AT335430B - PROCESS FOR PREPARING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS - Google Patents

PROCESS FOR PREPARING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Info

Publication number
AT335430B
AT335430B AT447775A AT447775A AT335430B AT 335430 B AT335430 B AT 335430B AT 447775 A AT447775 A AT 447775A AT 447775 A AT447775 A AT 447775A AT 335430 B AT335430 B AT 335430B
Authority
AT
Austria
Prior art keywords
sep
biphenylyl
amides
esters
salts
Prior art date
Application number
AT447775A
Other languages
German (de)
Other versions
ATA447775A (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732341507 external-priority patent/DE2341507A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to AT447775A priority Critical patent/AT335430B/en
Publication of ATA447775A publication Critical patent/ATA447775A/en
Application granted granted Critical
Publication of AT335430B publication Critical patent/AT335430B/en

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Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

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  ErHndtmgbetrifft <SEP> einVerfahrenSubstanz <SEP> Kaolinödem <SEP> Carrageenin- <SEP> Mittelakute <SEP> Toxizität <SEP> Ratte <SEP> Therapeut. <SEP> Index
<tb> ED35per <SEP> os <SEP> ödem <SEP> wert
<tb> mg/kg <SEP> ED35 <SEP> per <SEP> os <SEP> ED35 <SEP> mg/kg <SEP> Vertr <SEP> Grenzen <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> toximg/kg <SEP> mg/kg <SEP> 95%iger <SEP> Wahr- <SEP> scher <SEP> und <SEP> antiexsudativer <SEP> 
<tb> s <SEP> cheinlichkeit <SEP> Wirkung
<tb> LD50 <SEP> /ED <SEP> 35
<tb> Phenylbutazon <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13,6
<tb> A <SEP> 11 <SEP> 9, <SEP> 3 <SEP> 10, <SEP> 1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98,5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26,

   <SEP> 0 <SEP> 
<tb> Substanz <SEP> Mittelwert <SEP> Ulcerogene <SEP> Wirkung <SEP> Therapeutischer <SEP> Index
<tb> 35 <SEP> ED50 <SEP> (U) <SEP> Vertrauensbereich <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> ulcerogener <SEP> 
<tb> mg/kg <SEP> 95proz. <SEP> Wahrscheinlichkeit <SEP> und <SEP> antiexsudativer <SEP> Wirkung <SEP> 
<tb> mg/kg <SEP> ED50(U)/ED35
<tb> Phenylbutazon <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP> 
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, <SEP> 77 <SEP> 
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15, <SEP> 88 <SEP> - <SEP> 45, <SEP> 90 <SEP> 2, <SEP> 71 <SEP> 
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP> 
<tb> 
 
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<tb>
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  This concerns <SEP> a procedureSubstance <SEP> kaolin edema <SEP> carrageenin <SEP> medium acute <SEP> toxicity <SEP> rat <SEP> therapist. <SEP> index
<tb> ED35per <SEP> os <SEP> edema <SEP> worth
<tb> mg / kg <SEP> ED35 <SEP> per <SEP> os <SEP> ED35 <SEP> mg / kg <SEP> contract <SEP> limits <SEP> at <SEP> ratio <SEP> between <SEP > toximg / kg <SEP> mg / kg <SEP> 95% <SEP> true <SEP> shear <SEP> and <SEP> anti-exudative <SEP>
<tb> s <SEP> embarrassment <SEP> effect
<tb> LD50 <SEP> / ED <SEP> 35
<tb> Phenylbutazone <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13.6
<tb> A <SEP> 11 <SEP> 9, <SEP> 3 <SEP> 10, <SEP> 1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98.5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26,

   <SEP> 0 <SEP>
<tb> substance <SEP> mean value <SEP> ulcerogenic <SEP> effect <SEP> therapeutic <SEP> index
<tb> 35 <SEP> ED50 <SEP> (U) <SEP> Confidence range <SEP> at <SEP> ratio <SEP> between <SEP> ulcerogenic <SEP>
<tb> mg / kg <SEP> 95% <SEP> probability <SEP> and <SEP> anti-exudative <SEP> effect <SEP>
<tb> mg / kg <SEP> ED50 (U) / ED35
<tb> Phenylbutazone <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP>
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, < SEP> 77 <SEP>
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15, <SEP> 88 <SEP> - <SEP> 45, <SEP> 90 <SEP> 2, < SEP> 71 <SEP>
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP >
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Claims (1)

EMI5.2 EMI5.3 EMI5.4 EMI5.5 EMI5.2 EMI5.3 EMI5.4 EMI5.5
AT447775A 1973-08-16 1975-06-12 PROCESS FOR PREPARING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS AT335430B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT447775A AT335430B (en) 1973-08-16 1975-06-12 PROCESS FOR PREPARING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732341507 DE2341507A1 (en) 1973-08-16 1973-08-16 NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING
AT577674A AT331235B (en) 1973-08-16 1974-07-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT
AT447775A AT335430B (en) 1973-08-16 1975-06-12 PROCESS FOR PREPARING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Publications (2)

Publication Number Publication Date
ATA447775A ATA447775A (en) 1976-07-15
AT335430B true AT335430B (en) 1977-03-10

Family

ID=27149971

Family Applications (1)

Application Number Title Priority Date Filing Date
AT447775A AT335430B (en) 1973-08-16 1975-06-12 PROCESS FOR PREPARING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Country Status (1)

Country Link
AT (1) AT335430B (en)

Also Published As

Publication number Publication date
ATA447775A (en) 1976-07-15

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