PL2178863T3 - Sposób otrzymywania związków stosowanych w leczeniu wirusowego zapalenia wątroby typu C - Google Patents

Sposób otrzymywania związków stosowanych w leczeniu wirusowego zapalenia wątroby typu C

Info

Publication number
PL2178863T3
PL2178863T3 PL08796910T PL08796910T PL2178863T3 PL 2178863 T3 PL2178863 T3 PL 2178863T3 PL 08796910 T PL08796910 T PL 08796910T PL 08796910 T PL08796910 T PL 08796910T PL 2178863 T3 PL2178863 T3 PL 2178863T3
Authority
PL
Poland
Prior art keywords
compounds useful
treating hepatitis
synthesizing compounds
synthesizing
hepatitis
Prior art date
Application number
PL08796910T
Other languages
English (en)
Inventor
Shawn K Pack
Peng Geng
Michael J Smith
Jason Hamm
Original Assignee
Bristol Myers Squibb Holdings Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2178863(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Holdings Ireland filed Critical Bristol Myers Squibb Holdings Ireland
Publication of PL2178863T3 publication Critical patent/PL2178863T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
PL08796910T 2007-08-08 2008-07-31 Sposób otrzymywania związków stosowanych w leczeniu wirusowego zapalenia wątroby typu C PL2178863T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95459507P 2007-08-08 2007-08-08
PCT/US2008/071696 WO2009020825A1 (en) 2007-08-08 2008-07-31 Process for synthesizing compounds useful for treating hepatitis c
EP08796910A EP2178863B1 (en) 2007-08-08 2008-07-31 Process for synthesizing compounds useful for treating hepatitis c

Publications (1)

Publication Number Publication Date
PL2178863T3 true PL2178863T3 (pl) 2013-03-29

Family

ID=39865546

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08796910T PL2178863T3 (pl) 2007-08-08 2008-07-31 Sposób otrzymywania związków stosowanych w leczeniu wirusowego zapalenia wątroby typu C

Country Status (24)

Country Link
US (1) US7728027B2 (pl)
EP (1) EP2178863B1 (pl)
JP (2) JP5324574B2 (pl)
KR (1) KR101528542B1 (pl)
CN (1) CN101778841B (pl)
AR (2) AR067896A1 (pl)
AU (1) AU2008284097B2 (pl)
BR (1) BRPI0815611B1 (pl)
CA (1) CA2695711C (pl)
CL (1) CL2008002355A1 (pl)
CO (1) CO6251317A2 (pl)
CY (1) CY1113547T1 (pl)
DK (1) DK2178863T3 (pl)
EA (1) EA017173B1 (pl)
ES (1) ES2396267T3 (pl)
HR (1) HRP20120990T1 (pl)
IL (1) IL203685A (pl)
MX (1) MX2010001415A (pl)
PE (1) PE20090611A1 (pl)
PL (1) PL2178863T3 (pl)
PT (1) PT2178863E (pl)
SI (1) SI2178863T1 (pl)
TW (1) TWI423963B (pl)
WO (1) WO2009020825A1 (pl)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7728027B2 (en) * 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C
US8629171B2 (en) * 2007-08-08 2014-01-14 Bristol-Myers Squibb Company Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
KR20100123717A (ko) 2008-02-12 2010-11-24 브리스톨-마이어스 스큅 컴퍼니 Ｃ형 간염 바이러스 억제제로서의 헤테로시클릭 유도체
US8147818B2 (en) 2008-02-13 2012-04-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7704992B2 (en) 2008-02-13 2010-04-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7906655B2 (en) 2008-08-07 2011-03-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8383094B2 (en) 2008-10-01 2013-02-26 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
SG172352A1 (en) 2008-12-23 2011-07-28 Abbott Lab Anti-viral compounds
US8546405B2 (en) * 2008-12-23 2013-10-01 Abbott Laboratories Anti-viral compounds
US8242156B2 (en) 2009-02-17 2012-08-14 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US8394968B2 (en) 2009-02-17 2013-03-12 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8188132B2 (en) 2009-02-17 2012-05-29 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
TWI438200B (zh) 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑
WO2010094977A1 (en) * 2009-02-23 2010-08-26 Arrow Therapeutics Limited Novel biphenyl compounds useful for the treatment of hepatitis c
US9765087B2 (en) 2009-02-27 2017-09-19 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8101643B2 (en) 2009-02-27 2012-01-24 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
RU2544010C2 (ru) 2009-02-27 2015-03-10 Энанта Фармасьютикалс, Инк. Ингибиторы вируса гепатита с
US8673954B2 (en) 2009-02-27 2014-03-18 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8507522B2 (en) 2009-03-06 2013-08-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
SG174883A1 (en) * 2009-03-27 2011-11-28 Presidio Pharmaceuticals Inc Fused ring inhibitors of hepatitis c
US8796466B2 (en) 2009-03-30 2014-08-05 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW201038559A (en) 2009-04-09 2010-11-01 Bristol Myers Squibb Co Hepatitis C virus inhibitors
US8143414B2 (en) 2009-04-13 2012-03-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9278922B2 (en) * 2009-04-15 2016-03-08 Abbvie Inc. Anti-viral compounds
HUE030465T2 (hu) 2009-05-13 2017-05-29 Antivirális vegyületek
US8211928B2 (en) 2009-05-29 2012-07-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8138215B2 (en) 2009-05-29 2012-03-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
EA020031B1 (ru) * 2009-06-11 2014-08-29 Эббви Бахамаз Лтд. Противовирусные соединения
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
US8221737B2 (en) 2009-06-16 2012-07-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8609648B2 (en) 2009-07-02 2013-12-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
AU2010274001A1 (en) 2009-07-16 2012-02-23 Vertex Pharmaceuticals Incorporated Benzimidazole analogues for the treatment or prevention of Flavivirus infections
CN102480971B (zh) 2009-09-04 2014-11-26 杨森制药公司 化合物
US8703938B2 (en) 2009-09-11 2014-04-22 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US9156818B2 (en) 2009-09-11 2015-10-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8822700B2 (en) 2009-09-11 2014-09-02 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8815928B2 (en) 2009-09-11 2014-08-26 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8759332B2 (en) 2009-09-11 2014-06-24 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8927709B2 (en) 2009-09-11 2015-01-06 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8415374B2 (en) 2009-10-12 2013-04-09 Bristol-Myers Squibb Company Combinations of hepatitis C virus inhibitors
US20110269956A1 (en) * 2009-11-11 2011-11-03 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110281910A1 (en) 2009-11-12 2011-11-17 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110137633A1 (en) * 2009-12-03 2011-06-09 Abbott Laboratories Anti-viral compounds and methods of identifying the same
TWI429645B (en) * 2009-12-04 2014-03-11 Proline derivatives
US8653070B2 (en) 2009-12-14 2014-02-18 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20110152246A1 (en) * 2009-12-18 2011-06-23 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
US8362020B2 (en) 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PE20130244A1 (es) 2010-01-25 2013-03-10 Enanta Pharm Inc Inhibidores del virus de la hepatitis c
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US8178531B2 (en) 2010-02-23 2012-05-15 Enanta Pharmaceuticals, Inc. Antiviral agents
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
CN102858157A (zh) 2010-03-04 2013-01-02 埃南塔制药公司 作为hcv复制的抑制剂的组合药物活性剂
CN102869657A (zh) 2010-03-24 2013-01-09 沃泰克斯药物股份有限公司 用于治疗或预防黄病毒感染的类似物
EP2555622A4 (en) 2010-04-09 2013-09-18 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US8778938B2 (en) 2010-06-04 2014-07-15 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
WO2012006060A1 (en) 2010-06-28 2012-01-12 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
EP2585447A2 (en) 2010-06-28 2013-05-01 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flavivirus infections
US20120195857A1 (en) * 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
WO2012021704A1 (en) 2010-08-12 2012-02-16 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
EP2606041A2 (en) 2010-08-17 2013-06-26 Vertex Pharmaceuticals Incorporated Compounds and methods for the treatment or prevention of flaviviridae viral infections
US8859595B2 (en) 2010-08-26 2014-10-14 Rfs Pharma, Llc Potent and selective inhibitors of hepatitis C virus
SG189985A1 (en) 2010-10-26 2013-06-28 Presidio Pharmaceuticals Inc Inhibitors of hepatitis c virus
RU2452735C1 (ru) 2010-11-30 2012-06-10 Александр Васильевич Иващенко Замещенные азолы, противовирусный активный компонент, фармацевтическая композиция, способ получения и применения
US8552047B2 (en) 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9546160B2 (en) 2011-05-12 2017-01-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2012158861A2 (en) 2011-05-18 2012-11-22 Enanta Pharmaceuticals, Inc. Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives
WO2013016499A1 (en) 2011-07-26 2013-01-31 Vertex Pharmaceuticals Incorporated Methods for preparation of thiophene compounds
AU2012286853A1 (en) 2011-07-26 2013-05-02 Vertex Pharmaceuticals Incorporated Thiophene compounds
WO2013030750A1 (en) 2011-09-01 2013-03-07 Lupin Limited Antiviral compounds
EP2709613B2 (en) 2011-09-16 2020-08-12 Gilead Pharmasset LLC Methods for treating hcv
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
EP2583677A3 (en) 2011-10-21 2013-07-03 Abbvie Inc. Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon.
DE202012012955U1 (de) 2011-10-21 2014-07-14 Abbvie Inc. Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
US9326973B2 (en) 2012-01-13 2016-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2013217224B2 (en) 2012-02-10 2017-04-06 Lupin Limited Antiviral compounds with a dibenzooxaheterocycle moiety
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
EP2950786B1 (en) 2013-01-31 2019-11-27 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
RU2507201C1 (ru) 2013-02-07 2014-02-20 Александр Васильевич Иващенко Алкил [(s)-1-((s)-2-{5-[4-(4-{2-[(s)-1-((s)-2-метоксикарбониламино-3-метил-бутирил)-пирролидин-2-ил]-3н-имидазол-4-ил}-бута-1,3-диинил)-фенил]-1н-имидазол-2-ил}-пирролидин-1-карбонил)-2-метил-пропил]-карбамат нафталин-1,5-дисульфонат, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
WO2014134251A1 (en) 2013-02-28 2014-09-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
US20150023913A1 (en) 2013-07-02 2015-01-22 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US9717712B2 (en) 2013-07-02 2017-08-01 Bristol-Myers Squibb Company Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus
WO2015005901A1 (en) 2013-07-09 2015-01-15 Bristol-Myers Squibb Company Combinations of hepatitis c virus inhibitors
US9775831B2 (en) 2013-07-17 2017-10-03 Bristol-Myers Squibb Company Combinations comprising biphenyl derivatives for use in the treatment of HCV
PT3038601T (pt) 2013-08-27 2020-06-30 Gilead Pharmasset Llc Formulação combinada de dois compostos antivirais
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
CN104774194B (zh) * 2014-01-09 2018-01-30 正大天晴药业集团股份有限公司 氘代的丙型肝炎病毒抑制剂
CN106279122A (zh) * 2014-01-21 2017-01-04 杭州普晒医药科技有限公司 一种化合物的盐及晶型或无定型物、其制备方法、含有它们的药物组合物和用途
CN105524049B (zh) * 2014-09-28 2018-11-06 正大天晴药业集团股份有限公司 氘代的丙型肝炎病毒ns5a蛋白抑制剂
WO2016079697A1 (en) * 2014-11-19 2016-05-26 Sun Pharmaceutical Industries Limited Process for the preparation of an intermediate of daclatasvir dihydrochloride
WO2016089814A1 (en) 2014-12-02 2016-06-09 Concert Pharmaceuticals, Inc. Deuterated analogues of daclatasvir
CN105753944B (zh) * 2014-12-19 2019-10-01 正大天晴药业集团股份有限公司 达卡他韦及其衍生物的制备中间体
CN105985227A (zh) * 2015-02-06 2016-10-05 上海特化医药科技有限公司 4,4’-二卤乙酰联苯的制备及应用
CN106188015B (zh) * 2015-05-06 2019-10-18 广东东阳光药业有限公司 一种制备达卡他韦的方法
WO2016178250A1 (en) * 2015-05-07 2016-11-10 Mylan Laboratories Limited Process for the preparation of daclatasvir
CZ2015366A3 (cs) * 2015-05-29 2016-12-07 Zentiva, K.S. Pevné formy Daclatasviru
WO2017021904A1 (en) * 2015-08-03 2017-02-09 Laurus Labs Private Limited Daclatasvir free base and process for the preparation thereof
WO2017023631A1 (en) 2015-08-06 2017-02-09 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
CN105461701A (zh) * 2015-12-14 2016-04-06 上海步越化工科技有限公司 一种抗丙肝新药达卡他韦新的合成方法
CN105622583A (zh) * 2015-12-22 2016-06-01 苏州步跃医药科技有限公司 一种抗丙肝新药达卡他韦新的制备方法
CN105753844A (zh) * 2016-02-16 2016-07-13 江苏苏利精细化工股份有限公司 一种合成二氨基甲酸二甲酯二盐酸盐类化合物的新方法
CN107235965A (zh) * 2016-03-29 2017-10-10 上海医药工业研究院 一种达卡他韦的制备方法
CN107235884B (zh) * 2016-03-29 2021-03-26 上海医药工业研究院 一种达卡他韦中间体及其制备方法
CN105777719A (zh) * 2016-03-29 2016-07-20 安徽联创生物医药股份有限公司 一种达卡他韦的合成方法
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
CN106256825A (zh) * 2016-07-04 2016-12-28 四川同晟生物医药有限公司 达卡他韦的合成方法
US20190256498A1 (en) * 2016-07-08 2019-08-22 Lupin Limited Crystalline forms of daclatasvir dihydrochloride
CN106432204A (zh) * 2016-09-12 2017-02-22 上海步越化工科技有限公司 一种抗丙肝达卡他韦的合成方法
CN106496199A (zh) * 2016-10-19 2017-03-15 上海博志研新药物技术有限公司 达卡他韦及其中间体的制备方法
CN108069941A (zh) * 2016-11-15 2018-05-25 广东东阳光药业有限公司 一种制备达卡他韦的方法
CN109305962B (zh) * 2017-07-28 2022-01-18 扬子江药业集团有限公司 一种盐酸达拉他韦的精制方法
CN107501243A (zh) * 2017-09-08 2017-12-22 安徽灵药业有限公司 一种达卡他韦的合成方法
KR102835299B1 (ko) 2018-12-04 2025-07-18 브리스톨-마이어스 스큅 컴퍼니 다중 동위원소체 반응 모니터링에 의한 샘플내 보정 곡선을 사용한 분석 방법
US11442659B2 (en) 2019-11-20 2022-09-13 International Business Machines Corporation Reading sequentially stored files based on read ahead groups
US12497408B2 (en) 2021-05-21 2025-12-16 Gilead Sciences, Inc. Tetracyclic compounds and methods for the treatment of Zika virus infection
US12037340B2 (en) 2021-05-21 2024-07-16 Gilead Sciences, Inc. Pentacyclic derivatives as Zika virus inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
JPH08505854A (ja) 1993-01-14 1996-06-25 マガイニン ファーマシューティカルズ，インク． 修飾された末端を有するアミノ酸及びペプチド
US5654451B1 (en) 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
AU2003249977A1 (en) * 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
WO2006093867A1 (en) 2005-02-28 2006-09-08 The Rockefeller University Structure of the hepatitits c virus ns5a protein
US8143288B2 (en) * 2005-06-06 2012-03-27 Bristol-Myers Squibb Company Inhibitors of HCV replication
EP1940786B1 (en) 2005-09-16 2010-08-18 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
WO2007058384A1 (en) 2005-11-17 2007-05-24 Osaka University Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same
SG133452A1 (en) 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
KR20090012345A (ko) 2006-05-30 2009-02-03 애로우 쎄라퓨틱스 리미티드 바이페닐 유도체, 및 ｃ형 간염 치료에 있어서의 이들의 용도
US8329159B2 (en) * 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7759495B2 (en) 2006-08-11 2010-07-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8236950B2 (en) 2006-12-20 2012-08-07 Abbott Laboratories Anti-viral compounds
US7728027B2 (en) * 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C

Also Published As

Publication number Publication date
HK1137454A1 (en) 2010-07-30
IL203685A (en) 2015-04-30
CY1113547T1 (el) 2016-06-22
JP5324574B2 (ja) 2013-10-23
PE20090611A1 (es) 2009-05-16
PT2178863E (pt) 2013-01-14
BRPI0815611B1 (pt) 2018-08-21
CO6251317A2 (es) 2011-02-21
CN101778841B (zh) 2015-07-22
EA017173B1 (ru) 2012-10-30
AR106929A2 (es) 2018-02-28
CA2695711A1 (en) 2009-02-12
EP2178863B1 (en) 2012-10-24
DK2178863T3 (da) 2013-02-11
CL2008002355A1 (es) 2009-01-02
MX2010001415A (es) 2010-03-01
BRPI0815611A2 (pt) 2015-03-24
ES2396267T3 (es) 2013-02-20
KR20100045992A (ko) 2010-05-04
EP2178863A1 (en) 2010-04-28
TW200914441A (en) 2009-04-01
AR067896A1 (es) 2009-10-28
AU2008284097B2 (en) 2013-01-10
US7728027B2 (en) 2010-06-01
AU2008284097A1 (en) 2009-02-12
SI2178863T1 (sl) 2013-02-28
CA2695711C (en) 2014-09-09
US20090043107A1 (en) 2009-02-12
TWI423963B (zh) 2014-01-21
JP2013231072A (ja) 2013-11-14
EA201000300A1 (ru) 2010-06-30
WO2009020825A1 (en) 2009-02-12
KR101528542B1 (ko) 2015-06-15
JP2010535784A (ja) 2010-11-25
HRP20120990T1 (hr) 2012-12-31
CN101778841A (zh) 2010-07-14

Similar Documents

Publication Publication Date Title
PL2178863T3 (pl) Sposób otrzymywania związków stosowanych w leczeniu wirusowego zapalenia wątroby typu C
IL194508A0 (en) Process for synthesizing organoelemental compounds
AP2577A (en) Process for preparing diaminophenothiazinium compounds
IL211509A0 (en) Compounds for the treatment of hepatitis c
ZA200906129B (en) Compounds for the treatment of hepatitis c
IL199124A (en) A process for preparing fluoromethyl-converted heterocyclic compounds
EP2069406A4 (en) HIGHLY DEVELOPED BIORAFFINATION PROCESS
IL209895A0 (en) Compounds for treating beta-amyloidoses
PL2209784T3 (pl) Związki do leczenia zapalenia wątroby typu C
ZA201000923B (en) Compounds for the treatment of hepatitis c
IL213398A0 (en) Compounds for treating cancer
IL192231A0 (en) An improved process for the preparation of armodafinil
IL197099A0 (en) Process for preparing polybrominated compounds
IL186272A0 (en) Process for producing thiazole compound
IL192702A0 (en) Process for producing 5-alkoxy-4-hydroxymethylpyrazole compound
ZA200806903B (en) Process for preparing dibenzothiazepine compounds
ZA201000670B (en) Process for producing toluidine compound
IL207651A0 (en) Process for preparing benzothiazepines from gamma-aminoalkylbenzenes
ZA200907695B (en) Process for preparing dorzolam ide
IL189574A0 (en) Process for preparing 1-substituted-5-acylimidazole compounds
IL188273A0 (en) Process for preparing benzimidazole compounds
EP2283010A4 (en) METHOD FOR PRODUCING AN INTERMEDIATE PRODUCT FOR THE SYNTHESIS OF A MEDIUM AGAINST GASIFICATION
IL179235A0 (en) Process for preparing carbostyril compounds
GB0525710D0 (en) An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds
AP2010005225A0 (en) Process for treating sulphatecontaining effluent