AT528464A5 - VERFAHREN ZUR HERSTELLUNG von 5-{2-[BENZYL-(1-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO]-1-HYDROXYETHYL}BENZEN-1,3-DIOL-HEMIFUMARAT - Google Patents

VERFAHREN ZUR HERSTELLUNG von 5-{2-[BENZYL-(1-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO]-1-HYDROXYETHYL}BENZEN-1,3-DIOL-HEMIFUMARAT

Info

Publication number
AT528464A5
AT528464A5 ATA95011/2025A AT950112025A AT528464A5 AT 528464 A5 AT528464 A5 AT 528464A5 AT 950112025 A AT950112025 A AT 950112025A AT 528464 A5 AT528464 A5 AT 528464A5
Authority
AT
Austria
Prior art keywords
methylethyl
hydroxyphenyl
hydroxyethyl
benzene
amino
Prior art date
Application number
ATA95011/2025A
Other languages
English (en)
Other versions
AT528464A2 (de
AT528464B1 (de
Inventor
Lenna Roberto
Maria Luoni Giovanna
Magnifico Dalila
Noseda Monica
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Publication of AT528464A2 publication Critical patent/AT528464A2/de
Application granted granted Critical
Publication of AT528464B1 publication Critical patent/AT528464B1/de
Publication of AT528464A5 publication Critical patent/AT528464A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 5-{2-[Benzyl-(1-(4- hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzol-1,3-diol-Hemifumarat im industriellen Maßstab, einem Salz, das aus zwei Molekülen 5-{2-[Benzyl-(1-(4- hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzol-1,3-diol und einem Molekül Fumarsäure besteht und die folgende Formel hat: 5-{2-[Benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzol-1,3-diol- Hemifumarat ist ein nützliches Zwischenprodukt bei der Synthese von 5-[(1RS)-2-[(1RS)-2- (4-Hydroxyphenyl)-1-methylethyl]-amino-1-hydroxyethyl]benzol-1,3-diol-hydrobromid, das im pharmazeutischen Bereich unter dem gebräuchlichen Namen Fenoterolhydrobromid bekannt ist.
ATA95011/2025A 2023-04-26 2024-04-19 VERFAHREN ZUR HERSTELLUNG von 5-{2-[BENZYL-(1-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO]-1-HYDROXYETHYL}BENZEN-1,3-DIOL-HEMIFUMARAT AT528464B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102023000008112A IT202300008112A1 (it) 2023-04-26 2023-04-26 Processo per la preparazione di emifumarato di 5-{2-[benzil-(1-(4-idrossifenil)-1-metiletil)ammino]-1-idrossietil}benzene-1,3-diolo
PCT/EP2024/060701 WO2024223428A1 (en) 2023-04-26 2024-04-19 Process for preparing 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol hemifumarate

Publications (3)

Publication Number Publication Date
AT528464A2 AT528464A2 (de) 2025-12-15
AT528464B1 AT528464B1 (de) 2026-05-15
AT528464A5 true AT528464A5 (de) 2026-05-15

Family

ID=87514228

Family Applications (1)

Application Number Title Priority Date Filing Date
ATA95011/2025A AT528464B1 (de) 2023-04-26 2024-04-19 VERFAHREN ZUR HERSTELLUNG von 5-{2-[BENZYL-(1-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO]-1-HYDROXYETHYL}BENZEN-1,3-DIOL-HEMIFUMARAT

Country Status (10)

Country Link
KR (1) KR20260003013A (de)
CN (1) CN121358709A (de)
AT (1) AT528464B1 (de)
CO (1) CO2025016166A2 (de)
DE (1) DE112024001886T5 (de)
ES (1) ES3043807A2 (de)
FR (1) FR3148237B1 (de)
IT (1) IT202300008112A1 (de)
PE (1) PE20260045A1 (de)
WO (1) WO2024223428A1 (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300751A (de) 1962-11-30 1900-01-01

Also Published As

Publication number Publication date
WO2024223428A1 (en) 2024-10-31
ES3043807A2 (es) 2025-11-25
DE112024001886T5 (de) 2026-02-19
IT202300008112A1 (it) 2024-10-26
AT528464A2 (de) 2025-12-15
PE20260045A1 (es) 2026-01-09
KR20260003013A (ko) 2026-01-06
CN121358709A (zh) 2026-01-16
FR3148237A1 (fr) 2024-11-01
AT528464B1 (de) 2026-05-15
FR3148237B1 (fr) 2025-10-17
CO2025016166A2 (es) 2025-12-09