AT9258U2 - Transdermal-pflaster zum verabreichen von fentanyl - Google Patents
Transdermal-pflaster zum verabreichen von fentanyl Download PDFInfo
- Publication number
- AT9258U2 AT9258U2 AT0013207U AT1322007U AT9258U2 AT 9258 U2 AT9258 U2 AT 9258U2 AT 0013207 U AT0013207 U AT 0013207U AT 1322007 U AT1322007 U AT 1322007U AT 9258 U2 AT9258 U2 AT 9258U2
- Authority
- AT
- Austria
- Prior art keywords
- fentanyl
- administration
- transdermal plaster
- transdermal
- plaster
- Prior art date
Links
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002428 fentanyl Drugs 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000037317 transdermal delivery Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Ein Verfahren und ein nicht in seiner Abgaberate gesteuertes monolithisches, untersättigtes Pflaster zur transdermalen Verabreichung von Fentanyl und Analogstoffen desselben zu analgetischen Zwecken an eine Person durch die Haut über einen ausgedehnten Zeitraum.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27683701P | 2001-03-16 | 2001-03-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AT9258U2 true AT9258U2 (de) | 2007-07-15 |
| AT9258U3 AT9258U3 (de) | 2008-05-15 |
Family
ID=23058257
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02715112T ATE364380T1 (de) | 2001-03-16 | 2002-03-15 | Transdermales pflaster zur verabreichung von fentanyl |
| AT0031105U AT8273U1 (de) | 2001-03-16 | 2005-05-10 | Transdermal-pflaster zum verabreichen von fentanyl |
| AT0034606U AT8585U3 (de) | 2001-03-16 | 2006-04-26 | Transdermal-pflaster zum verabreichen von fentanyl |
| AT0013207U AT9258U3 (de) | 2001-03-16 | 2007-03-02 | Transdermal-pflaster zum verabreichen von fentanyl |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02715112T ATE364380T1 (de) | 2001-03-16 | 2002-03-15 | Transdermales pflaster zur verabreichung von fentanyl |
| AT0031105U AT8273U1 (de) | 2001-03-16 | 2005-05-10 | Transdermal-pflaster zum verabreichen von fentanyl |
| AT0034606U AT8585U3 (de) | 2001-03-16 | 2006-04-26 | Transdermal-pflaster zum verabreichen von fentanyl |
Country Status (21)
| Country | Link |
|---|---|
| US (11) | US20030026829A1 (de) |
| EP (1) | EP1381352B1 (de) |
| JP (7) | JP5354763B2 (de) |
| KR (1) | KR100904158B1 (de) |
| CN (2) | CN101524339A (de) |
| AT (4) | ATE364380T1 (de) |
| CA (1) | CA2440884C (de) |
| CY (1) | CY1106834T1 (de) |
| CZ (1) | CZ307857B6 (de) |
| DE (3) | DE02715112T1 (de) |
| DK (2) | DK1381352T3 (de) |
| ES (1) | ES2270746T3 (de) |
| FI (2) | FI6962U1 (de) |
| IL (3) | IL157822A0 (de) |
| MX (1) | MXPA03008349A (de) |
| NZ (1) | NZ528148A (de) |
| PL (1) | PL363079A1 (de) |
| PT (1) | PT1381352E (de) |
| RU (2) | RU2708563C2 (de) |
| WO (1) | WO2002074286A1 (de) |
| ZA (1) | ZA200308026B (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
| ES2270746T3 (es) * | 2001-03-16 | 2007-12-01 | Alza Corporation | Parche transdermico para administrar fentanilo. |
| US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
| US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| JP2005526839A (ja) * | 2002-04-23 | 2005-09-08 | アルザ・コーポレーシヨン | 不正使用の可能性が低い経皮鎮痛薬システム |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| DE10223835A1 (de) * | 2002-05-28 | 2003-12-11 | Labtec Gmbh | Pflaster, enthaltend Fentanylum |
| DE20321052U1 (de) * | 2002-05-28 | 2005-09-22 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Pflaster, enthaltend Fentanylum |
| EP1386604A1 (de) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Verbessertes transdermales Verabreichungssystem |
| TWI296531B (en) | 2002-10-18 | 2008-05-11 | Hisamitsu Pharmaceutical Co | Transdermal adhesive preparations for topical administration of fentanyl |
| US20040086551A1 (en) * | 2002-10-30 | 2004-05-06 | Miller Kenneth J. | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl |
| US20060078600A1 (en) * | 2003-02-07 | 2006-04-13 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof |
| US8790689B2 (en) | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| US7182955B2 (en) * | 2003-04-30 | 2007-02-27 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
| RS20050812A (sr) * | 2003-04-30 | 2007-12-31 | Purdue Pharma L.P., | Transdermalni dozni oblik otporan na promene |
| US20040219195A1 (en) * | 2003-04-30 | 2004-11-04 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
| CA2543610A1 (en) | 2003-10-30 | 2005-05-19 | Alza Corporation | Transdermal analgesic systems having reduced abuse potential |
| EP1530967B1 (de) | 2003-11-13 | 2006-05-03 | Ferring B.V. | Blisterverpackung und feste Dosierungsform enthaltend Desmopressin |
| WO2006023644A2 (en) * | 2004-08-20 | 2006-03-02 | 3M Innovative Properties Company | Transdermal drug delivery device with translucent protective film |
| JP2008512471A (ja) * | 2004-09-08 | 2008-04-24 | ダーマトレンズ,インコーポレイティド | 疎水性生体活性物質の経皮送達 |
| AU2012201164B2 (en) * | 2004-10-21 | 2014-07-24 | Durect Corporation | Transdermal delivery systems |
| US8252319B2 (en) * | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| SI1814531T1 (sl) * | 2004-10-21 | 2010-10-29 | Durect Corp | Transdermalni dostavni sistem |
| GB0509276D0 (en) * | 2005-05-06 | 2005-06-15 | Univ Cranfield | Synthetic receptor |
| ATE478659T1 (de) | 2005-05-13 | 2010-09-15 | Alza Corp | Mehrlagiges arzneimittelausbringsystem mit sperre gegen reservoirmaterialfluss |
| TWI419717B (zh) * | 2005-06-17 | 2013-12-21 | Altea Therapeutics Corp | 滲透傳送系統及其使用方法 |
| US20070014728A1 (en) * | 2005-07-18 | 2007-01-18 | Imbert Delphine C | Device and method for increasing the throughput of irritation testing of transdermal formulations |
| US20070134310A1 (en) * | 2005-09-23 | 2007-06-14 | Nedberge Diane E | Transdermal risperidone delivery system |
| WO2007035941A2 (en) * | 2005-09-23 | 2007-03-29 | Alza Corporation | Transdermal galantamine delivery system |
| US8383149B2 (en) * | 2005-09-23 | 2013-02-26 | Alza Corporation | High enhancer-loading polyacrylate formulation for transdermal applications |
| WO2007095147A2 (en) * | 2006-02-13 | 2007-08-23 | Aveva Drug Delivery Systems | Adhesive preparation comprising sufentanil and methods of using the same |
| WO2007121949A1 (en) * | 2006-04-21 | 2007-11-01 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Transdermal delivery system comprising sufentanil and its analogues |
| US20070278289A1 (en) * | 2006-05-31 | 2007-12-06 | Toshiba Tec Kabushiki Kaisha | Payment adjusting apparatus and program therefor |
| US20080004671A1 (en) * | 2006-06-28 | 2008-01-03 | Alza Corporation | Vagus nerve stimulation via orally delivered apparatus |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
| FR2912643B1 (fr) * | 2007-02-15 | 2009-04-17 | Dbv Technologies Sa | Patch pour application cutanee |
| JP5192722B2 (ja) * | 2007-04-27 | 2013-05-08 | 祐徳薬品工業株式会社 | 外用貼付剤 |
| US20090010998A1 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
| AU2008283929B2 (en) | 2007-08-06 | 2013-10-10 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
| MY154027A (en) * | 2007-10-15 | 2015-04-30 | Alza Corp | Once-a-day replacement transdermal administration of fentanyl |
| FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
| CN101925355B (zh) | 2008-01-28 | 2013-05-29 | 帝国制药株式会社 | 含芬太尼的外用贴剂 |
| EP2111857A1 (de) | 2008-04-25 | 2009-10-28 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| PL2712622T3 (pl) | 2008-05-21 | 2017-01-31 | Ferring B.V. | Ulegająca rozpadowi w ustach desmopresyna do zwiększania początkowego okresu snu niezakłócanego przez nokturię |
| CN101780057B (zh) * | 2009-01-21 | 2012-09-05 | 考司美德制药株式会社 | 经皮吸收贴剂 |
| EP2457570B1 (de) | 2009-07-24 | 2018-08-22 | Teikoku Seiyaku Co., Ltd. | Fentanylhaltiges haftpräparat zur äusseren anwendung |
| EP2295046B1 (de) | 2009-09-14 | 2012-12-19 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon |
| WO2011130455A1 (en) | 2010-04-13 | 2011-10-20 | Najib Babul | Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use |
| EP2462927A1 (de) | 2010-12-03 | 2012-06-13 | Hexal AG | Transdermales therapeutisches System mit Fentanyl |
| KR20120107153A (ko) * | 2011-03-15 | 2012-10-02 | 아이큐어 주식회사 | 펜타닐 경피 패치제 |
| US20140243765A1 (en) * | 2011-09-22 | 2014-08-28 | Samyang Biopharmaceuticals Corporation | Percutaneously absorbable preparation containing fentanyl and homologue thereof |
| EP2599478A1 (de) | 2011-11-30 | 2013-06-05 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon |
| EP3169318B1 (de) | 2014-07-18 | 2020-04-01 | Buzzz Pharmaceuticals Limited | Gegen missbrauch gesichertes transdermales system |
| JP6843741B2 (ja) * | 2014-08-25 | 2021-03-17 | ヘンケル アイピー アンド ホールディング ゲゼルシャフト ミット ベシュレンクテル ハフツング | アクリル系ポリマーおよび経皮吸収型ドラッグデリバリーにおけるその使用 |
| JP6940407B2 (ja) * | 2014-12-19 | 2021-09-29 | キンデーバ ドラッグ デリバリー リミティド パートナーシップ | フェンタニルを含む経皮薬物送達デバイス |
| US10010543B1 (en) | 2014-12-23 | 2018-07-03 | Barr Laboratories, Inc. | Transdermal dosage form |
| EP3067050A1 (de) | 2015-03-13 | 2016-09-14 | Acino AG | Transdermales therapeutisches system mit einem overtape mit zwei haftschichten |
| PL3302428T3 (pl) | 2015-06-04 | 2026-04-13 | Sol-Gel Technologies Ltd. | Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie |
| US9650338B1 (en) | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
| EP3556359A4 (de) | 2016-12-19 | 2020-08-05 | Nutritape, S.L. | Energetisierungspflaster für sportler |
| IL302184B2 (en) | 2017-04-18 | 2024-12-01 | Breakthrough Tech Llc | Sulfur production |
| WO2020008366A1 (en) | 2018-07-02 | 2020-01-09 | Clexio Biosciences Ltd. | Transdermal dosage form |
| WO2020009685A1 (en) | 2018-07-02 | 2020-01-09 | John Tang | Transdermal dosage form |
| WO2020008370A1 (en) | 2018-07-02 | 2020-01-09 | Clexio Biosciences Ltd. | Transdermal patch |
| RU2712918C1 (ru) * | 2019-08-01 | 2020-02-03 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ предотвращения острой боли при выполнении химического плевродеза после радикальных торакопластических операций онкологического характера |
| CN110693857B (zh) * | 2019-10-17 | 2023-08-11 | 宜昌人福药业有限责任公司 | 一种舒芬太尼透皮贴剂及其制备方法 |
| TW202200152A (zh) | 2020-04-30 | 2022-01-01 | 泰合生技藥品股份有限公司 | 氯巴占(clobazam)經皮傳遞系統及其用途 |
| RU204475U1 (ru) * | 2020-09-24 | 2021-05-26 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова" (ФГБНУ "НИИ МТ") | Медицинский аппликатор для местного лечения кожных заболеваний |
| US11369789B2 (en) | 2021-04-05 | 2022-06-28 | Ishaan Jain | Transdermal drug delivery system |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3352708A (en) * | 1964-03-02 | 1967-11-14 | Ball Brothers Co Inc | Glass having dual protective coatings thereon and method for forming such coatings |
| US3886126A (en) * | 1973-04-09 | 1975-05-27 | Monsanto Co | Solutions of pressure-sensitive resin solutions with improved viscosity and flow |
| US3900610A (en) * | 1973-04-09 | 1975-08-19 | Monsanto Co | Process of making a pressure sensitive adhesive article |
| US4291015A (en) * | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
| JPS57142258A (en) * | 1981-02-27 | 1982-09-02 | Nitto Electric Ind Co | Drug containing tape preparation |
| US5310559A (en) * | 1982-09-01 | 1994-05-10 | Hercon Laboratories Corporation | Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer |
| US4704282A (en) * | 1984-06-29 | 1987-11-03 | Alza Corporation | Transdermal therapeutic system having improved delivery characteristics |
| US4725439A (en) * | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
| US4954343A (en) * | 1986-03-29 | 1990-09-04 | Nitto Electric Industrial Co., Ltd. | Dermal pharmaceutical preparations |
| US5560922A (en) * | 1986-05-30 | 1996-10-01 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process |
| US5344656A (en) * | 1986-09-12 | 1994-09-06 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4908027A (en) * | 1986-09-12 | 1990-03-13 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4906463A (en) * | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
| US5006342A (en) * | 1986-12-22 | 1991-04-09 | Cygnus Corporation | Resilient transdermal drug delivery device |
| AU607172B2 (en) * | 1986-12-22 | 1991-02-28 | Cygnus, Inc. | Diffusion matrix for transdermal drug administration |
| US4822802A (en) * | 1987-02-24 | 1989-04-18 | Alza Corporation | Method of fentanly administration for postoperative pain relief |
| US5186939A (en) * | 1987-04-23 | 1993-02-16 | Cygnus Therapeutic Systems | Laminated composite for transdermal administration of fentanyl |
| JPH0818975B2 (ja) * | 1987-06-08 | 1996-02-28 | 日東電工株式会社 | 疾患治療用貼付剤 |
| DE3729299A1 (de) * | 1987-09-02 | 1989-03-23 | Beiersdorf Ag | Transdermales therapeutisches system |
| US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
| US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5364630A (en) * | 1988-06-14 | 1994-11-15 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| US5004610A (en) * | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| CA2065311C (en) * | 1989-09-08 | 2000-01-11 | Chia-Ming Chiang | Solid matrix system for transdermal drug delivery |
| JP3046346B2 (ja) * | 1990-03-12 | 2000-05-29 | 昭和電工株式会社 | 外用剤基剤又は補助剤とそれを含有する人又は動物の外用剤 |
| US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| US5164190A (en) * | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| RU2056865C1 (ru) * | 1992-02-25 | 1996-03-27 | Новокузнецкий филиал Института общей реаниматологии РАМН | Способ лечения печеночной недостаточности у больных с эндо- и экзогенными токсикозами |
| DE4310012A1 (de) | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
| US5762952A (en) * | 1993-04-27 | 1998-06-09 | Hercon Laboratories Corporation | Transdermal delivery of active drugs |
| US5613958A (en) * | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
| US5554381A (en) * | 1993-08-09 | 1996-09-10 | Cygnus, Inc. | Low flux matrix system for delivering potent drugs transdermally |
| JP3688293B2 (ja) * | 1993-09-29 | 2005-08-24 | アルザ・コーポレーション | モノグリセリド/乳酸エステル透過促進剤 |
| CA2198390C (en) | 1994-09-14 | 2009-08-11 | James E. Garbe | Matrix for transdermal drug delivery |
| US5714162A (en) * | 1994-09-16 | 1998-02-03 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Scopolamine patch |
| KR100188180B1 (ko) * | 1994-12-24 | 1999-06-01 | 서경배 | 경피투여용 패취제제 |
| US6154190A (en) * | 1995-02-17 | 2000-11-28 | Kent State University | Dynamic drive methods and apparatus for a bistable liquid crystal display |
| US5882676A (en) * | 1995-05-26 | 1999-03-16 | Alza Corporation | Skin permeation enhancer compositions using acyl lactylates |
| US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
| US5693335A (en) * | 1995-06-07 | 1997-12-02 | Cygnus, Inc. | Skin permeation enhancer composition for use with sex steroids |
| US6093419A (en) * | 1995-06-07 | 2000-07-25 | Lectec Corporation | Compliance verification method and device in compulsory drug administration |
| DE19527925C2 (de) * | 1995-07-29 | 1997-07-03 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einer trennmittelbeschichteten Schutzschicht |
| US5900198A (en) * | 1996-01-31 | 1999-05-04 | Hori; Yasunori | Method of producing molded resin product |
| TW411277B (en) * | 1996-05-13 | 2000-11-11 | Hisamitsu Pharmaceutical Co | Percutaneous tape preparation containing fentanyl |
| JP3836566B2 (ja) * | 1996-05-13 | 2006-10-25 | 久光製薬株式会社 | フェンタニル含有経皮投与テープ製剤 |
| US5985317A (en) * | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
| CA2264687C (en) * | 1996-10-24 | 2006-04-25 | Alza Corporation | Permeation enhancers for transdermal drug delivery compositions, devices, and methods |
| DE19653605C2 (de) * | 1996-12-20 | 2002-11-28 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems |
| DE19653606A1 (de) * | 1996-12-20 | 1998-06-25 | Roehm Gmbh | Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher |
| US6203817B1 (en) * | 1997-02-19 | 2001-03-20 | Alza Corporation | Reduction of skin reactions caused by transdermal drug delivery |
| US5948433A (en) * | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| IT1294748B1 (it) * | 1997-09-17 | 1999-04-12 | Permatec Tech Ag | Formulazione per un dispositivo transdermico |
| US6210705B1 (en) * | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
| WO1999032153A1 (en) * | 1997-12-22 | 1999-07-01 | Alza Corporation | Monoglyceride and ethyl palmitate permeation enhancer compositions |
| KR19980025307A (ko) * | 1998-04-11 | 1998-07-06 | 조태임 | 진통효과를 갖는 약물의 경피흡수제제 |
| AU3470600A (en) * | 1999-01-14 | 2000-08-01 | David Houze | Compositions and methods for drug delivery |
| KR100674108B1 (ko) * | 1999-04-13 | 2007-01-26 | 히사미쓰 세이야꾸 가부시키가이샤 | 경피흡수형 제제 |
| IT1312198B1 (it) * | 1999-04-21 | 2002-04-09 | De Nora Spa | Cella a combustibile raffreddata mediante iniezione diretta di acqualiquida |
| US20030178031A1 (en) * | 1999-05-07 | 2003-09-25 | Du Pen, Inc. | Method for cancer pain treatment |
| KR20010036685A (ko) * | 1999-10-11 | 2001-05-07 | 김윤 | 펜타닐을 함유하는 매트릭스형 경피투여제 |
| US6383511B1 (en) * | 1999-10-25 | 2002-05-07 | Epicept Corporation | Local prevention or amelioration of pain from surgically closed wounds |
| US6455066B1 (en) * | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
| US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
| US20050208117A1 (en) * | 2001-03-16 | 2005-09-22 | Venkatraman Subramanian S | Transdermal administration of fentanyl and analogs thereof |
| ES2270746T3 (es) * | 2001-03-16 | 2007-12-01 | Alza Corporation | Parche transdermico para administrar fentanilo. |
| DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| WO2003074035A1 (de) * | 2002-03-06 | 2003-09-12 | Hexal Ag | Transdermalsystem mit fentanyl |
| JP2005526839A (ja) * | 2002-04-23 | 2005-09-08 | アルザ・コーポレーシヨン | 不正使用の可能性が低い経皮鎮痛薬システム |
| TWI296531B (en) * | 2002-10-18 | 2008-05-11 | Hisamitsu Pharmaceutical Co | Transdermal adhesive preparations for topical administration of fentanyl |
| US20040086551A1 (en) * | 2002-10-30 | 2004-05-06 | Miller Kenneth J. | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl |
| DE10252725A1 (de) * | 2002-11-13 | 2004-06-03 | Lts Lohmann Therapie-Systeme Ag | Feuchtigkeitsaktivierbare Klebstoffe für medizinische Anwendungszwecke |
| CA2543610A1 (en) * | 2003-10-30 | 2005-05-19 | Alza Corporation | Transdermal analgesic systems having reduced abuse potential |
| JP4745747B2 (ja) * | 2004-08-12 | 2011-08-10 | 日東電工株式会社 | フェンタニル含有貼付製剤 |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
-
2002
- 2002-03-15 ES ES02715112T patent/ES2270746T3/es not_active Expired - Lifetime
- 2002-03-15 KR KR1020037012086A patent/KR100904158B1/ko not_active Expired - Fee Related
- 2002-03-15 NZ NZ528148A patent/NZ528148A/en not_active IP Right Cessation
- 2002-03-15 CN CNA2009100013299A patent/CN101524339A/zh active Pending
- 2002-03-15 US US10/098,656 patent/US20030026829A1/en not_active Abandoned
- 2002-03-15 CN CNB028101049A patent/CN100508974C/zh not_active Expired - Lifetime
- 2002-03-15 AT AT02715112T patent/ATE364380T1/de active
- 2002-03-15 DE DE02715112T patent/DE02715112T1/de active Pending
- 2002-03-15 EP EP02715112A patent/EP1381352B1/de not_active Revoked
- 2002-03-15 DK DK02715112T patent/DK1381352T3/da active
- 2002-03-15 WO PCT/US2002/007701 patent/WO2002074286A1/en not_active Ceased
- 2002-03-15 DE DE20221841U patent/DE20221841U1/de not_active Expired - Lifetime
- 2002-03-15 IL IL15782202A patent/IL157822A0/xx unknown
- 2002-03-15 RU RU2003127841A patent/RU2708563C2/ru active IP Right Revival
- 2002-03-15 CZ CZ2003-2813A patent/CZ307857B6/cs not_active IP Right Cessation
- 2002-03-15 PT PT02715112T patent/PT1381352E/pt unknown
- 2002-03-15 CA CA2440884A patent/CA2440884C/en not_active Expired - Lifetime
- 2002-03-15 MX MXPA03008349A patent/MXPA03008349A/es active IP Right Grant
- 2002-03-15 DE DE60220661T patent/DE60220661T2/de not_active Expired - Lifetime
- 2002-03-15 JP JP2002572994A patent/JP5354763B2/ja not_active Expired - Lifetime
- 2002-03-15 PL PL02363079A patent/PL363079A1/xx not_active Application Discontinuation
-
2003
- 2003-09-09 IL IL157822A patent/IL157822A/en unknown
- 2003-10-15 ZA ZA200308026A patent/ZA200308026B/en unknown
-
2004
- 2004-05-21 US US10/850,865 patent/US20040213832A1/en not_active Abandoned
-
2005
- 2005-01-25 DK DK200500030U patent/DK200500030Y4/da not_active IP Right Cessation
- 2005-05-10 AT AT0031105U patent/AT8273U1/de not_active IP Right Cessation
- 2005-06-02 FI FI20050202U patent/FI6962U1/fi active IP Right Grant
-
2006
- 2006-04-26 AT AT0034606U patent/AT8585U3/de not_active IP Right Cessation
- 2006-07-11 FI FI20060295U patent/FI7341U1/fi active IP Right Grant
-
2007
- 2007-03-02 AT AT0013207U patent/AT9258U3/de not_active IP Right Cessation
- 2007-04-10 RU RU2007113373A patent/RU2351318C2/ru not_active IP Right Cessation
- 2007-08-28 CY CY20071101128T patent/CY1106834T1/el unknown
-
2008
- 2008-07-16 US US12/174,086 patent/US20090004257A1/en not_active Abandoned
-
2010
- 2010-10-12 JP JP2010229628A patent/JP2011037884A/ja active Pending
-
2012
- 2012-06-13 JP JP2012133906A patent/JP5950704B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-11 US US13/939,627 patent/US20140030316A1/en not_active Abandoned
-
2014
- 2014-06-02 US US14/293,342 patent/US20140271799A1/en not_active Abandoned
- 2014-08-08 JP JP2014162340A patent/JP2014224145A/ja not_active Withdrawn
-
2015
- 2015-12-23 IL IL243302A patent/IL243302A0/en unknown
-
2016
- 2016-07-25 US US15/219,036 patent/US20160331740A1/en not_active Abandoned
- 2016-08-29 JP JP2016166651A patent/JP6437971B2/ja not_active Expired - Lifetime
-
2017
- 2017-12-08 US US15/835,756 patent/US20180098979A1/en not_active Abandoned
-
2018
- 2018-02-09 JP JP2018021953A patent/JP2018109021A/ja active Pending
-
2019
- 2019-02-08 US US16/271,002 patent/US20190167655A1/en not_active Abandoned
- 2019-10-15 JP JP2019188324A patent/JP2020023541A/ja active Pending
- 2019-10-24 US US16/662,316 patent/US20200054619A1/en not_active Abandoned
-
2020
- 2020-05-28 US US16/885,429 patent/US20200289488A1/en not_active Abandoned
- 2020-12-21 US US17/128,293 patent/US20210113541A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT9258U2 (de) | Transdermal-pflaster zum verabreichen von fentanyl | |
| ATE498395T1 (de) | Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung | |
| DE602004017720D1 (de) | Bausatz, vorrichtung und verfahren zur gesteuerten abgabe eines oxidationsmittels in die haut | |
| DK1476141T3 (da) | Manipulationssikrede anordninger til transdermal opioidadministration | |
| DK1530469T3 (da) | Transdermal dosisform omfattende et aktivt middel og et salt og fri baseform af en antagonist | |
| ATE390142T1 (de) | Synergistische zusammensetzung zur behandlung von diabetes mellitus | |
| ATE336276T1 (de) | Vorrichtung zur manipulation von nadeln oder polierarray | |
| ATE439123T1 (de) | Verwendung von emulsionen zur intra- und periocularen injection | |
| DE60037218D1 (de) | Pflaster und Verfahren zur transdermalen Verabreichung von Bupropion als freie base | |
| DE60204229D1 (de) | Verabreichung von Rotigotine zur Behandlung der Parkinson'schen Krankheit durch Iontophorese | |
| EP1518580A3 (de) | Vorrichtung zur Bestimmung des Sedierungsniveaus eines Patienten | |
| ATE299019T1 (de) | Transdermales therapeutisches system mit einem gehalt an tulobuterol-hydrochlorid zur verabreichung des bronchodilatators tulobuterol über die haut | |
| NO20071636L (no) | Flytende allergivaksineformulering for oromukosal administrering | |
| DE10342071A1 (de) | Vorrichtung und Verfahren zur Applikation von WIrkstoffen an eine Wundoberfläche | |
| ATE228843T1 (de) | Verwendung von desoxypeganin zur behandlung von drogenabhängigkeit | |
| DE60135390D1 (de) | Verwendung von nefiracetam zur behandlung von postischemischer neurodegeneration | |
| DK1617827T3 (da) | Farmaceutisk sammensætning i form af en hydrogel til den transdermale administration af aktivstoffer | |
| EP1767183A4 (de) | Verfahren zur wiederherstellung von haaren, verfahren zur fixierung und stabilisierung eines haarmittels und bei den verfahren verwendetes haarwiederherstellungs-setzmittel | |
| DE602004029993D1 (de) | Pharmazeutische zusammensetzung zur behandlung von drogenabhängigkeit | |
| EP1691779A4 (de) | Behandlung eines zustands in einem säugetier mit verabreichung von verbindungen und anwendungsverfahren dafür | |
| DE502004002706D1 (de) | Darreichungsform zur oralen verabreichung von wirkstoffen, vitaminen und/oder nährstoffen, kit und verwendung | |
| EP1875898A3 (de) | Transdermales Pflaster zur Verabreichung von Fentanyl | |
| DE502004007972D1 (de) | Mittel zur Pflege von Geschirrspülmaschinen sowie Verfahren zu dessen Herstellung | |
| EP1339253A3 (de) | Tragbares Kommunikationsgerät und Verfahren zum Betreiben desselben | |
| ATE432716T1 (de) | Verfahren zur behandlung von hepatozellulärem karzinom |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK07 | Expiry |
Effective date: 20120331 |
|
| MN9K | Cancelled due to lapse of time |