AR106929A2 - Procedimiento para sintetizar compuestos útiles para tratar hepatitis c - Google Patents

Procedimiento para sintetizar compuestos útiles para tratar hepatitis c

Info

Publication number
AR106929A2
AR106929A2 ARP160103748A ARP160103748A AR106929A2 AR 106929 A2 AR106929 A2 AR 106929A2 AR P160103748 A ARP160103748 A AR P160103748A AR P160103748 A ARP160103748 A AR P160103748A AR 106929 A2 AR106929 A2 AR 106929A2
Authority
AR
Argentina
Prior art keywords
ammonium
procedure
formula
alkyl
compound
Prior art date
Application number
ARP160103748A
Other languages
English (en)
Inventor
K Pack Shawn
Original Assignee
Bristol Myers Squibb Holdings Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR106929(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Holdings Ireland filed Critical Bristol Myers Squibb Holdings Ireland
Publication of AR106929A2 publication Critical patent/AR106929A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un procedimiento para sintetizar sal diclorhidrato de ((1S)-1-(((2S)-2-(5-(4’-(2-((2S)-1-((2S)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidini1)carbonil)-2-metilpropil)carbamato de metilo. También intermedios útiles en este procedimiento. Reivindicación 1: Un procedimiento caracterizado porque es para preparar un compuesto de fórmula (1) o una de sus sales farmacéuticamente aceptable; en la que n es 0, 1 ó 2; s es 0, 1, 2, 3 ó 4; u y v se selecciona cada uno independientemente de 0, 1, 2 ó 3; X se selecciona de O, S, S(O), SO₂, CH₂, CHR⁵ y C(R⁵)₂; con la condición de que cuando n es 0, X se selecciona de CH₂, CHR⁵ y C(R⁵)₂; R¹ y R² se selecciona cada uno independientemente de alcoxi, alquilo y halo; y cuando s es 2, 3 ó 4, cada R⁵ en el anillo se selecciona independientemente de alcoxi, alquilo y arilo, donde el alquilo puede formar opcionalmente un anillo condensado de tres a seis miembros con un átomo de carbono adyacente, estando el anillo de tres a seis miembros opcionalmente sustituido con uno o dos grupos alquilo; con la condición de que los dos anillos heterocíclicos que sustituyen los anillos imidazol son idénticos; comprendiendo el procedimiento: (a) hacer reaccionar un compuesto de fórmula (2) en la que u, v, R¹ y R² son como se describen para la fórmula (1); y LG es un grupo saliente; con un compuesto de fórmula (3) en la que PG es un grupo protector de nitrógeno; (b) tratar el producto de la etapa (a) con un reactivo seleccionado de acetato amónico, formiato amónico, sulfamato amónico, fosfato amónico, citrato amónico, carbamato amónico y amoníaco; y (c) tratar el producto de la etapa (b) con un agente de desprotección.
ARP160103748A 2007-08-08 2016-12-06 Procedimiento para sintetizar compuestos útiles para tratar hepatitis c AR106929A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95459507P 2007-08-08 2007-08-08

Publications (1)

Publication Number Publication Date
AR106929A2 true AR106929A2 (es) 2018-02-28

Family

ID=39865546

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP080103487A AR067896A1 (es) 2007-08-08 2008-08-08 Procedimiento para sintetizar compuestos utiles para tratar hepatitis c
ARP160103748A AR106929A2 (es) 2007-08-08 2016-12-06 Procedimiento para sintetizar compuestos útiles para tratar hepatitis c

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP080103487A AR067896A1 (es) 2007-08-08 2008-08-08 Procedimiento para sintetizar compuestos utiles para tratar hepatitis c

Country Status (24)

Country Link
US (1) US7728027B2 (es)
EP (1) EP2178863B1 (es)
JP (2) JP5324574B2 (es)
KR (1) KR101528542B1 (es)
CN (1) CN101778841B (es)
AR (2) AR067896A1 (es)
AU (1) AU2008284097B2 (es)
BR (1) BRPI0815611B1 (es)
CA (1) CA2695711C (es)
CL (1) CL2008002355A1 (es)
CO (1) CO6251317A2 (es)
CY (1) CY1113547T1 (es)
DK (1) DK2178863T3 (es)
EA (1) EA017173B1 (es)
ES (1) ES2396267T3 (es)
HR (1) HRP20120990T1 (es)
IL (1) IL203685A (es)
MX (1) MX2010001415A (es)
PE (1) PE20090611A1 (es)
PL (1) PL2178863T3 (es)
PT (1) PT2178863E (es)
SI (1) SI2178863T1 (es)
TW (1) TWI423963B (es)
WO (1) WO2009020825A1 (es)

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PL2178863T3 (pl) 2013-03-29
PE20090611A1 (es) 2009-05-16
PT2178863E (pt) 2013-01-14
BRPI0815611B1 (pt) 2018-08-21
CO6251317A2 (es) 2011-02-21
CN101778841B (zh) 2015-07-22
EA017173B1 (ru) 2012-10-30
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DK2178863T3 (da) 2013-02-11
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