DK1238065T3 - Faktor X-analog med forbedret evne til aktivering - Google Patents

Faktor X-analog med forbedret evne til aktivering

Info

Publication number
DK1238065T3
DK1238065T3 DK00949465T DK00949465T DK1238065T3 DK 1238065 T3 DK1238065 T3 DK 1238065T3 DK 00949465 T DK00949465 T DK 00949465T DK 00949465 T DK00949465 T DK 00949465T DK 1238065 T3 DK1238065 T3 DK 1238065T3
Authority
DK
Denmark
Prior art keywords
analog
factor
enhanced activation
activation capability
amino acid
Prior art date
Application number
DK00949465T
Other languages
English (en)
Inventor
Michele Himmelspach
Uwe Schlokat
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Application granted granted Critical
Publication of DK1238065T3 publication Critical patent/DK1238065T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK00949465T 1999-08-10 2000-08-07 Faktor X-analog med forbedret evne til aktivering DK1238065T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0137799A AT410216B (de) 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit
PCT/EP2000/007631 WO2001010896A2 (en) 1999-08-10 2000-08-07 Factor x analog with an improved ability to be activated

Publications (1)

Publication Number Publication Date
DK1238065T3 true DK1238065T3 (da) 2008-07-07

Family

ID=3512576

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00949465T DK1238065T3 (da) 1999-08-10 2000-08-07 Faktor X-analog med forbedret evne til aktivering

Country Status (9)

Country Link
US (1) US6958322B1 (da)
EP (1) EP1238065B1 (da)
AT (2) AT410216B (da)
AU (1) AU778571B2 (da)
CA (1) CA2380844A1 (da)
DE (1) DE60038312T2 (da)
DK (1) DK1238065T3 (da)
ES (1) ES2302696T3 (da)
WO (1) WO2001010896A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040480A1 (en) * 2001-07-20 2003-02-27 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
ATE469216T1 (de) * 2004-08-17 2010-06-15 Csl Behring Gmbh Modifizierte vitamin-k-abhängige polypeptide
EP1728798A1 (en) * 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
KR101660533B1 (ko) 2007-05-22 2016-10-10 박스알타 인코퍼레이티드 인간 푸린의 분취 정제 방법
TWI492951B (zh) * 2007-12-31 2015-07-21 Baxter Int 表現人類凝血因子的基因轉殖非人類動物及其用途
AU2010279463A1 (en) * 2009-08-04 2012-03-01 Baxter Healthcare S.A. Transgenic mouse knockout for FVIII and VWF - model of hemophilia A
JP6514893B2 (ja) 2011-09-30 2019-05-15 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ 止血を調節するための組成物および方法
MX365612B (es) 2012-07-25 2019-06-07 Catalyst Biosciences Inc Polipeptidos de factor x modificados y usos de los mismos.
EP2950813B1 (en) 2013-01-31 2019-09-04 Pfizer Inc Compositions and methods for counteracting factor xa inhibition
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
MY173548A (en) 2013-09-24 2020-02-04 Pfizer Fxa variant compositions
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
FR3050992A1 (fr) * 2016-05-06 2017-11-10 Lab Francais Du Fractionnement Mutants du facteur x

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5597799A (en) 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
JP4236698B2 (ja) 1990-11-26 2009-03-11 ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー 宿主細胞でのｐａｃｅの発現およびその使用法
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon

Also Published As

Publication number Publication date
AU6280700A (en) 2001-03-05
WO2001010896A3 (en) 2002-07-11
US6958322B1 (en) 2005-10-25
AT410216B (de) 2003-03-25
EP1238065A2 (en) 2002-09-11
AU778571B2 (en) 2004-12-09
CA2380844A1 (en) 2001-02-15
ATE389013T1 (de) 2008-03-15
DE60038312T2 (de) 2009-03-26
ATA137799A (de) 2002-07-15
EP1238065B1 (en) 2008-03-12
ES2302696T3 (es) 2008-08-01
WO2001010896A2 (en) 2001-02-15
DE60038312D1 (de) 2008-04-24

Similar Documents

Publication Publication Date Title
DK1238065T3 (da) Faktor X-analog med forbedret evne til aktivering
ATE310009T1 (de) Reaktionssysteme zur herstellung von n- (phosphonomethyl)glyzin verbindungen
HUP0300586A2 (hu) Módosított VIII-as faktor
DE60108042D1 (de) Prozesse zur Herstellung von pulverförmigen Schlagzäh-Modifizierern
ATE308550T1 (de) Verwendungen von sulfatierten fuko- oligosacchariden zum pflanzenschutz
NO994466D0 (no) Krystallinsk aminsalt av cefdinir
MY139206A (en) Pharmaceuticals compositions comprising mycophenolic acid or mycophenolate salt
HUP0001138A3 (en) Amino acids containing benzodioxane or benzoxazine, pharmaceutical compositions thereof and process for producing the same
DK0859766T3 (da) Chirale methylphenyloxazolidinoner
DE69938535D1 (de) Dampfphasenprozess zur Herstellung von Aluminid
MY129372A (en) Process to prepare oxazolidinones
ATE217889T1 (de) Humane antikörper gegen faktor ix/ixa
GB0216001D0 (en) Process and composition
DE60032894D1 (de) Verfahren zur herstellung von stadtgas
DE59709869D1 (de) Neue substanzbibliothek und damit hergestellte supramolekulare komplexe
DE50001758D1 (de) Verfahren und Anlage zur Herstellung von 1,2-Dichlorethan
MXPA02004829A (es) Metodo para la sintesis estereoselectiva de aminoacidos ciclicos.
DE69808475D1 (de) Aminosäurederivate zur behandlung von schlaganfall
DE60002254T2 (de) Verfahren zur Herstellung von 4,6-diaminoresorcin
DE19983485T1 (de) Verfahren zur Herstellung von Gasfedern
DE69812438T2 (de) Zusammensetzung zur herstellung von brennstoff-briketts
DE60103560D1 (de) Prozess zur herstellung von paclitaxel
ID27733A (id) Metoksiminofenilasetamida
PT1246790E (pt) Bases de mannich de 1- e 2-naftol substituido
ATE331733T1 (de) Metallhaltige ribonukleotidpolypeptide