BE817878A - Nouveaux derives du benzamido-2 nitro-5 thiazole - Google Patents

Nouveaux derives du benzamido-2 nitro-5 thiazole

Info

Publication number
BE817878A
BE817878A BE146759A BE146759A BE817878A BE 817878 A BE817878 A BE 817878A BE 146759 A BE146759 A BE 146759A BE 146759 A BE146759 A BE 146759A BE 817878 A BE817878 A BE 817878A
Authority
BE
Belgium
Prior art keywords
benzamido
thiazole
nitro
new derivatives
derivatives
Prior art date
Application number
BE146759A
Other languages
English (en)
Inventor
J-F Rossignol
R Cavier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE817878A publication Critical patent/BE817878A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/58—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BE146759A 1973-08-08 1974-07-19 Nouveaux derives du benzamido-2 nitro-5 thiazole BE817878A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3760873A GB1437800A (en) 1973-08-08 1973-08-08 Derivatives of 2-benzamido-5-nitro-thiazoles

Publications (1)

Publication Number Publication Date
BE817878A true BE817878A (fr) 1975-01-20

Family

ID=10397712

Family Applications (1)

Application Number Title Priority Date Filing Date
BE146759A BE817878A (fr) 1973-08-08 1974-07-19 Nouveaux derives du benzamido-2 nitro-5 thiazole

Country Status (14)

Country Link
US (1) US3950351A (fr)
JP (1) JPS5041858A (fr)
AR (1) AR201880A1 (fr)
BE (1) BE817878A (fr)
CA (1) CA1041519A (fr)
CH (1) CH583215A5 (fr)
DE (1) DE2438037C2 (fr)
ES (1) ES428906A1 (fr)
FR (1) FR2240010B1 (fr)
GB (1) GB1437800A (fr)
IL (1) IL45194A (fr)
NL (1) NL176779C (fr)
OA (1) OA04761A (fr)
ZA (1) ZA744409B (fr)

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* Cited by examiner, † Cited by third party
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GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
KR20070085371A (ko) 2004-10-16 2007-08-27 아스트라제네카 아베 페녹시 벤즈아미드 화합물의 제조 방법
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
AU2006235490A1 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
EP1891069A1 (fr) * 2005-05-24 2008-02-27 AstraZeneca AB Derives d'imidazol[4,5b]pyridine/pyrazine et purine substitues en 2-phenyl en tant que modulateurs de la glucokinase
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
EP2027113A1 (fr) * 2005-07-09 2009-02-25 AstraZeneca AB Dérivés d'hétéroaryl benzamide utilisés en tant qu'activateurs de la glk dans le traitement du diabète
JP2009500442A (ja) * 2005-07-09 2009-01-08 アストラゼネカ アクチボラグ ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物
KR101346902B1 (ko) * 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200738621A (en) * 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
CA2636527C (fr) 2006-01-09 2016-05-17 Romark Laboratories, L.C. Traitement de l'hepatite virale
WO2008008480A2 (fr) * 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Dérivés de rifamycine contenant du nitrohétéroaryl
CN100465169C (zh) * 2006-08-02 2009-03-04 杭州欣阳三友精细化工有限公司 硝唑尼特的制备方法
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
KR20090090390A (ko) * 2006-12-21 2009-08-25 아스트라제네카 아베 Ｇｌｋ 활성제로서 유용한 신규 결정 화합물
CN101007792B (zh) * 2007-01-31 2010-05-26 浙江大学 一种合成硝基噻唑苯酰胺化合物的方法
ES2550755T3 (es) 2007-08-03 2015-11-12 Romark Laboratories, L.C. Compuestos de tiazolida sustituidos con alquilsulfonilo
EP2324028A2 (fr) * 2008-08-04 2011-05-25 AstraZeneca AB Agents thérapeutiques 414
RS53347B (sr) 2008-12-09 2014-10-31 Gilead Sciences, Inc. Modulatori toll-sličnih receptora
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
SI2395840T1 (sl) 2009-02-13 2020-08-31 Romark Laboratories, L.C. Farmacevtske formulacije nitazoksanida z nadzorovanim sproščanjem
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
WO2010116177A1 (fr) 2009-04-09 2010-10-14 Astrazeneca Ab Dérivé de pyrazolo [4,5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité
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CN108042535A (zh) 2009-06-26 2018-05-18 罗马克实验室有限公司 用于治疗流感的化合物和方法
CN101602744B (zh) * 2009-06-30 2011-06-01 青岛康地恩药业有限公司 一种硝唑尼特的制备方法
WO2013110975A1 (fr) 2012-01-27 2013-08-01 Siegfried Rhein S.A. De C.V. Composition de nitazoxanide améliorée et son procédé de préparation
WO2014049397A1 (fr) 2012-09-27 2014-04-03 Siegfried Rhein S.A. De C.V. Composition synergique de nitazoxanide et de mébendazole, procédés de préparation correspondants et utilisation de cette composition dans le traitement de la parasitose humaine
EP3010345A4 (fr) * 2013-06-21 2017-04-12 The Regents of The University of California Potentiel thérapeutique étendu dans des antimicrobiens à nitrohétéroaryle
JP6522732B2 (ja) 2014-07-11 2019-05-29 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖを治療するためのトール様受容体の調節因子
SG11201701520TA (en) 2014-09-16 2017-04-27 Gilead Sciences Inc Solid forms of a toll-like receptor modulator
MX2017006083A (es) 2014-11-11 2017-11-08 Romark Laboratories Lc Composicones y metodos de tratamiento con profarmacos de tizoxanida, un analogo o sal de la misma.
CN105175352A (zh) * 2015-10-27 2015-12-23 杭州澳医保灵药业有限公司 一种硝唑尼特的制备方法
CN106831640A (zh) * 2015-12-03 2017-06-13 江苏正大丰海制药有限公司 一种硝唑尼特晶体的制备方法
PT3436074T (pt) 2016-03-31 2020-08-21 Romark Laboratories Lc Compostos tiazolida para tratamento de infeções virais
JP6894923B2 (ja) 2016-04-11 2021-06-30 ジェンフィＧｅｎｆｉｔ 胆汁うっ滞性及び線維性の疾患の処置方法
US11033534B2 (en) 2017-01-27 2021-06-15 Genfit Pharmaceutical compositions for combination therapy
WO2018195035A1 (fr) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition de la protéine disulfure-isomérase a3
WO2019241376A1 (fr) 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Traitement de troubles cognitifs à l'aide de nitazoxanide (ntz), d'analogues de nitazoxanide (ntz) et de leurs métabolites
CA3130518A1 (fr) 2019-04-12 2020-10-15 Nicolas STANKOVIC-VALENTIN Nitazoxanide et thiazolides destines a etre utilises dans le traitement de maladies associees au stress oxydatif
TWI810456B (zh) 2019-05-22 2023-08-01 美商基利科學股份有限公司 Tlr7調節化合物及hiv疫苗之組合
JP7741800B2 (ja) 2019-10-28 2025-09-18 ジェンフィット 抗酸化性質を有する併用療法
US20230303504A1 (en) 2020-07-20 2023-09-28 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
MX2023002208A (es) 2020-08-24 2023-05-17 Romark Laboratories Lc Uso de tiazolidas contra los coronavirus.
CN114044761B (zh) * 2021-02-24 2022-05-17 成都贝诺科成生物科技有限公司 一种新的硝基噻唑衍生物及其应用
CN115197164B (zh) * 2021-04-12 2025-04-01 杜心赟 新型噻唑类化合物及其制备方法和用途
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CA497537A (fr) * 1953-11-10 H. Clark Joe Amino-5-nitrothiazoles 2-substitues
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US3475446A (en) * 1967-06-27 1969-10-28 Parke Davis & Co N-(5-nitro-2-thiazolyl)-cycloalkanecarboxamides

Also Published As

Publication number Publication date
OA04761A (fr) 1980-08-31
FR2240010B1 (fr) 1978-03-24
IL45194A0 (en) 1974-10-22
CH583215A5 (fr) 1976-12-31
JPS5041858A (fr) 1975-04-16
NL7409321A (nl) 1975-02-11
NL176779C (nl) 1985-06-03
GB1437800A (en) 1976-06-03
NL176779B (nl) 1985-01-02
IL45194A (en) 1977-10-31
AU7135574A (en) 1976-01-22
FR2240010A1 (fr) 1975-03-07
ZA744409B (en) 1975-07-30
US3950351A (en) 1976-04-13
AR201880A1 (es) 1975-04-24
CA1041519A (fr) 1978-10-31
DE2438037C2 (de) 1982-06-09
ES428906A1 (es) 1976-08-16
DE2438037A1 (de) 1975-02-20

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ROSSIGNOL JEAN-FRANCOIS

Effective date: 19850731