AT335432B - PROCESS FOR PRODUCING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT - Google Patents

PROCESS FOR PRODUCING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Info

Publication number
AT335432B
AT335432B AT448275A AT448275A AT335432B AT 335432 B AT335432 B AT 335432B AT 448275 A AT448275 A AT 448275A AT 448275 A AT448275 A AT 448275A AT 335432 B AT335432 B AT 335432B
Authority
AT
Austria
Prior art keywords
sep
biphenylyl
amides
esters
salt
Prior art date
Application number
AT448275A
Other languages
German (de)
Other versions
ATA448275A (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732341507 external-priority patent/DE2341507A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to AT448275A priority Critical patent/AT335432B/en
Publication of ATA448275A publication Critical patent/ATA448275A/en
Application granted granted Critical
Publication of AT335432B publication Critical patent/AT335432B/en

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Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

   <Desc/Clms Page number 1> 
 
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<tb> 
<tb> betrifftSubstanz <SEP> Kaolinödem <SEP> Carrageeninödem <SEP> Mittelwert <SEP> akute <SEP> Toxizität <SEP> Ratte <SEP> Therapeut. <SEP> Index
<tb> ED <SEP> per <SEP> os <SEP> ED <SEP> per <SEP> os <SEP> ED35
<tb> mg <SEP> mg <SEP> mg/kg <SEP> mg/kg <SEP> Vertr.

   <SEP> Grenzen <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> toxischer
<tb> 95%iger <SEP> Wahr- <SEP> und <SEP> anti <SEP> exsudativer <SEP> Wirkung
<tb> scheinlichkeit <SEP> LD50/ED35
<tb> Phenylbutazon <SEP> 58 <SEP> 69 <SEP> 63,5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13,6
<tb> A <SEP> 11 <SEP> 9,3 <SEP> 10,1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98,5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 
<tb> 
 

 <Desc/Clms Page number 6> 

 
 EMI6.1 
 
<tb> 
<tb> Ulcerogene <SEP> Wirkung <SEP> Therapeutischer <SEP> Index
<tb> Substanz <SEP> Mittelwert
<tb> ED <SEP> ED <SEP> (U)

   <SEP> Vertrauensbereich <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> ulcerogener
<tb> mg/kg <SEP> 95%iger <SEP> Wahrscheinlichkeit <SEP> und <SEP> antiexsudativer <SEP> Wirkung
<tb> mg/kg <SEP> ED50 <SEP> (U)/ED35
<tb> Phenylbutazon <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP> 
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, <SEP> 77 <SEP> 
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15, <SEP> 88 <SEP> - <SEP> 45, <SEP> 90 <SEP> 2, <SEP> 71 <SEP> 
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> -101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP> 
<tb> 
 

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   <Desc / Clms Page number 1>
 
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<tb>
<tb> concerns substance <SEP> kaolin edema <SEP> carrageenin edema <SEP> mean value <SEP> acute <SEP> toxicity <SEP> rat <SEP> therapist. <SEP> index
<tb> ED <SEP> via <SEP> os <SEP> ED <SEP> via <SEP> os <SEP> ED35
<tb> mg <SEP> mg <SEP> mg / kg <SEP> mg / kg <SEP> re.

   <SEP> limits <SEP> at <SEP> ratio <SEP> between <SEP> more toxic
<tb> 95% <SEP> true- <SEP> and <SEP> anti <SEP> exudative <SEP> effect
<tb> probability <SEP> LD50 / ED35
<tb> Phenylbutazone <SEP> 58 <SEP> 69 <SEP> 63.5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13.6
<tb> A <SEP> 11 <SEP> 9.3 <SEP> 10.1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98.5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP>
<tb>
 

 <Desc / Clms Page number 6>

 
 EMI6.1
 
<tb>
<tb> Ulcerogenic <SEP> effect <SEP> Therapeutic <SEP> index
<tb> substance <SEP> mean value
<tb> ED <SEP> ED <SEP> (U)

   <SEP> Confidence range <SEP> with <SEP> ratio <SEP> between <SEP> more ulcerogenic
<tb> mg / kg <SEP> 95% <SEP> probability <SEP> and <SEP> antiexudative <SEP> effect
<tb> mg / kg <SEP> ED50 <SEP> (U) / ED35
<tb> Phenylbutazone <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP>
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, < SEP> 77 <SEP>
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15, <SEP> 88 <SEP> - <SEP> 45, <SEP> 90 <SEP> 2, < SEP> 71 <SEP>
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> -101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP>
<tb>
 

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 EMI7.1
 
 EMI7.2
 

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 EMI8.1
 
 EMI8.2

Claims (1)

näherPATENTANSPRüCHE : EMI9.1 (4-Biphenylyl) -buttersäuren,meinen Formel EMI9.2 in der EMI9.3 R1B die Hydroxygruppe, eine Alkoxy- oder Aralkoxygruppe oder die Aminogruppe darstellen und, falls B die Hydroxygruppe bedeutet, von deren Salzen mit anorganischen oder organischen Basen, dadurch gekennzeichnet, dass 2-[2-(4-Biphenylyl)-propyliden]-1,3-dithiane der allgemeinen Formel EMI9.4 in der EMI9.5 Einzelkomponentenaufgetrennthalogenid der allgemeinen Formel EMI9.6 in der EMI9.7 PATENT CLAIMS: EMI9.1 (4-Biphenylyl) -butyric acids, my formula EMI9.2 in the EMI9.3 R1B represent the hydroxyl group, an alkoxy or aralkoxy group or the amino group and, if B denotes the hydroxyl group, of their salts with inorganic or organic bases, characterized in that 2- [2- (4-biphenylyl) propylidene] -1, 3-dithianes of the general formula EMI9.4 in the EMI9.5 Individual components separated halide of the general formula EMI9.6 in the EMI9.7
AT448275A 1973-08-16 1975-06-12 PROCESS FOR PRODUCING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT AT335432B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT448275A AT335432B (en) 1973-08-16 1975-06-12 PROCESS FOR PRODUCING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732341507 DE2341507A1 (en) 1973-08-16 1973-08-16 NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING
AT577674A AT331235B (en) 1973-08-16 1974-07-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT
AT448275A AT335432B (en) 1973-08-16 1975-06-12 PROCESS FOR PRODUCING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Publications (2)

Publication Number Publication Date
ATA448275A ATA448275A (en) 1976-07-15
AT335432B true AT335432B (en) 1977-03-10

Family

ID=27149977

Family Applications (1)

Application Number Title Priority Date Filing Date
AT448275A AT335432B (en) 1973-08-16 1975-06-12 PROCESS FOR PRODUCING NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Country Status (1)

Country Link
AT (1) AT335432B (en)

Also Published As

Publication number Publication date
ATA448275A (en) 1976-07-15

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