AT44962B - Process for the preparation of arsenoarylglycolic acids and -thioglycolic acids. - Google Patents

Process for the preparation of arsenoarylglycolic acids and -thioglycolic acids.

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Publication number
AT44962B
AT44962B AT44962DA AT44962B AT 44962 B AT44962 B AT 44962B AT 44962D A AT44962D A AT 44962DA AT 44962 B AT44962 B AT 44962B
Authority
AT
Austria
Prior art keywords
acids
arsenoarylglycolic
preparation
thioglycolic
acid
Prior art date
Application number
Other languages
German (de)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AT44962B publication Critical patent/AT44962B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

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   wird abgesandt und wiederholt mit Wasser gewaschen. Durch Umlösen unter Zuhilfenahme des Natriums kann die neue Verbindung Arsenophenylglykolsäure, rein erhalten werden. Das     Natriujnsalz ist gelb, in Wasser leicht, in Alkohol schwer löslich.   Aus ihm wird die freie Säure durch Essigsäure als gelber,   voluminöser   Niederschlag abgeschieden. Sie reduziert ammoniakalische   Silberlösuhg   in der Kälte. 
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 eintritt. Durch Erwärmen wird die Umsetzung zu Ende geführt und in die erkaltete   Lösung.   welche die Arsenoxydphenylthioglykolsäure enthält, portionsweise 50 g 4prozentiges Natronamalgam eingetragen.

   Es scheidet sich dann das Natriumsalz der Arsenphenylthioglykolsäure 
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 gelbes Produkt aus der Lösung durch Mineralsäure abgeschieden ; ammoniakalische Silberlösung wird durch sie in der Kalte reduziert. 



   In analoger Weise können andere Arylglykol- und -thioglykolarsinsäuren in die entsprechende Arsenoarylglykol- und -thioglykolsäuren übergeführt werden. Der trypanozide Charakter der neuen Arsenoverbindungen ist so gross, dass durch sie auch Tiere geheilt werden, die mit hoch   gradig widerstandsfähigen   Trypanosomen infiziert sind. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



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   is sent and washed repeatedly with water. The new compound arsenophenylglycolic acid can be obtained in pure form by dissolving with the aid of sodium. The sodium salt is yellow, easily soluble in water and sparingly soluble in alcohol. Acetic acid separates the free acid from it as a voluminous yellow precipitate. It reduces ammoniacal silver solution in the cold.
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 entry. The reaction is completed by warming and the solution is cooled down. which contains the arsenic oxydphenylthioglycolic acid, added a portion of 50 g of 4 percent sodium amalgam.

   The sodium salt of arsenic phenylthioglycolic acid then separates out
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 yellow product deposited from solution by mineral acid; ammoniacal silver solution is reduced by them in the cold.



   In an analogous manner, other arylglycolic and thioglycolarsinic acids can be converted into the corresponding arsenoarylglycolic and thioglycolic acids. The trypanocidal character of the new arsenic compounds is so great that they can also cure animals that are infected with highly resistant trypanosomes.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANRPRUC'H : EMI2.3 **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT REQUEST: EMI2.3 ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT44962D 1908-10-08 1909-03-10 Process for the preparation of arsenoarylglycolic acids and -thioglycolic acids. AT44962B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE44962X 1908-10-08
AT41465T 1909-02-13

Publications (1)

Publication Number Publication Date
AT44962B true AT44962B (en) 1910-11-10

Family

ID=25600860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT44962D AT44962B (en) 1908-10-08 1909-03-10 Process for the preparation of arsenoarylglycolic acids and -thioglycolic acids.

Country Status (1)

Country Link
AT (1) AT44962B (en)

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