ATA137799A - Faktor x-analogon mit verbesserter aktivierbarkeit - Google Patents

Faktor x-analogon mit verbesserter aktivierbarkeit

Info

Publication number
ATA137799A
ATA137799A AT0137799A AT137799A ATA137799A AT A137799 A ATA137799 A AT A137799A AT 0137799 A AT0137799 A AT 0137799A AT 137799 A AT137799 A AT 137799A AT A137799 A ATA137799 A AT A137799A
Authority
AT
Austria
Prior art keywords
analog
factor
improved activation
analog factor
amino acid
Prior art date
Application number
AT0137799A
Other languages
English (en)
Other versions
AT410216B (de
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Priority to AT0137799A priority Critical patent/AT410216B/de
Priority to US09/632,722 priority patent/US6958322B1/en
Priority to DE60038312T priority patent/DE60038312T2/de
Priority to AU62807/00A priority patent/AU778571B2/en
Priority to AT00949465T priority patent/ATE389013T1/de
Priority to ES00949465T priority patent/ES2302696T3/es
Priority to CA002380844A priority patent/CA2380844A1/en
Priority to PCT/EP2000/007631 priority patent/WO2001010896A2/en
Priority to EP00949465A priority patent/EP1238065B1/de
Priority to DK00949465T priority patent/DK1238065T3/da
Publication of ATA137799A publication Critical patent/ATA137799A/de
Application granted granted Critical
Publication of AT410216B publication Critical patent/AT410216B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT0137799A 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit AT410216B (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AT0137799A AT410216B (de) 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit
US09/632,722 US6958322B1 (en) 1999-08-10 2000-08-04 Factor X analog with an improved ability to be activated
AU62807/00A AU778571B2 (en) 1999-08-10 2000-08-07 Factor X analog with an improved ability to be activated
AT00949465T ATE389013T1 (de) 1999-08-10 2000-08-07 Faktor x-analoge mit verbesserter fähigkeit zur aktivierung
DE60038312T DE60038312T2 (de) 1999-08-10 2000-08-07 Faktor x-analog mit einer verbesserten fähigkeit, aktiviert zu werden
ES00949465T ES2302696T3 (es) 1999-08-10 2000-08-07 Analogo de factor x con mejor capacidad de activacion.
CA002380844A CA2380844A1 (en) 1999-08-10 2000-08-07 Factor x analog with an improved ability to be activated
PCT/EP2000/007631 WO2001010896A2 (en) 1999-08-10 2000-08-07 Factor x analog with an improved ability to be activated
EP00949465A EP1238065B1 (de) 1999-08-10 2000-08-07 Faktor x-analoge mit verbesserter fähigkeit zur aktivierung
DK00949465T DK1238065T3 (da) 1999-08-10 2000-08-07 Faktor X-analog med forbedret evne til aktivering

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0137799A AT410216B (de) 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit

Publications (2)

Publication Number Publication Date
ATA137799A true ATA137799A (de) 2002-07-15
AT410216B AT410216B (de) 2003-03-25

Family

ID=3512576

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0137799A AT410216B (de) 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit
AT00949465T ATE389013T1 (de) 1999-08-10 2000-08-07 Faktor x-analoge mit verbesserter fähigkeit zur aktivierung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00949465T ATE389013T1 (de) 1999-08-10 2000-08-07 Faktor x-analoge mit verbesserter fähigkeit zur aktivierung

Country Status (9)

Country Link
US (1) US6958322B1 (de)
EP (1) EP1238065B1 (de)
AT (2) AT410216B (de)
AU (1) AU778571B2 (de)
CA (1) CA2380844A1 (de)
DE (1) DE60038312T2 (de)
DK (1) DK1238065T3 (de)
ES (1) ES2302696T3 (de)
WO (1) WO2001010896A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040480A1 (en) * 2001-07-20 2003-02-27 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
BRPI0514396A2 (pt) * 2004-08-17 2009-05-12 Csl Behring Gmbh polipeptìdeos dependentes de vitamina k modificada
EP1728798A1 (de) * 2005-06-01 2006-12-06 ZLB Behring GmbH Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (de) * 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
PT2157177E (pt) * 2007-05-22 2013-04-18 Baxter Int Processo de purificação preparativo para a furina humana
TWI492951B (zh) 2007-12-31 2015-07-21 Baxter Int 表現人類凝血因子的基因轉殖非人類動物及其用途
WO2011017414A2 (en) 2009-08-04 2011-02-10 Baxter International Inc. Transgenic mouse lacking endogenous fviii and vwf - a model of hemophilia a
US9371522B2 (en) 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
SG11201500579SA (en) 2012-07-25 2015-02-27 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof
KR20150103205A (ko) 2013-01-31 2015-09-09 화이자 인코포레이티드 인자 Xa 억제를 길항하기 위한 조성물 및 방법
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
SG11201601221XA (en) 2013-09-24 2016-04-28 Pfizer Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
FR3050992A1 (fr) * 2016-05-06 2017-11-10 Lab Francais Du Fractionnement Mutants du facteur x

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5597799A (en) 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
EP0785273A1 (de) 1990-11-26 1997-07-23 Genetics Institute, Inc. Gepaarte basische Aminosäuren konvertierendes Enzym und dafür kodierende DNA Sequenz
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle

Also Published As

Publication number Publication date
US6958322B1 (en) 2005-10-25
AU6280700A (en) 2001-03-05
ATE389013T1 (de) 2008-03-15
AT410216B (de) 2003-03-25
CA2380844A1 (en) 2001-02-15
DK1238065T3 (da) 2008-07-07
WO2001010896A3 (en) 2002-07-11
ES2302696T3 (es) 2008-08-01
EP1238065A2 (de) 2002-09-11
WO2001010896A2 (en) 2001-02-15
AU778571B2 (en) 2004-12-09
EP1238065B1 (de) 2008-03-12
DE60038312T2 (de) 2009-03-26
DE60038312D1 (de) 2008-04-24

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Legal Events

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