inhibitors
- Prior art date
Links
- 208000014951 hematologic disease Diseases 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 208000033981 Hereditary haemochromatosis Diseases 0.000 abstract 1
- 206010065973 Iron Overload Diseases 0.000 abstract 1
- 206010043395 Thalassaemia sickle cell Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention se rapporte à des composés, qui sont des inhibiteurs de glyt1, destinés à être utilisés dans le traitement de troubles hématologiques, en particulier destinés à être utilisés dans le traitement de la drépanocytose et de la thalassémie, ou dans le traitement de patients atteints de syndromes de surcharge en fer, tels que l'hémochromatose héréditaire.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14166497 | 2014-04-30 | ||
| PCT/EP2015/059037 WO2015165842A1 (fr) | 2014-04-30 | 2015-04-27 | Inhibiteurs de glyt1 destinés à être utilisés dans le traitement de troubles hématologiques |
| EP15717916.9A EP3137073B1 (fr) | 2014-04-30 | 2015-04-27 | Inhibiteurs de glyt1 pour le traitement de troubles hématologiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA39927A MA39927A (fr) | 2017-03-08 |
| MA39927B1 true MA39927B1 (fr) | 2018-09-28 |
Family
ID=50677958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA39927A MA39927B1 (fr) | 2014-04-30 | 2015-04-27 | Inhibiteurs de glyt1 pour le traitement de troubles hématologiques |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9877963B2 (fr) |
| EP (1) | EP3137073B1 (fr) |
| JP (1) | JP6283766B2 (fr) |
| KR (1) | KR101869185B1 (fr) |
| CN (1) | CN106163520B (fr) |
| AR (1) | AR100209A1 (fr) |
| CY (1) | CY1120508T1 (fr) |
| ES (1) | ES2683184T3 (fr) |
| HR (1) | HRP20181205T1 (fr) |
| MA (1) | MA39927B1 (fr) |
| MY (1) | MY189930A (fr) |
| PH (1) | PH12016501784A1 (fr) |
| PT (1) | PT3137073T (fr) |
| RS (1) | RS57535B1 (fr) |
| SG (2) | SG10201909382UA (fr) |
| SI (1) | SI3137073T1 (fr) |
| TR (1) | TR201809598T4 (fr) |
| WO (1) | WO2015165842A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3199156A1 (fr) * | 2016-02-01 | 2017-08-02 | Heinrich-Heine-Universität Düsseldorf | Utilisation d'antagonistes du transporteur de la glycine 1 comme analgésiques du systeme nerveux central |
| CU20200106A7 (es) * | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| US11813257B2 (en) | 2020-01-09 | 2023-11-14 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors |
| MX2023010477A (es) * | 2021-03-12 | 2023-11-09 | Disc Medicine Inc | Composiciones y metodos para tratar la anemia asociada con un trastorno ribosomico. |
| AU2022273051A1 (en) * | 2021-05-14 | 2023-12-07 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors |
| US20240390362A1 (en) * | 2021-05-27 | 2024-11-28 | Disc Medicine, Inc. | Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with a solid form of bitopertin |
| CN119584967A (zh) * | 2022-05-31 | 2025-03-07 | 迪斯克医药公司 | 用甘氨酸转运抑制剂治疗肝性卟啉症的组合物和方法 |
| AU2024339974A1 (en) * | 2023-09-15 | 2026-03-26 | Disc Medicine, Inc. | Glyt-1 inhibitors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS53252B (sr) * | 2003-08-11 | 2014-08-29 | F.Hoffmann-La Roche Ag. | Piperazin sa or-supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1 |
| DE602006010665D1 (en) * | 2005-02-07 | 2010-01-07 | Hoffmann La Roche | Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1 |
-
2015
- 2015-04-27 WO PCT/EP2015/059037 patent/WO2015165842A1/fr not_active Ceased
- 2015-04-27 EP EP15717916.9A patent/EP3137073B1/fr active Active
- 2015-04-27 RS RS20180897A patent/RS57535B1/sr unknown
- 2015-04-27 HR HRP20181205TT patent/HRP20181205T1/hr unknown
- 2015-04-27 KR KR1020167030222A patent/KR101869185B1/ko active Active
- 2015-04-27 ES ES15717916.9T patent/ES2683184T3/es active Active
- 2015-04-27 PT PT157179169T patent/PT3137073T/pt unknown
- 2015-04-27 CN CN201580016721.4A patent/CN106163520B/zh active Active
- 2015-04-27 SG SG10201909382U patent/SG10201909382UA/en unknown
- 2015-04-27 SI SI201530334T patent/SI3137073T1/sl unknown
- 2015-04-27 TR TR2018/09598T patent/TR201809598T4/tr unknown
- 2015-04-27 SG SG11201608397UA patent/SG11201608397UA/en unknown
- 2015-04-27 JP JP2017505724A patent/JP6283766B2/ja active Active
- 2015-04-27 MY MYPI2016001545A patent/MY189930A/en unknown
- 2015-04-27 MA MA39927A patent/MA39927B1/fr unknown
- 2015-04-28 AR ARP150101268A patent/AR100209A1/es not_active Application Discontinuation
-
2016
- 2016-09-13 PH PH12016501784A patent/PH12016501784A1/en unknown
- 2016-10-26 US US15/334,722 patent/US9877963B2/en active Active
-
2018
- 2018-08-06 CY CY20181100809T patent/CY1120508T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015165842A1 (fr) | 2015-11-05 |
| KR101869185B1 (ko) | 2018-06-19 |
| SI3137073T1 (sl) | 2018-09-28 |
| CY1120508T1 (el) | 2019-07-10 |
| ES2683184T3 (es) | 2018-09-25 |
| HRP20181205T1 (hr) | 2018-09-21 |
| PH12016501784B1 (en) | 2016-11-07 |
| TR201809598T4 (tr) | 2018-07-23 |
| AR100209A1 (es) | 2016-09-21 |
| EP3137073B1 (fr) | 2018-06-06 |
| EP3137073A1 (fr) | 2017-03-08 |
| RS57535B1 (sr) | 2018-10-31 |
| JP6283766B2 (ja) | 2018-02-21 |
| PT3137073T (pt) | 2018-07-27 |
| SG11201608397UA (en) | 2016-11-29 |
| CN106163520A (zh) | 2016-11-23 |
| MY189930A (en) | 2022-03-22 |
| MA39927A (fr) | 2017-03-08 |
| SG10201909382UA (en) | 2019-11-28 |
| US20170042888A1 (en) | 2017-02-16 |
| KR20160130517A (ko) | 2016-11-11 |
| JP2017511385A (ja) | 2017-04-20 |
| US9877963B2 (en) | 2018-01-30 |
| PH12016501784A1 (en) | 2016-11-07 |
| CN106163520B (zh) | 2019-12-13 |
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