AR201880A1 - Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol - Google Patents

Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol

Info

Publication number
AR201880A1
AR201880A1 AR255045A AR25504574A AR201880A1 AR 201880 A1 AR201880 A1 AR 201880A1 AR 255045 A AR255045 A AR 255045A AR 25504574 A AR25504574 A AR 25504574A AR 201880 A1 AR201880 A1 AR 201880A1
Authority
AR
Argentina
Prior art keywords
nitrotiazol
benzamido
procedure
preparation
new derivatives
Prior art date
Application number
AR255045A
Other languages
English (en)
Original Assignee
Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sprl filed Critical Sprl
Application granted granted Critical
Publication of AR201880A1 publication Critical patent/AR201880A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AR255045A 1973-08-08 1974-08-05 Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol AR201880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (1)

Publication Number Publication Date
AR201880A1 true AR201880A1 (es) 1975-04-24

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
AR255045A AR201880A1 (es) 1973-08-08 1974-08-05 Procedimiento para la preparacion de nuevos derivados de 2-benzamido-5-nitrotiazol

Country Status (14)

Country Link
US (1) US3950351A (es)
JP (1) JPS5041858A (es)
AR (1) AR201880A1 (es)
BE (1) BE817878A (es)
CA (1) CA1041519A (es)
CH (1) CH583215A5 (es)
DE (1) DE2438037C2 (es)
ES (1) ES428906A1 (es)
FR (1) FR2240010B1 (es)
GB (1) GB1437800A (es)
IL (1) IL45194A (es)
NL (1) NL176779C (es)
OA (1) OA04761A (es)
ZA (1) ZA744409B (es)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435905A1 (fr) * 1978-09-13 1980-04-11 Anvar Nouveaux agents molluscicides derives du benzamido-2 nitro-5 thiazole
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
EP0031563B1 (en) * 1979-12-21 1983-09-14 The Wellcome Foundation Limited Nitrothiazolines, their preparation and pharmaceutical formulations containing them
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
PT755386E (pt) * 1994-04-13 2002-11-29 Romark Lab Lc Derivado de benzamida composicoes contendo o referido derivado e sua utilizacao
US5968961A (en) * 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5859038A (en) * 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
AU756451B2 (en) * 1997-05-07 2003-01-16 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
ES2232687T3 (es) * 1997-05-07 2005-06-01 Romark Laboratories, L.C. Composiciones farmaceuticas de tizoxanida y/o nitazoxanida.
US5935591A (en) * 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US5925622A (en) * 1998-07-13 1999-07-20 Romark Laboratories, L.C. Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazolyl) benzamide, and pharmaceutical compositions comprising same
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7125568B2 (en) * 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0325402D0 (en) * 2003-10-31 2003-12-03 Astrazeneca Ab Compounds
GB0327761D0 (en) * 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
GB0328178D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Compounds
DE602005013491D1 (de) * 2004-02-18 2009-05-07 Astrazeneca Ab Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel
KR20070007104A (ko) * 2004-02-18 2007-01-12 아스트라제네카 아베 화합물
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
UA90864C2 (en) 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
KR20070085371A (ko) 2004-10-16 2007-08-27 아스트라제네카 아베 페녹시 벤즈아미드 화합물의 제조 방법
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
CA2604640A1 (en) * 2005-04-12 2006-10-19 Romark Laboratories L.C. Methods for treating diseases through interruption of protein maturation, compounds that inhibit the function of molecular chaperones such as protein disulfide isomerases or interfere with glycosylation, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
CA2614746C (en) * 2005-07-09 2011-05-10 Astrazeneca Ab Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
AP2907A (en) 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment
WO2008008480A2 (en) * 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) * 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
UY30822A1 (es) * 2006-12-21 2008-07-31 Astrazeneca Ab Fnueva forma cristalina de 3-{[5-azetidin-1-ylcabonyl)pyrazin-2-yl]oxy}-5-[1-methylethyloxy]-n-1h-pyrazol-3-ylbenzamida, composiciones conteniéndola, procesos de preparacion y aplicaciones
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
EP2178852B9 (en) 2007-08-03 2016-06-22 Romark Laboratories, L.C. Alkylsulfonyl-substituted thiazolide compounds
CA2732165A1 (en) * 2008-08-04 2010-02-11 Astrazeneca Ab Therapeutic agents 414
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
US8524278B2 (en) 2009-02-13 2013-09-03 Romark Laboratories L.C. Controlled release pharmaceutical formulations of nitazoxanide
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
PE20121118A1 (es) * 2009-05-12 2012-09-05 Romark Lab Lc Compuestos de haloalquil heteroaril benzamida
AP2012006064A0 (en) 2009-06-26 2012-02-29 Romark Lab Lc Compounds and methods for treating influenza.
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
US9498441B2 (en) 2012-01-27 2016-11-22 Siegfried Rhein S.A. De C.V. Nitazoxadine composition and process to prepare same
EP2902024B1 (en) 2012-09-27 2017-11-29 Siegfried Rhein S.A. De C.V. Synergic composition of nitazoxanide and mebendazole, methods for the preparation thereof, and use of said composition for the treatment of human parasitosis
WO2014205414A1 (en) * 2013-06-21 2014-12-24 The Regents Of The University Of California Expanded therapeutic potential in nitroheteroaryl antimicrobials
PT3166607T (pt) 2014-07-11 2022-12-07 Gilead Sciences Inc Moduladores de receptores de tipo toll para o tratamento do vih
CA2960436C (en) 2014-09-16 2021-01-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
CN107105660A (zh) 2014-11-11 2017-08-29 罗马克实验室有限公司 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
CN108289961A (zh) 2016-03-31 2018-07-17 罗马克实验室有限公司 用于治疗病毒性感染的噻唑化物化合物
EA202191466A1 (ru) 2016-04-11 2021-12-31 Женфит Способы лечения холестатических и фибротических заболеваний
SG11201906041QA (en) 2017-01-27 2019-08-27 Genfit Pharmaceutical compositions for combination therapy
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
WO2019241376A1 (en) 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof
CA3130518A1 (en) 2019-04-12 2020-10-15 Nicolas STANKOVIC-VALENTIN Nitazoxanide and thiazolides for use in the treatment of diseases associated with oxidative stress
CA3153784A1 (en) 2019-10-28 2021-05-06 Nicolas STANKOVIC-VALENTIN Combination therapy of elafibranor and nitazoxanide having antioxident properties
EP4182304A1 (en) 2020-07-20 2023-05-24 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
MX2023002208A (es) 2020-08-24 2023-05-17 Romark Laboratories Lc Uso de tiazolidas contra los coronavirus.
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
CN115197164B (zh) * 2021-04-12 2025-04-01 杜心赟 新型噻唑类化合物及其制备方法和用途
DE112022004799T5 (de) 2021-10-05 2024-08-14 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Verbessertes Verfahren zur Herstellung von Nitazoxanid und Zwischenprodukten davon
WO2023198095A1 (zh) * 2022-04-12 2023-10-19 成都贝诺科成生物科技有限公司 一种硝基噻唑衍生物在制备抑制幽门螺杆菌的抑菌剂中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2829084A (en) * 1958-04-01 Certain alkyl-n
CA497537A (en) * 1953-11-10 H. Clark Joe 2-substituted amino-5-nitrothiazoles
US2735798A (en) * 1956-02-21 Acyl amevo-nitrothiazole compositions
US2401522A (en) * 1942-04-17 1946-06-04 Firm Sandoz Ltd Aromatic carboxylic acid amides and a process for their manufacture
GB577418A (en) * 1942-04-17 1946-05-17 Sandoz Ltd Process for the preparation of amides of aromatic carboxylic acids
FR1306603A (fr) * 1958-08-14 1962-10-19 Innothera Lab Sa Dérivés thiazoliques et leur procédé de préparation
US3475446A (en) * 1967-06-27 1969-10-28 Parke Davis & Co N-(5-nitro-2-thiazolyl)-cycloalkanecarboxamides

Also Published As

Publication number Publication date
JPS5041858A (es) 1975-04-16
IL45194A (en) 1977-10-31
FR2240010A1 (es) 1975-03-07
FR2240010B1 (es) 1978-03-24
NL7409321A (nl) 1975-02-11
US3950351A (en) 1976-04-13
IL45194A0 (en) 1974-10-22
NL176779B (nl) 1985-01-02
OA04761A (fr) 1980-08-31
GB1437800A (en) 1976-06-03
CA1041519A (en) 1978-10-31
NL176779C (nl) 1985-06-03
DE2438037A1 (de) 1975-02-20
ES428906A1 (es) 1976-08-16
DE2438037C2 (de) 1982-06-09
ZA744409B (en) 1975-07-30
AU7135574A (en) 1976-01-22
BE817878A (fr) 1975-01-20
CH583215A5 (es) 1976-12-31

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