ATE250614T1 - Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat - Google Patents

Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat

Info

Publication number: ATE250614T1
Authority: AT; Austria
Prior art keywords: salt; opt; solvent; mixt; reduced
Prior art date: 1992-02-05

Application number

AT00111498T

Other languages

English (en)

Inventor

Johannes Ludescher

Bernhard Prager

Siegfried Wolf

Original Assignee

Biochemie Gesmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-05

Filing date

1992-12-21

Publication date

2003-10-15

1992-12-21 Application filed by Biochemie Gesmbh filed Critical Biochemie Gesmbh

1992-12-21 Priority claimed from PCT/EP1992/002965 external-priority patent/WO1993016084A1/en

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250614T1 publication Critical patent/ATE250614T1/de

Links

IKWLIQXIPRUIDU-ZCFIWIBFSA-N (6r)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class OC(=O)C1=CCS[C@@H]2CC(=O)N12 IKWLIQXIPRUIDU-ZCFIWIBFSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 6
239000002904 solvent Substances 0.000 abstract 6
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 2
150000003840 hydrochlorides Chemical class 0.000 abstract 2
230000001376 precipitating effect Effects 0.000 abstract 2
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)

AT00111498T 1992-02-05 1992-12-21 Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat ATE250614T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AT0019192A AT399876B (de)	1992-02-05	1992-02-05	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
PCT/EP1992/002965 WO1993016084A1 (en)	1992-02-05	1992-12-21	Process for the purification of a 3-cephem-4-carboxylic acid derivative

Publications (1)

Publication Number	Publication Date
ATE250614T1 true ATE250614T1 (de)	2003-10-15

Family

ID=3483900

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT0019192A AT399876B (de)	1992-02-05	1992-02-05	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
AT00111498T ATE250614T1 (de)	1992-02-05	1992-12-21	Verfahren zur reinigung von einem 3-cephem-4- carbonsäurederivat

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT0019192A AT399876B (de)	1992-02-05	1992-02-05	Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure

Country Status (5)

Country	Link
EP (1)	EP1029864B1 (de)
KR (1)	KR100303862B1 (de)
AT (2)	AT399876B (de)
DE (1)	DE69233221T2 (de)
ES (1)	ES2208181T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105001238B (zh) *	2015-07-21	2017-10-20	河北九天生物制品有限公司	制头孢丙烯母核7‑氨基‑3‑丙烯基头孢烷酸的方法
CN107011364B (zh) *	2017-05-26	2019-07-23	湖北凌晟药业有限公司	E型7-氨基-3-丙烯基-4-头孢烷酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2580652B1 (fr) *	1985-04-22	1989-01-06	Bristol Myers Co	Acide 7-amino-3-propenylcephalosporanique et ses esters
US4694079A (en) *	1985-07-29	1987-09-15	Bristol-Myers Company	3-propenyl cephalosporin solvates
DE3734005A1 (de) *	1987-05-26	1988-12-15	Bayer Ag	Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0503453B1 (de) *	1991-03-08	2001-05-09	Biochemie Gesellschaft M.B.H.	Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren

1992
- 1992-02-05 AT AT0019192A patent/AT399876B/de active
- 1992-12-21 AT AT00111498T patent/ATE250614T1/de not_active IP Right Cessation
- 1992-12-21 EP EP00111498A patent/EP1029864B1/de not_active Expired - Lifetime
- 1992-12-21 DE DE69233221T patent/DE69233221T2/de not_active Expired - Fee Related
- 1992-12-21 ES ES00111498T patent/ES2208181T3/es not_active Expired - Lifetime
1994
- 1994-08-04 KR KR940702673A patent/KR100303862B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1029864A1 (de)	2000-08-23
ATA19192A (de)	1994-12-15
KR100303862B1 (de)	2001-11-22
ES2208181T3 (es)	2004-06-16
AT399876B (de)	1995-08-25
EP1029864B1 (de)	2003-09-24
DE69233221T2 (de)	2004-07-15
DE69233221D1 (de)	2003-10-30

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Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties