ATE389013T1 - Faktor x-analoge mit verbesserter fähigkeit zur aktivierung - Google Patents
Faktor x-analoge mit verbesserter fähigkeit zur aktivierungInfo
- Publication number
- ATE389013T1 ATE389013T1 AT00949465T AT00949465T ATE389013T1 AT E389013 T1 ATE389013 T1 AT E389013T1 AT 00949465 T AT00949465 T AT 00949465T AT 00949465 T AT00949465 T AT 00949465T AT E389013 T1 ATE389013 T1 AT E389013T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- analogue
- activate
- improved capability
- analog
- Prior art date
Links
- 108010014173 Factor X Proteins 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0137799A AT410216B (de) | 1999-08-10 | 1999-08-10 | Faktor x-analogon mit verbesserter aktivierbarkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE389013T1 true ATE389013T1 (de) | 2008-03-15 |
Family
ID=3512576
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0137799A AT410216B (de) | 1999-08-10 | 1999-08-10 | Faktor x-analogon mit verbesserter aktivierbarkeit |
| AT00949465T ATE389013T1 (de) | 1999-08-10 | 2000-08-07 | Faktor x-analoge mit verbesserter fähigkeit zur aktivierung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0137799A AT410216B (de) | 1999-08-10 | 1999-08-10 | Faktor x-analogon mit verbesserter aktivierbarkeit |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6958322B1 (de) |
| EP (1) | EP1238065B1 (de) |
| AT (2) | AT410216B (de) |
| AU (1) | AU778571B2 (de) |
| CA (1) | CA2380844A1 (de) |
| DE (1) | DE60038312T2 (de) |
| DK (1) | DK1238065T3 (de) |
| ES (1) | ES2302696T3 (de) |
| WO (1) | WO2001010896A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030040480A1 (en) * | 2001-07-20 | 2003-02-27 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides |
| MX2007001294A (es) | 2004-08-17 | 2008-03-04 | Zlb Behring Gmbh | Polipeptidos modificados que dependen de vitamina k. |
| EP1728798A1 (de) | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften |
| MX2008006313A (es) | 2005-11-15 | 2008-11-06 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
| EP1820508A1 (de) * | 2006-02-21 | 2007-08-22 | CSL Behring GmbH | Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften |
| AU2008253230B2 (en) | 2007-05-22 | 2013-07-18 | Takeda Pharmaceutical Company Limited | Preparative purification process for human furin |
| TWI492951B (zh) * | 2007-12-31 | 2015-07-21 | Baxter Int | 表現人類凝血因子的基因轉殖非人類動物及其用途 |
| US20110072524A1 (en) * | 2009-08-04 | 2011-03-24 | Baxter International Inc. | Transgenic Mouse Lacking Endogenous FVIII and VWF - A Model of Hemophilia A |
| EP2760887B1 (de) | 2011-09-30 | 2024-10-23 | The Children's Hospital of Philadelphia | Zusammensetzungen und verfahren zur hämostasenmodulierung |
| US9145552B2 (en) | 2012-07-25 | 2015-09-29 | Catalyst Biosciences, Inc. | Modified factor X polypeptides and uses thereof |
| EP2950813B1 (de) | 2013-01-31 | 2019-09-04 | Pfizer Inc | Zusammensetzung und verfahren zur entgegenwirkung gegen faktor-xa-hemmung |
| FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
| JP6429885B2 (ja) | 2013-09-24 | 2018-11-28 | ファイザー・インク | 組換えヒト凝固第xa因子タンパク質の不均一集団を含む組成物 |
| US10676731B2 (en) | 2014-08-19 | 2020-06-09 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor IX function |
| FR3050992A1 (fr) * | 2016-05-06 | 2017-11-10 | Lab Francais Du Fractionnement | Mutants du facteur x |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT366916B (de) | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| US4501731A (en) | 1983-06-27 | 1985-02-26 | Tishkoff Garson H | Treatment of disparate bleeding disorders with factor X zymogen |
| AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| US5597799A (en) | 1990-09-04 | 1997-01-28 | Cor Therapeutics, Inc. | Recombinant agents affecting thrombosis |
| EP0785273A1 (de) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Gepaarte basische Aminosäuren konvertierendes Enzym und dafür kodierende DNA Sequenz |
| US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| DE4325872C1 (de) | 1993-08-02 | 1994-08-04 | Immuno Ag | Virusinaktivierte Faktor Xa-Präparation |
| AT401270B (de) | 1994-09-26 | 1996-07-25 | Immuno Ag | Verfahren zur quantifizierung von genomischer dna |
| AT404838B (de) | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
| AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
| AT405517B (de) | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-deletionsmutanten und analoge davon |
-
1999
- 1999-08-10 AT AT0137799A patent/AT410216B/de not_active IP Right Cessation
-
2000
- 2000-08-04 US US09/632,722 patent/US6958322B1/en not_active Expired - Lifetime
- 2000-08-07 AU AU62807/00A patent/AU778571B2/en not_active Ceased
- 2000-08-07 WO PCT/EP2000/007631 patent/WO2001010896A2/en not_active Ceased
- 2000-08-07 AT AT00949465T patent/ATE389013T1/de active
- 2000-08-07 CA CA002380844A patent/CA2380844A1/en not_active Abandoned
- 2000-08-07 DK DK00949465T patent/DK1238065T3/da active
- 2000-08-07 ES ES00949465T patent/ES2302696T3/es not_active Expired - Lifetime
- 2000-08-07 EP EP00949465A patent/EP1238065B1/de not_active Expired - Lifetime
- 2000-08-07 DE DE60038312T patent/DE60038312T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AT410216B (de) | 2003-03-25 |
| ES2302696T3 (es) | 2008-08-01 |
| DE60038312D1 (de) | 2008-04-24 |
| EP1238065A2 (de) | 2002-09-11 |
| US6958322B1 (en) | 2005-10-25 |
| DE60038312T2 (de) | 2009-03-26 |
| WO2001010896A3 (en) | 2002-07-11 |
| ATA137799A (de) | 2002-07-15 |
| AU6280700A (en) | 2001-03-05 |
| CA2380844A1 (en) | 2001-02-15 |
| EP1238065B1 (de) | 2008-03-12 |
| AU778571B2 (en) | 2004-12-09 |
| DK1238065T3 (da) | 2008-07-07 |
| WO2001010896A2 (en) | 2001-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE389013T1 (de) | Faktor x-analoge mit verbesserter fähigkeit zur aktivierung | |
| DE60114002D1 (de) | VERFAHREN ZUR HERSTELLUNG KRISTALLINEr PARTIKEL ZUR INHALATION | |
| DE69908998D1 (de) | Verfahren zur Herstellung von Kohlenstoff | |
| DE60006298D1 (de) | Verfahren zur Herstellung von Kohlendioxid | |
| ATE310009T1 (de) | Reaktionssysteme zur herstellung von n- (phosphonomethyl)glyzin verbindungen | |
| DE60230274D1 (de) | Verfahren zur herstellung von l-aminosäuren durch enterobacteriaceae-stämmen mit verstärkter expression des pts-g | |
| DE69835357D1 (de) | Verfahren zur Herstellung von Synthesegas | |
| DE69909003D1 (de) | Verfahren zur Herstellung von Polyamiden | |
| DE60108042D1 (de) | Prozesse zur Herstellung von pulverförmigen Schlagzäh-Modifizierern | |
| EP1349693A4 (de) | Elektrochemisches bearbeiten zur herstellung von nuten | |
| DE69429023D1 (de) | Vorrichtung zur Herstellung von Stempeln | |
| DE60323994D1 (de) | Verfahren zur herstellung von 2-chlor-1,1,1,2,3,3,3-heptafluorpropan, hexafluorpropen und 1,1,1,2,3,3,3-heptafluorpropan | |
| DE50015943D1 (de) | Verfahren zur Herstellung von Düngemittelpressgranulaten | |
| DE60239842D1 (de) | Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid | |
| DE50001758D1 (de) | Verfahren und Anlage zur Herstellung von 1,2-Dichlorethan | |
| DE60100217D1 (de) | Verfahren zur Herstellung von hochkonzentrierten Kohlendioxid | |
| DE69725580D1 (de) | Prozess zur herstellung von aza zyclohexapeptide | |
| ATE414156T1 (de) | Lipase-varianten | |
| DE59902109D1 (de) | Gaskarburierungsverfahren zur Herstellung von reinem WC-Pulver | |
| DE69822711D1 (de) | Verfarhen zur Herstellung von Dialkylnaphthalinen | |
| DE60239085D1 (de) | Prozess zur Herstellung von E-Caprolactam | |
| DE59506870D1 (de) | Verfahren zur Herstellung von Polyamiden auf Basis von alpha,omega-Dinitrilen | |
| DE69916332D1 (de) | Verfahren zur herstellung von etheraminalkoxylaten | |
| DE69812438T2 (de) | Zusammensetzung zur herstellung von brennstoff-briketts | |
| DE19983485T1 (de) | Verfahren zur Herstellung von Gasfedern |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1238065 Country of ref document: EP |