CL2008002355A1 - Procedimiento para preparar ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidnil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo útiles para tratar hepatitis c. - Google Patents

Procedimiento para preparar ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidnil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo útiles para tratar hepatitis c.

Info

Publication number
CL2008002355A1
CL2008002355A1 CL2008002355A CL2008002355A CL2008002355A1 CL 2008002355 A1 CL2008002355 A1 CL 2008002355A1 CL 2008002355 A CL2008002355 A CL 2008002355A CL 2008002355 A CL2008002355 A CL 2008002355A CL 2008002355 A1 CL2008002355 A1 CL 2008002355A1
Authority
CL
Chile
Prior art keywords
imidazol
preparing
pyrrolidnyl
methylbutanoyl
biphenylyl
Prior art date
Application number
CL2008002355A
Other languages
English (en)
Inventor
K Pack Shawn
Geng Peng
J Smith Michael
Hamm Jason
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008002355(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2008002355A1 publication Critical patent/CL2008002355A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Procedimiento para preparar compuestos derivados de imidazol, útiles para tratar hepatitis C, que comprende reaccionar compuesto derivado de bifenilo y compuesto derivado de heterociclo, tratar con acetato amónico, formiato amónico, fosfato amónico, citrato amónico, carbamato amónico o amoniaco, y tratar con agente de desprotección.
CL2008002355A 2007-08-08 2008-08-08 Procedimiento para preparar ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidnil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo útiles para tratar hepatitis c. CL2008002355A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95459507P 2007-08-08 2007-08-08

Publications (1)

Publication Number Publication Date
CL2008002355A1 true CL2008002355A1 (es) 2009-01-02

Family

ID=39865546

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002355A CL2008002355A1 (es) 2007-08-08 2008-08-08 Procedimiento para preparar ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidnil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo útiles para tratar hepatitis c.

Country Status (24)

Country Link
US (1) US7728027B2 (es)
EP (1) EP2178863B1 (es)
JP (2) JP5324574B2 (es)
KR (1) KR101528542B1 (es)
CN (1) CN101778841B (es)
AR (2) AR067896A1 (es)
AU (1) AU2008284097B2 (es)
BR (1) BRPI0815611B1 (es)
CA (1) CA2695711C (es)
CL (1) CL2008002355A1 (es)
CO (1) CO6251317A2 (es)
CY (1) CY1113547T1 (es)
DK (1) DK2178863T3 (es)
EA (1) EA017173B1 (es)
ES (1) ES2396267T3 (es)
HR (1) HRP20120990T1 (es)
IL (1) IL203685A (es)
MX (1) MX2010001415A (es)
PE (1) PE20090611A1 (es)
PL (1) PL2178863T3 (es)
PT (1) PT2178863E (es)
SI (1) SI2178863T1 (es)
TW (1) TWI423963B (es)
WO (1) WO2009020825A1 (es)

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AU2008284097B2 (en) 2013-01-10
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JP5324574B2 (ja) 2013-10-23
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BRPI0815611A2 (pt) 2015-03-24
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US7728027B2 (en) 2010-06-01
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