ATA19192A - Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure - Google Patents

Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure

Info

Publication number: ATA19192A
Authority: AT; Austria
Prior art keywords: salt; opt; solvent; mixt; reduced
Prior art date: 1992-02-05

Application number

AT0019192A

Other languages

English (en)

Other versions

AT399876B (de

Inventor

Hans Dr Ludescher

Siegfried Wolf

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-05

Filing date

1992-02-05

Publication date

1994-12-15

1992-02-05 Priority to AT0019192A priority Critical patent/AT399876B/de

1992-02-05 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

1992-12-21 Priority to KR1019940702673A priority patent/KR950700311A/ko

1992-12-21 Priority to AT93901714T priority patent/ATE205214T1/de

1992-12-21 Priority to ES00111498T priority patent/ES2208181T3/es

1992-12-21 Priority to EP01104309A priority patent/EP1103555B1/de

1992-12-21 Priority to EP93901714A priority patent/EP0630380B1/de

1992-12-21 Priority to DE69233249T priority patent/DE69233249T2/de

1992-12-21 Priority to ES93901714T priority patent/ES2162812T3/es

1992-12-21 Priority to CA002124322A priority patent/CA2124322C/en

1992-12-21 Priority to AT01104309T priority patent/ATE253583T1/de

1992-12-21 Priority to DK93901714T priority patent/DK0630380T3/da

1992-12-21 Priority to SG1996009496A priority patent/SG48415A1/en

1992-12-21 Priority to PT93901714T priority patent/PT630380E/pt

1992-12-21 Priority to DE69232048T priority patent/DE69232048T2/de

1992-12-21 Priority to PCT/EP1992/002965 priority patent/WO1993016084A1/en

1992-12-21 Priority to AT00111498T priority patent/ATE250614T1/de

1992-12-21 Priority to JP5513698A priority patent/JP2825655B2/ja

1992-12-21 Priority to DE69233221T priority patent/DE69233221T2/de

1992-12-21 Priority to ES01104309T priority patent/ES2210047T3/es

1992-12-21 Priority to EP00111498A priority patent/EP1029864B1/de

1992-12-29 Priority to TW081110453A priority patent/TW230775B/zh

1994-08-04 Priority to KR940702673A priority patent/KR100303862B1/ko

1994-12-15 Publication of ATA19192A publication Critical patent/ATA19192A/de

1995-06-06 Priority to US08/466,306 priority patent/US5869648A/en

1995-08-25 Application granted granted Critical

1995-08-25 Publication of AT399876B publication Critical patent/AT399876B/de

1998-11-12 Priority to US09/190,200 priority patent/US6136967A/en

2000-05-04 Priority to US09/564,833 priority patent/US6333409B1/en

2001-10-23 Priority to GR20010401855T priority patent/GR3036985T3/el

Links

150000003839 salts Chemical class 0.000 abstract 6
239000002904 solvent Substances 0.000 abstract 6
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 2
150000003840 hydrochlorides Chemical class 0.000 abstract 2
230000001376 precipitating effect Effects 0.000 abstract 2
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)

AT0019192A 1992-02-05 1992-02-05 Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure AT399876B (de)

Priority Applications (26)

Application Number	Priority Date	Filing Date	Title
AT0019192A AT399876B (de)	1992-02-05	1992-02-05	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
DE69232048T DE69232048T2 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung eines 3-cephem-4-carboxyl säure derivates
ES00111498T ES2208181T3 (es)	1992-02-05	1992-12-21	Procedimiento para la purificacion de un derivado de acido 3-cefem-4-carboxilico.
EP01104309A EP1103555B1 (de)	1992-02-05	1992-12-21	Verfahren zur Herstellung von einem 3-Cephem-4-Carbonsäurederivat
AT00111498T ATE250614T1 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat
DE69233249T DE69233249T2 (de)	1992-02-05	1992-12-21	Verfahren zur Herstellung von einem 3-Cephem-4-Carbonsäurederivat
ES93901714T ES2162812T3 (es)	1992-02-05	1992-12-21	Procedimiento para la purificacion de un derivado de acido 3-cefem-4-carboxilico.
CA002124322A CA2124322C (en)	1992-02-05	1992-12-21	Process for the purification of a 3-cephem-4-carboxylic acid derivative
AT01104309T ATE253583T1 (de)	1992-02-05	1992-12-21	Verfahren zur herstellung von einem 3-cephem-4- carbonsäurederivat
DK93901714T DK0630380T3 (da)	1992-02-05	1992-12-21	Fremgangsmåde til rensning af et 3-cephem-4-carboxylsyrederivat
SG1996009496A SG48415A1 (en)	1992-02-05	1992-12-21	Process for the purification of a 3-cephem-4-carboxylic acid derivative
PT93901714T PT630380E (pt)	1992-02-05	1992-12-21	Processo para a purificacao de um derivado do acido 3-cefem-4-carboxilico
KR1019940702673A KR950700311A (ko)	1992-02-05	1992-12-21	3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives)
PCT/EP1992/002965 WO1993016084A1 (en)	1992-02-05	1992-12-21	Process for the purification of a 3-cephem-4-carboxylic acid derivative
EP93901714A EP0630380B1 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung eines 3-cephem-4-carboxyl säure derivates
JP5513698A JP2825655B2 (ja)	1992-02-05	1992-12-21	３−セフェム−４−カルボン酸誘導体の精製方法
DE69233221T DE69233221T2 (de)	1992-02-05	1992-12-21	Verfahren zur Reinigung von einem 3-Cephem-4- Carbonsäurederivat
ES01104309T ES2210047T3 (es)	1992-02-05	1992-12-21	Procedimiento para la produccion de un derivado de acido 3-cefem-4-carboxilico.
EP00111498A EP1029864B1 (de)	1992-02-05	1992-12-21	Verfahren zur Reinigung von einem 3-Cephem-4- Carbonsäurederivat
AT93901714T ATE205214T1 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung eines 3-cephem-4-carboxyl säure derivates
TW081110453A TW230775B (de)	1992-02-05	1992-12-29
KR940702673A KR100303862B1 (de)	1992-02-05	1994-08-04
US08/466,306 US5869648A (en)	1992-02-05	1995-06-06	Process for the purification of a 3-cephem-4-carboxylic acid derivative
US09/190,200 US6136967A (en)	1992-02-05	1998-11-12	Process for the purification of a 3-cephem-4-carboxylic acid derivative
US09/564,833 US6333409B1 (en)	1992-02-05	2000-05-04	Process for the purification of a 3-cephem-4-carboxylic acid derivative
GR20010401855T GR3036985T3 (en)	1992-02-05	2001-10-23	Process for the purification of a 3-cephem-4-carboxylic acid derivative.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0019192A AT399876B (de)	1992-02-05	1992-02-05	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure

Publications (2)

Publication Number	Publication Date
ATA19192A true ATA19192A (de)	1994-12-15
AT399876B AT399876B (de)	1995-08-25

Family

ID=3483900

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0019192A AT399876B (de)	1992-02-05	1992-02-05	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
AT00111498T ATE250614T1 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT00111498T ATE250614T1 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat

Country Status (5)

Country	Link
EP (1)	EP1029864B1 (de)
KR (1)	KR100303862B1 (de)
AT (2)	AT399876B (de)
DE (1)	DE69233221T2 (de)
ES (1)	ES2208181T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105001238B (zh) *	2015-07-21	2017-10-20	河北九天生物制品有限公司	制头孢丙烯母核7‑氨基‑3‑丙烯基头孢烷酸的方法
CN107011364B (zh) *	2017-05-26	2019-07-23	湖北凌晟药业有限公司	E型7-氨基-3-丙烯基-4-头孢烷酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2580652B1 (fr) *	1985-04-22	1989-01-06	Bristol Myers Co	Acide 7-amino-3-propenylcephalosporanique et ses esters
US4694079A (en) *	1985-07-29	1987-09-15	Bristol-Myers Company	3-propenyl cephalosporin solvates
DE3734005A1 (de) *	1987-05-26	1988-12-15	Bayer Ag	Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0503453B1 (de) *	1991-03-08	2001-05-09	Biochemie Gesellschaft M.B.H.	Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren

1992
- 1992-02-05 AT AT0019192A patent/AT399876B/de active
- 1992-12-21 AT AT00111498T patent/ATE250614T1/de not_active IP Right Cessation
- 1992-12-21 EP EP00111498A patent/EP1029864B1/de not_active Expired - Lifetime
- 1992-12-21 DE DE69233221T patent/DE69233221T2/de not_active Expired - Fee Related
- 1992-12-21 ES ES00111498T patent/ES2208181T3/es not_active Expired - Lifetime
1994
- 1994-08-04 KR KR940702673A patent/KR100303862B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1029864A1 (de)	2000-08-23
KR100303862B1 (de)	2001-11-22
ES2208181T3 (es)	2004-06-16
AT399876B (de)	1995-08-25
ATE250614T1 (de)	2003-10-15
EP1029864B1 (de)	2003-09-24
DE69233221T2 (de)	2004-07-15
DE69233221D1 (de)	2003-10-30

Publication	Publication Date	Title
PL315169A1 (en)	1996-10-14	Tetrahydrofuranic antimycotic agents
BR9302065A (pt)	1994-07-26	Processo para a preparação de um composto
BR9406613A (pt)	1996-02-06	Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica
ATE501154T1 (de)	2011-03-15	Ein cefdinir-zwischenprodukt
EP1279665A3 (de)	2003-03-12	Ein Verfahren zur Herstellung von Perindopril, analogen Verbindungen dazu sowie Salzen davon unter Verwendung von 2,5-Dioxooxazolidin-Zwischenprodukten
BR9913670B1 (pt)	2010-09-08	processo para a preparação de um sal de um composto de ácido carboxìlico alifático.
NZ511503A (en)	2002-11-26	Manufacture of clevidipine by reacting an inorganic salt of a carboxylic acid with choromethyl butyrate
MXPA01013104A (es)	2003-07-14	Metodo para producir sales de esteres alcaloides acidos sulfograsos.
DK0658558T3 (da)	2001-04-17	Adskillelse af cephalosporinisomere
ATA19192A (de)	1994-12-15	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
EP0636600A4 (de)	1995-07-05	Verfahren zur reinigung aromatischer dicarbonsäuren.
BR9909898A (pt)	2000-12-26	Processo para purificação de um derivado de cefalosporina
DE50113398D1 (de)	2008-01-31	Verfahren zur herstellung von n-methyl-n'-nitroguanidin
EP1010701A4 (de)	2001-07-11	Verfahren zur herstellung von 3-cephemderivaten
AT399877B (de)	1995-08-25	Neues verfahren zur herstellung von ceftriaxon
AU2307297A (en)	1997-11-07	Production of 7-aminocephalosporanic acid derivative
BR0016668A (pt)	2002-10-08	Processo para a preparação de n-fosfonometilglicina, processo para a preparação de um composto fosfono, composto fosfono, e, intermediário
CA2072927A1 (fr)	1993-01-03	Procede de fabrication d'acrylates .alpha. fluores
EP1238644A4 (de)	2006-04-05	Stabilisatoren für l-ascorbinsäure-2-natriumphosphat
EP1211239A4 (de)	2003-08-06	Verfahren zur herstellung von 2,3-dihydroazepin-derivaten
DK0513055T3 (da)	1995-02-13	Fremgangsmåde til omsætning af en lavmolekylær hydroxyforbindelse med et carboxylsyrehalogenid
WO2002053091A3 (fr)	2004-06-10	Association medicamenteuse d'une biguanine (metformine) et d'arginine
DE60101391D1 (de)	2004-01-22	Verfahren zum Herstellen von Pivaloylessigsäureester
PT837066E (pt)	2004-01-30	Processo aperfeicoado para a producao de ester de penicilina g
EP0060301A4 (de)	1983-09-02	Verfahren zur herstellung von cephalosporinverbindungen.