AR218500A1 - Procedimiento para la obtencion de derivados de 1,5-dihidro-imidazo(2,1-b)quinazolin-2(3h)-ona 3-sustituidos - Google Patents

Procedimiento para la obtencion de derivados de 1,5-dihidro-imidazo(2,1-b)quinazolin-2(3h)-ona 3-sustituidos

Info

Publication number
AR218500A1
AR218500A1 AR273064A AR27306478A AR218500A1 AR 218500 A1 AR218500 A1 AR 218500A1 AR 273064 A AR273064 A AR 273064A AR 27306478 A AR27306478 A AR 27306478A AR 218500 A1 AR218500 A1 AR 218500A1
Authority
AR
Argentina
Prior art keywords
quinazolin
ona
imidazo
dihydro
substituted
Prior art date
Application number
AR273064A
Other languages
English (en)
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of AR218500A1 publication Critical patent/AR218500A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AR273064A 1977-07-25 1978-07-25 Procedimiento para la obtencion de derivados de 1,5-dihidro-imidazo(2,1-b)quinazolin-2(3h)-ona 3-sustituidos AR218500A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (1)

Publication Number Publication Date
AR218500A1 true AR218500A1 (es) 1980-06-13

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
AR273064A AR218500A1 (es) 1977-07-25 1978-07-25 Procedimiento para la obtencion de derivados de 1,5-dihidro-imidazo(2,1-b)quinazolin-2(3h)-ona 3-sustituidos

Country Status (29)

Country Link
US (1) US4256748A (fr)
EP (1) EP0000718B1 (fr)
JP (1) JPS5441894A (fr)
AR (1) AR218500A1 (fr)
AT (1) AT363479B (fr)
AU (1) AU519688B2 (fr)
BR (1) BR7804763A (fr)
CA (1) CA1094555A (fr)
CS (1) CS203014B2 (fr)
DE (2) DE2861688D1 (fr)
DK (1) DK144128C (fr)
ES (2) ES471981A1 (fr)
FI (1) FI63409C (fr)
FR (1) FR2398748A1 (fr)
GB (1) GB2001638B (fr)
GR (1) GR72968B (fr)
HU (1) HU177643B (fr)
IE (1) IE47280B1 (fr)
IL (1) IL55183A (fr)
IT (1) IT1097337B (fr)
MC (1) MC1199A1 (fr)
MY (1) MY8500249A (fr)
NL (1) NL7807507A (fr)
NO (1) NO150800C (fr)
NZ (1) NZ187921A (fr)
PH (1) PH14642A (fr)
PT (1) PT68342A (fr)
SE (1) SE7808111L (fr)
YU (1) YU177578A (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
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EP0029559A3 (fr) * 1979-11-24 1981-09-30 Sandoz Ag 5,10 Dihydroimidazo (2,1-b) quinazoléines, leur préparation et compositions pharmaceutiques les contenant
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (fr) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Procédé pour la préparation de dérivés de l'imidazoquinazoline
JPS57178234U (fr) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
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US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
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JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
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US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
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US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
CZ281628B6 (cs) * 1991-07-29 1996-11-13 Warner-Lambert Company Deriváty chinazolinu a farmaceutické přípravky na jejich bázi
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
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JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
EP1216037A2 (fr) * 1999-09-21 2002-06-26 Emory University Procedes et compositions pour le traitement de troubles lies aux plaquettes au moyen d'agents inhibiteurs de trajet de mpl
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
US20040209907A1 (en) * 2003-01-23 2004-10-21 Richard Franklin Formulation and methods for the treatment of thrombocythemia
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (fr) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
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GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
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EP2810951B1 (fr) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905438A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
WO2020237096A1 (fr) 2019-05-21 2020-11-26 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient
EP4201403A1 (fr) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2

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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
GR72968B (fr) 1984-01-20
FI782248A7 (fi) 1979-01-26
EP0000718A3 (en) 1979-06-13
CA1094555A (fr) 1981-01-27
IE47280B1 (en) 1984-02-08
NO150800C (no) 1984-12-27
GB2001638B (en) 1982-02-10
FR2398748B1 (fr) 1981-09-04
PT68342A (en) 1978-08-01
DK144128C (da) 1982-05-17
DE2861688D1 (en) 1982-04-29
MY8500249A (en) 1985-12-31
IL55183A (en) 1981-11-30
FI63409C (fi) 1983-06-10
MC1199A1 (fr) 1979-03-19
CS203014B2 (en) 1981-02-27
FR2398748A1 (fr) 1979-02-23
JPS5441894A (en) 1979-04-03
YU177578A (en) 1983-01-21
IL55183A0 (en) 1978-09-29
IE781478L (en) 1979-01-25
DK328978A (da) 1979-01-26
SE7808111L (sv) 1979-01-26
AU3812778A (en) 1980-01-24
NO782541L (no) 1979-01-26
NO150800B (no) 1984-09-10
ES471981A1 (es) 1979-10-16
DK144128B (da) 1981-12-14
US4256748A (en) 1981-03-17
PH14642A (en) 1981-10-12
IT7826019A0 (it) 1978-07-24
ES476955A1 (es) 1979-10-16
EP0000718A2 (fr) 1979-02-21
BR7804763A (pt) 1979-04-10
AU519688B2 (en) 1981-12-17
ATA535178A (de) 1981-01-15
NZ187921A (en) 1981-03-16
HU177643B (en) 1981-11-28
NL7807507A (nl) 1979-01-29
EP0000718B1 (fr) 1982-03-24
GB2001638A (en) 1979-02-07
FI63409B (fi) 1983-02-28
IT1097337B (it) 1985-08-31
DE2832138A1 (de) 1979-02-08
AT363479B (de) 1981-08-10

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